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Journal Articles

Effects of Ibrutinib on Metabolic Alterations and Micro-Environmental Signalling in Chronic Lymphocytic Leukaemia

Zhenghao Chen, Gaspard Cretenet, Beatriz Valle-Argos, Francesco Forconi, MD PhD FRCPath, Arnon P. Kater, MDPhD, Graham Packham, PhD, Eric Eldering, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 36–37.
https://doi.org/10.1182/blood-2020-142839
Published: 2020
Journal Articles

High Surface IgM Levels Associate with Shorter Response Duration and Bypass of the BTK Blockade during Ibrutinib Therapy in CLL Patients

Giorgia Chiodin, David Dutton, MD, Enrica Antonia Martino, MD, Samantha Drennan, PhD, Ian Tracy, PhD, Laura Ondrisova, Isla Henderson, Annalisa D'Avola, PhD, Christina Pitsillidou, Marek Mraz, MD, Peter Johnson, MDFRCP, Andrew Duncombe, MD, Graham Packham, PhD, Andrew J Steele, PhD, Helen Parker, PhD, Silvia Bonfiglio, Lydia Scarfo, MD, Lesley-Ann Sutton, Paolo Ghia, MD PhD, Matthew John Jerome Rose-Zerilli, PhD, Jonathan C Strefford, PhD, Freda K. Stevenson, DPhil, Francesco Forconi, MD DM, PhD FRCPath
Journal: Blood
Blood (2019) 134 (Supplement_1): 1752.
https://doi.org/10.1182/blood-2019-128899
Published: 2019
Journal Articles

Mannosylation of the Tumor Immunoglobulin Variable Region Informs Cell of Origin and Environmental Interactions in DLBCL Subsets

Giorgia Chiodin, Joel Allen, Philip J Rock, Enrica Antonia Martino, MD, Beatriz Valle Argos, PhD, Graham Packham, PhD, Patrick Duriez, PhD, Teunis Geijtenbeek, PhD, Carl Figdor, PhD, Richard Burack, MD PhD, Max Crispin, PhD, Freda K Stevenson, PhD, Francesco Forconi, MD DM, PhD FRCPath
Journal: Blood
Blood (2019) 134 (Supplement_1): 1505.
https://doi.org/10.1182/blood-2019-127159
Published: 2019
Journal Articles

Lymphoma-Specific Subversion of B-Cell Receptor Signaling By Macrophage Lectins

Beatriz Valle Argos, PhD, Giorgia Chiodin, PhD, Francesco Forconi, MD DM, PhD FRCPath, Richard Burack, MD PhD, Philip Rock, Graham Packham, PhD, Freda K Stevenson, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2865.
https://doi.org/10.1182/blood-2018-99-110954
Published: 2018
Journal Articles

Acquisition of Mannoses on the Surface Immunoglobulin Binding Site Reveals Functional Status and Cell of Origin in Diffuse Large B Cell Lymphomas

Giorgia Chiodin, PhD, Philip Rock, Enrica Antonia Martino, MD, Beatriz Valle Argos, PhD, Graham Packham, PhD, Richard Burack, MD PhD, Freda K Stevenson, PhD, Francesco Forconi, MD DM, PhD FRCPath
Journal: Blood
Blood (2018) 132 (Supplement 1): 677.
https://doi.org/10.1182/blood-2018-99-118318
Published: 2018
Journal Articles

NOTCH1 Stabilization By PEST Mutations Enhances IgM-Mediated Activity in Chronic Lymphocytic Leukemia

Francesca Arruga, PhD, Valeria Bracciamà, Alison Yeomans, PhD, Annalisa D'Avola, PhD, Marta Coscia, MD, Giovanni Francesco D'Arena, MD, Gianluca Gaidano, MD PhD, John N. Allan, MD, Richard R. Furman, MD, Graham Packham, PhD, Silvia Deaglio, MD PhD, Francesco Forconi, MD DM, PhD FRCPath
Journal: Blood
Blood (2018) 132 (Supplement 1): 1832.
https://doi.org/10.1182/blood-2018-99-118064
Published: 2018
Journal Articles

The Marine Natural Compound Elatol Is a Novel Protein Translation Inhibitor with Potent Activity Against Aggressive Non-Hodgkin Lymphomas

Tara Peters, BA, Joseph Tillotson, PhD, Sarah C Wilmore, BSc, Alison Yeomans, PhD, Graham Packham, PhD, Eli Chapman, PhD, Jonathan H. Schatz, MD, Lingxiao Li, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4112.
https://doi.org/10.1182/blood.V130.Suppl_1.4112.4112
Published: 2017
Journal Articles

PI3Kδ/AKT Inhibition Augments 2-Phenylethynesulfonamide Induced Apoptosis Via the Unfolded Protein Response in Chronic Lymphocytic Leukemia

Matthew D Blunt, PhD, Lindsay D Smith, PhD, Adam Linley, PhD BSc, Jonathan C Strefford, PhD, Peter Johnson, Francesco Forconi, MD DM, PhD FRCPath, Freda K. Stevenson, DPhil, Graham Packham, PhD, Andrew J Steele, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4290.
https://doi.org/10.1182/blood.V130.Suppl_1.4290.4290
Published: 2017
Journal Articles

Regulation and Impact of BCR Induced Autophagy in Chronic Lymphocytic Leukemia

Lindsay D Smith, PhD, Laura I Karydis, PhD, Margaret Ashton-Key, MD, Jonathan C Strefford, PhD, Freda K. Stevenson, DPhil, Graham Packham, PhD, Mark Cragg, PhD, David A Tumbarello, PhD, Matthew D Blunt, PhD, Francesco Forconi, MD DM, PhD FRCPath, Andrew J Steele, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1717.
https://doi.org/10.1182/blood.V130.Suppl_1.1717.1717
Published: 2017
Journal Articles

Early Enhancement of IgM Expression and Signaling Capacity during Ibrutinib Therapy in CLL Patients

Samantha Drennan, PhD, Giorgia Chiodin, MS, Annalisa D'Avola, MSc, Peter W Johnson, MD, Livio Trentin, MD, Graham Packham, PhD, Andrew J Steele, PhD, Freda K Stevenson, DPhil, Francesco Forconi, MD DM, PhD FRCPath
Journal: Blood
Blood (2016) 128 (22): 4381.
https://doi.org/10.1182/blood.V128.22.4381.4381
Published: 2016
Journal Articles

Chemical Activation of the SHIP1 Inositol Lipid Phosphatase: A Novel Therapeutic Strategy to Suppress B-Cell Receptor Signaling and CXCR4 Expression in Malignant Human B Cells

Graham Packham, PhD, Beatriz Valle-Argos, Elizabeth Lemm, Lindsay D Smith, PhD, Nicola J Weston-Bell, PhD, Yohannes Gebreselassie, Andrew J Steele, PhD, Freda K Stevenson, Mark S Cragg, PhD, Francesco Forconi, MD DM, PhD FRCPath, Jennifer Cross, Curtis Harwig, Lloyd Mackenzie
Journal: Blood
Blood (2016) 128 (22): 2037.
https://doi.org/10.1182/blood.V128.22.2037.2037
Published: 2016
Journal Articles

PI3Kδ Inhibition Elicits Anti-Leukemic Effects through Bim-Dependent Apoptosis

Matthew J Carter, PhD, Kerry L Cox, Stuart J Blakemore, Anna H Turaj, MSc, Robert J Oldham, Lekh N. Dahal, PhD, Stacey Tannheimer, Francesco Forconi, MD DM, PhD FRCPath, Graham Packham, PhD, Mark S Cragg, PhD
Journal: Blood
Blood (2016) 128 (22): 3241.
https://doi.org/10.1182/blood.V128.22.3241.3241
Published: 2016
Journal Articles

Regulation of B-Cell Receptor Signalling By the Tumour Microenvironment in Chronic Lymphocytic Leukemia (CLL) and Its Impact on Adhesion and miRNA Expression

Matthew D Blunt, PhD, Rachel Dobson, BSc(Hons), Lindsay D Smith, PhD, Jonathan C. Strefford, Pamela B. Conley, PhD, Anjali Pandey, PhD, Andrew J Davies, FRCP PhD, Peter M Johnson, MA, MD, Graham Packham, PhD, Freda K Stevenson, DPhil, Francesco Forconi, MD DM, PhD FRCPath, Greg P Coffey, PhD, Andrew J Steele, PhD
Journal: Blood
Blood (2016) 128 (22): 351.
https://doi.org/10.1182/blood.V128.22.351.351
Published: 2016
Journal Articles

Global and MYC-Specific Translation Is Enhanced in Activated Chronic Lymphocytic Leukemia Cells Carrying NOTCH1 C.7541_7542delct Mutations

Annalisa D'Avola, MSc, Alison Yeomans, PhD, Samantha Drennan, PhD, Matthew Rose-Zerilli, PhD, Jonathan C. Strefford, Freda K Stevenson, DPhil, Andrew J Steele, PhD, Graham Packham, PhD, Francesco Forconi, MD DM, PhD FRCPath
Journal: Blood
Blood (2016) 128 (22): 970.
https://doi.org/10.1182/blood.V128.22.970.970
Published: 2016
Journal Articles

Genomic Disruption of the Histone Methyltransferase SETD2 in Chronic Lymphocytic Leukemia

Matthew John Jerome Rose-Zerilli, PhD, Helen Parker, Marta Larrayoz, PhD, Ruth Clifford, Stuart Blakemore, Jennifer Edelmann, MD, Jane Gibson, Jun Wang, Viktor Ljungstrom, Tracy Chaplin, Ali Roghanian, Zadie Davis, Anton Parker, BSc, Eugen Tausch, MD, Stavroula Ntoufa, Sara Ramos, Pauline Robbe, MSc, Andrew J Steele, PhD, Graham Packham, PhD, Ana E. Rodriguez, Lee Brown, Feargal McNicholl, Francesco Forconi, MD DM, PhD FRCPath, Andrew R Pettitt, MRCP PhD, Peter Hillmen, Martin J.S. Dyer, Prof., Mark S Cragg, PhD, Bryan D Young, BSc, PhD, Claude Chelala, Richard Rosenquist, Kostas Stamatopoulos, MD, Stephan Stilgenbauer, Samantha Knight, Anna Schuh, MD PhD, David Oscier, Jonathan C Strefford, PhD
Journal: Blood
Blood (2015) 126 (23): 365.
https://doi.org/10.1182/blood.V126.23.365.365
Published: 2015
Journal Articles

IL-10 Production By CLL Cells Is Enhanced in the Anergic IGHV Mutated Subset and Associates with Reduced DNA Methylation of the IL-10 Locus

Samantha Drennan, PhD, Annalisa D'Avola, MSc, Yifang Gao, PhD, Eleni Chrysostomou, MSc, Andrew J Steele, PhD, Thorsten Zenz, MD, Christoph Plass, PhD, Peter W Johnson, MD, Anthony P Williams, PhD FRCPath, Graham Packham, PhD, Freda K Stevenson, DPhil, Christopher C. Oakes, PhD, Francesco Forconi, MD DM, PhD FRCPath
Journal: Blood
Blood (2015) 126 (23): 2917.
https://doi.org/10.1182/blood.V126.23.2917.2917
Published: 2015
Journal Articles

Biological Significance of B Cell Receptor Mediated Regulation of Autophagy in Chronic Lymphocytic Leukemia

Lindsay Smith, PhD, Elizabeth Hogg, BSc(Hons), Angus Haynes, Jonathan C Strefford, PhD, Francesco Forconi, MD DM, PhD FRCPath, Freda K Stevenson, DPhil, Graham Packham, PhD, Mark S Cragg, PhD, David Tumbarello, Matthew D Blunt, PhD, Andrew J Steele, PhD
Journal: Blood
Blood (2015) 126 (23): 4130.
https://doi.org/10.1182/blood.V126.23.4130.4130
Published: 2015
Journal Articles

The Syk\Jak Inhibitor Cerdulatinib (PRT062070) Shows Promising Preclinical Activity in Chronic Lymphocytic Leukemia By Antagonising B Cell Receptor and Microenvironmental Signalling

Matthew D Blunt, PhD, Jack Parnell, BSc(hons), Marta Larrayoz, PhD, Lindsay Smith, PhD, Rachel Dobson, BSc(Hons), Jonathan C Strefford, PhD, Freda K Stevenson, DPhil, Francesco Forconi, MD DM, PhD FRCPath, Andrew J Davies, MRCP, Peter W Johnson, MD, Graham Packham, PhD, Greg P. Coffey, PhD, Mark S Cragg, PhD, Andrew J Steele, PhD
Journal: Blood
Blood (2015) 126 (23): 1716.
https://doi.org/10.1182/blood.V126.23.1716.1716
Published: 2015
Journal Articles

The Dual PI3K/mTOR Inhibitor PF-04691502 Induces Substantial Apoptosis in Chronic Lymphocytic Leukemia Cells in Vitro and Prolongs Survival in the Eµ-TCL1 Mouse Model

Matthew D Blunt, PhD, Matthew J Carter, PhD, Marta Larrayoz, PhD, Maria Montserrat Aguilar, PhD, Sarah Murphy, Mark Reynolds, Thomas Tipton, Kerry Cox, Jonathan C Strefford, PhD, Freda K Stevenson, DPhil, Francesco Forconi, Graham Packham, PhD, Mark Cragg, PhD, Andrew J Steele, PhD
Journal: Blood
Blood (2014) 124 (21): 832.
https://doi.org/10.1182/blood.V124.21.832.832
Published: 2014
Journal Articles

Surface IgM Levels Independently Influence Clinical Behavior and Associate with Altered Phenotype and Genetics in Chronic Lymphocytic Leukemia

Samantha J Drennan, PhD, Annalisa D'Avola, MSc, Ian Tracy, Isla Henderson, Marta Larrayoz, PhD, Carina Mundy, Andrew S. Duncombe, MD, Andrew J. Davies, MD PhD, Davide Rossi, MD PhD, Fiona M Ross, DPhil, Laura Chiecchio, PhD, Kathleen N. Potter, PhD, Jonathan Strefford, PhD, Andrew J Steele, PhD, Peter W Johnson, MD, Graham Packham, PhD, Freda K Stevenson, DPhil, Francesco Forconi, MD DM, PhD FRCPath
Journal: Blood
Blood (2014) 124 (21): 830.
https://doi.org/10.1182/blood.V124.21.830.830
Published: 2014