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Journal Articles

The secreted tyrosine kinase VLK is essential for normal platelet activation and thrombus formation

Leila Revollo, Glenn Merrill-Skoloff, Karen De Ceunynck, James R. Dilks, Shihui Guo, Mattia R. Bordoli, Christian G. Peters, Leila Noetzli, Andreia Ionescu, Vicki Rosen, Joseph E. Italiano, Malcolm Whitman, Robert Flaumenhaft

Blood (2022) 139 (1): 104–117.

https://doi.org/10.1182/blood.2020010342

Published: 2022

Includes: Supplemental data

Journal Articles

Parmodulins inhibit thrombus formation without inducing endothelial injury caused by vorapaxar

Omozuanvbo Aisiku, Christian G. Peters, Karen De Ceunynck, Chandra C. Ghosh, James R. Dilks, Susanna F. Fustolo-Gunnink, Mingdong Huang, Chris Dockendorff, Samir M. Parikh, Robert Flaumenhaft

Blood (2015) 125 (12): 1976–1985.

https://doi.org/10.1182/blood-2014-09-599910

Published: 2015

Includes: Supplemental data

Journal Articles

Regulation of Protein Disulfide Isomerase By S-Nitrosylation Controls Its Function during Thrombus Formation

Roelof H Bekendam, MD, Gopal Srila, MD, Pavan K Bendapudi, MD, James R Dilks, Lin Lin, PhD, Sheryl Bowley, PhD, Jack Stopa, PhD, Mingdong Huang, PhD, Bruce Furie, MD, Kevin Croce, MD/ PhD, Robert Flaumenhaft, MD/ PhD

Blood (2014) 124 (21): 93.

https://doi.org/10.1182/blood.V124.21.93.93

Published: 2014

Journal Articles

Development Of Second Generation Thiol Isomerase Inhibitors To Prevent Thrombus Formation

Daniel R Kennedy, Ph.D., Partha P Nag, Ph.D., Christine N. Galinski, Pharm.D. Candidate, Sheryl Bowley, Ph.D., Roelof H. Bekendam, Ph.D., James R. Dilks, Alissa A Scalise, Pharm.D. Candidate, Lotte van Hessem, Ph.D., Jun Pu, Ph.D., Tatiana Pilyugina, Sivaraman Dandapani, Ph.D., Benito Munoz, Ph.D., Robert Flaumenhaft, M.D. Ph.D

Blood (2013) 122 (21): 926.

https://doi.org/10.1182/blood.V122.21.926.926

Published: 2013

Journal Articles

Effects Of Biased PAR1 Ligands On Platelets and Endothelial Cells

Omozuanvbo R. Aisiku, PhD, Christian G. Peters, PhD, Suzanne Gunnink, MD, James R. Dilks, Chris Dockendorff, Robert Flaumenhaft, M.D. Ph.D

Blood (2013) 122 (21): 23.

https://doi.org/10.1182/blood.V122.21.23.23

Published: 2013

Journal Articles

Acyl-Protein Thioesterase 1 Functions in Palmitoylation/Depalmitoylation Cycles of G Proteins and Regulates Platelet Activation

Louisa M. Dowal, James R. Dilks, Nathalie A. Fadel, Omozuanvbo R. Aisiku, Glenn Merrill-Skoloff, Robert C. Flaumenhaft

Blood (2012) 120 (21): 1062.

https://doi.org/10.1182/blood.V120.21.1062.1062

Published: 2012

Journal Articles

Protein Disulfide Isomerase Inhibitors: A New Class of Antithrombotic Agents

Reema Jasuja, Ph.D., Freda H. Passam, MD, PhD, Daniel R Kennedy, Ph.D., Sarah H Kim, Lotte van Hessem, Lin Lin, PhD, Sucharit S Joshi, MD, James R. Dilks, Bruce Furie, MD, Barbara C. Furie, PhD, Robert C. Flaumenhaft, MD, PhD

Blood (2011) 118 (21): 369.

https://doi.org/10.1182/blood.V118.21.369.369

Published: 2011

Journal Articles

Dynamin-Related Protein-1 Controls Fusion Pore Dynamics During Platelet Granule Secretion and Thrombus Formation In Vivo

Robert C. Flaumenhaft, MD, PhD, Secil Koseoglu, James R. Dilks, Christian G. Peters, Ph.D., Nathalie A. Fadel, Reema Jasuja, Ph.D., Christy L. Haynes, Ph.D.

Blood (2011) 118 (21): 361.

https://doi.org/10.1182/blood.V118.21.361.361

Published: 2011

Journal Articles

An Allosteric Modulator of PAR1 Demonstrates Selective Inhibition of G Protein Coupling and Impairs Thrombus Formation In Vivo

Omozuanvbo R Aisiku, Chris Dockendorff, Suzanne F Gunnick, Daniel A. Smith, James R. Dilks, Louisa M. Dowal, Robert C. Flaumenhaft, MD, PhD

Blood (2011) 118 (21): 1138.

https://doi.org/10.1182/blood.V118.21.1138.1138

Published: 2011

Journal Articles

Identification of a Novel Par1 inhibitor Using a Chemical Genetic Screen

Robert Flaumenhaft, Lynn VerPlank, James R. Dilks, Daniel A. Smith, Price Blair, Albert T. Mairuhu, Joseph Negri, Chris Dockendorff, Lawrence McPherson, Michelle Palmer, Stuart L. Scheiber

Blood (2010) 116 (21): 2018.

https://doi.org/10.1182/blood.V116.21.2018.2018

Published: 2010

Journal Articles

A Chemical Genetic Analysis of Platelet Activation Identifies An Antithrombotic Allosteric Modulator That Acts through Helix 8 of Par1

Louisa M. Dowal, Derek Sim, James R Dilks, Price Blair, Sarah Beaudry, Bradley Denker, George Koukos, Athan Kuliopulos, Robert Flaumenhaft

Blood (2010) 116 (21): 483.

https://doi.org/10.1182/blood.V116.21.483.483

Published: 2010

Journal Articles

A Chemical Genetic Analysis of Platelet Activation.

Robert Flaumenhaft, Lynn VerPlank, James R. Dilks, Price S. Blair, Albert Mairuhu, Joseph Negri, Jason Burbank, Gil Walzer, Tyler Aldredge, Chris Dockendorff, Robert Gould, Lawrence MacPherson, Michelle Palmer

Blood (2009) 114 (22): 4009.

https://doi.org/10.1182/blood.V114.22.4009.4009

Published: 2009

Journal Articles

Endobrevin/VAMP-8–dependent dense granule release mediates thrombus formation in vivo

Gwenda J. Graham, Qiansheng Ren, James R. Dilks, Price Blair, Sidney W. Whiteheart, Robert Flaumenhaft

Blood (2009) 114 (5): 1083–1090.

https://doi.org/10.1182/blood-2009-03-210211

Published: 2009

Includes: Multimedia, Supplemental data

Journal Articles

Megakaryocyte-derived microparticles: direct visualization and distinction from platelet-derived microparticles

Robert Flaumenhaft, James R. Dilks, Jennifer Richardson, Eva Alden, Sunita R. Patel-Hett, Elisabeth Battinelli, Giannoula L. Klement, Martha Sola-Visner, Joseph E. Italiano, Jr

Blood (2009) 113 (5): 1112–1121.

https://doi.org/10.1182/blood-2008-06-163832

Published: 2009

Includes: Multimedia, Supplemental data

Journal Articles

Endobrevin/VAMP-8-Mediated Dense Granule Release Is Required for Efficient Thrombus Formation in Vivo .

Price S. Blair, Qiansheng Ren, Gwenda J. Graham, James R. Dilks, Sidney W. Whiteheart, Robert C. Flaumenhaft

Blood (2008) 112 (11): 1836.

https://doi.org/10.1182/blood.V112.11.1836.1836

Published: 2008

Journal Articles

The Platelet Actin Cytoskeleton Associates Directly with Syntaxin-4 and Participates in α-Granule Secretion.

Robert Flaumenhaft, James R. Dilks, Nataliya Rozenvayn, Kamil Woronowicz

Blood (2008) 112 (11): 1839.

https://doi.org/10.1182/blood.V112.11.1839.1839

Published: 2008

Journal Articles

Megakaryocyte-Derived Microparticles: Mechanism of Formation and Circulation in Plasma.

Robert Flaumenhaft, MD, PhD, James R. Dilks, M.S., Sunita R. Patel, Ph.D., Giannoula Klement, M.D., Joseph E. Italiano, Ph.D.

Blood (2006) 108 (11): 1507.

https://doi.org/10.1182/blood.V108.11.1507.1507

Published: 2006

Journal Articles

Protein Palmitoylation in Platelet Function: Role in G Protein-Mediated Platelet Activation and Platelet Recruitment into Thrombi.

Robert Flaumenhaft, MD, PhD, James R. Dilks, Derek S. Sim, PhD

Blood (2005) 106 (11): 650.

https://doi.org/10.1182/blood.V106.11.650.650

Published: 2005

Journal Articles

The actin cytoskeleton differentially regulates platelet α-granule and dense-granule secretion

Robert Flaumenhaft, James R. Dilks, Nataliya Rozenvayn, Rita A. Monahan-Earley, Dian Feng, Ann M. Dvorak

Blood (2005) 105 (10): 3879–3887.

https://doi.org/10.1182/blood-2004-04-1392

Published: 2005

Journal Articles

Differential Regulation of α-Granule and Dense Granule Secretion by an Actin Cytoskeletal Barrier.

Robert Flaumenhaft, M.D., Ph.D., James R. Dilks, Nataliya Rozenvayn, Rita A. Monahan-Earley, Dian Feng, M.D., Ann M. Dvorak, M.D.

Blood (2004) 104 (11): 3528.

https://doi.org/10.1182/blood.V104.11.3528.3528

Published: 2004

NARROW

The secreted tyrosine kinase VLK is essential for normal platelet activation and thrombus formation

Parmodulins inhibit thrombus formation without inducing endothelial injury caused by vorapaxar

Regulation of Protein Disulfide Isomerase By S-Nitrosylation Controls Its Function during Thrombus Formation

Development Of Second Generation Thiol Isomerase Inhibitors To Prevent Thrombus Formation

Effects Of Biased PAR1 Ligands On Platelets and Endothelial Cells

Acyl-Protein Thioesterase 1 Functions in Palmitoylation/Depalmitoylation Cycles of G Proteins and Regulates Platelet Activation

Protein Disulfide Isomerase Inhibitors: A New Class of Antithrombotic Agents

Dynamin-Related Protein-1 Controls Fusion Pore Dynamics During Platelet Granule Secretion and Thrombus Formation In Vivo

An Allosteric Modulator of PAR1 Demonstrates Selective Inhibition of G Protein Coupling and Impairs Thrombus Formation In Vivo

Identification of a Novel Par1 inhibitor Using a Chemical Genetic Screen

A Chemical Genetic Analysis of Platelet Activation Identifies An Antithrombotic Allosteric Modulator That Acts through Helix 8 of Par1

A Chemical Genetic Analysis of Platelet Activation.

Endobrevin/VAMP-8–dependent dense granule release mediates thrombus formation in vivo

Megakaryocyte-derived microparticles: direct visualization and distinction from platelet-derived microparticles

Endobrevin/VAMP-8-Mediated Dense Granule Release Is Required for Efficient Thrombus Formation in Vivo .

The Platelet Actin Cytoskeleton Associates Directly with Syntaxin-4 and Participates in α-Granule Secretion.

Megakaryocyte-Derived Microparticles: Mechanism of Formation and Circulation in Plasma.

Protein Palmitoylation in Platelet Function: Role in G Protein-Mediated Platelet Activation and Platelet Recruitment into Thrombi.

The actin cytoskeleton differentially regulates platelet α-granule and dense-granule secretion

Differential Regulation of α-Granule and Dense Granule Secretion by an Actin Cytoskeletal Barrier.

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American Society of Hematology

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American Society of Hematology

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