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Journal Articles

A phase 2 trial of HQK-1001 in HbE-β thalassemia demonstrates HbF induction and reduced anemia

Poramin Patthamalai, Suthat Fuchareon, Nattawara Chaneiam, Richard G. Ghalie, David H. K. Chui, Michael S. Boosalis, Susan P. Perrine

Blood (2014) 123 (12): 1956–1957.

https://doi.org/10.1182/blood-2013-11-538470

Published: 2014

Journal Articles

Next Generation Clinical-Stage HbF Inducers Exhibit Multiple Molecular Actions In Vitro and In Vivo and Offer Personalized Therapeutic Regimens

Betty S. Pace, MD, Jose I Sangerman, PhD, Michael S Boosalis, PhD, Roman Wolf, DVM, Yan Dai, PhD, David H.K. Chui, MD, Levi Makala, PhD, DVM, Biadru Li, PhD, Douglas V Faller, MD, PhD, Susan P Perrine, MD

Blood (2013) 122 (21): 560.

https://doi.org/10.1182/blood.V122.21.560.560

Published: 2013

Journal Articles

An Approach for Tailoring Diverse Therapeutic Inducers of Fetal Globin to Genetic Modifier Profiles,

Susan P Perrine, MD, David H.K. Chui, MD, Jose I Sangerman, PhD, Michael S Boosalis, PhD, Douglas V Faller, MD, PhD

Blood (2011) 118 (21): 3188.

https://doi.org/10.1182/blood.V118.21.3188.3188

Published: 2011

Journal Articles

Phase 1/2 Clinical Trial of HQK-1001, An Oral Fetal Hemoglobin Stimulant, In Sickle Cell Anemia

Abdullah Kutlar, MD, Kenneth I. Ataga, MD, Marvin Reid, PhD, Loray A Blair-Britt, MD, Elliott Vichinsky, MD, Lynne Neumayr, MD, Richard J. Labotka, MD, MS, Jonathan Glass, MD, FACP, Andrea Small-WIlliams, MBBS, DM(HAEM), Jeffrey Keefer, MD, PhD, Ling Shen, MD, Michael S Boosalis, PhD, Audrey Thomson, BSc, Patrick Bobbitt, BS, Wayne Wallis, MD, Elsa Johnson, MBA, Ronald J Berenson, MD, Susan P Perrine, MD

Blood (2010) 116 (21): 943.

https://doi.org/10.1182/blood.V116.21.943.943

Published: 2010

Journal Articles

Identification of New and Diverse Inducers of Fetal Hemoglobin with High Throughput Screening (HTS)

Jose I Sangerman, PhD, Michael S Boosalis, PhD, Ling Shen, MD, Sarah Haigh, PhD, Ada Kane, Gary L White, DVM, MMS, Susan P Perrine, MD, Douglas V Faller, MD, PhD

Blood (2010) 116 (21): 4277.

https://doi.org/10.1182/blood.V116.21.4277.4277

Published: 2010

Journal Articles

HQK-1001 Is Well Tolerated and Augments Hemoglobin F and Hemoglobin Levels In Patients with Beta Thalassemia Intermedia

Suthat Fuchareon, MD, Adlette C. Inati, MD, Noppadol Siritanaratkul, MD, Suzanne Koussa, MD, Ali Taher, MD, Michael S Boosalis, PhD, Swee Lay Thein, DSc, FRCP, MB, BS, FRCPath, Wayne Wallis, MD, Patrick Bobbitt, BS, Audrey Thomson, BSc, Elsa Johnson, MBA, Ronald J Berenson, MD, Susan P Perrine, MD

Blood (2010) 116 (21): 4280.

https://doi.org/10.1182/blood.V116.21.4280.4280

Published: 2010

Journal Articles

Phase 1 Clinical Testing of HQK-1001, a Novel Oral Fetal Globin Gene Inducer

Susan Perrine, MD, William C Welch, PhD, Jeffrey Keefer, MD, PhD, Robin L Downey, MD, Michael S Boosalis, PhD, Sally Case, RN, Douglas V Faller, MD, PhD, Ronald Berenson, MD

Blood (2008) 112 (11): 130.

https://doi.org/10.1182/blood.V112.11.130.130

Published: 2008

Journal Articles

EKLF Is Recruited to the γ-Globin Gene Promoter as a Co-Activator and Is Required for γ-Globin Gene Induction by Short-Chain Fatty Acids.

Susan P. Perrine, MD, Rishikesh Mankidy, PhD, Michael S. Boosalis, PhD, James J. Bieker, PhD, Douglas V. Faller, MD, PhD

Blood (2007) 110 (11): 1771.

https://doi.org/10.1182/blood.V110.11.1771.1771

Published: 2007

Journal Articles

A New Generation of γGlobin Gene Inducers Act on Novel Molecular and Cellular Targets.

Susan Perrine, MD, Marie Trudel, DSc, Serguei A. Castaneda, MD, Rishikesh Mankidy, PhD, Michael S. Boosalis, PhD, Marthe-Sandrine Eiymo, Mwa Mpollo, Gary L. White, PhD, Regine Bohacek, PhD, Douglas V. Faller, PhD

Blood (2006) 108 (11): 1580.

https://doi.org/10.1182/blood.V108.11.1580.1580

Published: 2006

Journal Articles

Short-chain fatty acids induce γ-globin gene expression by displacement of a HDAC3-NCoR repressor complex

Rishikesh Mankidy, Douglas V. Faller, Rodwell Mabaera, Christopher H. Lowrey, Michael S. Boosalis, Gary L. White, Serguei A. Castaneda, Susan P. Perrine

Blood (2006) 108 (9): 3179–3186.

https://doi.org/10.1182/blood-2005-12-010934

Published: 2006

Journal Articles

Mechanisms of γ-Globin Gene Promoter Activation by HBF-Inducing Short Chain Fatty Acid Derivatives.

Rishikesh Mankidy, PhD, Douglas V. Faller, MD, PhD, Michael S. Boosalis, PhD, Regine Bohacek, PhD, Susan P. Perrine, MD

Blood (2005) 106 (11): 826.

https://doi.org/10.1182/blood.V106.11.826.826

Published: 2005

Journal Articles

Short-chain fatty acid derivatives induce fetal globin expression and erythropoiesis in vivo

Betty S. Pace, Gary L. White, George J. Dover, Michael S. Boosalis, Douglas V. Faller, Susan P. Perrine

Blood (2002) 100 (13): 4640–4648.

https://doi.org/10.1182/blood-2002-02-0353

Published: 2002

Journal Articles

Short-chain fatty acid derivatives stimulate cell proliferation and induce STAT-5 activation

Michael S. Boosalis, Ram Bandyopadhyay, Emery H. Bresnick, Betty S. Pace, Karyn Van DeMark, Baohua Zhang, Douglas V. Faller, Susan P. Perrine

Blood (2001) 97 (10): 3259–3267.

https://doi.org/10.1182/blood.V97.10.3259

Published: 2001

NARROW

A phase 2 trial of HQK-1001 in HbE-β thalassemia demonstrates HbF induction and reduced anemia

Next Generation Clinical-Stage HbF Inducers Exhibit Multiple Molecular Actions In Vitro and In Vivo and Offer Personalized Therapeutic Regimens

An Approach for Tailoring Diverse Therapeutic Inducers of Fetal Globin to Genetic Modifier Profiles,

Phase 1/2 Clinical Trial of HQK-1001, An Oral Fetal Hemoglobin Stimulant, In Sickle Cell Anemia

Identification of New and Diverse Inducers of Fetal Hemoglobin with High Throughput Screening (HTS)

HQK-1001 Is Well Tolerated and Augments Hemoglobin F and Hemoglobin Levels In Patients with Beta Thalassemia Intermedia

Phase 1 Clinical Testing of HQK-1001, a Novel Oral Fetal Globin Gene Inducer

EKLF Is Recruited to the γ-Globin Gene Promoter as a Co-Activator and Is Required for γ-Globin Gene Induction by Short-Chain Fatty Acids.

A New Generation of γGlobin Gene Inducers Act on Novel Molecular and Cellular Targets.

Short-chain fatty acids induce γ-globin gene expression by displacement of a HDAC3-NCoR repressor complex

Mechanisms of γ-Globin Gene Promoter Activation by HBF-Inducing Short Chain Fatty Acid Derivatives.

Short-chain fatty acid derivatives induce fetal globin expression and erythropoiesis in vivo

Short-chain fatty acid derivatives stimulate cell proliferation and induce STAT-5 activation

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American Society of Hematology

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American Society of Hematology

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