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John B Porter
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Journal Articles

Luspatercept for the Treatment of Anemia in Non-Transfusion-Dependent β-Thalassemia: Final Safety and Efficacy Data from the BEYOND Trial

Ali T Taher, Vip Viprakasit, Antonis Kattamis, Silverio Perrotta, Paolo Ricchi, John B. Porter, Thomas D Coates, Gian Luca Forni, Khaled M. Musallam, Oriana Esposito, Ana Carolina Giuseppi, Wen-Ling Kuo, Marta Reverte, Richard Wei, Luciana Moro Bueno, Maria Domenica Cappellini
Journal: Blood
Blood (2023) 142 (Supplement 1): 3847.
https://doi.org/10.1182/blood-2023-174097
Published: 2023
Journal Articles

Iron Chelation Efficiency in Human Hepatocytes Is Enhanced By Exogenous Hepcidin

Pimpisid Koonyosying, Maciej Garbowski, Ute Schaeper, Alberto Martinez, John B. Porter
Journal: Blood
Blood (2023) 142 (Supplement 1): 2468.
https://doi.org/10.1182/blood-2023-182214
Published: 2023
Journal Articles

Sustained Efficacy, Safety, and Improved Quality of Life in Adult and Pediatric Patients with Transfusion-Dependent β-Thalassemia up to 9 Years Post Treatment with Betibeglogene Autotemcel (Beti-cel)

Alexis A. Thompson, Timothy S. Olson, Mark C. Walters, John B. Porter, Jennifer Schneiderman, Suradej Hongeng, Andreas Kulozik, Marina Cavazzana, Martin G. Sauer, Adrian J. Thrasher, Isabelle Thuret, Ashutosh Lal, John E. J. Rasko, Evangelia Yannaki, Shamshad Ali, Gloria Tao, Himal L. Thakar, Ami Deora, Katiana Gruppioni, Richard A. Colvin, Franco Locatelli, Janet L. Kwiatkowski
Journal: Blood
Blood (2023) 142 (Supplement 1): 1102.
https://doi.org/10.1182/blood-2023-174068
Published: 2023
Journal Articles

Improvement in Iron Burden in Patients with Transfusion-Dependent β-Thalassemia (TDT) Treated with Betibeglogene Autotemcel (Beti-cel) Gene Therapy: Up to 9 Years of Follow-up

Janet L. Kwiatkowski, Timothy S. Olson, Mark C. Walters, John B. Porter, Jennifer Schneiderman, Suradej Hongeng, Andreas Kulozik, Marina Cavazzana, Martin G. Sauer, Adrian J. Thrasher, Isabelle Thuret, Ashutosh Lal, John E. J. Rasko, Evangelia Yannaki, Shamshad Ali, Gloria Tao, Ami Deora, Himal L. Thakar, Richard A. Colvin, Franco Locatelli, Alexis A. Thompson
Journal: Blood
Blood (2023) 142 (Supplement 1): 2480.
https://doi.org/10.1182/blood-2023-173869
Published: 2023
Journal Articles

Effect of Luspatercept in β-Thalassemia Patients with β0/β0 Genotype: A Subgroup Analysis of the BELIEVE Study

Sujit Sheth, Olivier Hermine, Ali T. Taher, Kevin H.M. Kuo, John B. Porter, Antonio Piga, Thomas D. Coates, Antonis Kattamis, Loyse Felber Medlin, Wen-Ling Kuo, Natalia Holot, Maria Domenica Domenica Cappellini
Journal: Blood
Blood (2022) 140 (Supplement 1): 1946–1948.
https://doi.org/10.1182/blood-2022-157511
Published: 2022
Journal Articles

A Closer Look at Changes in Hemoglobin Levels in Patients with Non-Transfusion Dependent β-Thalassemia Treated with Luspatercept: Post Hoc Analysis of the Phase 2 BEYOND Trial

Khaled M. Musallam, Ali T. Taher, John B. Porter, Antonis Kattamis, Mrudula B. Glassberg, Luciana Bueno, Jeevan K. Shetty, Frederik Lersch, Barbara Rosettani, Maria Domenica Domenica Cappellini
Journal: Blood
Blood (2022) 140 (Supplement 1): 5358–5359.
https://doi.org/10.1182/blood-2022-157113
Published: 2022
Journal Articles

Long Term Outcomes of 63 Patients with Transfusion-Dependent β-Thalassemia (TDT) Followed up to 7 Years Post-Treatment with betibeglogene autotemcel (beti-cel) Gene Therapy and Exploratory Analysis of Predictors of Successful Treatment Outcomes in Phase 3 Trials

Mark C. Walters, Janet L. Kwiatkowski, John B. Porter, Jennifer Schneiderman, Suradej Hongeng, Andreas E. Kulozik, Marina Cavazzana, Martin G. Sauer, Adrian J. Thrasher, Isabelle Thuret, Ashutosh Lal, John E.J. Rasko, Evangelia Yannaki, Shamshad Ali, Ilya Shestopalov, Maeva Fincker, Richard A. Colvin, Dustin Whitney, Franco Locatelli, Alexis A. Thompson
Journal: Blood
Blood (2022) 140 (Supplement 1): 5355–5357.
https://doi.org/10.1182/blood-2022-162400
Published: 2022
Journal Articles

Effect of Luspatercept on Red Blood Cell (RBC) Transfusion Burden, Iron Chelation Therapy (ICT), and Iron Overload in Adults with Transfusion-Dependent β-Thalassemia (TDT) from the BELIEVE Trial: A Long-Term Analysis

Olivier Hermine, Maria Domenica Domenica Cappellini, Ali T. Taher, Thomas D. Coates, Vip Viprakasit, Antonis Kattamis, Jeevan K. Shetty, Marija Bosilkovska Weisskopf, Natalia Holot, Sadanand Vodala, Wen-Ling Kuo, John B. Porter
Journal: Blood
Blood (2022) 140 (Supplement 1): 8215–8217.
https://doi.org/10.1182/blood-2022-156985
Published: 2022
Journal Articles

Erythroid Response in Patients with Non-Transfusion-Dependent β-Thalassemia Treated with Luspatercept: Long-Term Data from the BEYOND Trial

Ali T. Taher, Vip Viprakasit, Maria Domenica Domenica Cappellini, Antonio Piga, John B. Porter, Thomas D. Coates, Khaled M. Musallam, Gian Luca Forni, Jeevan K. Shetty, Marija Bosilkovska Weisskopf, Richard Wei, Wen-Ling Kuo, Antonis Kattamis
Journal: Blood
Blood (2022) 140 (Supplement 1): 8210–8212.
https://doi.org/10.1182/blood-2022-157512
Published: 2022
Journal Articles

Long-Term Patient-Reported Outcomes Following Treatment with betibeglogene autotemcel in Patients with Transfusion-Dependent β-Thalassemia

Franco Locatelli, Mark C. Walters, Janet L. Kwiatkowski, Marina Cavazzana, Suradej Hongeng, John B. Porter, Adrian J. Thrasher, Andreas E. Kulozik, Isabelle Thuret, John E.J. Rasko, Evangelia Yannaki, Martin G. Sauer, Shamshad Ali, Himal Thakar, Katiana Gruppioni, Alexis A. Thompson
Journal: Blood
Blood (2022) 140 (Supplement 1): 8200–8202.
https://doi.org/10.1182/blood-2022-163178
Published: 2022
Journal Articles

Investigations into the Mechanisms and Clinical Implications of Modulation of Hepcidin Levels By Luspatercept in TD MDS and TD b-Thalassemia

Aarif Ahsan, Wei Fang, Manuel Ugidos, Danny V Jeyaraju, Pierre Fenaux, Uwe Platzbecker, Olivier Hermine, John B. Porter, Rajasekhar N.V.S. Suragani, Sadanand Vodala, Anita K. Gandhi
Journal: Blood
Blood (2022) 140 (Supplement 1): 8188–8189.
https://doi.org/10.1182/blood-2022-166559
Published: 2022
Journal Articles

Mitapivat Improves Iron Overload in Patients with Pyruvate Kinase Deficiency

Eduard J. van Beers, Hanny Al-Samkari, Rachael F. Grace, Wilma Barcellini, Andreas Glenthøj, Melissa Dibacco, Penelope A. Kosinski, Emily Xu, Vanessa Beynon, Parija Patel, John B. Porter, Kevin H.M. Kuo
Journal: Blood
Blood (2022) 140 (Supplement 1): 2460–2462.
https://doi.org/10.1182/blood-2022-169098
Published: 2022
Journal Articles

SLN124, a GalNAc Conjugated 19-Mer Double-Stranded SiRNA Reduces Iron and Increases Hepcidin Levels of Healthy Volunteers in a Phase 1 Clinical Study

John B. Porter, Alison Scrimgeour, Alberto Martinez, Leo James, Manuela Aleku, Rosamund Wilson, Martina U. Muckenthaler, Ute Schaeper, Giles V Campion
Journal: Blood
Blood (2021) 138 (Supplement 1): 2009.
https://doi.org/10.1182/blood-2021-147852
Published: 2021
Journal Articles

Mitapivat Improves Ineffective Erythropoiesis and Reduces Iron Overload in Patients with Pyruvate Kinase Deficiency

Eduard J. Van Beers, Hanny Al-Samkari, Rachael F. Grace, Wilma Barcellini, Andreas Glenthoej, Malia P. Judge, Penelope A. Kosinski, Emily Xu, Vanessa Beynon, Bryan McGee, John B. Porter, Kevin H.M. Kuo
Journal: Blood
Blood (2021) 138 (Supplement 1): 2005.
https://doi.org/10.1182/blood-2021-147317
Published: 2021
Journal Articles

Luspatercept Improves Quality of Life and Reduces Red Blood Cell Transfusion Burden in Patients with Non-Transfusion-Dependent β-Thalassemia in the BEYOND Trial

Antonis Kattamis, Vip Viprakasit, Maria Domenica Cappellini, Ersi Voskaridou, Antonio Piga, John B. Porter, Thomas D. Coates, Gian Luca Forni, Jeevan K. Shetty, Dimana Miteva, Oriana Esposito, Wen-Ling Kuo, Shien Guo, Christopher Pelligra, Jennifer Lord-Bessen, Aylin Yucel, Ali T. Taher
Journal: Blood
Blood (2021) 138 (Supplement 1): 3081.
https://doi.org/10.1182/blood-2021-148535
Published: 2021
Journal Articles

Improvement in Health-Related Quality of Life Following Treatment with Betibeglogene Autotemcel in Patients with Transfusion-Dependent β-Thalassemia Enrolled in Phase 3 Studies

Janet L. Kwiatkowski, Franco Locatelli, Mark C. Walters, John B. Porter, Suradej Hongeng, Evangelia Yannaki, Andreas E. Kulozik, Martin G. Sauer, Adrian J. Thrasher, Isabelle Thuret, Ashutosh Lal, Ruiting Guo, Richard A. Colvin, Katiana Gruppioni, Alexis A. Thompson
Journal: Blood
Blood (2021) 138 (Supplement 1): 3085.
https://doi.org/10.1182/blood-2021-150392
Published: 2021
Journal Articles

Restoring Iron Homeostasis in Pts Who Achieved Transfusion Independence after Treatment with Betibeglogene Autotemcel Gene Therapy: Results from up to 7 Years of Follow-up

Alexis A. Thompson, Franco Locatelli, Evangelia Yannaki, Mark C. Walters, John B. Porter, Suradej Hongeng, Andreas E. Kulozik, Martin G. Sauer, Adrian J. Thrasher, Isabelle Thuret, Ashutosh Lal, Marina Cavazzana, John E.J. Rasko, Lin Du, Richard A. Colvin, Janet L. Kwiatkowski
Journal: Blood
Blood (2021) 138 (Supplement 1): 573.
https://doi.org/10.1182/blood-2021-148177
Published: 2021
Journal Articles

Durability of Hemoglobin Response and Reduction in Transfusion Burden Is Maintained over Time in Patients with Pyruvate Kinase Deficiency Treated with Mitapivat in a Long-Term Extension Study

Rachael F. Grace, Andreas Glenthoej, Wilma Barcellini, Madeleine Verhovsek, Jennifer A. Rothman, Marta Morado, D. Mark Layton, Oliver Andres, Frédéric Galactéros, Eduard J. Van Beers, Koichi Onodera, Vip Viprakasit, Satheesh Chonat, John B. Porter, Malia P. Judge, Penelope A. Kosinski, Peter Hawkins, Sarah Gheuens, Emily Xu, Bryan McGee, Vanessa Beynon, Hanny Al-Samkari
Journal: Blood
Blood (2021) 138 (Supplement 1): 848.
https://doi.org/10.1182/blood-2021-147711
Published: 2021
Journal Articles

Bone Mineral Density Remains Stable in Pyruvate Kinase Deficiency Patients Receiving Long-Term Treatment with Mitapivat

Hanny Al-Samkari, Rachael F. Grace, Andreas Glenthoej, Oliver Andres, Wilma Barcellini, Frédéric Galactéros, Kevin H.M. Kuo, D. Mark Layton, Marta Morado, Vip Viprakasit, Yan Dong, Feng Tai, Liz Grekas, Karishma Khoja, Sarah Gheuens, Bryan McGee, John B. Porter, Eduard J. Van Beers
Journal: Blood
Blood (2021) 138 (Supplement 1): 924.
https://doi.org/10.1182/blood-2021-147156
Published: 2021
Journal Articles

Luspatercept Redistributes Body Iron to the Liver in Transfusion-Dependent-Thalassemia (TDT) during Erythropoietic Response

Maciej W. Garbowski, Manuel Ugidos, Alberto Risueño, Rajasekhar N.V.S. Suragani, Jeevan K. Shetty, Sadanand Vodala, Anjan Thakurta, Martin Schwickart, John B. Porter
Journal: Blood
Blood (2021) 138 (Supplement 1): 761.
https://doi.org/10.1182/blood-2021-145975
Published: 2021