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Journal Articles

Repurposing a novel anti-cancer RXR agonist to attenuate murine acute GVHD and maintain graft-versus-leukemia responses

Govindarajan Thangavelu, Chao Wang, Michael Loschi, Asim Saha, Mark J. Osborn, Scott N. Furlan, Kazutoshi Aoyama, Cameron McDonald-Hyman, Ethan G. Aguilar, Amanda S. Janesick, Roshantha A. Chandraratna, Yosef Refaeli, Angela Panoskaltsis-Mortari, Kelli P. MacDonald, Geoffrey R. Hill, Robert Zeiser, Ivan Maillard, Jonathan S. Serody, William J. Murphy, David H. Munn, Bruce Blumberg, Chrysothemis Brown, Vijay Kuchroo, Leslie S. Kean, Keli L. Hippen, Randolph J. Noelle, Bruce R. Blazar
Journal: Blood
Blood (2021) 137 (8): 1090–1103.
https://doi.org/10.1182/blood.2020005628
Published: 2021
Includes: Supplemental data
Journal Articles

Inhibition of inositol kinase B controls acute and chronic graft-versus-host disease

Govindarajan Thangavelu, Jing Du, Katelyn G. Paz, Michael Loschi, Michael C. Zaiken, Ryan Flynn, Patricia A. Taylor, Andrew Kemal Kirchmeier, Angela Panoskaltsis-Mortari, Leo Luznik, Kelli P. MacDonald, Geoffrey R. Hill, Ivan Maillard, David H. Munn, Jonathan S. Serody, William J. Murphy, David Miklos, Corey S. Cutler, John Koreth, Joseph H. Antin, Robert J. Soiffer, Jerome Ritz, Carol Dahlberg, Andrew T. Miller, Bruce R. Blazar
Journal: Blood
Blood (2020) 135 (1): 28–40.
https://doi.org/10.1182/blood.2019000032
Published: 2020
Includes: Supplemental data
Journal Articles

Small-molecule BCL6 inhibitor effectively treats mice with nonsclerodermatous chronic graft-versus-host disease

Brief Report
Katelyn Paz, Ryan Flynn, Jing Du, Jun Qi, Leo Luznik, Ivan Maillard, Kelli P. MacDonald, Geoffrey R. Hill, Jonathan S. Serody, William J. Murphy, Peter T. Sage, Arlene H. Sharpe, David Miklos, Corey S. Cutler, John Koreth, Joseph H. Antin, Robert J. Soiffer, Jerome Ritz, James E. Bradner, Ari M. Melnick, Bruce R. Blazar
Journal: Blood
Blood (2019) 133 (1): 94–99.
https://doi.org/10.1182/blood-2018-03-839993
Published: 2019
Journal Articles

Self-repopulating recipient bone marrow resident macrophages promote long-term hematopoietic stem cell engraftment

Simranpreet Kaur, Liza J. Raggatt, Susan M. Millard, Andy C. Wu, Lena Batoon, Rebecca N. Jacobsen, Ingrid G. Winkler, Kelli P. MacDonald, Andrew C. Perkins, David A. Hume, Jean-Pierre Levesque, Allison R. Pettit
Journal: Blood
Blood (2018) 132 (7): 735–749.
https://doi.org/10.1182/blood-2018-01-829663
Published: 2018
Includes: Supplemental data
Journal Articles

Pirfenidone ameliorates murine chronic GVHD through inhibition of macrophage infiltration and TGF-β production

Jing Du, Katelyn Paz, Ryan Flynn, Ante Vulic, Tara M. Robinson, Katie E. Lineburg, Kylie A. Alexander, Jingjing Meng, Sabita Roy, Angela Panoskaltsis-Mortari, Michael Loschi, Geoffrey R. Hill, Jonathan S. Serody, Ivan Maillard, David Miklos, John Koreth, Corey S. Cutler, Joseph H. Antin, Jerome Ritz, Kelli P. MacDonald, Timothy W. Schacker, Leo Luznik, Bruce R. Blazar
Journal: Blood
Blood (2017) 129 (18): 2570–2580.
https://doi.org/10.1182/blood-2017-01-758854
Published: 2017
Includes: Supplemental data
Journal Articles

Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism

Ryan Flynn, Katelyn Paz, Jing Du, Dawn K. Reichenbach, Patricia A. Taylor, Angela Panoskaltsis-Mortari, Ante Vulic, Leo Luznik, Kelli K. P. MacDonald, Geoffrey R. Hill, Melanie S. Nyuydzefe, Jonathan M. Weiss, Wei Chen, Alissa Trzeciak, Jon S. Serody, Ethan G. Aguilar, William J. Murphy, Ivan Maillard, David Munn, John Koreth, Corey S. Cutler, Joseph H. Antin, Jerome Ritz, Samuel D. Waksal, Alexandra Zanin-Zhorov, Bruce R. Blazar
Journal: Blood
Blood (2016) 127 (17): 2144–2154.
https://doi.org/10.1182/blood-2015-10-678706
Published: 2016
Includes: Supplemental data
Journal Articles

Targeting Syk-activated B cells in murine and human chronic graft-versus-host disease

Ryan Flynn, Jessica L. Allen, Leo Luznik, Kelli P. MacDonald, Katelyn Paz, Kylie A. Alexander, Ante Vulic, Jing Du, Angela Panoskaltsis-Mortari, Patricia A. Taylor, Jonathan C. Poe, Jonathan S. Serody, William J. Murphy, Geoffrey R. Hill, Ivan Maillard, John Koreth, Corey S. Cutler, Robert J. Soiffer, Joseph H. Antin, Jerome Ritz, Nelson J. Chao, Raphael A. Clynes, Stefanie Sarantopoulos, Bruce R. Blazar
Journal: Blood
Blood (2015) 125 (26): 4085–4094.
https://doi.org/10.1182/blood-2014-08-595470
Published: 2015
Includes: Supplemental data
Journal Articles

Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans

Ryan Flynn, Jing Du, Rachelle G. Veenstra, Dawn K. Reichenbach, Angela Panoskaltsis-Mortari, Patricia A. Taylor, Gordon J. Freeman, Jonathan S. Serody, William J. Murphy, David H. Munn, Stefanie Sarantopoulos, Leo Luznik, Ivan Maillard, John Koreth, Corey Cutler, Robert J. Soiffer, Joseph H. Antin, Jerome Ritz, Jason A. Dubovsky, John C. Byrd, Kelli P. MacDonald, Geoff R. Hill, Bruce R. Blazar
Journal: Blood
Blood (2014) 123 (25): 3988–3998.
https://doi.org/10.1182/blood-2014-03-562231
Published: 2014
Includes: Supplemental data
Journal Articles

Host B cells produce IL-10 following TBI and attenuate acute GVHD after allogeneic bone marrow transplantation

Vanessa Rowe, Tatjana Banovic, Kelli P. MacDonald, Rachel Kuns, Alistair L. Don, Edward S. Morris, Angela C. Burman, Helen M. Bofinger, Andrew D. Clouston, Geoffrey R. Hill
Journal: Blood
Blood (2006) 108 (7): 2485–2492.
https://doi.org/10.1182/blood-2006-04-016063
Published: 2006
Journal Articles

The identification and characterization of a novel human differentiation-inhibiting protein that selectively blocks erythroid differentiation

JP Durkin, JM Biquard, JF Whitfield, N Morardet, J Royer, P Macdonald, R Tremblay, JD Legal, R Doyonnas, JP Blanchet
Journal: Blood
Blood (1992) 79 (5): 1161–1171.
https://doi.org/10.1182/blood.V79.5.1161.1161
Published: 1992