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Journal Articles

Fried Frailty Phenotype Predicts Mortality for Newly Diagnosed Older Patients with Acute Myeloid Leukemia or High Risk Myelodysplastic Syndrome

Shannon R. McCurdy, MD, Shannon H. Gier, BS, Daria V. Babushok, MD PhD, Noelle V. Frey, MD, Saar I. Gill, MD PhD, Elizabeth O. Hexner, MD, Alison W. Loren, MD MSCE, James K. Mangan, MD PhD, Mary Ellen Martin, MD, Alexander E. Perl, MD, Ivan Maillard, MD PhD, Keith W. Pratz, MD, David L. Porter, MD, Martin P. Carroll, MD, Phyllis A. Gimotty, PhD, Selina M. Luger, MD FRCPC

Blood (2019) 134 (Supplement_1): 2209.

https://doi.org/10.1182/blood-2019-124468

Published: 2019

Journal Articles

Dll1 and Dll4 Notch Ligands Prime T Cell Alloimmunity and Are Expressed in Non-Overlapping Populations of Fibroblastic Stromal Cells in Spleen and Lymph Nodes at the Onset of Gvhd

Joshua D Brandstadter, MD PhD, Eric Perkey, Brian T. Gaudette, PhD, Léolène Carrington, PhD, Daniela Gomez-Atria, PhD, Bruce R. Blazar, MD, Burkhard Ludewig, PhD, Anastasia Tikhonova, PhD, Iannis Aifantis, PhD, David Allman, PhD, Ivan Maillard, MD PhD

Blood (2019) 134 (Supplement_1): 588.

https://doi.org/10.1182/blood-2019-123533

Published: 2019

Journal Articles

SETDB1 Mediated H3K9 Methylation Suppresses MLL-Fusion Target Expression and Leukemic Transformation

Andrew G. Muntean, PhD, James Ropa, Nirmalya SAHA, PhD MSc, BSc, Hsiang-Yu Hu, BS, Justin Serio, Lili Zhao, Venkatesha Basrur, Alexei Nesvizhskii, Ivan Maillard, MD PhD

Blood (2019) 134 (Supplement_1): 110.

https://doi.org/10.1182/blood-2019-122610

Published: 2019

Journal Articles

From Graft-Versus-Host Disease to Lymphoma Pathogenesis: Emerging Roles for Stromal Notch Ligands in Hematology

Ivan Maillard, MD PhD

Blood (2019) 134 (Supplement_1): SCI-47.

https://doi.org/10.1182/blood-2019-121067

Published: 2019

Journal Articles

The PAF1c Subunit Cdc73 Is Essential for Hematopoiesis and Displays Differential Gene Regulation in MLL-AF9 Driven Leukemia

Nirmalya SAHA, PhD MSc, BSc, James Ropa, BS, Lili Chen, PhD, Hsiang-Yu Hu, BS, Maria Mysliwski, Ann Friedman, BS, Ivan Maillard, MD, Andrew G. Muntean, PhD

Blood (2018) 132 (Supplement 1): 1280.

https://doi.org/10.1182/blood-2018-99-118703

Published: 2018

Journal Articles

Pharmacologic Blockade of Notch/Delta-like Ligand 4 Signaling Protects from Gastrointestinal Acute Graft-Versus-Host Disease in Non-Human Primates

Victor Tkachev, PhD, Frank Kuhnert, PhD, Scott N Furlan, MD, Hengqi Zheng, MD, Daniel J Hunt, Lucrezia Colonna, PhD, Judith M Carlson, BS, Agne Taraseviciute, MD PhD, Angela Panoskaltsis-Mortari, PhD, Virginia Hoglund, Kayla Betz, Alison Yu, PhD, Bruce R. Blazar, MD, Steve Carpenter, MD PhD, Olivier Harari, MD PhD, Gavin Thurston, PhD, Ivan Maillard, MD PhD, Leslie Kean, MD PhD

Blood (2018) 132 (Supplement 1): 2027.

https://doi.org/10.1182/blood-2018-99-110030

Published: 2018

Journal Articles

The Trithorax-Group Protein ASH1L Regulates Hematopoietic Stem Cell Homeostasis Independently of Its Histone Methyltransferase Activity

Gloria Jih, PhD, Jennifer Chase, PhD, Yile Zhou, MD PhD, Ann Friedman, BS, Xiaomin Feng, MD PhD, Manabu Nakayama, PhD, Haruhiko Koseki, PhD, Kenichi Nishioka, PhD, Gang Huang, PhD, Ivan Maillard, MD PhD

Blood (2018) 132 (Supplement 1): 1270.

https://doi.org/10.1182/blood-2018-99-117367

Published: 2018

Journal Articles

Donor T Cells Require Notch Signals but Not Alloantigen Presentation from Specialized Secondary Lymphoid Organ Fibroblasts to Drive Graft-Versus-Host Disease

Eric Perkey, BS, Léolène Carrington, PhD, Jooho Chung, MDPhD, David Granadier, BS, Alexander Dils, Ann Friedman, BS, Anastasia Tikhonova, PhD, Bruce R. Blazar, MD, Ute Koch, PhD, Nathalie Labrecque, PhD, Freddy Radtke, PhD, Chris Siebel, PhD BA, Iannis Aifantis, PhD, Ivan Maillard, MD PhD

Blood (2018) 132 (Supplement 1): 810.

https://doi.org/10.1182/blood-2018-99-110258

Published: 2018

Journal Articles

The AF9-Binding Domain of DOT1L Is Critical for Its Recruitment By MLL Fusion Proteins in Leukemia and Contributes to Its Functions in Normal Hematopoiesis

Sierrah Marie Grigsby, BS, James Ropa, BS, Justin Serio, BS, Jennifer Chase, PhD, Chenxi Shen, PhD, Andrew G. Muntean, PhD, Ivan Maillard, MD PhD, Zaneta Nikolovska-Coleska, PhD

Blood (2017) 130 (Supplement 1): 3785.

https://doi.org/10.1182/blood.V130.Suppl_1.3785.3785

Published: 2017

Journal Articles

Mice with LMAN1 Deficiency Exhibit Thrombocytopenia and Reduced Serum Thrombopoietin Level

Rami Khoriaty, MD, Lesley Everett, BS, MPhil, Jennifer Chase, Guojing Zhu, Bin Zhang, PhD, Ivan Maillard, MD PhD, David Ginsburg, MD

Blood (2016) 128 (22): 412.

https://doi.org/10.1182/blood.V128.22.412.412

Published: 2016

Journal Articles

The Direct Notch1 Cofactor Zmiz1 Differentially Regulates Notch1 Signals in a Stage-Specific Manner to Preserve Early T-Cell Precursors and Expand Committed T Cells

Qing Wang, Ran Yan, Nancy Pinnell, Yiran Liu, Amparo Serna Alarcon, Jason Qin, Yitong Chen, Erin Kim, Noah Garber, Ivan Maillard, MD PhD, Tomasz Cierpicki, PhD, Mark Chiang, MD PhD

Blood (2016) 128 (22): 426.

https://doi.org/10.1182/blood.V128.22.426.426

Published: 2016

Journal Articles

All- Trans Retinoic Acid (ATRA) Targets IRF4 Deficient, NOTCH2-Activated B Cells from Chronic Gvhd Patients

Jonathan C. Poe, PhD, Wei Jia, MD, Hsuan Su, MS, Zhiguo Li, PhD, Frances T. Hakim, PhD, Steven Z. Pavletic, MD, Jeremy J. Rose, MS, David A Rizzieri, MD, Yiping Yang, MD PhD, Benny J. Chen, MD, Sarah Anand, MD, Jerome Ritz, MD, Christian W. Siebel, PhD, Nelson J. Chao, MD, Ivan Maillard, MD PhD, Stefanie Sarantopoulos, MD PhD

Blood (2016) 128 (22): 669.

https://doi.org/10.1182/blood.V128.22.669.669

Published: 2016

Journal Articles

Pirfenidone Reverses Murine Chronic Graft Versus Host Disease

Jing Du, Ryan P Flynn, PhD, Katelyn Paz, Ante Vulic, MD, Tara M. Robinson, MD PhD, Katie E Lineburg, BSc, Kelli P A Macdonald, PhD, Geoffrey R Hill, Jonathan S Serody, MD, Ivan Maillard, MD PhD, Angela Panoskaltsis-Mortari, PhD, Timothy Schacker, MD, Leo Luznik, MD, Bruce R. Blazar, MD

Blood (2016) 128 (22): 1158.

https://doi.org/10.1182/blood.V128.22.1158.1158

Published: 2016

Journal Articles

Notch Signaling Mediated By Dll1/4 Notch Ligands Controls the Pathogenesis of Both Multi-Organ System Non-Sclerodermatous and Sclerodermatous Chronic Graft-Versus-Host Disease

Vedran Radojcic, MD, Ryan P Flynn, PhD, Jooho Chung, BS, Jing Du, Eric Perkey, BS, Katelyn Paz, Michael Zaiken, Ann Friedman, Minhong Yan, PhD, Christian W. Siebel, PhD, Bruce R. Blazar, MD, Ivan Maillard, MD PhD

Blood (2016) 128 (22): 805.

https://doi.org/10.1182/blood.V128.22.805.805

Published: 2016

Journal Articles

SEC23A Functionally Compensates for SEC23B Deficiency in Mice

Rami Khoriaty, MD, Lesley Everett, BS, MPhil, Jennifer Chase, Guojing Zhu, Bin Zhang, PhD, Mark Hoenerhoff, DVM, PhD DACVP, Ivan Maillard, MD PhD, David Ginsburg, MD

Blood (2015) 126 (23): 935.

https://doi.org/10.1182/blood.V126.23.935.935

Published: 2015

Journal Articles

Targeting the Human Notch 2-BCR Axis: A Driver of B-Cell Hyper-Responsiveness in Active Chronic Graft-Versus Host Disease (cGVHD)

Jonathan C. Poe, PhD, Wei Jia, MD, Zhiguo Li, PhD, Frances T. Hakim, PhD, Steven Z. Pavletic, MD, Jeremy J. Rose, BA, David A. Rizzieri, MD, Yiping Yang, MD PhD, Benny J. Chen, MD, Michael Green, MD, Sarah Anand, MD, Christian W. Siebel, PhD, Ivan Maillard, MD PhD, Nelson J. Chao, MD, Stefanie Sarantopoulos, MD PhD

Blood (2015) 126 (23): 145.

https://doi.org/10.1182/blood.V126.23.145.145

Published: 2015

Journal Articles

Delta-like Ligands Expressed By Stromal Cells in Secondary Lymphoid Organs Deliver an Early Pulse of Notch Signaling and Drive T Cell Pathogenicity in Acute Graft-Versus-Host Disease

Jooho Chung, BS, Christen L. Ebens, MDMPH, Vedran Radojcic, MD, Ute Koch, PhD, Ann Friedman, BS, Ivy T. Tran, BS, Qian Chai, PhD, Lucas Onder, PhD, Minhong Yan, PhD, Pavan Reddy, MD, Bruce R. Blazar, MD, Burkhard Ludewig, PhD, Christian W. Siebel, PhD, Freddy Radtke, PhD, Ivan Maillard, MD PhD

Blood (2014) 124 (21): 841.

https://doi.org/10.1182/blood.V124.21.841.841

Published: 2014

Journal Articles

Direct Coregulation of Notch1 By Zmiz1 in T-Cell Development and Leukemia

Nancy Pinnell, Ran Yan, Hyoje Cho, PhD, Paula Jeon, Theresa Keeley, Jordan McHugh, Yiran Liu, Kojo S.J. Elenitoba-Johnson, MD, Ivan Maillard, MD PhD, Linda C. Samuelson, PhD, Tomasz Cierpicki, PhD, Mark Y. Chiang, MD PhD

Blood (2014) 124 (21): 55.

https://doi.org/10.1182/blood.V124.21.55.55

Published: 2014

Journal Articles

SEC23B Deficiency Results in Different Phenotypes in Humans and Mice

Rami Khoriaty, MD, Matthew Vasievich, MD PhD, Morgan Jones, BS, MS, Jennifer Chase, Lesley Everett, BS, MPhil, Bin Zhang, PhD, Ivan Maillard, MD PhD, David Ginsburg, MD

Blood (2014) 124 (21): 1341.

https://doi.org/10.1182/blood.V124.21.1341.1341

Published: 2014

Journal Articles

Targeting BCL6 and Germinal Centers (GCs) in Chronic Graft-Versus-Host Disease (cGVHD) Using Direct and Epigenomic Therapies

Blood (2014) 124 (21): 535.

https://doi.org/10.1182/blood.V124.21.535.535

Published: 2014

NARROW

Fried Frailty Phenotype Predicts Mortality for Newly Diagnosed Older Patients with Acute Myeloid Leukemia or High Risk Myelodysplastic Syndrome

Dll1 and Dll4 Notch Ligands Prime T Cell Alloimmunity and Are Expressed in Non-Overlapping Populations of Fibroblastic Stromal Cells in Spleen and Lymph Nodes at the Onset of Gvhd

SETDB1 Mediated H3K9 Methylation Suppresses MLL-Fusion Target Expression and Leukemic Transformation

From Graft-Versus-Host Disease to Lymphoma Pathogenesis: Emerging Roles for Stromal Notch Ligands in Hematology

The PAF1c Subunit Cdc73 Is Essential for Hematopoiesis and Displays Differential Gene Regulation in MLL-AF9 Driven Leukemia

Pharmacologic Blockade of Notch/Delta-like Ligand 4 Signaling Protects from Gastrointestinal Acute Graft-Versus-Host Disease in Non-Human Primates

The Trithorax-Group Protein ASH1L Regulates Hematopoietic Stem Cell Homeostasis Independently of Its Histone Methyltransferase Activity

Donor T Cells Require Notch Signals but Not Alloantigen Presentation from Specialized Secondary Lymphoid Organ Fibroblasts to Drive Graft-Versus-Host Disease

The AF9-Binding Domain of DOT1L Is Critical for Its Recruitment By MLL Fusion Proteins in Leukemia and Contributes to Its Functions in Normal Hematopoiesis

Mice with LMAN1 Deficiency Exhibit Thrombocytopenia and Reduced Serum Thrombopoietin Level

The Direct Notch1 Cofactor Zmiz1 Differentially Regulates Notch1 Signals in a Stage-Specific Manner to Preserve Early T-Cell Precursors and Expand Committed T Cells

All- Trans Retinoic Acid (ATRA) Targets IRF4 Deficient, NOTCH2-Activated B Cells from Chronic Gvhd Patients

Pirfenidone Reverses Murine Chronic Graft Versus Host Disease

Notch Signaling Mediated By Dll1/4 Notch Ligands Controls the Pathogenesis of Both Multi-Organ System Non-Sclerodermatous and Sclerodermatous Chronic Graft-Versus-Host Disease

SEC23A Functionally Compensates for SEC23B Deficiency in Mice

Targeting the Human Notch 2-BCR Axis: A Driver of B-Cell Hyper-Responsiveness in Active Chronic Graft-Versus Host Disease (cGVHD)

Delta-like Ligands Expressed By Stromal Cells in Secondary Lymphoid Organs Deliver an Early Pulse of Notch Signaling and Drive T Cell Pathogenicity in Acute Graft-Versus-Host Disease

Direct Coregulation of Notch1 By Zmiz1 in T-Cell Development and Leukemia

SEC23B Deficiency Results in Different Phenotypes in Humans and Mice

Targeting BCL6 and Germinal Centers (GCs) in Chronic Graft-Versus-Host Disease (cGVHD) Using Direct and Epigenomic Therapies

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American Society of Hematology

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American Society of Hematology

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