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Journal Articles

Constitutive PRMT5 Expression Drives Spontaneous Lymphoblastic Lymphoma In Vivo

Lynda Villagomez, Porsha Smith, Fengting Yan, Victor Chen, Shelby Sloan, John T. Patton, Mackenzie Long, Fiona Brown, Elshafa H. Ahmed, Natarajan Muthusamy, Vincenzo Coppola, Anjali Mishra, Kris Vaddi, Peggy Scherle, Rosa Lapalombella, Lapo Alinari, Robert A. Baiocchi

Blood (2022) 140 (Supplement 1): 6381–6382.

https://doi.org/10.1182/blood-2022-168160

Published: 2022

Journal Articles

BET Bromodomain Inhibition Selectively Targets the Epstein-Barr Virus Oncogene LMP1 While Promoting Virus-Specific, Adaptive Anti-Tumor Activity

Emily Smith, Andrew Stiff, BS, John T. Patton, PhD, William Carson, III, Rosa Lapalombella, PhD, Robert A Baiocchi, MD PhD

Blood (2016) 128 (22): 46.

https://doi.org/10.1182/blood.V128.22.46.46

Published: 2016

Journal Articles

PRMT5 Transgenic Mice Develop Aggressive Lymphoblastic Lymphomas

Porsha L. Smith, PhD, Fengting Yan, MD PhD, John T. Patton, PhD, Lapo Alinari, MD PhD, Vrajesh Karkhanis, PhD, Leona Ayers, MD, Natarajan Muthusamy, DVM, PhD, Anjali Mishra, PhD, Elshafa Ahmed, DVM, Said Sif, PhD, Rosa Lapalombella, PhD, Robert A Baiocchi, MD PhD

Blood (2016) 128 (22): 2936.

https://doi.org/10.1182/blood.V128.22.2936.2936

Published: 2016

Journal Articles

Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation

Blood (2015) 125 (16): 2530–2543.

https://doi.org/10.1182/blood-2014-12-619783

Published: 2015

Includes: Supplemental data

Journal Articles

Identifying and Targeting Cytotoxic Tumor-Associated Macrophages in Epstein-Barr Virus-Driven Lymphoproliferative Disease

John T. Patton, PhD, Monica L Mitchell, Li Pan, PhD, A. Douglas Kinghorn, PhD, D.Sc, Michael R. Grever, MD, David M. Lucas, PhD, Robert A. Baiocchi, MD PhD

Blood (2014) 124 (21): 4489.

https://doi.org/10.1182/blood.V124.21.4489.4489

Published: 2014

Journal Articles

The Epstein-Barr Virus Lytic Protein BZLF1 As a Candidate Target Antigen for Vaccine Development

Alex S. Hartlage, Tom Liu, PhD, John T. Patton, Sabrina L Garman, Xiaoli Zhang, PhD MS, Habibe Kurt, MD, Gerard Lozanski, MD, Mark E Lustberg, MD PhD, Michael A. Caligiuri, MD, Robert A. Baiocchi, MD PhD

Blood (2014) 124 (21): 4144.

https://doi.org/10.1182/blood.V124.21.4144.4144

Published: 2014

Journal Articles

Epstein-Barr Virus Kinase-Targeted Therapy for Primary Central Nervous System Post-Transplant Lymphoproliferative Disorder

James Dugan, MD MS, Bradley M. Haverkos, MD MPH, Ludmila Katherine Martin, MD, Marisa F. Martin, Mark E Lustberg, MD PhD, John T. Patton, PhD, Gerard Nuovo, MD, Fengting Yan, MD, PhD, Robert Cavaliere, MD, Shannon C. Kenney, MD, Joyce Fingeroth, MD, Gerard Lozanski, MD, Juan Carlos Ramos, MD, Pierluigi Porcu, MD, Michael A. Caligiuri, MD, Robert A. Baiocchi, MD PhD

Blood (2014) 124 (21): 1750.

https://doi.org/10.1182/blood.V124.21.1750.1750

Published: 2014

Journal Articles

Determination of Optimal Target Antigen and Immune Modulatory Approaches to Improve and Standardize Epstein-Barr Virus-Specific Adoptive T Cell Therapy

Monica L Mitchell, John T. Patton, PhD, Lynn O'Donnell, PhD, Robert A. Baiocchi, MD PhD

Blood (2014) 124 (21): 5817.

https://doi.org/10.1182/blood.V124.21.5817.5817

Published: 2014

Journal Articles

Silvestrol Modulates Indirect Anti-Tumor Activity and Potentiates Immune Response To Epstein-Barr Virus-Driven Lymphoproliferative Disease

John T. Patton, Alex S. Hartlage, Li Pan, PhD, Mark E Lustberg, MD, PhD, Callie M. Drohan, Marisa F. Martin, A. Douglas Kinghorn, Ph.D., D.Sc, Michael A. Caligiuri, MD, Michael R. Grever, MD, David M. Lucas, PhD, Robert A. Baiocchi, M.D., Ph.D.

Blood (2013) 122 (21): 4422.

https://doi.org/10.1182/blood.V122.21.4422.4422

Published: 2013

Journal Articles

Protein Arginine Methyltransferase 5 (PRMT5) Over-Expression Is Essential for Epstein-Barr Virus-Driven B-Cell Transformation.

Lapo Alinari, MD., Ph.D., Fengting Yan, M.D., Ph.D., Porsha Smith, John T. Patton, Carl Quinion, Bo Yu, Ph.D, Christian Tyler Earl, Mark E Lustberg, MD, PhD, Lynda Villagomez, Erin K Hertlein, PhD, John C. Byrd, MD, Leona Ayers, MD, Tasneem Motiwala, PhD, Sarmila Majumder, PhD, Chenglong Li, Ph.D., Said Sif, Ph.D., Samson T. Jacob, PhD, Robert A. Baiocchi, M.D., Ph.D.

Blood (2012) 120 (21): 2378.

https://doi.org/10.1182/blood.V120.21.2378.2378

Published: 2012

Journal Articles

Novel E-Selectin Antagonist GMI-1271 Decreases Venous Thrombosis without Increased Bleeding Potential in a Mouse Model

Daniel Durant Myers, Jr., DVM, MPH, Dorian L Culmer, DVM, Jose A. Diaz, MD, Angela E. Hawley, MS, Peter K. Henke, MD, Suman L. Sood, MD, Robert E Sigler, DVM, PhD, Andrea T Obi, MD, John T. Patton, PhD, Thomas W. Wakefield, MD, John L. Magnani, PhD

Blood (2012) 120 (21): 3422.

https://doi.org/10.1182/blood.V120.21.3422.3422

Published: 2012

Journal Articles

Pan-Selectin Antagonist GMI-1070 Affects Biomarkers of Adhesion, Activation and the Coagulation Cascade in Sickle Cell Adults At Steady State

John L. Magnani, PhD, Frans A Kuypers, PhD, John T. Patton, PhD, Sandra K Larkin, MS, Lori Styles, MD, Laura M DeCastro, MD, Marilyn J. Telen, MD, Ted Wun, MD, Helen Thackray, MD

Blood (2012) 120 (21): 87.

https://doi.org/10.1182/blood.V120.21.87.87

Published: 2012

Journal Articles

A Novel Small Molecule E-Selectin Inhibitor GMI-1271 Blocks Adhesion of AML Blasts to E-Selectin and Mobilizes Blood Cells in Nodscid IL2Rgc −/− Mice Engrafted with Human AML

Sylvia Chien, Xin Zhao, MD, Margaret Brown, Akanksha Saxena, BS, John T. Patton, PhD, John L. Magnani, PhD, Pamela S Becker, MD, PhD

Blood (2012) 120 (21): 4092.

https://doi.org/10.1182/blood.V120.21.4092.4092

Published: 2012

Journal Articles

P-selectin glycoprotein ligand regulates the interaction of multiple myeloma cells with the bone marrow microenvironment

Abdel Kareem Azab, Phong Quang, Feda Azab, Costas Pitsillides, Brian Thompson, Triona Chonghaile, John T. Patton, Patricia Maiso, Val Monrose, Antonio Sacco, Hai T. Ngo, Ludmila M. Flores, Charles P. Lin, John L. Magnani, Andrew L. Kung, Anthony Letai, Ruben Carrasco, Aldo M. Roccaro, Irene M. Ghobrial

Blood (2012) 119 (6): 1468–1478.

https://doi.org/10.1182/blood-2011-07-368050

Published: 2012

Includes: Supplemental data

Journal Articles

Pan-Selectin Antagonist, GMI-1070 Decreases Venous Thrombosis in a Mouse Model,

Daniel Durant Myers, Jr., DVM, MPH, Peter K. Henke, MD, Jose A. Diaz, MD, Shirley K. Wrobleski, BS, Angela E. Hawley, MS, Dallas Slack, BS, Thomas W. Wakefield, MD, John T. Patton, PhD, John L. Magnani

Blood (2011) 118 (21): 3273.

https://doi.org/10.1182/blood.V118.21.3273.3273

Published: 2011

Journal Articles

Silvestrol Modulates Direct Anti-Tumor Activity Against Epstein-Barr Virus (EBV)-Associated Lymphomas While Sparing Innate and Antigen Specific Adaptive Immunity

John T. Patton, Mark E Lustberg, MD, PhD, Sabrina L Garman, A Douglas Kinghorn, Ph.D., D.Sc, Li Pan, PhD, David M. Lucas, PhD, Michael R. Grever, M.D., Robert A. Baiocchi, M.D., Ph.D.

Blood (2011) 118 (21): 104.

https://doi.org/10.1182/blood.V118.21.104.104

Published: 2011

Journal Articles

Novel Dual E-Selectin-CXCR4 Inhibitors Mobilize Human Acute Myeloid Leukemia (AML) Cells in the NODscid IL2Rγc−/− Xenograft and Confer Susceptibility to Cytarabine

Sylvia Chien, Xin Zhao, MD, John T. Patton, PhD, Theodore Smith, Arun Sarkar, PhD, John L. Magnani, Frederick R. Appelbaum, MD, Pamela S Becker, MD, PhD

Blood (2011) 118 (21): 579.

https://doi.org/10.1182/blood.V118.21.579.579

Published: 2011

Journal Articles

Developing a Novel Class of Drug to Inhibit Protein Arginine Methyltransferase 5 (PRMT5) Enzyme Dysregulation in Mantle Cell Lymphoma

Fengting Yan, M.D., Ph.D., Porsha Smith, Lapo Alinari, MD., Ph.D., John Ryu, Bo Yu, Ph.D., Vrajesh Karkhanis, Ph.D., Sookil Tae, Ph.D., John T. Patton, Emily E. Wilding, Kate Gordon, Kiran Mahasenan, Ph.D., Deepak Bhasin, Ph.D., Claudio Agostinelli, M.D., Ph.D., Stefano A. Pileri, M.D., John C. Byrd, MD, Said Sif, Ph.D., Pui-kai Li, Ph.D., Chenglong Li, Ph.D., Robert A. Baiocchi, M.D., Ph.D.

Blood (2011) 118 (21): 595.

https://doi.org/10.1182/blood.V118.21.595.595

Published: 2011

Journal Articles

FTY720 Increases CD74 Expression and Sensitizes Mantle Cell Lymphoma Cells to Milatuzumab-Mediated Cell Death

Lapo Alinari, MD., Ph.D., Emilia Mahoney, MD, PhD, John T. Patton, Xiaoli Zhang, PhD, MS, Lenguyen Huynh, Christian Tyler Earl, Rajeswaran Mani, DVM, Yicheng Mao, Bo Yu, Ph.D., William H. Towns, Ching-Shih Chen, Ph.D, David M. Goldenberg, Kristie A. Blum, MD, John C. Byrd, MD, Natarajan Muthusamy, DVM, Ph.D, Mette Ibba, PhD, Robert A. Baiocchi, M.D., Ph.D.

Blood (2011) 118 (21): 600.

https://doi.org/10.1182/blood.V118.21.600.600

Published: 2011

Journal Articles

Successful Treatment of Primary Central Nervous System Post-Transplant Lymphoproliferative Disorder (PCNS-PTLD) with Zidovudine (AZT), Ganciclovir (GCV), Rituximab and Dexamethasone: A Single-Institution Case Series

Ludmila Katherine Martin, MD, Mark E Lustberg, MD, PhD, Fengting Yan, M.D., Ph.D., John T. Patton, Pierluigi Porcu, MD, Gerard Nuovo, M.D., Robert Cavaliere, MD, Robert A. Baiocchi, M.D., Ph.D.

Blood (2011) 118 (21): 3067.

https://doi.org/10.1182/blood.V118.21.3067.3067

Published: 2011

NARROW

Constitutive PRMT5 Expression Drives Spontaneous Lymphoblastic Lymphoma In Vivo

BET Bromodomain Inhibition Selectively Targets the Epstein-Barr Virus Oncogene LMP1 While Promoting Virus-Specific, Adaptive Anti-Tumor Activity

PRMT5 Transgenic Mice Develop Aggressive Lymphoblastic Lymphomas

Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation

Identifying and Targeting Cytotoxic Tumor-Associated Macrophages in Epstein-Barr Virus-Driven Lymphoproliferative Disease

The Epstein-Barr Virus Lytic Protein BZLF1 As a Candidate Target Antigen for Vaccine Development

Epstein-Barr Virus Kinase-Targeted Therapy for Primary Central Nervous System Post-Transplant Lymphoproliferative Disorder

Determination of Optimal Target Antigen and Immune Modulatory Approaches to Improve and Standardize Epstein-Barr Virus-Specific Adoptive T Cell Therapy

Silvestrol Modulates Indirect Anti-Tumor Activity and Potentiates Immune Response To Epstein-Barr Virus-Driven Lymphoproliferative Disease

Protein Arginine Methyltransferase 5 (PRMT5) Over-Expression Is Essential for Epstein-Barr Virus-Driven B-Cell Transformation.

Novel E-Selectin Antagonist GMI-1271 Decreases Venous Thrombosis without Increased Bleeding Potential in a Mouse Model

Pan-Selectin Antagonist GMI-1070 Affects Biomarkers of Adhesion, Activation and the Coagulation Cascade in Sickle Cell Adults At Steady State

A Novel Small Molecule E-Selectin Inhibitor GMI-1271 Blocks Adhesion of AML Blasts to E-Selectin and Mobilizes Blood Cells in Nodscid IL2Rgc −/− Mice Engrafted with Human AML

P-selectin glycoprotein ligand regulates the interaction of multiple myeloma cells with the bone marrow microenvironment

Pan-Selectin Antagonist, GMI-1070 Decreases Venous Thrombosis in a Mouse Model,

Silvestrol Modulates Direct Anti-Tumor Activity Against Epstein-Barr Virus (EBV)-Associated Lymphomas While Sparing Innate and Antigen Specific Adaptive Immunity

Novel Dual E-Selectin-CXCR4 Inhibitors Mobilize Human Acute Myeloid Leukemia (AML) Cells in the NODscid IL2Rγc−/− Xenograft and Confer Susceptibility to Cytarabine

Developing a Novel Class of Drug to Inhibit Protein Arginine Methyltransferase 5 (PRMT5) Enzyme Dysregulation in Mantle Cell Lymphoma

FTY720 Increases CD74 Expression and Sensitizes Mantle Cell Lymphoma Cells to Milatuzumab-Mediated Cell Death

Successful Treatment of Primary Central Nervous System Post-Transplant Lymphoproliferative Disorder (PCNS-PTLD) with Zidovudine (AZT), Ganciclovir (GCV), Rituximab and Dexamethasone: A Single-Institution Case Series

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American Society of Hematology

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American Society of Hematology

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