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Journal Articles

Serum O-Glycan Antigenicity in Pediatric Immune Thrombocytopenia Predicts Disease Persistence

Katelyn E. Rosenbalm, George Steinhardt, Melissa M. Lee-Sundlov, Alejandro Roisman, Shikan Zheng, Amanda B. Grimes, Taylor Olmsted Kim, Karin M. Hoffmeister

Blood (2024) 144 (Supplement 1): 3952.

https://doi.org/10.1182/blood-2024-208706

Published: 2024

Journal Articles

A CD33-Deleted Allograft (Trem-cel) Enables Post-Hematopoietic Cell Transplant (HCT) Maintenance Dosing of Gemtuzumab Ozogamicin (GO) with Therapeutic Levels of Drug Exposure and Low Hematologic and Hepatic Toxicity in Patients with High-Risk Acute Myeloid Leukemia (AML)

John F. DiPersio, Guenther Koehne, Nirali N. Shah, Lea Bernard, Hyung C Suh, Divya Koura, Miguel Angel Perales, Roni Tamari, Muhammad Umair Mushtaq, Joseph E. Maakaron, Michael R. Loken, Darren A Stanizzi, Melissa M. Lee-Sundlov, Sanjana Thosar, Sharon L Hyzy, Glen D Raffel, Brenda W Cooper

Blood (2024) 144 (Supplement 1): 2873.

https://doi.org/10.1182/blood-2024-205641

Published: 2024

Journal Articles

Trial in Progress: A First-in-Human Phase 1/2 Study of Hematopoietic Stem Cell Transplantation (HCT) with VOR33 (CD33-Deleted Allograft) Followed By Treatment with Gemtuzumab Ozogamicin (GO) in Patients with CD33+ Acute Myeloid Leukemia (AML) Who Are at High-Risk of Post-HCT Relapse

Brenda W. Cooper, Hyung C. Suh, Divya Koura, Guenther Koehne, Christina Cho, Nadia M. Bambace, Léa Bernard, Nirali N. Shah, Roland B. Walter, John F. DiPersio, Sritama Nath, Melissa M. Lee-Sundlov, Ali Lacy, Darren Stanizzi, Karen Kuhn, Jennifer S. Whangbo, Christopher Slapak, Glen D. Raffel

Blood (2022) 140 (Supplement 1): 12973–12975.

https://doi.org/10.1182/blood-2022-165289

Published: 2022

Journal Articles

Immune cells surveil aberrantly sialylated O -glycans on megakaryocytes to regulate platelet count

Melissa M. Lee-Sundlov, Robert T. Burns, Taylor O. Kim, Renata Grozovsky, Silvia Giannini, Leonardo Rivadeneyra, Yongwei Zheng, Simon H. Glabere, Walter H. A. Kahr, Reza Abdi, Jenny M. Despotovic, Demin Wang, Karin M. Hoffmeister

Blood (2021) 138 (23): 2408–2424.

https://doi.org/10.1182/blood.2020008238

Published: 2021

Includes: Multimedia, Supplemental data

Journal Articles

Sialylated Glycans Regulate MUC13 and the Proto-Oncogenes Pim-1 and Myc to Control Hematopoietic Stem and Progenitor Cell Numbers

Leonardo Rivadeneyra, PhD, Melissa M. Lee-Sundlov, PhD, Simon Glabere, Heather Ashwood, Robert Burns, PhD, Karin M. Hoffmeister, MD

Blood (2020) 136 (Supplement 1): 8.

https://doi.org/10.1182/blood-2020-143365

Published: 2020

Journal Articles

Plasmacytoid Dendritic Cells Surveil Megakaryocyte Sialic Acid to Regulate Thrombopoiesis

Melissa M. Lee-Sundlov, PhD, Robert Burns, PhD, Renata Grozovsky, PhD, Silvia Giannini, PhD, Leonardo Rivadeneyra, PhD, Yongwei Zheng, PhD, Simon Glabere, Walter H. Kahr, MDPhDFRCPC, Reza Abdi, Demin Wang, PhD, Karin M. Hoffmeister, MD

Blood (2020) 136 (Supplement 1): 12–13.

https://doi.org/10.1182/blood-2020-142737

Published: 2020

Journal Articles

RGS10 and RGS18 differentially limit platelet activation, promote platelet production, and prolong platelet survival

Daniel DeHelian, Shuchi Gupta, Jie Wu, Chelsea Thorsheim, Brian Estevez, Matthew Cooper, Kelly Litts, Melissa M. Lee-Sundlov, Karin M. Hoffmeister, Mortimer Poncz, Peisong Ma, Lawrence F. Brass

Blood (2020) 136 (15): 1773–1782.

https://doi.org/10.1182/blood.2019003251

Published: 2020

Includes: Multimedia, Supplemental data

Journal Articles

Endocytosis of the Thrombopoietin Receptor Mpl Regulates Both Megakaryocyte and Erythroid Maturation in Mice

Nathan Eaton, BS, Melissa M. Lee-Sundlov, PhD, Theresa A. Dlugi, PhD, Jon Wieser, BS, Haley E. Ramsey, PhDMSc, Martha Sola-Visner, MD, Karin M. Hoffmeister, MD, Hervé Falet, PhD

Blood (2019) 134 (Supplement_1): 2477.

https://doi.org/10.1182/blood-2019-126820

Published: 2019

Journal Articles

In Non-Selected Patients Treated for Influenza, Oseltamivir, a Glycosialidase Inhibitor, Demonstrates Improvement in Platelet Counts Compared to Time of Dosing, but Not over Baseline Levels

Sabina I. Cashin, BS, Melissa M. Lee-Sundlov, PhD, Karin M. Hoffmeister, MD, Laura C. Michaelis, MD

Blood (2017) 130 (Supplement 1): 3626.

https://doi.org/10.1182/blood.V130.Suppl_1.3626.3626

Published: 2017

Journal Articles

β1,4-Galactosyltransferase 1 Is a Key Regulator of Thrombopoiesis

Silvia Giannini, PhD, Melissa M. Lee-Sundlov, PhD, Max Adelman, Antonija Jurak Begonja, PhD, Joseph T. Lau, PhD, Herve Falet, PhD, Karin M. Hoffmeister, MD

Blood (2017) 130 (Supplement 1): 1018.

https://doi.org/10.1182/blood.V130.Suppl_1.1018.1018

Published: 2017

Journal Articles

Endocytosis of the Thrombopoietin Receptor Mpl Regulates Both Megakaryocyte and Erythroid Progenitors and Is Critical for Myelofibrosis Development

Melissa M Lee-Sundlov, PhD, Haley E Ramsey, PhD MSc, Robert J Dickey, Martha Sola-Visner, MD, Karin M Hoffmeister, MD, Herve Falet, PhD

Blood (2016) 128 (22): 3714.

https://doi.org/10.1182/blood.V128.22.3714.3714

Published: 2016

Journal Articles

Effects of Platelet Circulatory Age on Platelet Function

Moritz Stolla, MD, Renata Grozovsky, PhD, Melissa M Lee-Sundlov, PhD, Herve Falet, PhD, Karin M. Hoffmeister, MD

Blood (2016) 128 (22): 413.

https://doi.org/10.1182/blood.V128.22.413.413

Published: 2016

Journal Articles

Bone Marrow Macrophage Galectin-3 Regulates Platelet Production through Recognition of O-Glycans on Megakaryocytes

Melissa M Lee-Sundlov, PhD, Renata Grozovsky, PhD, Silvia Giannini, PhD, Martina McGrath, MD, Haley E Ramsey, PhD MSc, Martha Sola-Visner, MD, Karin M. Hoffmeister, MD

Blood (2016) 128 (22): 409.

https://doi.org/10.1182/blood.V128.22.409.409

Published: 2016

Journal Articles

Recognition of Megakaryocyte-Specific T-Antigen By Macrophages Negatively Regulates Platelet Production in Bone Marrow

Melissa M. Lee-Sundlov, PhD, Renata Grozovsky, PhD, Silvia Giannini, PhD, Martina McGrath, MD, Haley Elizabeth Ramsey, PhD MSc, Reza Abdi, MD, Martha Sola-Visner, MD, Karin M. Hoffmeister, MD

Blood (2015) 126 (23): 420.

https://doi.org/10.1182/blood.V126.23.420.420

Published: 2015

NARROW

Serum O-Glycan Antigenicity in Pediatric Immune Thrombocytopenia Predicts Disease Persistence

A CD33-Deleted Allograft (Trem-cel) Enables Post-Hematopoietic Cell Transplant (HCT) Maintenance Dosing of Gemtuzumab Ozogamicin (GO) with Therapeutic Levels of Drug Exposure and Low Hematologic and Hepatic Toxicity in Patients with High-Risk Acute Myeloid Leukemia (AML)

Trial in Progress: A First-in-Human Phase 1/2 Study of Hematopoietic Stem Cell Transplantation (HCT) with VOR33 (CD33-Deleted Allograft) Followed By Treatment with Gemtuzumab Ozogamicin (GO) in Patients with CD33+ Acute Myeloid Leukemia (AML) Who Are at High-Risk of Post-HCT Relapse

Immune cells surveil aberrantly sialylated O -glycans on megakaryocytes to regulate platelet count

Sialylated Glycans Regulate MUC13 and the Proto-Oncogenes Pim-1 and Myc to Control Hematopoietic Stem and Progenitor Cell Numbers

Plasmacytoid Dendritic Cells Surveil Megakaryocyte Sialic Acid to Regulate Thrombopoiesis

RGS10 and RGS18 differentially limit platelet activation, promote platelet production, and prolong platelet survival

Endocytosis of the Thrombopoietin Receptor Mpl Regulates Both Megakaryocyte and Erythroid Maturation in Mice

In Non-Selected Patients Treated for Influenza, Oseltamivir, a Glycosialidase Inhibitor, Demonstrates Improvement in Platelet Counts Compared to Time of Dosing, but Not over Baseline Levels

β1,4-Galactosyltransferase 1 Is a Key Regulator of Thrombopoiesis

Endocytosis of the Thrombopoietin Receptor Mpl Regulates Both Megakaryocyte and Erythroid Progenitors and Is Critical for Myelofibrosis Development

Effects of Platelet Circulatory Age on Platelet Function

Bone Marrow Macrophage Galectin-3 Regulates Platelet Production through Recognition of O-Glycans on Megakaryocytes

Recognition of Megakaryocyte-Specific T-Antigen By Macrophages Negatively Regulates Platelet Production in Bone Marrow

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American Society of Hematology

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ASH Publications

American Society of Hematology

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