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Journal Articles

Uncovering Therapeutic Resistance in BPDCN through Single-Cell Transcriptome Profiling

Ji Ma, Qiang He, Qian Wu, Lili Feng, Y. Lynn Wang, Linna Xie
Journal: Blood
Blood (2024) 144 (Supplement 1): 1557.
https://doi.org/10.1182/blood-2024-204227
Published: 2024
Journal Articles

Inosine Monophosphate Dehydrogenase-2 (IMPDH2) As the Potential Novel Therapeutic Target in Mantle Cell Lymphoma (MCL): The Underlying Tyrosine Phosphorylation-Based Activation Mechanism and Translational Implications

Johnvesly Basappa, Shengchun Wang, Cosimo Lobello, David Rushmore, Olga Melnikov, Neil Sen, Vinay Mallikarjuna, Priyanka Jain, Pin Lu, Y. Lynn Wang, Kathy Cai, Reza Nejati, Aaron Goldman, Mariusz Wasik
Journal: Blood
Blood (2024) 144 (Supplement 1): 1602.
https://doi.org/10.1182/blood-2024-203257
Published: 2024
Journal Articles

Clinical Validation of a Personalized NHL-TME Model System: One-on-One Comparison between Modeled Drug Responses and Patients' Clinical Responses

Shazia K. Nakhoda, Pin Lu, Tingwei Guo, Denise Connelly, Marcus Messmer, Zachary AK Frosch, Henry C. Fung, Asya Varshavsky Yanovsky, Y. Lynn Wang
Journal: Blood
Blood (2024) 144 (Supplement 1): 2214.
https://doi.org/10.1182/blood-2024-203843
Published: 2024
Journal Articles

Molecular Monitoring with Tumor DNA and Nivolumab Maintenance: A Pilot Study in Diffuse Large B-Cell Lymphoma

Shazia Nakhoda, Tamarrah Sklarz, Cheyenne Pagan, Matthew Matasar, Marcus Messmer, Zachary AK Frosch, Y. Lynn Wang, Asya Varshavsky Yanovsky, Rashmi Khanal, Carlyn Rose Tan, Henry C. Fung, Eli Mikkelsen, Kevin A. David, Mark Roschewski, Eric Ross, Allison P. Jacob, Erin Ahn, Nadia Khan
Journal: Blood
Blood (2023) 142 (Supplement 1): 6231.
https://doi.org/10.1182/blood-2023-179980
Published: 2023
Journal Articles

Live Lymphoma and CLL Cells inside the Bone Marrow Fibroblasts: Implication in Residual Disease Persistence

Y. Lynn Wang, Carrie Frazen, Andrey Efimov, Priyal Patel, Pin Lu, Shuo Ma, Katherine Amira Carrol, Edna Cukierman, Marcus R. Messmer, Janusz Franco-Barraza, Juehua Gao, Aldana Vistarop
Journal: Blood
Blood (2023) 142 (Supplement 1): 6506.
https://doi.org/10.1182/blood-2023-179994
Published: 2023
Journal Articles

Zanubrutinib PLUS RCHOP(ZR-CHOP) Regimen Achieves High Complete Response Rate in the Treatment of Newly-Diagnosed Double-Expression Diffuse Large B Cell Lymphoma

Qiang He, Linna Xie, Rongrong Zhao, Ji Ma, Hui Wang, Jie Li, Chuanli Zhao, Y. Lynn Wang, Zengjun Li
Journal: Blood
Blood (2022) 140 (Supplement 1): 6614–6615.
https://doi.org/10.1182/blood-2022-168859
Published: 2022
Journal Articles

Isatuximab in Combination with Chemotherapy in Pediatric Patients with Relapsed/Refractory Acute Lymphoblastic Leukemia or Acute Myeloid Leukemia (ISAKIDS): Interim Analysis

Andre Baruchel, Jonas Abrahamsson, Yves Bertrand, Oscar Gonzalez, Karsten Nysom, Willy Quinones, Carmelo Rizzari, Jochen Buechner, Simone Cesaro, Joaquin Duarte, Franca Fagioli, Hyoung Jin Kang, Antonis Kattamis, Guy Leverger, Kathleen Ludwig, Monica L Makiya, Concetta Micalizzi, Brigitte Nelken, Camilla Tøndel, Keon Hee Yoo, Inna Ivanina, Claire Brillac, Lynn Wang, Corina Oprea, Giovanni Abbadessa, C. Michel Zwaan
Journal: Blood
Blood (2021) 138 (Supplement 1): 516.
https://doi.org/10.1182/blood-2021-150272
Published: 2021
Journal Articles

SHP1 Loss Augments DLBCL Cellular Response to Ibrutinib: A Candidate Predictive Biomarker

Y. Lynn Wang, Ji Ma, Vinay Mallikarjuna, Pin Lu, Shengchun Wang, Sahar Poureghbali, Mariusz A Wasik, Reza Nejati, Wenjun Wu
Journal: Blood
Blood (2021) 138 (Supplement 1): 3490.
https://doi.org/10.1182/blood-2021-146086
Published: 2021
Journal Articles

Ibrutinib and Venetoclax Target Distinct Subpopulation of CLL Cells: Rationale for Drug Combination and Implication of Minimal Residual Disease Eradication

Y. Lynn Lynn Wang, MD PhD, Carrie Franzen, PhD, Shengchun Wang, MD PhD, Girish Venkataraman, MD MBBS, Lei Li, MS, Nifang Niu, PhD, Madina Sukhanova, PhD, Yifan Tu, MD PhD, Juehua Gao, MD PhD, Yi-Hua Chen, MD, Shuo Ma, MD PhD, Richard A. Larson, MD, Lu Pin, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 475.
https://doi.org/10.1182/blood-2019-125396
Published: 2019
Journal Articles

Inhibition of B-Cell Receptor Signaling Disrupts Cell Adhesion in Mantle Cell Lymphoma Via RAC2

Weige Wang, MD, Franzen Carrie, Hui Guo, PhD, Jimmy Lee, MD, Yan Li, Madina Sukhanova, PhD, Dong Sheng, MD, Girish Venkataraman, MD MBBS, Ming Mei, Pin Lu, PhD, Anhui Gao, Chunmei Xia, Li Jia, Liang Zhang, MD PhD, Michael Wang, MD, Jorge Andrade, Zhou Xiaoyan, Y. Lynn Lynn Wang, MDPhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1369.
https://doi.org/10.1182/blood-2018-99-118598
Published: 2018
Journal Articles

TP53 Aberrations By FISH in CLL and Complex Karyotype at Transformation Predict for Worse Outcome in Diffuse Large B-Cell Lymphoma - Richter Transformation: A Single Institution Series of 75 DLBCL-RT Cases

Shiraz Fidai, MD, Madina Sukhanova, PhD, Brian C.-H. Chiu, PhD, Y. Lynn Lynn Wang, MD PhD, Wendy Stock, MD, Peter A Riedell, MD, Sonali M. Smith, MD, Elizabeth Hyjek, MD, Girish Venkataraman, MD MBBS
Journal: Blood
Blood (2018) 132 (Supplement 1): 2984.
https://doi.org/10.1182/blood-2018-99-112242
Published: 2018
Journal Articles

PET-CT Invisible Diffuse Large B-Cell Lymphoma Features a Silent B-Cell Receptor Signaling

Dong Sheng, MD, Ting Li, MD, Xiangnan Jiang, MD, Weige Wang, MD, Y. Lynn Wang, MD PhD, Xiaoqiu Li
Journal: Blood
Blood (2017) 130 (Supplement 1): 2853.
https://doi.org/10.1182/blood.V130.Suppl_1.2853.2853
Published: 2017
Journal Articles

Cerdulatinib Pharmacodynamics and Relationships to Tumor Response Following Oral Dosing in Patients with Relapsed/Refractory B Cell Malignancies: Results from a Phase I Dose Escalation Study

Gregory P. Coffey, PhD, Jiajia Feng, MD, Andreas Betz, PhD, Anjali Pandey, PhD, Matt Birrell, B.S., Janet M. Leeds, PhD, Kenneth Der, PhD, Sabah Kadri, PhD, Pin Lu, PhD, Jeremy Segal, PhD, Lynn Wang, MD PhD, Glenn Michelson, MD, John T Curnutte, MD PhD, Pamela B. Conley, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2782.
https://doi.org/10.1182/blood.V130.Suppl_1.2782.2782
Published: 2017
Journal Articles

RAC2 Links B-Cell Receptor Signaling and Cell Adhesion in Mantle Cell Lymphoma

Weige Wang, Franzen Carrie, Madina Sukhanova, Venkataraman Girish, Ming Mei, Guo Ailin, Pin Lu, PhD, Dong Sheng, MD, Gao Anhui, Xia Chunmei, Li Jia, Zhou Xiaoyan, Y Lynn Wang
Journal: Blood
Blood (2017) 130 (Supplement 1): 2752.
https://doi.org/10.1182/blood.V130.Suppl_1.2752.2752
Published: 2017
Journal Articles

XPO1 Inhibitor Selinexor Overcomes Ibrutinib Resistance in Mantle Cell Lymphoma Via Nuclear Retention of IκB

Y. Lynn Wang, MD PhD, Mei Ming, PhD, Bingqing Xie, Madina Sukhanova, Weige Wang, MD, Sabah Kadri, PhD, Shruti Sharma, Jimmy Lee, Sharon Shacham, PhD MBA, Yosef Landesman, PhD, Natalia Maltsev, Pin Lu, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3837.
https://doi.org/10.1182/blood.V130.Suppl_1.3837.3837
Published: 2017
Journal Articles

Dual SYK/JAK Inhibition Overcomes Ibrutinib Resistance in Chronic Lymphocytic Leukemia

Yue Lynn Wang, MD PhD, Pin Lu, PhD, Greg P Coffey, PhD, Anjali Pandey, PhD, Ailin Guo, PhD MD
Journal: Blood
Blood (2016) 128 (22): 5377.
https://doi.org/10.1182/blood.V128.22.5377.5377
Published: 2016
Journal Articles

HSP90 Stabilizes B-Cell Receptor Kinases in a Multi-Client Interactome: PU-H71 Induces CLL Apoptosis in a Cytoprotective Microenvironment

Yue Lynn Wang, MD PhD, Pin Lu, PhD, Jimmy Lee, MD, Chao Jie Zhen, BS, Gabriela Chiosis, PhD, Ailin Guo, Ph DMD
Journal: Blood
Blood (2016) 128 (22): 5105.
https://doi.org/10.1182/blood.V128.22.5105.5105
Published: 2016
Journal Articles

Genetic or CD40L-Mediated Loss of Iκbα Is Associated with Resistance to the Dual SYK/JAK Inhibitor Cerdulatinib in DLBCL Cell Lines

Greg P Coffey, PhD, Jiajia Feng, MD, Sabah Kadri, PhD, Y. Lynn Wang, MD PhD, Pin Lu, PhD, Shruti Sharma, PhD, Jeremy Segal, PhD, Glenn Michelson, MD, Anjali Pandey, PhD, John T. Curnutte, MD PhD, Pamela B. Conley, PhD
Journal: Blood
Blood (2016) 128 (22): 2768.
https://doi.org/10.1182/blood.V128.22.2768.2768
Published: 2016
Journal Articles

Clonal Evolution Pattern of Leukemia Progression and Richter Transformation in Ibrutinib-Relapsed CLL Patients

Sabah Kadri, PhD, Jimmy Lee, MD, Carrie Fitzpatrick, PhD DABMG, Natalie Galanina, MD, Madina Sukhanova, PhD, Girish Venkataraman, MD MBBS, Shruti Sharma, PhD, Bradley Long, Megan Theissen, Mei Ming, PhD, Yuri Kobzev, Kang Wenjun, Ailin Guo, PhD MD, Weige V Wang, MD, Nifang Niu, PhD, Howie Lawrence Weiner, Michael J. Thirman, MD, Sonali M. Smith, MD, Jeremy P. Segal, MD PhD, Pin Lu, PhD, Y. Lynn Wang, MD PhD
Journal: Blood
Blood (2016) 128 (22): 3961.
https://doi.org/10.1182/blood.V128.22.3961.3961
Published: 2016
Journal Articles

An HSP90 Inhibitor, PU-H71, Antagonizes Stroma-Induced Pro-Survival Effects in CLL through Its Inhibition of Multi-Component B-Cell Receptor Signaling Pathway

Ailin Guo, PhDMD, Pin Lu, PhD, Chaojie Zhen, PhD, Gabriela Chiosis, PhD, Yue Lynn Wang, MD PhD
Journal: Blood
Blood (2015) 126 (23): 5289.
https://doi.org/10.1182/blood.V126.23.5289.5289
Published: 2015