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Journal Articles

Targeting PYK2 Mediates Microenvironment-Specific Myeloma Cell Death

Mark B Meads, PhD, Bin Fang, PhD, Linda Mathews, Jennifer Gemmer, MS, Liang Nong, MD, Ismael Rosado-Lopez, Tuan Nguyen, Jennifer E. Ring, William Matsui, MD, Robert MacLeod, PhD, David T. Weaver, PhD, Jonathan A. Pachter, PhD, Lori A. Hazlehurst, PhD, John M. Koomen, PhD, Kenneth H. Shain, MD PhD

Blood (2015) 126 (23): 3008.

https://doi.org/10.1182/blood.V126.23.3008.3008

Published: 2015

Journal Articles

Bone Marrow Beta-Catenin Expression In Chronic Myelogenous Leukemia Patients Treated With Imatinib

Xiaohui Zhang, MD, Kendra L Sweet, MD, MS, Lynn Moscinski, MD, Lori A Hazlehurst, Ph.D, Javier Pinilla-Ibarz, MD, PhD, Ling Zhang, MD

Blood (2013) 122 (21): 2739.

https://doi.org/10.1182/blood.V122.21.2739.2739

Published: 2013

Journal Articles

PYK2 Mediates Microenvironment-Specific Myeloma Survival

Mark Meads, PhD, Bin Fang, PhD, Linda Mathews, Jennifer Gemmer, Liang Nong, M.D., Lori A Hazlehurst, Ph.D, Robert MacLeod, PhD, John Koomen, Ph.D., Kenneth Shain, MD, PhD

Blood (2013) 122 (21): 4443.

https://doi.org/10.1182/blood.V122.21.4443.4443

Published: 2013

Journal Articles

Personalizing Myeloma Chemotherapy Using Evolutionary Computational Models and Ex Vivo Assays.

Ariosto Siqueira Silva, PhD, Zayar Khin, BSc, Kenneth H Shain, MD, Ph.D, Rachid Baz, MD, Lori A Hazlehurst, Ph.D, Ashley Durand, BSc, Robert Gatenby, MD

Blood (2012) 120 (21): 2960.

https://doi.org/10.1182/blood.V120.21.2960.2960

Published: 2012

Journal Articles

Mti-101 Induces Necrotic Cell Death in AML Cells Through Its Binding to Cell Surface Complexes Containing CD44 and ITGA4

Rajesh R Nair, Ph.D., Joel H Tolentino, PhD, Milijana Ugrenovic, BSc, Priyesh R Jain, Ph.D., Mark L McLaughlin, Ph.D., Jeffrey E Lancet, MD, Lori A Hazlehurst, Ph.D

Blood (2012) 120 (21): 869.

https://doi.org/10.1182/blood.V120.21.869.869

Published: 2012

Journal Articles

Prognostic Significance of VLA4 and CD44 Expression by Flow Cytometry in Multiple Myeloma (MM)

Wasif Riaz, MBBS, John Pham, Ling Zhang, MD, Lynn Moscinski, MD, Lori A Hazlehurst, Ph.D, Michael Emmons, Ph.D, Daniel M Sullivan, MD, Kenneth H Shain, MD, Ph.D, Conor Lynch, Ph.D, Yue Binglin, Hui-Yi Lin, Ph.D, Rachid Baz, MD

Blood (2012) 120 (21): 4975.

https://doi.org/10.1182/blood.V120.21.4975.4975

Published: 2012

Journal Articles

Mti-101 (cyclized HYD1) Binds to CD44 and Induces Necrotic Cell Death in Multiple Myeloma

Anthony W. Gebhard, M.S., Rajesh R Nair, Ph.D., Michael Emmons, Ph.D, Priyesh R Jain, Ph.D., Andreas Becker, Ph.D., John Koomen, Ph.D., Ernst Schonbrunn, Ph.D., Daniel M Sullivan, MD, Mark L McLaughlin, Ph.D., Lori A Hazlehurst, Ph.D

Blood (2012) 120 (21): 4022.

https://doi.org/10.1182/blood.V120.21.4022.4022

Published: 2012

Journal Articles

NF-kB as a Regulator of FA/BRCA Gene Expression in Multiple Myeloma.

Vasco A. Oliveira, PhD, Linda Mathews, B.Sc., Danielle Yarde, B.Sc, Xingyu Wang, Ph.D., David Boulware, M.Sc., Lori A. Hazlehurst, Ph.D., Dung-Tsa Chen, Ph.D., Amer Beg, Ph.D., William S. Dalton, M.D., Ph.D.

Blood (2007) 110 (11): 3508.

https://doi.org/10.1182/blood.V110.11.3508.3508

Published: 2007

Journal Articles

Cell adhesion induces p27 Kip1 -associated cell-cycle arrest through down-regulation of the SCF Skp2 ubiquitin ligase pathway in mantle-cell and other non-Hodgkin B-cell lymphomas

Tint Lwin, Lori A. Hazlehurst, Sophie Dessureault, Raymond Lai, Wenlong Bai, Eduardo Sotomayor, Lynn C. Moscinski, William S. Dalton, Jianguo Tao

Blood (2007) 110 (5): 1631–1638.

https://doi.org/10.1182/blood-2006-11-060350

Published: 2007

Journal Articles

Bortezomib Enhances Melphalan Response by Altering Fanconi Anemia (FA)/BRCA Pathway Expression and Function.

Danielle N. Yarde, BS, Lori A. Hazlehurst, Ph.D., Vasco A. Oliveira, Ph.D., Qing Chen, Ph.D., William S. Dalton, Ph.D, M.D.

Blood (2006) 108 (11): 840.

https://doi.org/10.1182/blood.V108.11.840.840

Published: 2006

Journal Articles

Bone Marrow Stroma (BMS) Prevents Apoptosis of Lymphoma Cells by Upregulation of BMS-Derived B-Cell Activating Factor (BAFF) and Activation of NF-kB.

Tint Lwin, MD, PhD, Lori A. Hazlehurst, PhD, Lynn C. Moscinski, MD, William S. Dalton, PhD, MD, Jianguo Tao, MD, PhD

Blood (2006) 108 (11): 2378.

https://doi.org/10.1182/blood.V108.11.2378.2378

Published: 2006

Journal Articles

Cell Adhesion Induces p27Kip1-Associated Cell-Cycle Arrest through Down-Regulating SCF Skp2 Ubiquitin Ligase Pathway in Mantle Cell and Other Non-Hodgkin’s B-Cell Lymphomas.

Tint Lwin, MD, PhD, Lori A. Hazlehurst, PhD, Lynn C. Moscinski, MD, William S. Dalton, PhD,MD, Jianguo Tao, MD, PhD

Blood (2006) 108 (11): 2048.

https://doi.org/10.1182/blood.V108.11.2048.2048

Published: 2006

Journal Articles

The FA/BRCA pathway is involved in melphalan-induced DNA interstrand cross-link repair and accounts for melphalan resistance in multiple myeloma cells

Qing Chen, Pieter C. Van der Sluis, David Boulware, Lori A. Hazlehurst, William S. Dalton

Blood (2005) 106 (2): 698–705.

https://doi.org/10.1182/blood-2004-11-4286

Published: 2005

Journal Articles

Investigations on the Mechanisms of Resistance to Pixantrone in Tumor Cells.

Lori A. Hazlehurst, PhD, Melissa Alsina, MD, Miles P. Hacker, PhD

Blood (2004) 104 (11): 3402.

https://doi.org/10.1182/blood.V104.11.3402.3402

Published: 2004

Journal Articles

Reduction in drug-induced DNA double-strand breaks associated with β1 integrin–mediated adhesion correlates with drug resistance in U937 cells

Lori A. Hazlehurst, Nikola Valkov, Lee Wisner, Jonathan A. Storey, David Boulware, Daniel M. Sullivan, William S. Dalton

Blood (2001) 98 (6): 1897–1903.

https://doi.org/10.1182/blood.V98.6.1897

Published: 2001

Journal Articles

Cell Adhesion Mediated Drug Resistance (CAM-DR): Role of Integrins and Resistance to Apoptosis in Human Myeloma Cell Lines

Jason S. Damiano, Anne E. Cress, Lori A. Hazlehurst, Alexander A. Shtil, William S. Dalton

Blood (1999) 93 (5): 1658–1667.

https://doi.org/10.1182/blood.V93.5.1658

Published: 1999

NARROW

Targeting PYK2 Mediates Microenvironment-Specific Myeloma Cell Death

Bone Marrow Beta-Catenin Expression In Chronic Myelogenous Leukemia Patients Treated With Imatinib

PYK2 Mediates Microenvironment-Specific Myeloma Survival

Personalizing Myeloma Chemotherapy Using Evolutionary Computational Models and Ex Vivo Assays.

Mti-101 Induces Necrotic Cell Death in AML Cells Through Its Binding to Cell Surface Complexes Containing CD44 and ITGA4

Prognostic Significance of VLA4 and CD44 Expression by Flow Cytometry in Multiple Myeloma (MM)

Mti-101 (cyclized HYD1) Binds to CD44 and Induces Necrotic Cell Death in Multiple Myeloma

NF-kB as a Regulator of FA/BRCA Gene Expression in Multiple Myeloma.

Cell adhesion induces p27 Kip1 -associated cell-cycle arrest through down-regulation of the SCF Skp2 ubiquitin ligase pathway in mantle-cell and other non-Hodgkin B-cell lymphomas

Bortezomib Enhances Melphalan Response by Altering Fanconi Anemia (FA)/BRCA Pathway Expression and Function.

Bone Marrow Stroma (BMS) Prevents Apoptosis of Lymphoma Cells by Upregulation of BMS-Derived B-Cell Activating Factor (BAFF) and Activation of NF-kB.

Cell Adhesion Induces p27Kip1-Associated Cell-Cycle Arrest through Down-Regulating SCF Skp2 Ubiquitin Ligase Pathway in Mantle Cell and Other Non-Hodgkin’s B-Cell Lymphomas.

The FA/BRCA pathway is involved in melphalan-induced DNA interstrand cross-link repair and accounts for melphalan resistance in multiple myeloma cells

Investigations on the Mechanisms of Resistance to Pixantrone in Tumor Cells.

Reduction in drug-induced DNA double-strand breaks associated with β1 integrin–mediated adhesion correlates with drug resistance in U937 cells

Cell Adhesion Mediated Drug Resistance (CAM-DR): Role of Integrins and Resistance to Apoptosis in Human Myeloma Cell Lines

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American Society of Hematology

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American Society of Hematology

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