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Journal Articles

HMGA1 Chromatin Regulators Disrupt 3D Genome Architecture and Chromatin Looping to Repress MHC II Genes and Drive Immune Evasion during MPN Progression

Linda Resar, Joseph Kim, Audrey-Ann Supreme, Hyunsung Woo, Bailey West, Mariah C. Antopia, Zanshe Thompson, Karen Reddy, Jung-Hyun Kim, Leslie Cope, Raajit Rampal, Richard Koche, Alison R. Moliterno, Jerry L. Spivak

Blood (2024) 144 (Supplement 1): 756.

https://doi.org/10.1182/blood-2024-211336

Published: 2024

Journal Articles

A c- MPL Splice Variant up-Regulated in Myeloproliferative Neoplasms Modulates Thrombopoietin Signaling and Induces Cycling of Hematopoietic Stem Cells and Inflammatory Progenitors

Linda Resar, Zanshe Thompson, Li Z Luo, Donna Marie Williams, Liping Li, Leslie Cope, Iliana Herrera, Ophelia Rogers, Alison R. Moliterno, Jerry L. Spivak

Blood (2023) 142 (Supplement 1): 3147.

https://doi.org/10.1182/blood-2023-189825

Published: 2023

Journal Articles

HMGA1 Chromatin Regulators Drive Immune Evasion in MPN Progression through Epigenetic Rewiring to Repress Antigen Presentation

Joseph Kim, Audrey-Ann Supreme, Bailey West, Mariah C. Antopia, Karen Reddy, Leslie Cope, Jung-Hyun Kim, Raajit K. Rampal, Richard Koche, Jerry L. Spivak, Alison R. Moliterno, Linda Resar

Blood (2023) 142 (Supplement 1): 992.

https://doi.org/10.1182/blood-2023-186452

Published: 2023

Journal Articles

Single Cell Transcriptomics Reveal That HMGA1 Chromatin Regulators Drive Transcriptional Networks Involved in Megakaryocyte Expansion, Platelet Activation, and Interferon Signaling in JAK2 V617F Myeloproliferative Neoplasms

Zanshe Thompson, Li Z Luo, Liping Li, Bowen Wang, Jung-Hyun Kim, Hyunsung Woo, Bailey West, Anandi Krishnan, Leslie Cope, Alison R. Moliterno, Jerry L. Spivak, Linda Resar

Blood (2023) 142 (Supplement 1): 3145.

https://doi.org/10.1182/blood-2023-190323

Published: 2023

Journal Articles

The High Mobility Group A1 Chromatin Regulator Drives Immune Evasion during MPN Progression By Repressing Genes Involved in Antigen Presentation

Joseph Kim, Jung-Hyun Kim, Leslie Cope, Liping Li, Raajit K Rampal, Richard Koche, Jerry L. Spivak, Alison R. Moliterno, Linda Resar

Blood (2022) 140 (Supplement 1): 801–802.

https://doi.org/10.1182/blood-2022-166969

Published: 2022

Journal Articles

HMGA1 chromatin regulators induce transcriptional networks involved in GATA2 and proliferation during MPN progression

Blood (2022) 139 (18): 2797–2815.

https://doi.org/10.1182/blood.2021013925

Published: 2022

Includes: Supplemental data

Journal Articles

HMGA1 Chromatin Regulators Drive Progression in Myeloproliferative Neoplasms through Epigenetic Rewiring to Induce Networks Involved in GATA2 and Proliferation

Liping Li, Jung-Hyun Kim, Wenyan Lu, Leslie Cope, Donna M Williams, Joseph Kim, Raajit Rampal, Richard Koche, Lingling Xian, Li Luo, Marija Vasiljevic, Daniel R Matson, Zhizhuang Joe Zhao, Ophelia Rogers, Matthew C. Stubbs, Karen Reddy, Jerry L. Spivak, Alison R. Moliterno, Linda Resar

Blood (2021) 138 (Supplement 1): 625.

https://doi.org/10.1182/blood-2021-144712

Published: 2021

Journal Articles

The High Mobility Group A1 Chromatin Regulator Drives Immune Evasion during MPN Progression By Repressing Genes Involved in Antigen Presentation and Immune Attack

Joseph Kim, Jung-Hyun Kim, Leslie Cope, Liping Li, Raajit Rampal, Richard Koche, Donna M Williams, Jerry L. Spivak, Alison R. Moliterno, Linda Resar

Blood (2021) 138 (Supplement 1): 2546.

https://doi.org/10.1182/blood-2021-151139

Published: 2021

Journal Articles

The High Mobility Group A1 Chromatin Regulator Is Required for Pathologic Megakaryocyte Development and Progression to Myelofibrosis in JAK2V617F Murine Models

Alison R. Moliterno, MD, Donna Marie Williams, PhD, Liping Li, MD PhD, Lingling Xian, MD PhD, Li Luo, PhD, Amy S. Duffield, MD PhD, Ophelia Rogers, Jerry L. Spivak, MD, Linda Resar, MD

Blood (2019) 134 (Supplement_1): 472.

https://doi.org/10.1182/blood-2019-131432

Published: 2019

Journal Articles

High Mobility Group A1 Chromatin Regulators: Key Epigenetic Switches and Therapeutic Targets Required for Leukemic Transformation in JAK2 Mutant MPN

Liping Li, MD PhD, Wenyan Lu, PhD, Alison R. Moliterno, MD, Lingling Xian, MD PhD, Joseph Kim, BS, Ophelia Rogers, Jerry L. Spivak, MD, Linda Resar, MD

Blood (2019) 134 (Supplement_1): 1680.

https://doi.org/10.1182/blood-2019-130262

Published: 2019

Journal Articles

Worse Outcomes in Males with MPN Are Associated with Qualitative and Quantitative Differences in Non-Driver Mutational Burden

Theodoros Karantanos, MD PhD, Evan M Braunstein, MD PhD, Shruti Chaturvedi, MBBS, MS, Jerry L. Spivak, MD, Linda Resar, MD, Styliani Karanika, MD, Donna Marie Williams, PhD, Christopher D Gocke, MD, Alison R. Moliterno, MD

Blood (2019) 134 (Supplement_1): 837.

https://doi.org/10.1182/blood-2019-125393

Published: 2019

Journal Articles

How I treat polycythemia vera

Jerry L. Spivak

Blood (2019) 134 (4): 341–352.

https://doi.org/10.1182/blood.2018834044

Published: 2019

Includes: Supplemental data

Journal Articles

Mutated CALR : tails from the crypt

Jerry L. Spivak

Blood (2019) 133 (25): 2630–2631.

https://doi.org/10.1182/blood-2019-04-901132

Published: 2019

Journal Articles

Development of Liver-Specific Thrombopoietin Targeted Sirnas: Impact on Platelet Count, Megakaryocyte Mass, and Hematopoietic Progenitors in Normal and MPN Murine Models

Dhruv Desai, MSc, Anna Borodovsky, PhD, Wendell P Davis, DVM DACVP, Rohan Degaonkar, Kristina Yucius, Kellie D'Angelo, MLS(ASCP)CM, Paul Gedman, BS, Donna Marie Williams, PhD, Ophelia Rogers, Zhizhuang Joe Zhao, PhD, Jerry L. Spivak, MD, Alison R. Moliterno, MD

Blood (2018) 132 (Supplement 1): 4329.

https://doi.org/10.1182/blood-2018-99-117142

Published: 2018

Journal Articles

High Mobility Group A1 Chromatin Remodeling Proteins Amplify Inflammatory Networks to Drive Leukemic Transformation in Chronic Myeloproliferative Neoplasia in Humans and JAK2 V617F Transgenic Mouse Models

Linda Resar, MD, Donna Marie Williams, PhD, Lingling Xian, MD PhD, Wenyan Lu, PhD, Briyana Chisholm, BS, Li Luo, PhD, Zhizhuang Joe Zhao, PhD, Ophelia Rogers, Jerry L. Spivak, MD, Alison R. Moliterno, MD

Blood (2018) 132 (Supplement 1): 102.

https://doi.org/10.1182/blood-2018-99-119549

Published: 2018

Journal Articles

Independent Association of Male Sex with Presentation and Clinical Outcomes in Myeloproliferative Neoplasms

Theodoros Karantanos, MDPhD, Shruti Chaturvedi, MBBS,MS, Jerry L. Spivak, MD, Linda Resar, MD, Evan M Braunstein, MDPhD, Styliani Karanika, MD, Donna Marie Williams, PhD, Ophelia Rogers, Alison R. Moliterno, MD

Blood (2018) 132 (Supplement 1): 1768.

https://doi.org/10.1182/blood-2018-99-112683

Published: 2018

Journal Articles

Myeloproliferative Neoplasms in Pediatrics and Young Adults: Genetic Lesions, Diagnostic Features, and Clinical Outcomes

Linda Resar, MD, Donna Marie Williams, PhD, Evan M Braunstein, MDPhD, Jerry L. Spivak, MD, Alison R. Moliterno, MD

Blood (2017) 130 (Supplement 1): 4180.

https://doi.org/10.1182/blood.V130.Suppl_1.4180.4180

Published: 2017

Journal Articles

Mechanism of Escape from LNK Negative Regulation: Constitutively Active JAK2V617F Retains Lysine63-Ubiquitin

Jeffrey Patterson-Fortin, MD PhD, Jerry L. Spivak, MD, Amy S. Duffield, MD PhD, Donna Marie Williams, PhD, Ophelia Rogers, Zhizhuang Joe Zhao, PhD, Alison R. Moliterno, MD

Blood (2017) 130 (Supplement 1): 2931.

https://doi.org/10.1182/blood.V130.Suppl_1.2931.2931

Published: 2017

Journal Articles

High Mobility Group A1 Chromatin Remodeling Proteins: Potential Therapeutic Targets Involved in Polycythemia Vera Transformation to Acute Leukemia in Humans and JAK2 V617F Transgenic Mouse Models

Linda Resar, MD, Donna Marie Williams, PhD, Lingling Xian, MD PhD, Zhizhuang Joe Zhao, PhD, Ophelia Rogers, Jerry L. Spivak, MD, Alison R. Moliterno, MD

Blood (2017) 130 (Supplement 1): 489.

https://doi.org/10.1182/blood.V130.Suppl_1.489.489

Published: 2017

Journal Articles

Germline ERBB2 Variants Associate with Myeloproliferative Neoplasms

Evan M Braunstein, MDPhD, Donna Marie Williams, PhD, Igor Makhlin, MD, Aparna Pallavajjala, Christopher D Gocke, MD, Nara Sobreira, MD, Kala Visvanathan, MD, Linda Resar, MD, Jerry L. Spivak, MD, Alison R. Moliterno, MD

Blood (2017) 130 (Supplement 1): 1663.

https://doi.org/10.1182/blood.V130.Suppl_1.1663.1663

Published: 2017

NARROW

HMGA1 Chromatin Regulators Disrupt 3D Genome Architecture and Chromatin Looping to Repress MHC II Genes and Drive Immune Evasion during MPN Progression

A c- MPL Splice Variant up-Regulated in Myeloproliferative Neoplasms Modulates Thrombopoietin Signaling and Induces Cycling of Hematopoietic Stem Cells and Inflammatory Progenitors

HMGA1 Chromatin Regulators Drive Immune Evasion in MPN Progression through Epigenetic Rewiring to Repress Antigen Presentation

Single Cell Transcriptomics Reveal That HMGA1 Chromatin Regulators Drive Transcriptional Networks Involved in Megakaryocyte Expansion, Platelet Activation, and Interferon Signaling in JAK2 V617F Myeloproliferative Neoplasms

The High Mobility Group A1 Chromatin Regulator Drives Immune Evasion during MPN Progression By Repressing Genes Involved in Antigen Presentation

HMGA1 chromatin regulators induce transcriptional networks involved in GATA2 and proliferation during MPN progression

HMGA1 Chromatin Regulators Drive Progression in Myeloproliferative Neoplasms through Epigenetic Rewiring to Induce Networks Involved in GATA2 and Proliferation

The High Mobility Group A1 Chromatin Regulator Drives Immune Evasion during MPN Progression By Repressing Genes Involved in Antigen Presentation and Immune Attack

The High Mobility Group A1 Chromatin Regulator Is Required for Pathologic Megakaryocyte Development and Progression to Myelofibrosis in JAK2V617F Murine Models

High Mobility Group A1 Chromatin Regulators: Key Epigenetic Switches and Therapeutic Targets Required for Leukemic Transformation in JAK2 Mutant MPN

Worse Outcomes in Males with MPN Are Associated with Qualitative and Quantitative Differences in Non-Driver Mutational Burden

How I treat polycythemia vera

Mutated CALR : tails from the crypt

Development of Liver-Specific Thrombopoietin Targeted Sirnas: Impact on Platelet Count, Megakaryocyte Mass, and Hematopoietic Progenitors in Normal and MPN Murine Models

High Mobility Group A1 Chromatin Remodeling Proteins Amplify Inflammatory Networks to Drive Leukemic Transformation in Chronic Myeloproliferative Neoplasia in Humans and JAK2 V617F Transgenic Mouse Models

Independent Association of Male Sex with Presentation and Clinical Outcomes in Myeloproliferative Neoplasms

Myeloproliferative Neoplasms in Pediatrics and Young Adults: Genetic Lesions, Diagnostic Features, and Clinical Outcomes

Mechanism of Escape from LNK Negative Regulation: Constitutively Active JAK2V617F Retains Lysine63-Ubiquitin

High Mobility Group A1 Chromatin Remodeling Proteins: Potential Therapeutic Targets Involved in Polycythemia Vera Transformation to Acute Leukemia in Humans and JAK2 V617F Transgenic Mouse Models

Germline ERBB2 Variants Associate with Myeloproliferative Neoplasms

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American Society of Hematology

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American Society of Hematology

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