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Journal Articles

Eradication of the CLECL1+ CLL Subset That Is Prone to Carrying Novel Genomic Mutations and Promoting a Pro-Tumor Microenvironment By a Series of New Monoclonal Antibodies Reactive with Distinct Target Epitopes

Shih-Shih Chen, Susan Buhl, Anita Kar Yun Ng, Laila Schipper, Bianca Cinquemani, Nikhil Trepeta, Martina Cardillo, Gonzalo Blanco, Kelly Wong, Yu-Ju Chen, Xiao J. Yan, Matthew Scharff, Nicholas Chiorazzi

Blood (2024) 144 (Supplement 1): 74.

https://doi.org/10.1182/blood-2024-200296

Published: 2024

Journal Articles

Normal B Cells in MBL Are Biased Toward Antigen-Experienced B Cells, with Increased Percentages of DN1 Cells in IGHV-Mutated MBL and ABC/DN2 Cells in IGHV-Unmutated MBL Suggesting Distinct Follicular/Extrafollicular Maturation Pathways

Gonzalo Blanco, Xiao J. Yan, Anita Kar Yun Ng, Andrew Shih, Jonathan E. Kolitz, Steven L. Allen, Kanti R. Rai, Nicholas Chiorazzi

Blood (2024) 144 (Supplement 1): 1851.

https://doi.org/10.1182/blood-2024-211202

Published: 2024

Journal Articles

Delivery of Foreign Antigen Selectively to Membrane IgD on CLL and Normal B Cells Leads to Superior T-Cell Activation: A Possible Approach to Restore/Enhance T-Cell Immunity and T-Cell Help

Martina Cardillo, Matthew J Friedman, Anita Ng, Randall S. Davis, Xiao J. Yan, Ashna Shah, Michael Ryan, Peter K Gregersen, Steven L. Allen, Jonathan E Kolitz, Kanti R. Rai, Paolo Ghia, Nicholas Chiorazzi

Blood (2024) 144 (Supplement 1): 1849.

https://doi.org/10.1182/blood-2024-210710

Published: 2024

Journal Articles

Transcriptomic Analyses Indicate That Pre-Leukemic B Cells from People with Monoclonal B Lymphocytosis Are Surprisingly Much Less Active Than Normal B Cells from People with Monoclonal B Lymphocytosis and from Healthy Donors

Xiao J. Yan, Gonzalo Blanco, Anita Ng, Andrew Shih, Martina Cardillo, Jonathan E Kolitz, Jacqueline C. Barrientos, Steven L. Allen, Joanna M. Rhodes, Kanti R. Rai, Nicholas Chiorazzi

Blood (2023) 142 (Supplement 1): 6512.

https://doi.org/10.1182/blood-2023-191042

Published: 2023

Journal Articles

Normal B Cells in MBL Exhibit Distinct Transcriptomes Compared to Those of Healthy Individuals, Although They Differ in Activation State Based on IGHV Mutation Status

Gonzalo Blanco, Xiao J. Yan, Anita Ng, Andrew Shih, Jonathan E Kolitz, Jacqueline C. Barrientos, Steven L. Allen, Joanna M. Rhodes, Kanti R. Rai, Nicholas Chiorazzi

Blood (2023) 142 (Supplement 1): 4632.

https://doi.org/10.1182/blood-2023-190901

Published: 2023

Journal Articles

Integrin Signaling Pathway Is Crucial for the Recently Divided Fraction of CLL Cells and Facilitates Cell Migration in a Disease Progressive Manner

Xiao J. Yan, Florencia Palacios, Shih-Shih Chen, Wentian Li, Joanna M. Rhodes, Jacqueline C. Barrientos, Steven L Allen, Jonathan E. Kolitz, Kanti R Rai, Nicholas Chiorazzi

Blood (2022) 140 (Supplement 1): 4125–4126.

https://doi.org/10.1182/blood-2022-170042

Published: 2022

Journal Articles

CLL Intraclonal Fractions Defined By Time Since Cell Birth/Division Promote a Leukemia-Supportive, Immune-Tolerant Microenvironment By Distinct Mechanisms

Shih-Shih Chen, PhD, Xiao J. Yan, MD PhD, Thomas M. Herndon, MD, Clare C. Sun, MD, Priyadarshini Ravichandran, Michael Ibrahim, Barbara Sherry, PhD, Adrian Wiestner, MD, Kanti R Rai, MD, Nicholas Chiorazzi, MD

Blood (2018) 132 (Supplement 1): 1836.

https://doi.org/10.1182/blood-2018-99-119843

Published: 2018

Journal Articles

IGHV Gene Replacement: A Potential Mechanism for Establishing Stereotypy in Certain Cases of Chronic Lymphocytic Leukemia

Sophia Yancopoulos, PhD, Wentian Li, PhD, Xiao J. Yan, MD PhD, Andreas Agathangelidis, PhD, Anastasia Hadzidimitriou, PhD, Frederic Davi, MD PhD, Richard Rosenquist, MD PhD, Paolo Ghia, MD PhD, Kostas Stamatopoulos, MD PhD, Nicholas Chiorazzi, MD

Blood (2018) 132 (Supplement 1): 1841.

https://doi.org/10.1182/blood-2018-99-119803

Published: 2018

Journal Articles

Ibrutinib Treatment Reduces Myeloid Derived Suppressor Cell Numbers and Function in Chronic Lymphocytic Leukemia

Gerardo Ferrer, PhD, Byeongho Jung, BS, Aslam Rukhsana, MD, Pui Yan Chiu, Andrea Nicola Mazzarello, PhD, Florenca Palacios, PhD, Shih-Shih Chen, PhD, Xiao J. Yan, MDPhD, Jacqueline C. Barrientos, MD MS, Jan A. Burger, MD PhD, Jonathan E. Kolitz, MD, Steven L. Allen, MD, Kanti R Rai, MD, Barbara Sherry, PhD, Nicholas Chiorazzi, MD

Blood (2018) 132 (Supplement 1): 239.

https://doi.org/10.1182/blood-2018-99-114799

Published: 2018

Journal Articles

CLL Stereotyped Subset #4 Igs Acquire Binding to Viable B Lymphocyte Surfaces By Somatic Mutations, Isotype Class Switching, and with the Prerequisite of IG Self-Association

Yun Liu, MS, Rosa Catera, PhD, Chao Gao, PhD, Xiao J. Yan, MDPhD, Steven L. Allen, MD, Jonathan E. Kolitz, MD, Kanti Rai, MD, Charles C Chu, PhD, Ten Feizi, MD, Kostas Stamatopoulos, Nicholas Chiorazzi, MD

Blood (2017) 130 (Supplement 1): 58.

https://doi.org/10.1182/blood.V130.Suppl_1.58.58

Published: 2017

Journal Articles

Reactive Oxygen Species and Metabolic Gene Expression Profiling Further Differentiate CXCR4/CD5 Fractions in Chronic Lymphocytic Leukemia

Eric Sturgill, BA, Xiao J. Yan, MDPhD, Florencia Palacios, PhD, Kanti Rai, MD, Jacqueline C. Barrientos, MD, Steven L. Allen, MD, Jonathan E. Kolitz, MD, Nicholas Chiorazzi, MD

Blood (2017) 130 (Supplement 1): 4287.

https://doi.org/10.1182/blood.V130.Suppl_1.4287.4287

Published: 2017

Journal Articles

Over-Expression of Activation-Induced Cytidine Deaminase in TCL1 Mice Leads to the Development of IGHV-Mutated CLL Clones That Associate with More Aggressive Disease

Xiao J. Yan, MDPhD, Pablo Morande, PhD, Mei Qi, Ezra B Kolitz, Crystal D Grant, Gautam Nayyar, Pablo Oppezzo, PhD, Nicholas Chiorazzi, MD

Blood (2017) 130 (Supplement 1): 4293.

https://doi.org/10.1182/blood.V130.Suppl_1.4293.4293

Published: 2017

Journal Articles

Myeloid-Derived Suppressor Cell Subtypes Are Responsible for the Th2 Phenotype of T Cells in CLL

Gerardo Ferrer, PhD, Brendan Franca, BS, Pui Yan Chiu, Stefano Vergani, PhD, Andrea Nicola Mazzarello, PhD, Florenca Palacios, PhD, Shihshih Chen, PhD, Davide Bagnara, PhD, Sophia Yancopoulos, Yun Liu, MS, Aliki Xochelli, MD, Xiao J. Yan, MDPhD, Jonathan E. Kolitz, MD, Steven L. Allen, MD, Jacqueline C. Barrientos, MD, Kostas Stamatopoulos, Kanti Rai, MD, Barbara Sherry, PhD, Nicholas Chiorazzi, MD

Blood (2017) 130 (Supplement 1): 4294.

https://doi.org/10.1182/blood.V130.Suppl_1.4294.4294

Published: 2017

Journal Articles

IgM and IgD Differential CLL BCRs Organization and Interaction with Co-Receptors before and during Ibrutinib Therapy

Andrea Nicola Mazzarello, PhD, Marcus Dühren-von Minden, PhD, Palash Chandra Maity, PhD, Gentner Eva, PhD, Stefano Vergani, PhD, Gerardo Ferrer, PhD, Davide Bagnara, PhD, Shih-Shih Chen, PhD, Sophia Yancopoulos, Xiao J. Yan, MDPhD, Jacqueline C. Barrientos, MD, Kanti Rai, MD, Hassan Jumaa, PhD, Nicholas Chiorazzi, MD

Blood (2017) 130 (Supplement 1): 1716.

https://doi.org/10.1182/blood.V130.Suppl_1.1716.1716

Published: 2017

Journal Articles

The RNA-Binding Protein Musashi 2 Is Upregulated in the Proliferative Fraction of CLL Clones, Particularly in U-CLL Patients, and Its Silencing Induces Programmed Cell Death

Florencia Palacios, PhD, Xiao J. Yan, MD PhD, Jacqueline C. Barrientos, MD, Jonathan E. Kolitz, MD, Steven L. Allen, MD, Kanti R. Rai, MD, Nicholas Chiorazzi, MD

Blood (2016) 128 (22): 3216.

https://doi.org/10.1182/blood.V128.22.3216.3216

Published: 2016

Journal Articles

Long-term multilineage engraftment of autologous genome-edited hematopoietic stem cells in nonhuman primates

Christopher W. Peterson, Jianbin Wang, Krystin K. Norman, Zachary K. Norgaard, Olivier Humbert, Collette K. Tse, Jenny J. Yan, Richard G. Trimble, David A. Shivak, Edward J. Rebar, Philip D. Gregory, Michael C. Holmes, Hans-Peter Kiem

Blood (2016) 127 (20): 2416–2426.

https://doi.org/10.1182/blood-2015-09-672337

Published: 2016

Includes: Supplemental data

Journal Articles

CLL with Mutated IGHV4-34 Antigen Receptors Is Clinically Heterogeneous: Antigen Receptor Stereotypy Makes the Difference

Aliki Xochelli, Panagiotis Baliakas, Andreas Agathangelidis, Anastasia Hadzidimitriou, Lesley-Ann Sutton, Eva Minga, Eugen Tausch, MD, Xiao J. Yan, Tait D. Shanafelt, MD, Karla Plevova, PhD, Myriam Boudjogra, Davide Rossi, MD PhD, Zadie Davis, Alba Navarro, Yorick Sandberg, Fie Juhl Vojdeman, Lydia Scarfo, Niki Stavroyianni, Andrey B. Sudarikov, PhD, Silvio Veronese, Tatiana Tzenou, MD, Teodora Karan-Djurasevic, Mark Catherwood, PhD, Dirk Kienle, Maria Chatzouli, Monica Facco, MS, Jasmin Bahlo, Lone Bredo Pedersen, Larry Mansouri, Karin E Smedby, MD PhD, Charles C Chu, Véronique Giudicelli, Marie-Paule Lefranc, Panagiotis Panagiotidis, Gunnar Juliusson, Achilles Anagnostopoulos, Darko Antic, Livio Trentin, Marco Montillo, Carsten Niemann, Hartmut Döhner, MD, Anton W. Langerak, Nikos Darzentas, Sarka Pospisilova, Michael Hallek, MD, Elias Campo, Nicholas Chiorazzi, MD, David Oscier, Gianluca Gaidano, MD PhD, Chrysoula Belessi, Diane F. Jelinek, Stephan Stilgenbauer, MD, Frederic Davi, Richard Rosenquist, Paolo Ghia, Kostas Stamatopoulos

Blood (2015) 126 (23): 5263.

https://doi.org/10.1182/blood.V126.23.5263.5263

Published: 2015

Journal Articles

Charting Unique Signatures of Somatic Hypermutation Amongst Chronic Lymphocytic Leukemia Patients Expressing IGHV4-34 Clonotypic B Cell Receptors

Blood (2014) 124 (21): 1969.

https://doi.org/10.1182/blood.V124.21.1969.1969

Published: 2014

Journal Articles

CLL Sera Drive Maturation of Normal Monocytes to M2-like Macrophages By Direct and Indirect Mechanisms

Sonia Marsilio, PhD, Barbara Sherry, PhD, Xiao J. Yan, MD PhD, Jacqueline C. Barrientos, MD, Steven L. Allen, MD, Jonathan E. Kolitz, MD, Kanti R. Rai, MD, Nicholas Chiorazzi, MD

Blood (2014) 124 (21): 1970.

https://doi.org/10.1182/blood.V124.21.1970.1970

Published: 2014

Journal Articles

Lenalidomide Promotes The Expansion Of CD8 T Cells With An Effector Memory Phenotype In a Murine Xenograft Model Of Chronic Lymphocytic Leukemia

Rita Simone, PhD, Sonia Marsilio, PhD, Piers E.M. Patten, MD, PhD, Gerardo Ferrer, PhD, Shih-Shih Chen, Ph.D., Xiao J. Yan, MD, PhD, Stefano Vergani, Msc, Andrea Nicola Mazzarello, PhD, Jacqueline C. Barrientos, MD, Steven L. Allen, M.D., Jonathan E. Kolitz, MD, Kanti R. Rai, MD, Nicholas Chiorazzi, MD

Blood (2013) 122 (21): 119.

https://doi.org/10.1182/blood.V122.21.119.119

Published: 2013

NARROW

Eradication of the CLECL1+ CLL Subset That Is Prone to Carrying Novel Genomic Mutations and Promoting a Pro-Tumor Microenvironment By a Series of New Monoclonal Antibodies Reactive with Distinct Target Epitopes

Normal B Cells in MBL Are Biased Toward Antigen-Experienced B Cells, with Increased Percentages of DN1 Cells in IGHV-Mutated MBL and ABC/DN2 Cells in IGHV-Unmutated MBL Suggesting Distinct Follicular/Extrafollicular Maturation Pathways

Delivery of Foreign Antigen Selectively to Membrane IgD on CLL and Normal B Cells Leads to Superior T-Cell Activation: A Possible Approach to Restore/Enhance T-Cell Immunity and T-Cell Help

Transcriptomic Analyses Indicate That Pre-Leukemic B Cells from People with Monoclonal B Lymphocytosis Are Surprisingly Much Less Active Than Normal B Cells from People with Monoclonal B Lymphocytosis and from Healthy Donors

Normal B Cells in MBL Exhibit Distinct Transcriptomes Compared to Those of Healthy Individuals, Although They Differ in Activation State Based on IGHV Mutation Status

Integrin Signaling Pathway Is Crucial for the Recently Divided Fraction of CLL Cells and Facilitates Cell Migration in a Disease Progressive Manner

CLL Intraclonal Fractions Defined By Time Since Cell Birth/Division Promote a Leukemia-Supportive, Immune-Tolerant Microenvironment By Distinct Mechanisms

IGHV Gene Replacement: A Potential Mechanism for Establishing Stereotypy in Certain Cases of Chronic Lymphocytic Leukemia

Ibrutinib Treatment Reduces Myeloid Derived Suppressor Cell Numbers and Function in Chronic Lymphocytic Leukemia

CLL Stereotyped Subset #4 Igs Acquire Binding to Viable B Lymphocyte Surfaces By Somatic Mutations, Isotype Class Switching, and with the Prerequisite of IG Self-Association

Reactive Oxygen Species and Metabolic Gene Expression Profiling Further Differentiate CXCR4/CD5 Fractions in Chronic Lymphocytic Leukemia

Over-Expression of Activation-Induced Cytidine Deaminase in TCL1 Mice Leads to the Development of IGHV-Mutated CLL Clones That Associate with More Aggressive Disease

Myeloid-Derived Suppressor Cell Subtypes Are Responsible for the Th2 Phenotype of T Cells in CLL

IgM and IgD Differential CLL BCRs Organization and Interaction with Co-Receptors before and during Ibrutinib Therapy

The RNA-Binding Protein Musashi 2 Is Upregulated in the Proliferative Fraction of CLL Clones, Particularly in U-CLL Patients, and Its Silencing Induces Programmed Cell Death

Long-term multilineage engraftment of autologous genome-edited hematopoietic stem cells in nonhuman primates

CLL with Mutated IGHV4-34 Antigen Receptors Is Clinically Heterogeneous: Antigen Receptor Stereotypy Makes the Difference

Charting Unique Signatures of Somatic Hypermutation Amongst Chronic Lymphocytic Leukemia Patients Expressing IGHV4-34 Clonotypic B Cell Receptors

CLL Sera Drive Maturation of Normal Monocytes to M2-like Macrophages By Direct and Indirect Mechanisms

Lenalidomide Promotes The Expansion Of CD8 T Cells With An Effector Memory Phenotype In a Murine Xenograft Model Of Chronic Lymphocytic Leukemia

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American Society of Hematology

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American Society of Hematology

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