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Journal Articles

Elevated P21 (CDKN1a) Mediates Apoptosis of Beta-Thalassemic Erythroid Cells in Mice but Its Ablation Doesn't Improve Erythroid Maturation

Miao Lin, Vijay Menon, PhD, Raymond Liang, PhD, Tasleem Arif, PhD, Laura Breda, PhD, Stefano Rivella, PhD, Saghi Ghaffari, MDPhD

Blood (2020) 136 (Supplement 1): 19.

https://doi.org/10.1182/blood-2020-143384

Published: 2020

Journal Articles

Preclinical Evaluation of ALS20, a New and Improved Lentiviral Vector for Beta-Globinopathies

Laura Breda, PhD, Valentina Ghiaccio, PhD, Silvia Pires Lourenco, MSc, Danuta Jadwiga Jarocha, PhD, Yasuhiro Ikawa, MD PhD, Naoto Tanaka, PhD, Virginia Guzikowski, Carla Casu, PhD, Kim Smith-Whitley, MD, Janet L. Kwiatkowski, MD MSCE, Stefano Rivella, PhD

Blood (2019) 134 (Supplement_1): 2242.

https://doi.org/10.1182/blood-2019-124043

Published: 2019

Journal Articles

2'-O-Methoxyethyl Splice-Switching Oligos to Reverse Splicing from IVS2-745 β-Thalassemia Patient Cells: A Foundation for Potential Therapies

Blood (2019) 134 (Supplement_1): 2244.

https://doi.org/10.1182/blood-2019-127017

Published: 2019

Journal Articles

Improved Lentiviral Vectors for the Cure of Hemoglobinopathies

Laura Breda, PhD, Valentina Ghiaccio, PhD, Hanyia Zaidi, Silvia Pires Lourenco, MSc, Carla Casu, Kim Smith-Whitley, MD, Janet L. Kwiatkowski, MD, Vanessa Carrion, RN, CPN, Virginia Guzikowski, RN, MSN, CRNP, Ryo Kurita, PhD, Yukio Nakamura, MD PhD, Stefano Rivella, PhD

Blood (2018) 132 (Supplement 1): 3477.

https://doi.org/10.1182/blood-2018-99-111319

Published: 2018

Journal Articles

AMPK Regulates the Expression of the Fe-S Cluster Assembly Enzyme (ISCU) and ALAS2, Modulating Cellular Iron Metabolism and Increasing Hemoglobin Synthesis

Ping La, Silvia Pires Lourenco, MSc, Laura Breda, PhD, Stefano Rivella

Blood (2018) 132 (Supplement 1): 851.

https://doi.org/10.1182/blood-2018-99-112175

Published: 2018

Journal Articles

Lack of GDF11 Does Not Ameliorate Erythropoiesis in β-Thalassemia and Does Not Prevent the Activity of the Trap-Ligand RAP-536

Amaliris Guerra, PhD, Rea Oikonomidou, MD, Sinha Gonzalez, PhD, Jianbing Zhang, PhD, Vania Lo Presti, Callum R Hamilton, Laura Breda, PhD, Carla Casu, Mark D. Fleming, MD DPhil, Pedro Martinez, PhD, Rajasekhar Suragani, PhD, Ravi Kumar, PhD, Stefano Rivella

Blood (2018) 132 (Supplement 1): 165.

https://doi.org/10.1182/blood-2018-165

Published: 2018

Journal Articles

Generation of New Cell Models to Screen Improved Vectors for Functional Hemoglobin Expression

Silvia Pires Lourenco, MSc, Amaliris Gonzalez, PhD, Tobias Raabe, PhD, Ryo Kurita, PhD, Yukio Nakamura, MD PhD, Laura Breda, PhD, Stefano Rivella, PhD

Blood (2017) 130 (Supplement 1): 5563.

https://doi.org/10.1182/blood.V130.Suppl_1.5563.5563

Published: 2017

Journal Articles

Adult Hemoglobin Production, Chain Rebalance, and Splice Correction in IVS2-745 Beta-Thalassemia Patient Cells Using 2'-O-Methoxyethyl Splice-Switching Oligos

Alisa Cheung Dong, Valentina Ghiaccio, Irene Motta, MD, Shuling Guo, PhD, Raechel Peralta, MS, Coralea Stephanou, PhD, Paola Delbini, PhD, Connie Chen, Soteroula Christou, Marina Kleanthous, PhD, Maria Domenica Cappellini, MD, Osheiza Abdulmalik, DVM, MS, Laura Breda, PhD, Stefano Rivella, PhD

Blood (2016) 128 (22): 1014.

https://doi.org/10.1182/blood.V128.22.1014.1014

Published: 2016

Journal Articles

Genetic Investigation of the Role of GDF11 in the Treatment of β-Thalassemia and MDS

Paraskevi Rea Oikonomidou, MD, Ping La, PhD, Ritama Gupta, MSc, Vania Lo Presti, Carla Casu, PhD, Laura Breda, PhD, Deborah Watson, PhD, Rajasekhar NVS Suragani, PhD, Ravindra Kumar, PhD, Stefano Rivella, PhD

Blood (2016) 128 (22): 2439.

https://doi.org/10.1182/blood.V128.22.2439.2439

Published: 2016

Journal Articles

Comparing Strategies to Reactivate Fetal Globin Expression for the Treatment of Beta-Globinopathies

Laura Breda, PhD, Jeremy W. Rupon, MD PhD, Irene Motta, MD, Wulan Deng, Gerd A. Blobel, MD PhD, Stefano Rivella, PhD

Blood (2014) 124 (21): 333.

https://doi.org/10.1182/blood.V124.21.333.333

Published: 2014

Journal Articles

Exogenous Apo-Transferrin Increases Monoferric Transferrin, Decreasing Cytosolic Iron Uptake and Heme and Globin Synthesis in β-Thalassemic Mice

Tenzin Choesang, Huihui Li, MS, Michael Dussiot, Thiago Maciel, PhD, Laura Breda, PhD, Daniel Garcia Santos, PhD, Huiyong Chen, PhD, Maria Feola, Weili Bao, Petra Pham, Antonia Follenzi, Guiyuan Li, Ivan Cruz Moura, PhD, Prem Ponka, MD PhD, Robert E Fleming, MD, Stefano Rivella, PhD, Yelena Ginzburg, MD

Blood (2014) 124 (21): 4037.

https://doi.org/10.1182/blood.V124.21.4037.4037

Published: 2014

Journal Articles

Macrophages Regulate Stress Erythropoiesis Through Direct Cellular Interactions Associated With Integrin β1-Focal Adhesion Kinase Signaling

Bart J Crielaard, MD, PhD, Carla Casu, PhD, Pedro Ramos, PhD, Sara Gardenghi, PhD, Laura Breda, PhD, Ritama Gupta, Stefano Rivella, PhD

Blood (2013) 122 (21): 307.

https://doi.org/10.1182/blood.V122.21.307.307

Published: 2013

Journal Articles

The Human Ankyrin Insulator Supports Production of Therapeutic Levels of Adult Hemoglobin Following β-Globin Gene Transfer in Hematopoietic Cells Derived From Thalassemic and Sickle Cell Patients

Laura Breda, PhD, Carla Casu, Nicoletta Bianchi, Luca Cartegni, Karina Yazdanbakhsh, PhD, Deepa Manwani, MD, Narla Mohandas, Petar Jelinic, Gregory David, Lawrence B. Gardner, MD, Dorothy A Kleinert, NP, MPH, Eugenia Prus, Eitan Fibach, PhD, Patricia Giardina, MD, Roberto Gambari, Stefano Rivella, PhD

Blood (2011) 118 (21): 2055.

https://doi.org/10.1182/blood.V118.21.2055.2055

Published: 2011

Journal Articles

Following Beta-Globin Gene Transfer, the Production of Hemoglobin Depends Upon the Beta-Thalassemia Genotype.

Laura Breda, PhD, Carla Casu, PhD, Laura Casula, PhD, Dorothy A. Kleinert, NP, MPH, Nicoletta Bianchi, PhD, Evgenia Prus, PhD, Luca Cartegni, PhD, Eitan Fibach, PhD, Lawrence B. Gardner, MD, Patricia J Giardina, MD, Roberto Gambari, PhD, Stefano Rivella, PhD

Blood (2009) 114 (22): 978.

https://doi.org/10.1182/blood.V114.22.978.978

Published: 2009

Journal Articles

Absence of the Hemochromatosis Gene HFE Confers Protection Under Conditions of Stress Erythropoiesis.

Pedro Ramos, Ella Guy, Laura Breda, PhD, Sara Gardenghi, PhD, Robert W Grady, Ph.D, Maria De Sousa, MD, Stefano Rivella, PhD

Blood (2008) 112 (11): 3848.

https://doi.org/10.1182/blood.V112.11.3848.3848

Published: 2008

Journal Articles

Accelerated Proliferation and Limited Differentiation, Mediated through Jak2, Exacerbate Ineffective Erythropoiesis in β-Thalassemia.

Ella Guy, Ilaria Libani, PhD, Luca Melchiori, Thomas Scholzen, PhD, Raffaella Schiro, MD, Pedro Ramos, Margrit Kernbach, Bettina Baron-Luehr, Laura Breda, PhD, Matteo Porotto, PhD, Maria de Sousa, MD, Maria Domenica Cappellini, MD, Patricia J. Giardina, MD, Robert W. Grady, PhD, Johannes Gerdes, PhD, Stefano Rivella, PhD

Blood (2007) 110 (11): 275.

https://doi.org/10.1182/blood.V110.11.275.275

Published: 2007

Journal Articles

Ineffective Erythropoiesis in β-Thalassemia Is Characterized by Increased Iron Absorption Mediated by down Regulation of Hepcidin and up Regulation of Ferroportin.

Sara Gardenghi, PhD, Maria Marongiu, Pedro Ramos, Ella Guy, Laura Breda, PhD, Amy Chadburn, MD, Yifang Liu, Gideon Rechavi, MD, Ninette Amariglio, PhD, E.A. Rachmilewitz, MD, Diedra Wrighting, PhD, Nancy C. Andrews, MD, Maria de Sousa, MD, Patricia Giardina, MD, Robert W. Grady, PhD, Stefano Rivella, PhD

Blood (2006) 108 (11): 1543.

https://doi.org/10.1182/blood.V108.11.1543.1543

Published: 2006

Journal Articles

Role of HFE in Hepatic Iron Overload: Novel Findings Demonstrate Direct Effects of Mutant C282Y on Hepcidin and Calreticulin mRNA Expression.

Jorge P. Pinto, PhD, Pedro Ramos, Sergio de Almeida, Susana Oliveira, Laura Breda, PhD, Marek Michalak, PhD, Stefano Rivella, PhD, Maria de Sousa, MD, PhD

Blood (2006) 108 (11): 1549.

https://doi.org/10.1182/blood.V108.11.1549.1549

Published: 2006

Journal Articles

Kinetic of Iron Absorption and Expression of Iron Related Genes in Beta-Thalassemia.

Laura Breda, PhD, Sara Gardenghi, PhD, Ella Guy, Ninette Amariglio, PhD, Konstantin Adamsky, PhD, Orly Weizer-Stern, PhD, Eliezer Rachmilewitz, MD, Gideon Rechavi, MD, Patricia J. Giardina, MD, Robert W. Grady, PhD, Stefano Rivella, PhD

Blood (2005) 106 (11): 3846.

https://doi.org/10.1182/blood.V106.11.3846.3846

Published: 2005

NARROW

Elevated P21 (CDKN1a) Mediates Apoptosis of Beta-Thalassemic Erythroid Cells in Mice but Its Ablation Doesn't Improve Erythroid Maturation

Preclinical Evaluation of ALS20, a New and Improved Lentiviral Vector for Beta-Globinopathies

2'-O-Methoxyethyl Splice-Switching Oligos to Reverse Splicing from IVS2-745 β-Thalassemia Patient Cells: A Foundation for Potential Therapies

Improved Lentiviral Vectors for the Cure of Hemoglobinopathies

AMPK Regulates the Expression of the Fe-S Cluster Assembly Enzyme (ISCU) and ALAS2, Modulating Cellular Iron Metabolism and Increasing Hemoglobin Synthesis

Lack of GDF11 Does Not Ameliorate Erythropoiesis in β-Thalassemia and Does Not Prevent the Activity of the Trap-Ligand RAP-536

Generation of New Cell Models to Screen Improved Vectors for Functional Hemoglobin Expression

Adult Hemoglobin Production, Chain Rebalance, and Splice Correction in IVS2-745 Beta-Thalassemia Patient Cells Using 2'-O-Methoxyethyl Splice-Switching Oligos

Genetic Investigation of the Role of GDF11 in the Treatment of β-Thalassemia and MDS

Comparing Strategies to Reactivate Fetal Globin Expression for the Treatment of Beta-Globinopathies

Exogenous Apo-Transferrin Increases Monoferric Transferrin, Decreasing Cytosolic Iron Uptake and Heme and Globin Synthesis in β-Thalassemic Mice

Macrophages Regulate Stress Erythropoiesis Through Direct Cellular Interactions Associated With Integrin β1-Focal Adhesion Kinase Signaling

The Human Ankyrin Insulator Supports Production of Therapeutic Levels of Adult Hemoglobin Following β-Globin Gene Transfer in Hematopoietic Cells Derived From Thalassemic and Sickle Cell Patients

Following Beta-Globin Gene Transfer, the Production of Hemoglobin Depends Upon the Beta-Thalassemia Genotype.

Absence of the Hemochromatosis Gene HFE Confers Protection Under Conditions of Stress Erythropoiesis.

Accelerated Proliferation and Limited Differentiation, Mediated through Jak2, Exacerbate Ineffective Erythropoiesis in β-Thalassemia.

Ineffective Erythropoiesis in β-Thalassemia Is Characterized by Increased Iron Absorption Mediated by down Regulation of Hepcidin and up Regulation of Ferroportin.

Role of HFE in Hepatic Iron Overload: Novel Findings Demonstrate Direct Effects of Mutant C282Y on Hepcidin and Calreticulin mRNA Expression.

Kinetic of Iron Absorption and Expression of Iron Related Genes in Beta-Thalassemia.

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American Society of Hematology

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American Society of Hematology

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