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Journal Articles

Enhanced Thrombotic Susceptibility, Endotheliopathy, and Abnormal Cognitive Behavior for up to 5 Months after Sars-Cov-2 Infection in a Mouse Model of Long COVID

Roberto Aiolfi, Antonella Zampolli, Miriam Hauer-Jensen, Jose A. Fernandez, Xiao Xu, Angel Gandarilla, Julia C.O. Mosnier, Amanda J. Roberts, Juan Carlos de la Torre, Laurent O. Mosnier

Blood (2024) 144 (Supplement 1): 1230.

https://doi.org/10.1182/blood-2024-212054

Published: 2024

Journal Articles

Heterobivalent Peptide Agonists Comprising Covalently Linked Protease Activated Receptor 1 and Protease Activated Receptor 3 Peptides Mimic the Cytoprotective Cell Signaling Activities of Activated Protein C

Jose A. Fernandez, Laura D. Healy, Laurent O. Mosnier, John H. Griffin

Blood (2023) 142 (Supplement 1): 3976.

https://doi.org/10.1182/blood-2023-185096

Published: 2023

Journal Articles

Survival Advantage Associated with Heterozygous Factor V Leiden Mutation in Sars-Cov-2-Infected K18-hACE2 Mice

Roberto Aiolfi, Jose A. Fernandez, Hiroshi Deguchi, Xiao Xu, Jeanine Ahmed, Miriam Hauer-Jensen, John H. Griffin, Juan Carlos de la Torre, Hartmut Weiler, Laurent O. Mosnier

Blood (2023) 142 (Supplement 1): 2563.

https://doi.org/10.1182/blood-2023-190742

Published: 2023

Journal Articles

Intravenous 3K3A-Activated Protein C Inhibits Murine Ocular Inflammation and Suppresses Ocular Choroidal Neovascularization

Tami Livnat, Yael Nisgav, José A Fernández, Ivan Budnik, Sarina Levy-Mendelovich, Dov Weinberger, Gili Kenet, John Griffin

Blood (2023) 142 (Supplement 1): 2602.

https://doi.org/10.1182/blood-2023-181533

Published: 2023

Journal Articles

Procoagulant activities of skeletal muscle and cardiac myosins require both myosin protein and myosin-associated anionic phospholipids

Shravan Morla, Hiroshi Deguchi, José A. Fernández, Wolfram Ruf, Rolf A. Brekken, John H. Griffin

Blood (2021) 137 (13): 1839–1842.

https://doi.org/10.1182/blood.2020008580

Published: 2021

Journal Articles

Platelet protein S limits venous but not arterial thrombosis propensity by controlling coagulation in the thrombus

Sara Calzavarini, Raja Prince-Eladnani, François Saller, Luca Bologna, Laurent Burnier, Anne C. Brisset, Claudia Quarroz, Maria Desiré Reina Caro, Vladimir Ermolayev, Yasuhiro Matsumura, José A. Fernández, Tilman M. Hackeng, John H. Griffin, Anne Angelillo-Scherrer

Blood (2020) 135 (22): 1969–1982.

https://doi.org/10.1182/blood.2019003630

Published: 2020

Includes: Multimedia, Supplemental data

Journal Articles

Activated protein C ameliorates chronic graft-versus-host disease by PAR1-dependent biased cell signaling on T cells

Ranjeet K. Sinha, Ryan Flynn, Michael Zaiken, Katelyn Paz, Amanda L. Gavin, David Nemazee, José A. Fernández, Xiao Xu, John H. Griffin, Bruce R. Blazar

Blood (2019) 134 (9): 776–781.

https://doi.org/10.1182/blood.2019001259

Published: 2019

Journal Articles

Targeting anticoagulant protein S to improve hemostasis in hemophilia

Blood (2018) 131 (12): 1360–1371.

https://doi.org/10.1182/blood-2017-09-800326

Published: 2018

Includes: Supplemental data

Journal Articles

PAR1 biased signaling is required for activated protein C in vivo benefits in sepsis and stroke

Ranjeet K. Sinha, Yaoming Wang, Zhen Zhao, Xiao Xu, Laurent Burnier, Naveen Gupta, José A. Fernández, Greg Martin, Sergey Kupriyanov, Laurent O. Mosnier, Berislav V. Zlokovic, John H. Griffin

Blood (2018) 131 (11): 1163–1171.

https://doi.org/10.1182/blood-2017-10-810895

Published: 2018

Includes: Supplemental data

Journal Articles

Blocking Protein S Improves Hemostasis in Hemophilia a and B

Luca Bologna, PhDstudent, Raja Prince, PhDstudent, Mirko Manetti, PhD, Daniela Melchiorre, MD, Irene Rosa, PhDstudent, Natacha Dewarrat, Poorya Amini, PhDstudent, Jose A Fernandez, Claudia Quarroz, Yasuhiro Matsumura, MD PhD, Johanna A Kremer Hovinga, MD PhD, Shida Yousefi, PhD, John H. Griffin, PhD, Simon Hans-Uwe, MD PhD, Lidia Ibba Manneschi, Francois Saller, PhD, Sara Calzavarini, PhD, Anne Angelillo-Scherrer, MD

Blood (2016) 128 (22): 79.

https://doi.org/10.1182/blood.V128.22.79.79

Published: 2016

Journal Articles

Novel R41Q- and R46Q-PAR1-Modified Mice Enable Proof-of-Concept Studies for In Vivo Protective Mechanisms of Action for Activated Protein C (APC) in Sepsis and Stroke

Ranjeet Kumar Sinha, PhD MSc, Yaoming Wang, PhD, Zhen Zhao, PhD, Jose A. Fernandez, MD PhD, Naveen Gupta, Xiao Xu, MSc, Greg Martin, MSc, Sergey Kupriyanov, PhD MSc, Laurent O Mosnier, PhD, Berislav Zlokovic, PhD, John H. Griffin, PhD

Blood (2016) 128 (22): 13.

https://doi.org/10.1182/blood.V128.22.13.13

Published: 2016

Journal Articles

Activated Protein C (APC) Therapy Ameliorates Chronic Graft Versus Host Disease By Cell Signaling Mechanisms That Require Cleavage at Arg46 in PAR1 on T Cells

Ranjeet Kumar Sinha, PhD MSc, Ryan P Flynn, PhD, Jose A. Fernandez, MD PhD, Xiao Xu, MSc, Greg Martin, MSc, Sergey Kupriyanov, PhD MSc, John H. Griffin, PhD, Bruce R. Blazar, MD

Blood (2016) 128 (22): 808.

https://doi.org/10.1182/blood.V128.22.808.808

Published: 2016

Journal Articles

Plasma Constitutive Serum Amyloid A4 Is Procoagulant and Is Elevated in Venous Thrombosis Patients

John H. Griffin, PhD, Jose A. Fernandez, MD PhD, Ranjeet Kumar Sinha, PhD MSc, Darlene J. Elias, MD, Hiroshi Deguchi, MD PhD

Blood (2015) 126 (23): 3486.

https://doi.org/10.1182/blood.V126.23.3486.3486

Published: 2015

Journal Articles

Coagulation Factor V Mediates Inhibition of Tissue Factor Signaling By Activated Protein C

Hartmut Weiler, Hai-Po Liang, PhD, Edward J Kerschen, PhD, Alireza Rezaie, PhD, Jose A. Fernandez, MD PhD, Rodney M. Camire, PhD, Wolfram Ruf, MD, John H. Griffin, PhD, Raffaele Toso, PhD

Blood (2015) 126 (23): 216.

https://doi.org/10.1182/blood.V126.23.216.216

Published: 2015

Journal Articles

Coagulation factor V mediates inhibition of tissue factor signaling by activated protein C in mice

Hai Po H. Liang, Edward J. Kerschen, Sreemanti Basu, Irene Hernandez, Mark Zogg, Shuang Jia, Martin J. Hessner, Raffaella Toso, Alireza R. Rezaie, José A. Fernández, Rodney M. Camire, Wolfram Ruf, John H. Griffin, Hartmut Weiler

Blood (2015) 126 (21): 2415–2423.

https://doi.org/10.1182/blood-2015-05-644401

Published: 2015

Includes: Supplemental data

Journal Articles

Exacerbated venous thromboembolism in mice carrying a protein S K196E mutation

Fumiaki Banno, Toshiyuki Kita, José A. Fernández, Hiroji Yanamoto, Yuko Tashima, Koichi Kokame, John H. Griffin, Toshiyuki Miyata

Blood (2015) 126 (19): 2247–2253.

https://doi.org/10.1182/blood-2015-06-653162

Published: 2015

Includes: Supplemental data

Journal Articles

Acylcarnitines are anticoagulants that inhibit factor Xa and are reduced in venous thrombosis, based on metabolomics data

Hiroshi Deguchi, Yajnavalka Banerjee, Sunia Trauger, Gary Siuzdak, Ewa Kalisiak, José A. Fernández, Linh Hoang, Minerva Tran, Subramanian Yegneswaran, Darlene J. Elias, John H. Griffin

Blood (2015) 126 (13): 1595–1600.

https://doi.org/10.1182/blood-2015-03-636761

Published: 2015

Includes: Supplemental data

Journal Articles

Acylcarnitines Are Novel Anticoagulant Lipids That Target Factor Xa and That Are Reduced in Plasma of Venous Thrombosis Patients Based on Untargeted and Targeted Metabolomics

Hiroshi Deguchi, MD PhD, Yajnavalka Banerjee, PhD, Gary Siuzdak, PhD, Sunia Trauger, PhD, Ewa Kalisiak, PhD, Jose A. Fernandez, MD PhD, Linh Hoang, Minerva Tran, Subramanian Yegneswaran, PhD, Darlene J Elias, MD, John H. Griffin, PhD

Blood (2014) 124 (21): 2797.

https://doi.org/10.1182/blood.V124.21.2797.2797

Published: 2014

Journal Articles

Factor V Inhibits PAR2-Mediated Lethal Inflammation

Edward J Kerschen, PhD, Hai-Po Helena Liang, Jose A. Fernandez, MD, PhD, Raffaella Toso, PhD, Wolfram Ruf, MD, Rodney M. Camire, PhD, John H. Griffin, PhD, Hartmut Weiler, PhD

Blood (2012) 120 (21): 3360.

https://doi.org/10.1182/blood.V120.21.3360.3360

Published: 2012

Journal Articles

In Vitro and in Vivo Neutralization of Murine Activated Protein C

Laurent Burnier, PhD, Jose A. Fernandez, MD, PhD, John H. Griffin, PhD

Blood (2012) 120 (21): 3364.

https://doi.org/10.1182/blood.V120.21.3364.3364

Published: 2012

NARROW

Enhanced Thrombotic Susceptibility, Endotheliopathy, and Abnormal Cognitive Behavior for up to 5 Months after Sars-Cov-2 Infection in a Mouse Model of Long COVID

Heterobivalent Peptide Agonists Comprising Covalently Linked Protease Activated Receptor 1 and Protease Activated Receptor 3 Peptides Mimic the Cytoprotective Cell Signaling Activities of Activated Protein C

Survival Advantage Associated with Heterozygous Factor V Leiden Mutation in Sars-Cov-2-Infected K18-hACE2 Mice

Intravenous 3K3A-Activated Protein C Inhibits Murine Ocular Inflammation and Suppresses Ocular Choroidal Neovascularization

Procoagulant activities of skeletal muscle and cardiac myosins require both myosin protein and myosin-associated anionic phospholipids

Platelet protein S limits venous but not arterial thrombosis propensity by controlling coagulation in the thrombus

Activated protein C ameliorates chronic graft-versus-host disease by PAR1-dependent biased cell signaling on T cells

Targeting anticoagulant protein S to improve hemostasis in hemophilia

PAR1 biased signaling is required for activated protein C in vivo benefits in sepsis and stroke

Blocking Protein S Improves Hemostasis in Hemophilia a and B

Novel R41Q- and R46Q-PAR1-Modified Mice Enable Proof-of-Concept Studies for In Vivo Protective Mechanisms of Action for Activated Protein C (APC) in Sepsis and Stroke

Activated Protein C (APC) Therapy Ameliorates Chronic Graft Versus Host Disease By Cell Signaling Mechanisms That Require Cleavage at Arg46 in PAR1 on T Cells

Plasma Constitutive Serum Amyloid A4 Is Procoagulant and Is Elevated in Venous Thrombosis Patients

Coagulation Factor V Mediates Inhibition of Tissue Factor Signaling By Activated Protein C

Coagulation factor V mediates inhibition of tissue factor signaling by activated protein C in mice

Exacerbated venous thromboembolism in mice carrying a protein S K196E mutation

Acylcarnitines are anticoagulants that inhibit factor Xa and are reduced in venous thrombosis, based on metabolomics data

Acylcarnitines Are Novel Anticoagulant Lipids That Target Factor Xa and That Are Reduced in Plasma of Venous Thrombosis Patients Based on Untargeted and Targeted Metabolomics

Factor V Inhibits PAR2-Mediated Lethal Inflammation

In Vitro and in Vivo Neutralization of Murine Activated Protein C

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American Society of Hematology

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ASH Publications

American Society of Hematology

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