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Journal Articles

Selective Targeting of Alternative Splicing Deregulation in Pediatric Acute Myeloid Stem and Progenitor Cells

Inge Van Der Werf, MSc, Phoebe Mondala, BS, Raymond Diep, BS, Larissa Balaian, PhD, Cayla Mason, BS, Jacqueline Cloos, PhD, Gertjan J.L. Kaspers, Prof. MD PhD, Jim La Clair, Peggy Wentworth, Leslie A Crews, PhD, Thomas Whisenant, PhD, Kathleen Fisch, PhD, Michael Burkart, PhD, Catriona Jamieson, MD PhD

Blood (2020) 136 (Supplement 1): 8.

https://doi.org/10.1182/blood-2020-136596

Published: 2020

Journal Articles

Durable Responses and Survival in High Risk AML and MDS Patients Treated with an Allogeneic Leukemia-Derived Dendritic Cell Vaccine

Luca L.G. Janssen, MD, Theresia M. Westers, PhD, Jeroen Rovers, MD PhD, Peter Valk, PhD, Jacqueline Cloos, PhD, Tanja D. de Gruijl, PhD, Arjan A. Van de Loosdrecht, MD PhD

Blood (2019) 134 (Supplement_1): 1381.

https://doi.org/10.1182/blood-2019-127881

Published: 2019

Journal Articles

Statins Potentiate Aminopeptidase Inhibitor (pro)Drug Activity in Acute Myeloid Leukemia Cells

Jacqueline Cloos, PhD, Godefridus J Peters, PhD, Marjon Al, BSc, Yehuda G Assaraf, PhD, Lixia Wang, PhD, Jack W. Singer, MD, Jorge E. Cortes, MD, Gert J. Ossenkoppele, MD PhD, Gerrit Jansen, PhD

Blood (2018) 132 (Supplement 1): 3945.

https://doi.org/10.1182/blood-2018-99-114447

Published: 2018

Journal Articles

A Dynamic Epigenetic Landscape in Genetic and Immunophenotypic Stable Pediatric AML

Diana Hanekamp, MSc, Jennifer R. Scheick, Yaseswini Neelamraju, Edwin Sonneveld, PhD, Valerie de Haas, MD PhD, Gert J. Ossenkoppele, MD PhD, Gerrit J. Schuurhuis, PhD, Gertjan J.L. Kaspers, MD PhD, Francine E. Garrett-Bakelman, MDPhD, Jacqueline Cloos, PhD

Blood (2017) 130 (Supplement 1): 2686.

https://doi.org/10.1182/blood.V130.Suppl_1.2686.2686

Published: 2017

Journal Articles

The Prognostic Impact of Cytogenetics and Karyotype Changes in Pediatric Patients with Relapsed Acute Myeloid Leukemia: A Retrospective Cohort Study within the Relapsed AML 2001/01 Study

Blood (2016) 128 (22): 2896.

https://doi.org/10.1182/blood.V128.22.2896.2896

Published: 2016

Journal Articles

The Relevance of Stem Cell Load at Diagnosis for the Development of Relapse in Pediatric Acute Myeloid Leukemia

Dirkje W. Hanekamp, Barbara Denys, Gertjan J.L. Kaspers, MD PhD, Jeroen G. te Marvelde, Gerrit Jan Schuurhuis, PhD, Valerie De Haas, MD PhD, Barbara De Moerloose, MD PhD, Eveline S. de Bont, Anja de Jong, Jan Philippé, MD PhD, Jacqueline Cloos, PhD, Vincent H.J. van der Velden, PhD

Blood (2015) 126 (23): 2584.

https://doi.org/10.1182/blood.V126.23.2584.2584

Published: 2015

Journal Articles

Marcks Marks Resistance to Proteasome Inhibitors: Exocytosis of Polyubiquitinated Proteins in Bortezomib-Resistant Leukemia Cells

Niels Franke, MD, Gertjan J.L. Kaspers, MD PhD, Yehuda G Assaraf, PhD, Johan Van Meerloo, MSc, Denise Niewerth, PhD, Terzah M. Horton, MD PhD, Wee Joo Chng, MD PhD, Chonglei Bi, B.S, Rene X. Menezes, PhD, Renée J. Musters, PhD, Pino J. Poddighe, PhD, Floortje Kessler, Serge Smeets, PhD, Bauke Ylstra, PhD, Sonja Zweegman, MD PhD, Gerrit Jansen, PhD, Jacqueline Cloos, PhD

Blood (2015) 126 (23): 3712.

https://doi.org/10.1182/blood.V126.23.3712.3712

Published: 2015

Journal Articles

Clinical Impact of Additional Cytogenetic Aberrations, cKIT- and RAS Mutations and Other Factors in Pediatric t(8;21)-AML

Blood (2014) 124 (21): 481.

https://doi.org/10.1182/blood.V124.21.481.481

Published: 2014

Journal Articles

Spliceosome Inhibitor Meayamycin B As a Novel Potential Chemotherapeutic Agent in ALL and AML

Anna Wojtuszkiewicz, MSc, Yehuda G Assaraf, PhD, Gerrit Jansen, PhD, Kazunori Koide, PhD, Robert K. Bressin, Upamanyu Basu, Edwin Sonneveld, PhD, Elisa Giovannetti, PhD, Gertjan Kaspers, MD PhD, Jacqueline Cloos, PhD

Blood (2014) 124 (21): 924.

https://doi.org/10.1182/blood.V124.21.924.924

Published: 2014

Journal Articles

Microrna-106b~25 Cluster Is Involved in Relapsed MLL -Rearranged Pediatric AML

Lonneke Verboon, Maarten Fornerod, PhD, Askar Obulkasim, Edwin Sonneveld, PhD, André Baruchel, MD, Jan Trka, MD PhD, Dirk Reinhardt, MD PhD, Rob Pieters, MD PhD, Jacqueline Cloos, PhD, Gertjan JL Kaspers, MD PhD, Jan-Henning Klusmann, MD, C. Michel Zwaan, MD PhD, Marry van den Heuvel-Eibrink, MD PhD

Blood (2014) 124 (21): 1038.

https://doi.org/10.1182/blood.V124.21.1038.1038

Published: 2014

Journal Articles

Prediction of Relapse By microRNA Expression in Pediatric B-Lineage Acute Lymphoblastic Leukemia

Blood (2014) 124 (21): 3793.

https://doi.org/10.1182/blood.V124.21.3793.3793

Published: 2014

Journal Articles

The Novel Immunoproteasome Inhibitor PR-924: Anti-Leukemic Activity and Mechanisms Of Resistance

Denise Niewerth, MSc, Johan van Meerloo, MSc, Yehuda Assaraf, PhD, Gerrit Jansen, PhD, Tessa C Hendrickx, BSc, Christopher J. Kirk, Ph.D, Janet Anderl, MS, Sonja Zweegman, MD PhD, Jacqueline Cloos, PhD, Gertjan Kaspers, MD, PhD

Blood (2013) 122 (21): 3841.

https://doi.org/10.1182/blood.V122.21.3841.3841

Published: 2013

Journal Articles

Frequency and Prognostic Relevance of Gene Mutations in Pediatric AML Patients At First Relapse.

Costa Bachas, MSc, Gerrit Jan Schuurhuis, PhD, Dirk Reinhardt, MD, Ursula Creutzig, MD, PhD, Zinia J. Kwidama, BSc, C. Michel Zwaan, MD, PhD, Marry M. van den Heuvel-Eibrink, Evelina S De Bont, MD, PhD, Sara Elitzur, MD, Carmelo Rizzari, MD, PhD, Valérie de Haas, MD, PhD, Martin Zimmermann, Jacqueline Cloos, PhD, Gertjan J.L. Kaspers, MD, PhD

Blood (2012) 120 (21): 2480.

https://doi.org/10.1182/blood.V120.21.2480.2480

Published: 2012

Journal Articles

Harnessing Gene Expression Profiles for the Identification of Drug Resistance Genes in Pediatric AML

Costa Bachas, MSc, Gerrit Jan Schuurhuis, PhD, C. Michel Zwaan, MD, PhD, Marry M. van den Heuvel-Eibrink, Monique L. Den Boer, PhD, Zinia J. Kwidama, BSc, Evelina S. De Bont, MD, PhD, Dirk Reinhardt, MD, Ursula Creutzig, MD, PhD, Valérie de Haas, MD, PhD, Yehuda Assaraf, PhD, Gertjan J.L. Kaspers, MD, PhD, Jacqueline Cloos, PhD

Blood (2012) 120 (21): 283.

https://doi.org/10.1182/blood.V120.21.283.283

Published: 2012

Journal Articles

Interferon-γ-Induced Upregulation of Immunoproteasome Subunit Assembly Overcomes Bortezomib Resistance of Leukemia Cell Lines Harbouring Bortezomib-Induced Mutations in Constitutive PSMB5

Denise Niewerth, MSc, Niels Franke, MD, Gerrit Jansen, PhD, Yehuda Assaraf, PhD, Johan van Meerloo, MSc, Christopher J Kirk, PhD, Sonja Zweegman, MD, PhD, Gertjan J.L. Kaspers, MD, PhD, Jacqueline Cloos, PhD

Blood (2012) 120 (21): 1346.

https://doi.org/10.1182/blood.V120.21.1346.1346

Published: 2012

Journal Articles

Sensitivity of Pediatric Acute Leukemia Cells to Bortezomib and Epoxyketone-Based Proteasome Inhibitors: Correlations with Proteasome Subunit Expression

Denise Niewerth, MSc, Niels Franke, MD, Gerrit Jansen, PhD, Johan van Meerloo, MSc, Yehuda Assaraf, Prof, Christopher J Kirk, Elena T Chan, Sonja Zweegman, MD, PhD, Gertjan J. Kaspers, MD, PhD, Jacqueline Cloos, PhD

Blood (2011) 118 (21): 1513.

https://doi.org/10.1182/blood.V118.21.1513.1513

Published: 2011

Journal Articles

Glucocorticoid-Induced Proliferation and Differentiation of Untreated Pediatric AML Cells

Eric Haarman, MD, PhD, Jacqueline Cloos, PhD, Christian M. Zwaan, MD, PhD, Valerie de Haas, MD, PhD, Dirk Reinhardt, MD, PhD, Ursula Creutzig, MD, PhD, Gertjan J. Kaspers, MD, PhD

Blood (2011) 118 (21): 4873.

https://doi.org/10.1182/blood.V118.21.4873.4873

Published: 2011

Journal Articles

Relapsed AML Patients with Mutational Shifts Harbor An Oligoclonal Primitive Cell Compartment at Presentation; Evidence for Clonal Selection towards Relapse

Costa Bachas, Gerrit Jan Schuurhuis, PhD, Zinia J. Kwidama, Angèle Kelder, Alexander N. Snel, Gertjan J. Kaspers, MD, PhD, Jacqueline Cloos, PhD

Blood (2010) 116 (21): 751.

https://doi.org/10.1182/blood.V116.21.751.751

Published: 2010

Journal Articles

Frequent Instability of Type I and II Aberrations Between Diagnosis and Relapse Observed in Pediatric Aml; Implications for Targeted Therapy and MRD Detection.

Costa Bachas, MSc, Gerrit-Jan Schuurhuis, Iris H.I.M. Hollink, MD, Bianca F. Goemans, MD, PhD, Dirk Reinhardt, MD, PhD, Christian M Zwaan, MD, PhD, Marry M. van den Heuvel, MD, PhD, Eveline S.J.M de Bont, Elisabeth R. Van Wering, Gertjan Kaspers, MD, PhD, Jacqueline Cloos, PhD

Blood (2009) 114 (22): 1624.

https://doi.org/10.1182/blood.V114.22.1624.1624

Published: 2009

Journal Articles

The Novel Proteasome Inhibitor 5-Amino-8-Hydroxyquinole (5AHQ) Overcomes Bortezomib Resistance in Malignant Hematological Cell Line Models Harboring Mutations in the PSMB5 Gene.

Niels E Franke, MD, MSc, Johan van Meerloo, B.ASc, Linda Slot, MSc, Xiaoming Li, PhD, Tabitha E Wood, PhD, Katarina Vojtekova, MSc, Sue Ellen Verbrugge, MSc, Gertjan Kaspers, MD, PhD, Robert A. Batey, PhD, Aaron D. Schimmer, MD, PhD, Gerrit Jansen, PhD, Jacqueline Cloos, PhD

Blood (2009) 114 (22): 940.

https://doi.org/10.1182/blood.V114.22.940.940

Published: 2009

NARROW

Selective Targeting of Alternative Splicing Deregulation in Pediatric Acute Myeloid Stem and Progenitor Cells

Durable Responses and Survival in High Risk AML and MDS Patients Treated with an Allogeneic Leukemia-Derived Dendritic Cell Vaccine

Statins Potentiate Aminopeptidase Inhibitor (pro)Drug Activity in Acute Myeloid Leukemia Cells

A Dynamic Epigenetic Landscape in Genetic and Immunophenotypic Stable Pediatric AML

The Prognostic Impact of Cytogenetics and Karyotype Changes in Pediatric Patients with Relapsed Acute Myeloid Leukemia: A Retrospective Cohort Study within the Relapsed AML 2001/01 Study

The Relevance of Stem Cell Load at Diagnosis for the Development of Relapse in Pediatric Acute Myeloid Leukemia

Marcks Marks Resistance to Proteasome Inhibitors: Exocytosis of Polyubiquitinated Proteins in Bortezomib-Resistant Leukemia Cells

Clinical Impact of Additional Cytogenetic Aberrations, cKIT- and RAS Mutations and Other Factors in Pediatric t(8;21)-AML

Spliceosome Inhibitor Meayamycin B As a Novel Potential Chemotherapeutic Agent in ALL and AML

Microrna-106b~25 Cluster Is Involved in Relapsed MLL -Rearranged Pediatric AML

Prediction of Relapse By microRNA Expression in Pediatric B-Lineage Acute Lymphoblastic Leukemia

The Novel Immunoproteasome Inhibitor PR-924: Anti-Leukemic Activity and Mechanisms Of Resistance

Frequency and Prognostic Relevance of Gene Mutations in Pediatric AML Patients At First Relapse.

Harnessing Gene Expression Profiles for the Identification of Drug Resistance Genes in Pediatric AML

Interferon-γ-Induced Upregulation of Immunoproteasome Subunit Assembly Overcomes Bortezomib Resistance of Leukemia Cell Lines Harbouring Bortezomib-Induced Mutations in Constitutive PSMB5

Sensitivity of Pediatric Acute Leukemia Cells to Bortezomib and Epoxyketone-Based Proteasome Inhibitors: Correlations with Proteasome Subunit Expression

Glucocorticoid-Induced Proliferation and Differentiation of Untreated Pediatric AML Cells

Relapsed AML Patients with Mutational Shifts Harbor An Oligoclonal Primitive Cell Compartment at Presentation; Evidence for Clonal Selection towards Relapse

Frequent Instability of Type I and II Aberrations Between Diagnosis and Relapse Observed in Pediatric Aml; Implications for Targeted Therapy and MRD Detection.

The Novel Proteasome Inhibitor 5-Amino-8-Hydroxyquinole (5AHQ) Overcomes Bortezomib Resistance in Malignant Hematological Cell Line Models Harboring Mutations in the PSMB5 Gene.

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American Society of Hematology

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American Society of Hematology

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