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Monique L. Den Boer, PhD
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Journal Articles

A Phase II Study of Single-Agent Inotuzumab Ozogamicin in Pediatric CD22-Positive Relapsed/Refractory Acute Lymphoblastic Leukemia: Results of the ITCC-059 Study

Erica Brivio, MD, Franco Locatelli, MD, Adriana Thano, Arnaud Petit, MD PhD, Britta Julia Vormoor, MD, Susana Rives, Bella Bielorai, MD, Claudia Rossig, Carmelo Rizzari, Vincent H.J. Van Der Velden, PhD, Anneke C.J. Ammerlaan, Monique L. Den Boer, PhD, Barbara Sleight, MD, Gernot Engstler, Jan Stary, MD PhD, Francisco José Bautista Sirvent, MD PhD, Christiane Chen-Santel, Bénédicte Bruno, MD, Yves Bertrand, MD, Fanny Rialland, MD, Geneviève Plat, Dirk Reinhardt, MD, Luciana Vinti, MD, Arend von Stackelberg, MD, Christian Michel Zwaan
Journal: Blood
Blood (2020) 136 (Supplement 1): 8–9.
https://doi.org/10.1182/blood-2020-134774
Published: 2020
Journal Articles

B-Cell Precursor Acute Lymphoblastic Leukemia Instructs Mesenchymal Stromal Cells to Alter Interferon-Related Gene Expression and Cyto/Chemokine Secretion

Mandy W.E. Smeets, Femke Stalpers, BSc, Myrthe M.P. Vermeeren, BSc, Alex Q. Hoogkamer, BSc, Stefan Nierkens, PhD, Cesca Van De Ven, PhD, Monique L. Den Boer, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 4.
https://doi.org/10.1182/blood-2020-134649
Published: 2020
Journal Articles

NUTM1 -Rearranged Infant and Pediatric B Cell Precursor Acute Lymphoblastic Leukemia: A Good Prognostic Subtype Identified in a Collaborative International Study

Judith M. Boer, PhD, Maria Grazia Valsecchi, PhD, Femke M. Hormann, MSc, Zeljko Antic, MD, Marketa Zaliova, MD PhD, Claire Schwab, PhD, Giovanni Cazzaniga, PhD, Chloé Arfeuille, MD, Hélène Cavé, PharmD, PhD, Andishe Attarbaschi, MD, Sabine Strehl, PhD, Gabriele Escherich, MD, Toshihiko Imamura, MD PhD, Kentaro Ohki, MD PhD, Tanja A. Gruber, MD PhD, Rosemary Sutton, BSc MSc PhD, Agata Pastorczak, Tim Lammens, PhD, Frederic Lambert, MD, Chi Kong Li, MD, Enrique Carrillo de Santa Pau, PhD, Steve Hoffmann, MD PhD, Anja Möricke, MD, Christine J. Harrison, PhD FRCPath, Monique L. Den Boer, PhD, Paola De Lorenzo, Ronald W. Stam, PhD, Anke K. Bergmann, MD PhD, Rob Pieters, MDPhDMSc
Journal: Blood
Blood (2020) 136 (Supplement 1): 25–26.
https://doi.org/10.1182/blood-2020-139376
Published: 2020
Journal Articles

A Phase I Study of Single-Agent Inotuzumab Ozogamicin in Pediatric CD22-Positive Relapsed/Refractory Acute Lymphoblastic Leukemia: Preliminary Results of the ITCC-059 Study

Erica Brivio, MD, Marta Lopez-Yurda, PhD, Cormac Ownes, MD, Cristina Díaz de Heredia, MD PhD, Bella Bielorai, MD, Claudia Rossig, Vincent van der Velden, PhD, Anneke C.J. Ammerlaan, Inge M. van der Sluis, MD PhD, Monique L. Den Boer, PhD, Ying Chen, Barbara Sleight, MD, Benoit Brethon, MD, Karsten Nysom, Jan Stary, Prof., MD PhD, Ingrid Øra, Christiane Chen-Santel, Luciana Vinti, MD, Franco Locatelli, MD PhD, Christian Michel Zwaan, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2629.
https://doi.org/10.1182/blood-2019-122411
Published: 2019
Journal Articles

Minimal Residual Disease and IKZF1 As Predictors of Relapse, and Increased Treatment Related Mortality in Down Syndrome Acute Lymphoblastic Leukemia: A Unique and Large International Matched Case-Control Study

Naomi Michels, BSc, Judith M. Boer, PhD, Marta Lopez-Yurda, PhD, Hester A. De Groot-Kruseman, PhD, Vincent van der Velden, PhD, Anthony V. Moorman, Amir Enshaei, PhD, Ajay Vora, Rosemary Sutton, BSc MSc PhD, Toby Trahair, PhD, Luciano Dalla-Pozza, MBBS FRACP, Rob Pieters, MDPhDMSc, Michel C Zwaan, MD PhD, Monique L. Den Boer, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 827.
https://doi.org/10.1182/blood-2019-124290
Published: 2019
Journal Articles

NUTM1 Is a Rare but Recurrent Fusion Gene Partner in B Cell Precursor Acute Lymphoblastic Leukemia Associated with Increased Expression of Genes on Cytoband 10p12.31

Femke M. Hormann, MSc, Alex Q. Hoogkamer, BSc, H. Berna Beverloo, PhD, Aurélie Boeree, BSc, Ronald W. Stam, PhD, Gabriele Escherich, Rob Pieters, MD PhD MSc, Monique L. Den Boer, PhD, Judith M. Boer, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2823.
https://doi.org/10.1182/blood-2018-99-112480
Published: 2018
Journal Articles

High PDGFRA Expression Does Not Serve As Effective Therapeutic Target in ERG -Deleted B-Cell Precursor Acute Lymphoblastic Leukemia

Isabel S. Jerchel, MSc, Judith M. Boer, PhD, Alex Q. Hoogkamer, BSc, H. Berna Beverloo, PhD, Rob Pieters, MD PhD, Monique L. den Boer, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1274.
https://doi.org/10.1182/blood.V130.Suppl_1.1274.1274
Published: 2017
Journal Articles

JAK2 Aberrations in Childhood B-Cell Precursor Acute Lymphoblastic Leukemia

Elisabeth M.P. Steeghs, MSc, Isabel S. Jerchel, MSc, Willemieke de Goffau-Nobel, MSc, Alex Q. Hoogkamer, BSc, Judith M. Boer, PhD, Aurélie Boeree, BSc, Cesca van de Ven, PhD, Marco J. Koudijs, PhD, Nicolle J.M. Besselink, BSc, Hester A. de Groot-Kruseman, PhD, C. Michel Zwaan, MD PhD, Martin A. Horstmann, MD, Rob Pieters, MD PhD, Monique L. Den Boer, PhD
Journal: Blood
Blood (2016) 128 (22): 583.
https://doi.org/10.1182/blood.V128.22.583.583
Published: 2016
Journal Articles

Targeted Locus Amplification & Next Generation Sequencing for the Detection of Recurrent and Novel Gene Fusions for Improved Treatment Decisions in Pediatric Acute Lymphoblastic Leukemia

Roland P. Kuiper, PhD, Simon V. van Reijmersdal, Marieke Simonis, PhD, Jiangyan Yu, MSc, Edwin Sonneveld, PhD, Blanca Scheijen, PhD, Judith M. Boer, PhD, Aurélie Boeree, BSc, Petra Klous, MSc, Peter M Hoogerbrugge, MD PhD, Mehmet Yilmaz, MSc, Frank N. van Leeuwen, PhD, Monique L. Den Boer, PhD, Erik Splinter, PhD
Journal: Blood
Blood (2015) 126 (23): 696.
https://doi.org/10.1182/blood.V126.23.696.696
Published: 2015
Journal Articles

Tumor Suppressors BTG1 and IKZF1 Cooperate during Mouse Leukemia Development and Impact Relapse Rate in Childhood Acute Lymphoblastic Leukemia

Blanca Scheijen, PhD, Esther Tijchon, Dorette van Ingen Schenau, Rene Marke, Liesbeth van Emst, Laurens T Van Der Meer, PhD, Roland P Kuiper, PhD, Judith M. Boer, PhD, Rob Pieters, MD PhD, Peter M Hoogerbrugge, MD PhD, Monique L. Den Boer, PhD, Frank N van Leeuwen, PhD
Journal: Blood
Blood (2015) 126 (23): 905.
https://doi.org/10.1182/blood.V126.23.905.905
Published: 2015
Journal Articles

B-Cell Precursor Acute Lymphoblastic Leukemia Cells Create a Self-Reinforcing Niche Independent of the CXCR4/CXCL12 Axis

Bob de Rooij, MSc, Roel Polak, MD, Rob Pieters, MD PhD, Monique L. Den Boer, PhD
Journal: Blood
Blood (2015) 126 (23): 1297.
https://doi.org/10.1182/blood.V126.23.1297.1297
Published: 2015
Journal Articles

Small Molecule Inhibition of LARG/RhoA Signaling Blocks Migration of ETV6-RUNX1 Positive B-Cell Precursor Acute Lymphoblastic Leukemia

Roel Polak, MD, Marc B Bierings, MDPhD, Rob Pieters, MD PhD, Miranda Buitenhuis, PhD, Monique L. Den Boer, PhD
Journal: Blood
Blood (2015) 126 (23): 1293.
https://doi.org/10.1182/blood.V126.23.1293.1293
Published: 2015
Journal Articles

Clinical Relevance of Tyrosine Kinase Fusion Genes in Pediatric BCR-ABL1 -like Acute Lymphoblastic Leukemia

Judith M. Boer, PhD, Aurélie Boeree, BSc, João R.M. Marchante, MSc, Berna Beverloo, PhD, Gabriele Escherich, MD, Hester A. de Groot-Kruseman, PhD, Rob Pieters, MD PhD, Monique L. Den Boer, PhD
Journal: Blood
Blood (2015) 126 (23): 3735.
https://doi.org/10.1182/blood.V126.23.3735.3735
Published: 2015
Journal Articles

Targeted Therapy for ETV6-RUNX1-Driven B-Cell Precursor Acute Lymphoblastic Leukemia

Roel Polak, MD, Marc B. Bierings, MD PhD, Cindy S. van der Leije, MSc, Rosanna E.S. van den Dungen, Mathijs A. Sanders, MSc, Onno Roovers, Jan J. Cornelissen, MD PhD, João R.M. Marchante, MSc, Rob Pieters, MD PhD, Monique L. den Boer, PhD, Miranda Buitenhuis, PhD
Journal: Blood
Blood (2014) 124 (21): 62.
https://doi.org/10.1182/blood.V124.21.62.62
Published: 2014
Journal Articles

Primary Acute Lymphoblastic Leukemia Cells Create a Drug-Resistant Niche By Tunneling Nanotube Signaling with Mesenchymal Stromal Cells

Roel Polak, MD, Bob De Rooij, MSc, Rob Pieters, MD PhD, Monique L. den Boer, PhD
Journal: Blood
Blood (2014) 124 (21): 64.
https://doi.org/10.1182/blood.V124.21.64.64
Published: 2014
Journal Articles

Disturbed CXCR4/CXCL12 Axis In Pediatric Precursor B-Cell Acute Lymphoblastic Leukemia

Lieke C.J. van den Berk, PhD, Arian van der Veer, MD, Marieke E. Willemse, MSc, Myrte J.G.A. Theeuwes, BSc, Mirjam W. Luijendijk, PhD, Wing H. Tong, MD, Inge M. van der Sluis, MD, PhD, Rob Pieters, Monique L. den Boer, PhD
Journal: Blood
Blood (2013) 122 (21): 2643.
https://doi.org/10.1182/blood.V122.21.2643.2643
Published: 2013
Journal Articles

Prednisolone Resistance in Pediatric Acute Lymphoblastic Leukemia Can Be Synergistically Overcome by Inhibition of Anti-Apoptotic MCL1 and Glycolysis

Ingrid M. Ariës, MSc, Bo R. Hansen, PhD, Troels Koch, PhD, William E. Evans, PharmD, Rob Pieters, MD, PhD, Monique L. Den Boer, PhD
Journal: Blood
Blood (2012) 120 (21): 3528.
https://doi.org/10.1182/blood.V120.21.3528.3528
Published: 2012
Journal Articles

Polo-Like Kinase 1 (PLK1) Inhibition Reduces Cell Proliferation and Induces Apoptosis in Childhood Acute Lymphoblastic Leukemia

Stefanie A. Hartsink-Segers, Carla Exalto, Steven C. Clifford, Huib N. Caron, Rob Pieters, MD, PhD, Monique L. Den Boer, PhD
Journal: Blood
Blood (2012) 120 (21): 3529.
https://doi.org/10.1182/blood.V120.21.3529.3529
Published: 2012
Journal Articles

The Potential of Aurora Kinases A and B As Therapeutic Targets in Pediatric Acute Leukemia

Stefanie A. Hartsink-Segers, C. Michel Zwaan, Carla Exalto, Mirjam W.J. Luijendijk, Valerie S. Calvert, Emanuel F. Petricoin, PhD, William E. Evans, PharmD, Dirk Reinhardt, MD, Válerie de Haas, Maj Hedtjärn, Bo R. Hansen, PhD, Troels Koch, PhD, Huib N. Caron, Rob Pieters, MD, PhD, Monique L. Den Boer, PhD
Journal: Blood
Blood (2012) 120 (21): 1465.
https://doi.org/10.1182/blood.V120.21.1465.1465
Published: 2012
Journal Articles

Collaboration Between MiR-125b, MiR-100 and MiR-99a Induces Vincristine Resistance in Childhood TEL-AML1 -Positive Acute Lymphoblastic Leukemia

Farhad Akbari Moqadam, Ellen Lange-Turenhout, Rob Pieters, MD, PhD, Monique L. Den Boer, PhD
Journal: Blood
Blood (2012) 120 (21): 1475.
https://doi.org/10.1182/blood.V120.21.1475.1475
Published: 2012