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Journal Articles

Preclinical efficacy of CDK7 inhibitor-based combinations against myeloproliferative neoplasms transformed to AML

Warren Fiskus, Christopher P Mill, Prithviraj Bose, Lucia Masarova, Naveen Pemmaraju, Andrew Dunbar, Christine Birdwell, John A Davis, Kaberi Das, Hanxi Hou, Taghi Manshouri, Antrix Jain, Anna Malovannaya, Kevin Philip, Noor Alhamadani, Alicia Matthews, Katie Lin, Lauren Flores, Sanam Loghavi, Courtney D. DiNardo, Xiaoping Su, Raajit K. Rampal, Kapil N Bhalla
Journal: Blood
Blood blood.2024026388.
https://doi.org/10.1182/blood.2024026388
Published: 2024
Includes: Supplemental data
Journal Articles

ASXL1 Mutations in AML Are Associated with a Distinct Epigenetic State Which Highlights Vulnerabilities to Specific Epigenetic-Targeted Agents

Christopher Peter Mill, Warren C. Fiskus, Christine Birdwell, John A. Davis, Kaberi Das, Hanxi Hou, Surbhi Sharma, Koji Sasaki, Sanam Loghavi, Tapan M. Kadia, Naval Daver, Courtney D. DiNardo, Lu Wang, Kapil N. Bhalla
Journal: Blood
Blood (2024) 144 (Supplement 1): 1349.
https://doi.org/10.1182/blood-2024-204117
Published: 2024
Journal Articles

Evaluation of the Lethal Activity and Its Mechanism of Tasquinimod in Advanced Myeloproliferative Neoplasm (MPN) in Blastic Phase

Warren C. Fiskus, Lucia Masarova, Christopher Peter Mill, Christine Birdwell, Kaberi Das, John A. Davis, Hanxi Hou, Kevin Philip, Alicia Matthews, Taghi Manshouri, Surbhi Sharma, Tapan M. Kadia, Courtney D. DiNardo, Prithviraj Bose, Naveen Pemmaraju, Sanam Loghavi, Marie Törngren, Kapil N. Bhalla
Journal: Blood
Blood (2024) 144 (Supplement 1): 3142.
https://doi.org/10.1182/blood-2024-203947
Published: 2024
Journal Articles

Identifying ‘Druggable’ Targets and Preclinically Overcoming Non-Genetic/Adaptive Resistance to Menin Inhibitors in AML with MLL1r or mtNPM1

Warren C. Fiskus, Christopher Peter Mill, Jessica Piel, Mike Collins, Murphy Hentemann, Christine Birdwell, Kaberi Das, John A. Davis, Hanxi Hou, Surbhi Sharma, Koji Sasaki, Sanam Loghavi, Branko Cuglievan, Tapan M. Kadia, Naval Daver, Courtney D. DiNardo, Kapil N. Bhalla
Journal: Blood
Blood (2024) 144 (Supplement 1): 1373.
https://doi.org/10.1182/blood-2024-206374
Published: 2024
Journal Articles

Efficacy of Combinations of Targeted Agents Against Dependencies in Mecom Rearranged AML Identified By Unbiased Chemical and CRISPR Screens

Christine Birdwell, Warren C. Fiskus, Christopher Peter Mill, Surbhi Sharma, Tapan M. Kadia, Naval Daver, Courtney D. DiNardo, Koji Sasaki, John A. Davis, Kaberi Das, Hanxi Hou, Michele Ceribelli, Kapil N. Bhalla
Journal: Blood
Blood (2024) 144 (Supplement 1): 5739.
https://doi.org/10.1182/blood-2024-206206
Published: 2024
Journal Articles

BRG1/BRM inhibitor targets AML stem cells and exerts superior preclinical efficacy combined with BET or menin inhibitor

Warren Fiskus, Jessica Piel, Mike Collins, Murphy Hentemann, Branko Cuglievan, Christopher P. Mill, Christine E. Birdwell, Kaberi Das, John A. Davis, Hanxi Hou, Antrix Jain, Anna Malovannaya, Tapan M. Kadia, Naval Daver, Koji Sasaki, Koichi Takahashi, Danielle Hammond, Patrick K. Reville, Jian Wang, Sanam Loghavi, Rwik Sen, Xinjia Ruan, Xiaoping Su, Lauren B. Flores, Courtney D. DiNardo, Kapil N. Bhalla
Journal: Blood
Blood (2024) 143 (20): 2059–2072.
https://doi.org/10.1182/blood.2023022832
Published: 2024
Includes: Supplemental data
Journal Articles

Actionable Findings from an Unbiased Drug Screen for Novel Single Agent and Combination Therapies Against AML with Mecom Re-Arrangement

Christine Birdwell, Warren C. Fiskus, Christopher Peter Mill, Tapan M. Kadia, Naval Daver, Courtney D. DiNardo, Koji Sasaki, John Davis, Kaberi Das, Hanxi Hou, Michele Ceribelli, Kapil N. Bhalla
Journal: Blood
Blood (2023) 142 (Supplement 1): 1419.
https://doi.org/10.1182/blood-2023-188371
Published: 2023
Journal Articles

Preclinical Studies Demonstrating Efficacy of Tasquinimod in Models of Advanced Myeloproliferative Neoplasm (MPN) in Blastic Phase

Warren C. Fiskus, Lucia Masarova, Christopher Peter Mill, Christine Birdwell, Kaberi Das, John Davis, Hanxi Hou, Noor Alhamadani, Kevin Philip, Alicia Matthews, Taghi Manshouri, Tapan M. Kadia, Courtney D. DiNardo, Prithviraj Bose, Naveen Pemmaraju, Sanam Loghavi, Marie Törngren, Kapil N. Bhalla
Journal: Blood
Blood (2023) 142 (Supplement 1): 741.
https://doi.org/10.1182/blood-2023-185031
Published: 2023
Journal Articles

Novel Agents with Efficacy Against Cellular Models of Familial Platelet Disorder with Myeloid Malignancy (FPD-MM) Associated with Germline Mutant RUNX1

Christopher Peter Mill, Warren C. Fiskus, Courtney D. DiNardo, Patrick K Reville, John Davis, Christine Birdwell, Kaberi Das, Hanxi Hou, Koichi Takahashi, Sanam Loghavi, Joseph D. Khoury, Kapil N. Bhalla
Journal: Blood
Blood (2023) 142 (Supplement 1): 2765.
https://doi.org/10.1182/blood-2023-190655
Published: 2023
Journal Articles

Pre-Clinical Efficacy of CDK7 Inhibitor-Based Combinations in Cellular Models of Advanced Myeloproliferative Neoplasms (MPN) Transformed to AML

Warren C. Fiskus, Prithviraj Bose, Lucia Masarova, Christopher Peter Mill, Christine Birdwell, John Davis, Kaberi Das, Hanxi Hou, Taghi Manshouri, Kevin Philip, Noor Alhamadani, Alicia Matthews, Sanam Loghavi, Kapil N. Bhalla
Journal: Blood
Blood (2023) 142 (Supplement 1): 1783.
https://doi.org/10.1182/blood-2023-185089
Published: 2023
Journal Articles

Notable Efficacy of Co-Treatment with FHD-286, a Dual BRG1/BRM ATP-Ase Inhibitor, and Menin or BET Inhibitor, Decitabine or Venetoclax Against AML with MLL-r or Mutant NPM1

Warren C. Fiskus, Jessica Piel, Murphy Hentemann, Christopher Peter Mill, Christine Birdwell, Kaberi Das, John Davis, Hanxi Hou, Noor Alhamadani, Kevin Philip, Alicia Matthews, Tapan M. Kadia, Naval Daver, Sanam Loghavi, Branko Cuglievan, Courtney D. DiNardo, Kapil N. Bhalla
Journal: Blood
Blood (2023) 142 (Supplement 1): 4160.
https://doi.org/10.1182/blood-2023-182575
Published: 2023