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Robert C. Flaumenhaft
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Journal Articles

The Unfolded Protein Response Causes Prothrombotic Transformation of Pancreatic Cancer Linking Tumor Progression with Cancer-Associated Thrombosis

Oluwatoyosi Muse, PhD, Rushad Patell, MD, Christian Peters, PhD, Sol Schulman, MD PhD, Emale Darzi, MS, Calvin Schuster, BA, Ling Huang, PhD, Shibani Mukherjee, PhD, Senthil Muthuswamy, PhD, Jeffrey I. Zwicker, MD, Robert C. Flaumenhaft, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 632.
https://doi.org/10.1182/blood-2019-123544
Published: 2019
Journal Articles

VWF Exocytosis and Biogenesis of Weibel Palade Bodies in Endothelial Cells Are Differentially Controlled By Interactions between Bloc-2 and the Exocyst Complex

Anish V. Sharda, MBBS, MPH, Joshua Harrison, BS, Adrian R. Wilkie, PhD, Chao Fang, PhD, Lourdes M. Mendez, MD PhD, Joseph E. Italiano, Jr., BS, PhD, Robert C. Flaumenhaft, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 8.
https://doi.org/10.1182/blood-2019-127712
Published: 2019
Journal Articles

The Effects of Antiplatelet Agents on Endocytosis

Harvey G. Roweth, BSc,PhD, Michael Malloy, BS, Jodi A. Forward, BS, Julia Ceglowski, BA, Robert C. Flaumenhaft, MD PhD, Joseph E. Italiano, Jr., BS, PhD, Elisabeth Battinelli, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1058.
https://doi.org/10.1182/blood-2019-131912
Published: 2019
Journal Articles

Targeting Protein Disulfide Isomerase with the Oral Flavonoid Isoquercetin Prevents Venous Thromboembolism in Advanced Cancer: Results of a Multi-Dose, Multi-Center, Phase II Clinical Trial (CATIQ Study)

Jeffrey I. Zwicker, MD, Benjamin L. Schlechter, MD, Jack Davis Stopa, PhD, Howard A. Liebman, MD, Anita Aggarwal, PhDDO, Thomas Caughey, MD, Ken A. Bauer, MD, Nancy Kuemmerle, D.O., Ellice Y. Wong, MD, Ted Wun, MD, Marilyn Mclaughlin, MD, Maneka Puligandla, MS, Donna S Neuberg, ScD, Bruce Furie, MD, Robert C. Flaumenhaft, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 985.
https://doi.org/10.1182/blood-2018-99-114946
Published: 2018
Journal Articles

Inhibition of Protein Disulfide Isomerase Ameliorates Vaso-Occlusion and Thrombosis in a Mouse Model of Sickle Cell Disease

Chao Fang, PhD, Anish V. Sharda, MBBS, MPH, Lin Lin, PhD, Robert C. Flaumenhaft, MD PhD, Bruce Furie, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 442.
https://doi.org/10.1182/blood.V130.Suppl_1.442.442
Published: 2017
Journal Articles

Protein Disulfide Isomerase Negatively Regulates Platelet Function through Modulation of the Thromboxane A2 Receptor

Noppacharn Uaprasert, MB, BCH, Oskar Eriksson, MD PhD, Robert C. Flaumenhaft, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2297.
https://doi.org/10.1182/blood.V130.Suppl_1.2297.2297
Published: 2017
Journal Articles

Dysfunctional Endothelium Drives a Pre-DIC State in Endotoxemia

Karen E.P. De Ceunynck, PhD, Sarah J. Higgins, PhD, Sharjeel A. Chaudhry, B.S., Samir Parikh, MD PhD, Robert C. Flaumenhaft, MD PhD
Journal: Blood
Blood (2016) 128 (22): 3725.
https://doi.org/10.1182/blood.V128.22.3725.3725
Published: 2016
Journal Articles

A Chemical APC Mimetic Protects Endothelium from Thromboinflammatory Injury

Karen E.P. De Ceunynck, PhD, Christian G. Peters, PhD, Sharjeel A. Chaudhry, B.S., Abhishek Jain, PhD, Sarah J. Higgins, PhD, Omozuanvbo Aisiku, PhD, Jennifer Fitch-Tewfik, PhD, Christopher Dockendorff, PhD, Samir Parikh, MD PhD, Donald E. Ingber, PhD, Robert C. Flaumenhaft, MD PhD
Journal: Blood
Blood (2016) 128 (22): 3835.
https://doi.org/10.1182/blood.V128.22.3835.3835
Published: 2016
Journal Articles

Stimulated Platelets but Not Endothelium Generate Thrombin Via a Factor XIIa-Dependent Mechanism Requiring Phosphatidylserine Exposure

Pavan K. Bendapudi, MD, Karen Deceunynck, PhD, Secil Koseoglu, PhD, Roelof Hendrik Bekendam, MD, Shauna D Mason, Jon Kenniston, Robert C. Flaumenhaft, MD PhD
Journal: Blood
Blood (2016) 128 (22): 258.
https://doi.org/10.1182/blood.V128.22.258.258
Published: 2016
Journal Articles

PDI Inhibition Blocks Thrombin Generation in Humans By Interfering with Platelet Factor V Activation

Jack D Stopa, PhD, Donna S. Neuberg, ScD, Maneka Puligandla, MS, Bruce Furie, MD, Robert C. Flaumenhaft, MD PhD, Jeffrey I. Zwicker, MD
Journal: Blood
Blood (2016) 128 (22): 2628.
https://doi.org/10.1182/blood.V128.22.2628.2628
Published: 2016
Journal Articles

Gα 13 Switch Region 2 Relieves Talin Autoinhibition to Activate Platelet αIIbβ3 Integrin

James Schiemer, BS, Andrew Bohm, PhD, Glenn Merrill-Skoloff, PhD, Robert C. Flaumenhaft, MD PhD, Guy Le Breton, PhD, Athar Chishti, PhD
Journal: Blood
Blood (2016) 128 (22): 712.
https://doi.org/10.1182/blood.V128.22.712.712
Published: 2016
Journal Articles

VAMP-7 Interacts With The Actin Cytoskeleton To Control Platelet Spreading and Mediate α-Granule Exocytosis During Thrombus Formation

Secil Koseoglu, PhD, Jennifer L Fitch-Tewfik, PhD, Christian G. Peters, PhD, Lydia Danglot, PhD, Thierry Galli, PhD, Robert C. Flaumenhaft, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 1058.
https://doi.org/10.1182/blood.V122.21.1058.1058
Published: 2013
Journal Articles

Acyl-Protein Thioesterase 1 Functions in Palmitoylation/Depalmitoylation Cycles of G Proteins and Regulates Platelet Activation

Louisa M. Dowal, James R. Dilks, Nathalie A. Fadel, Omozuanvbo R. Aisiku, Glenn Merrill-Skoloff, Robert C. Flaumenhaft
Journal: Blood
Blood (2012) 120 (21): 1062.
https://doi.org/10.1182/blood.V120.21.1062.1062
Published: 2012
Journal Articles

The Functional Role of TLR9 in Human Platelets

Jonathan Noah Thon, Ph.D., Christian G. Peters, Ph.D., Rukhsana Aslam, Ph.D., Jesse Rowley, Ph.D., Andrew S. Weyrich, Ph.D., John W. Semple, PhD, Robert C. Flaumenhaft, MD, PhD, Joseph E. Italiano, Jr., PhD
Journal: Blood
Blood (2011) 118 (21): 366.
https://doi.org/10.1182/blood.V118.21.366.366
Published: 2011
Journal Articles

Protein Disulfide Isomerase Inhibitors: A New Class of Antithrombotic Agents

Reema Jasuja, Ph.D., Freda H. Passam, MD, PhD, Daniel R Kennedy, Ph.D., Sarah H Kim, Lotte van Hessem, Lin Lin, PhD, Sucharit S Joshi, MD, James R. Dilks, Bruce Furie, MD, Barbara C. Furie, PhD, Robert C. Flaumenhaft, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 369.
https://doi.org/10.1182/blood.V118.21.369.369
Published: 2011
Journal Articles

Platelet Spreading Requires Exocytosis of a Subpopulation of α-Granules Expressing VAMP-7,

Robert C. Flaumenhaft, MD, PhD, Alan D. Michelson, MD, Christian G. Peters, Ph.D.
Journal: Blood
Blood (2011) 118 (21): 3248.
https://doi.org/10.1182/blood.V118.21.3248.3248
Published: 2011
Journal Articles

Dynamin-Related Protein-1 Controls Fusion Pore Dynamics During Platelet Granule Secretion and Thrombus Formation In Vivo

Robert C. Flaumenhaft, MD, PhD, Secil Koseoglu, James R. Dilks, Christian G. Peters, Ph.D., Nathalie A. Fadel, Reema Jasuja, Ph.D., Christy L. Haynes, Ph.D.
Journal: Blood
Blood (2011) 118 (21): 361.
https://doi.org/10.1182/blood.V118.21.361.361
Published: 2011
Journal Articles

An Allosteric Modulator of PAR1 Demonstrates Selective Inhibition of G Protein Coupling and Impairs Thrombus Formation In Vivo

Omozuanvbo R Aisiku, Chris Dockendorff, Suzanne F Gunnick, Daniel A. Smith, James R. Dilks, Louisa M. Dowal, Robert C. Flaumenhaft, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 1138.
https://doi.org/10.1182/blood.V118.21.1138.1138
Published: 2011
Journal Articles

Endobrevin/VAMP-8-Mediated Dense Granule Release Is Required for Efficient Thrombus Formation in Vivo .

Price S. Blair, Qiansheng Ren, Gwenda J. Graham, James R. Dilks, Sidney W. Whiteheart, Robert C. Flaumenhaft
Journal: Blood
Blood (2008) 112 (11): 1836.
https://doi.org/10.1182/blood.V112.11.1836.1836
Published: 2008