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Journal Articles

Phase III Randomized COMMODORE 2 Trial: 2-Year Efficacy and Safety of Crovalimab in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Naive to Complement Inhibition

Alexander Röth, Guangsheng He, Andres Brodsky, Chatree Chai-Adisaksopha, Narcisa Sonia Comia, Anna Gaya, Martin Höglund, Richard J. Kelly, Ahlam Naila Kori, Je-Hwan Lee, Naoshi Obara, Antonio M Risitano, Anita Appius, Leigh Beveridge, Brittany Gentile, Zilu Zhang, Bing Han, Sasha Sreckovic
Journal: Blood
Blood (2024) 144 (Supplement 1): 2687.
https://doi.org/10.1182/blood-2024-208072
Published: 2024
Journal Articles

PHI-101, a Novel FLT3 TKI, Shows Clinical Efficacy in Relapsed/Refractory FLT3-Mutated AML

Dong-Yeop Shin, Sung-Soo Yoon, Junshik Hong, Je-Hwan Lee, Jun-Ho Jang, June-won Cheong, Ho-Jin Shin, Jeong-Ok Lee, Yoo Jin Lee, Jae-Sook Ahn, Byoung-Sik Cho, Hee-Je Kim, Joseph Clarey, Gi-Jun Sung, Jeejin Im, Ky-Youb Nam, June Han, Kyu-Tae Kim, JeongHyeok Yoon, Bao Nguyen, Li Li, Donald Small
Journal: Blood
Blood (2024) 144 (Supplement 1): 1495.
https://doi.org/10.1182/blood-2024-207033
Published: 2024
Journal Articles

Intensity-Adjusted Salvage Chemotherapy Plus FLT3-Inhibitor Gilteritinib in Relapsed/Refractory Acute Myeloid Leukemia with Mutated FLT3-ITD/TKD (SAPPHIRE-G)

Hawk Kim, Jae-Sook Ahn, Sung-Hyun Kim, Ho-Young Yhim, Sung-Nam Lim, Yoo Jin Lee, Jeong-Ok Lee, Eun-Ji Choi, Je-Hwan Lee
Journal: Blood
Blood (2024) 144 (Supplement 1): 2897.
https://doi.org/10.1182/blood-2024-201404
Published: 2024
Journal Articles

PHI-101 As a Potent Next-Generation FLT3 Inhibitor, Overcome Resistances in Previously Treated Patients with FLT3-ITD or TKD Acute Myeloid Leukemia: Results of a Phase Ia/Ib Clinical Trial

Sung-Soo Yoon, Dongyeop Shin, Je-Hwan Lee, Jun Ho Jang, June-Won Cheong, Ho-Jin Shin, Jeong-Ok Lee, Yoo Jin Lee, Joseph Clarey, Gi-Jun Sung, Kyung-Ah Kim, Ky-Youb Nam, Kyu-Tae Kim, June Han, JeongHyeok Yoon, Bao Nguyen, Li Li, Donald Small
Journal: Blood
Blood (2023) 142 (Supplement 1): 4283.
https://doi.org/10.1182/blood-2023-185606
Published: 2023
Journal Articles

The Optimal Busulfan Dose of Conditioning Regimens for Allogeneic Hematopoietic Cell Transplantation in Younger Patients with Acute Myeloid Leukemia

Yunsuk Choi, Eun-Ji Choi, Han-Seung Park, Jung-Hee Lee, Kyoo-Hyung Lee, Young-Shin Lee, Young-A Kang, Mijin Jeon, Ji Min Woo, Hyeran Kang, Je-Hwan Lee
Journal: Blood
Blood (2023) 142 (Supplement 1): 6991.
https://doi.org/10.1182/blood-2023-189327
Published: 2023
Journal Articles

Predicting Disease Progression from Idiopathic Cytopenia of Undetermined Significance to Myeloid Malignancies Using a Machine Learning-Based Approach

Eun-Ji Choi, Jiye Han, Tae Joon Jun, Han-Seung Park, Yunsuk Choi, Jung-Hee Lee, Kyoo Hyung Lee, Young-Hak Kim, Je-Hwan Lee
Journal: Blood
Blood (2023) 142 (Supplement 1): 7154.
https://doi.org/10.1182/blood-2023-188822
Published: 2023
Journal Articles

Role of Autologous or Allogeneic Stem Cell Transplantation in Patients with Peripheral T Cell Lymphomas (PTCLs)

Dong Won Baek, Sr., Je-Hwan Lee, Ho Joon Im, Juhyung Kim, Joon Seong Park, Deok-Hwan Yang, Sung-Hyun Kim, Yeung-Chul Mun, Jae Hoon Lee, Ho Sup Lee, Ka-Won Kang, Chuhl Joo Lyu, Seong Kyu Park, Jong Ho Won, Chul Won Jung, Keon Hee Yoo, Sung-Soo Yoon, Soo-Mee Bang, Jae-Cheol Jo, Joon Ho Moon, Sang Kyun Sohn
Journal: Blood
Blood (2022) 140 (Supplement 1): 6592–6593.
https://doi.org/10.1182/blood-2022-171149
Published: 2022
Journal Articles

A Potent Small Molecule Inhibitor of FLT3, PHI-101 Overcomes Resistance in Acute Myeloid Leukemia: Efficacy and PK/PD Profile in Phase 1 First in Human Study

Sung-Soo Yoon, Dong-Yeop Shin, Je-Hwan Lee, Jun Ho Jang, June-Won Cheong, Ho-Jin Shin, Jeong-Ok Lee, Yunsuk Choi, Joseph Clarey, Jeejin Im, Suntae Kim, Ky-Youb Nam, Kyu-Tae Kim, June Han, Jeong Hyeok Yoon, Bao Nguyen, Li Li, Donald Small
Journal: Blood
Blood (2022) 140 (Supplement 1): 3365–3366.
https://doi.org/10.1182/blood-2022-165000
Published: 2022
Journal Articles

Antileukemic Activity of Ypn-005, a CDK7 Inhibitor, Inducing Apoptosis through c-MYC and FLT3 Suppression in Acute Myeloid Leukemia

Bon-Kwan Koo, Je-Hwan Lee, Eun-Ji Choi, Eun-Hye Hur, Ju Hyun Moon, Ji Yun Kim, Han-Seung Park, Yunsuk Choi, Jung-Hee Lee, Kyoo Hyung Lee, Jinhwan Kim
Journal: Blood
Blood (2022) 140 (Supplement 1): 8803–8804.
https://doi.org/10.1182/blood-2022-168726
Published: 2022
Journal Articles

Phase 3 trial of gilteritinib plus azacitidine vs azacitidine for newly diagnosed FLT3 mut+ AML ineligible for intensive chemotherapy

Clinical Trials & Observations
Eunice S. Wang, Pau Montesinos, Mark D. Minden, Je-Hwan Lee, Michael Heuser, Tomoki Naoe, Wen-Chien Chou, Kamel Laribi, Jordi Esteve, Jessica K. Altman, Violaine Havelange, Anne-Marie Watson, Carlo Gambacorti-Passerini, Elzbieta Patkowska, Shufang Liu, Ruishan Wu, Nisha Philipose, Jason E. Hill, Stanley C. Gill, Elizabeth Shima Rich, Ramon V. Tiu
Journal: Blood
Blood (2022) 140 (17): 1845–1857.
https://doi.org/10.1182/blood.2021014586
Published: 2022
Includes: Supplemental data
Journal Articles

Post-Transplantation Cyclophosphamide for Graft-Versus-Host Disease Prophylaxis in Allogeneic Hematopoietic Cell Transplantation for Higher-Risk Myelodysplastic Syndrome

Eun-Ji Choi, Han-Seung Park, Jung-Hee Lee, Kyoo Hyung Lee, Youngshin Lee, Young-Ah Kang, Mijin Jeon, Ji Min Woo, Hyeran Kang, Je-Hwan Lee
Journal: Blood
Blood (2021) 138 (Supplement 1): 2873.
https://doi.org/10.1182/blood-2021-150389
Published: 2021
Journal Articles

Multicenter Phase II Study to Evaluate Therapeutic Efficacy of Imatinib Mesylate in Patients with Steroid-Refractory Chronic Graft-Versus-Host Disease

Dong Won Baek, Sr., Joon Ho Moon, Jae-Sook Ahn, Seong Kyu Park, Ik Chan Song, Ho-Sup Lee, Won Sik Lee, Jong Ho Won, Hong Ghi Lee, June-Won Cheong, Yeung-Chul Mun, Chul W. Jung, Je-Hwan Lee, Hyeoung-Joon Kim, Sang Kyun Sohn
Journal: Blood
Blood (2021) 138 (Supplement 1): 2889.
https://doi.org/10.1182/blood-2021-154470
Published: 2021
Journal Articles

A Phase 1a/1b First in Human Study of PHI-101, a Potent Small Molecule Inhibitor of FLT3 in Relapsed and Refractory Acute Myeloid Leukemia

Sung-Soo Yoon, Dong-Yeop Shin, Je-Hwan Lee, Jun Ho Jang, June-Won Cheong, Ho-Jin Shin, Jeong-Ok Lee, Yunsuk Choi, Anish Puliyayil, Joseph Clarey, Jeejin Im, Ky-Youb Nam, Kyu-Tae Kim, June H-J. Han, Jeong-Hyeok Yoon, Bao Nguyen, Li Li, Donald Small
Journal: Blood
Blood (2021) 138 (Supplement 1): 3425.
https://doi.org/10.1182/blood-2021-149395
Published: 2021
Journal Articles

Phase 3, Open-Label, Randomized Study of Gilteritinib and Azacitidine Vs Azacitidine for Newly Diagnosed FLT3 -Mutated Acute Myeloid Leukemia in Patients Ineligible for Intensive Induction Chemotherapy

Eunice S. Wang, Pau Montesinos, Mark D. Minden, Je-Hwan Lee, Michael Heuser, Tomoki Naoe, Wen-Chien Chou, Kamel Laribi, Jordi Esteve, Jessica K. Altman, Violaine Havelange, Anne-Marie Watson, Elzbieta Patkowska, Shufang Liu, Ruishan Wu, Nisha Philipose, Jason E. Hill, Stanley Gill, Elizabeth Shima Rich, Ramon V. Tiu
Journal: Blood
Blood (2021) 138 (Supplement 1): 700.
https://doi.org/10.1182/blood-2021-145379
Published: 2021
Journal Articles

Similar Survival and Genetic Features between Clonal Cytopenia of Undetermined Significance and Lower-Risk Myelodysplastic Syndrome

Eun-Ji Choi, Young-Uk Cho, Han-Seung Park, Jung-Hee Lee, Kyoo Hyung Lee, Sang-Hyun Hwang, Seongsoo Jang, Chan-jeoung Park, Je-Hwan Lee
Journal: Blood
Blood (2021) 138 (Supplement 1): 3683.
https://doi.org/10.1182/blood-2021-150368
Published: 2021
Journal Articles

Machine Learning-Based Approach to Predict Survival after Allogeneic Hematopoietic Cell Transplantation in Hematologic Malignancies

Eun-Ji Choi, MDPhD, Je-Hwan Lee, MDPhD, Jun-Hong Park, MD, Han-Seung Park, MD, Jung-Hee Lee, MD PhD, Youngshin Lee, Young-Ah Kang, Mijin Jeon, Ji Min Woo, Hyeran Kang, Kyoo Hyung Lee, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 33–34.
https://doi.org/10.1182/blood-2020-142337
Published: 2020
Journal Articles

Clinical Implications of Copy Number Variant Detection from Panel-Based Next-Generation Sequencing Data in Myelodysplastic Syndrome

Je-Hwan Lee, MD PhD, Yoo-Jin Kim, MD PhD, Seung-Hyun Jung, Eun-Hye Hur, Eun-Ji Choi, MD, Kyoo Hyung Lee, MD PhD, Seon-Hee Yim, Hye-Jung Kim, Yong-Rim Kwon, Young-Woo Jeon, MD PhD, Sug Hyung Lee, Yeun-Jun Chung
Journal: Blood
Blood (2019) 134 (Supplement_1): 4264.
https://doi.org/10.1182/blood-2019-131570
Published: 2019
Journal Articles

DDX41 mutation in Patients with Idiopathic Cytopenia of Undetermined Significance, Myelodysplastic Syndrome, and Acute Myeloid Leukemia

Eun-Ji Choi, MD, Young-Uk Cho, MD, Seongsoo Jang, Chan-jeoung Park, Han-Seung Park, MD, Jung-Hee Lee, MD PhD, Kyoo Hyung Lee, MD PhD, Eun-Hye Hur, PhD, Nayoung Kim, PhD, Hee Jeong Ouk, MD, Je-Hwan Lee, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3002.
https://doi.org/10.1182/blood-2019-129906
Published: 2019
Journal Articles

Mutational Characteristics and Changing Pattern from Idiopathic Cytopenia of Undetermined Significance to High-Risk Myelodysplastic Syndrome Stratified By IPSS-R

Eun-Ji Choi, MD, Young-Uk Cho, MD, Seongsoo Jang, Chan-jeoung Park, Han-Seung Park, MD, Jung-Hee Lee, MD PhD, Kyoo-Hyung Lee, MD PhD, Eun-Hye Hur, PhD, Nayoung Kim, PhD, Hee Jeong Ouk, MD, Je-Hwan Lee, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3009.
https://doi.org/10.1182/blood-2019-125236
Published: 2019
Journal Articles

Multicenter, Open-Label, 3-Arm Study of Gilteritinib, Gilteritinib Plus Azacitidine, or Azacitidine Alone in Newly Diagnosed FLT 3 Mutated ( FLT3 mut+ ) Acute Myeloid Leukemia (AML) Patients Ineligible for Intensive Induction Chemotherapy: Findings from the Safety Cohort

Jordi Esteve, MD PhD, Rik Schots, Teresa Bernal Del Castillo, MD PhD, Je-Hwan Lee, MD PhD, Eunice S. Wang, MD, Shira Dinner, MD, Mark D. Minden, MD PhD, Olga Salamero, MD, Jorge Sierra, MD, Goichi Yoshimoto, MD PhD, Kamel Laribi, MD, Janusz Halka, MD, Pau Montesinos, MD PhD, Shufang Liu, Elizabeth Shima Rich, MD PhD, Erkut Bahceci, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2736.
https://doi.org/10.1182/blood-2018-99-110976
Published: 2018