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Manar S Shafat
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Journal Articles

Acute myeloid leukemia induces protumoral p16INK4a-driven senescence in the bone marrow microenvironment

Amina M. Abdul-Aziz, Yu Sun, Charlotte Hellmich, Christopher R. Marlein, Jayna Mistry, Eoghan Forde, Rachel E. Piddock, Manar S. Shafat, Adam Morfakis, Tarang Mehta, Federica Di Palma, Iain Macaulay, Christopher J. Ingham, Anna Haestier, Angela Collins, Judith Campisi, Kristian M. Bowles, Stuart A. Rushworth
Journal: Blood
Blood (2019) 133 (5): 446–456.
https://doi.org/10.1182/blood-2018-04-845420
Published: 2019
Includes: Supplemental data
Journal Articles

NADPH oxidase-2 derived superoxide drives mitochondrial transfer from bone marrow stromal cells to leukemic blasts

Christopher R. Marlein, Lyubov Zaitseva, Rachel E. Piddock, Stephen D. Robinson, Dylan R. Edwards, Manar S. Shafat, Zhigang Zhou, Matthew Lawes, Kristian M. Bowles, Stuart A. Rushworth
Journal: Blood
Blood (2017) 130 (14): 1649–1660.
https://doi.org/10.1182/blood-2017-03-772939
Published: 2017
Includes: Supplemental data
Journal Articles

Leukemic blasts program bone marrow adipocytes to generate a protumoral microenvironment

Manar S. Shafat, Thomas Oellerich, Sebastian Mohr, Stephen D. Robinson, Dylan R. Edwards, Christopher R. Marlein, Rachel E. Piddock, Matthew Fenech, Lyubov Zaitseva, Amina Abdul-Aziz, Jeremy Turner, Johnathan A. Watkins, Matthew Lawes, Kristian M. Bowles, Stuart A. Rushworth
Journal: Blood
Blood (2017) 129 (10): 1320–1332.
https://doi.org/10.1182/blood-2016-08-734798
Published: 2017
Includes: Supplemental data
Journal Articles

Hypoxia Drives AML Proliferation in the Bone Marrow Microenvironment Via Macrophage Inhibitory Factor

Amina M Abdul-Aziz, MSc., Manar S Shafat, MSc, Lyubov Zaitseva, BSc, PhD, Matthew J Lawes, MD, Stuart A Rushworth, PhD BSc, Kristian M Bowles, MBBS, PhD
Journal: Blood
Blood (2016) 128 (22): 1721.
https://doi.org/10.1182/blood.V128.22.1721.1721
Published: 2016
Journal Articles

Dual Activation of NRF2 in Multiple Myeloma and Bone Marrow Mesenchymal Stromal Cells Regulates Chemotherapy Resistance

Yu Sun, MRes, Lyubov Zaitseva, BSc, PhD, Manar S Shafat, MSc, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhDBSc
Journal: Blood
Blood (2016) 128 (22): 3287.
https://doi.org/10.1182/blood.V128.22.3287.3287
Published: 2016
Journal Articles

Bone Marrow Mesenchymal Stromal Cells Transfer Their Mitochondria to Acute Myeloid Leukaemia Blasts to Support Their Proliferation and Survival

Christopher Marlein, BSc, Lyubov Zaitseva, BSc, PhD, Rachel E Piddock, BSc, Stephen Robinson, BSc, PhD, Dylan R Edwards, BSc, PhD, Manar S Shafat, MSc, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, Ph DBSc
Journal: Blood
Blood (2016) 128 (22): 772.
https://doi.org/10.1182/blood.V128.22.772.772
Published: 2016
Journal Articles

Protein Kinase C-ß Dependent IL-8 Release Promotes Acute Myeloid Leukemia Blast Cell Survival in Co-Cultures with Bone Marrow Stromal Cells

Amina M Abdul-Aziz, MSc., Manar S Shafat, MSc, Matthew J Lawes, MD, Kristian M Bowles, MB BS, PhD, Stuart A Rushworth, PhDBSc
Journal: Blood
Blood (2015) 126 (23): 3064.
https://doi.org/10.1182/blood.V126.23.3064.3064
Published: 2015
Journal Articles

FABP4 Regulates Fatty Acid Transfer from Bone Marrow Adipocytes to Acute Myeloid Leukemia Blasts

Manar S Shafat, MSc, Matthew E Fenech, MD PhD, Amina M Abdul-Aziz, MSc., Jeremy Turner, MB, DPhil, Kristian M Bowles, MB BS, PhD, Stuart A Rushworth, PhDBSc
Journal: Blood
Blood (2015) 126 (23): 3065.
https://doi.org/10.1182/blood.V126.23.3065.3065
Published: 2015