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Journal Articles

Human GATA1 Driven By the Human Μicro LCR/β-Globin Promoter Rescues the Erythroid but Not the Megakaryocytic Phenotype Induced in Mice By the Gata1 low Mutation

Maria Zingariello, Laura Sancillo, Fabrizio Martelli, Rosa Alba Rana, Laura Calabresi, PhD BSc, Niccolò Bartalucci, PhDBSc, Alessandro M. Vannucchi, MD, George Stamatoyannopoulos, Anna Rita Migliaccio, PhD

Blood (2018) 132 (Supplement 1): 1042.

https://doi.org/10.1182/blood-2018-99-115970

Published: 2018

Journal Articles

Reactivation of γ-globin in adult β-YAC mice after ex vivo and in vivo hematopoietic stem cell genome editing

Chang Li, Nikoletta Psatha, Pavel Sova, Sucheol Gil, Hongjie Wang, Jiho Kim, Chandana Kulkarni, Cristina Valensisi, R. David Hawkins, George Stamatoyannopoulos, André Lieber

Blood (2018) 131 (26): 2915–2928.

https://doi.org/10.1182/blood-2018-03-838540

Published: 2018

Includes: Supplemental data

Journal Articles

In Vivo HSC Transduction and Selection Results in Long-Term, High-Level Expression of Human Gamma Globin in Peripheral Blood Erythrocytes of Mice

Andre Lieber, MD PhD, Hongjie Wang, PhD, Nikoleta Psatha, PhD, Chang Li, PhD, Kevin G Haworth, BS, PhD, Anja Ehrhardt, PhD, Zsuzsanna Izsvak, Hans-Peter Kiem, MD PhD, George Stamatoyannopoulos, MD, Thalia Papayannopoulou, MD

Blood (2017) 130 (Supplement 1): 4616.

https://doi.org/10.1182/blood.V130.Suppl_1.4616.4616

Published: 2017

Journal Articles

Introduction of Two Simultaneous Mutations By Genome Editing Greatly Enhances the Accumulation of the Endogenous Fetal Hemoglobin in Human Normal Erythroid Cells

Nikoleta Psatha, PhD, Chang Li, PhD, Hongjie Wang, PhD, Demetri Dalas, George Stamatoyannopoulos, MD, Thalia Papayannopoulou, MD, Andre Lieber, MD PhD

Blood (2017) 130 (Supplement 1): 947.

https://doi.org/10.1182/blood.V130.Suppl_1.947.947

Published: 2017

Journal Articles

Clinical-Scale Genome Editing of the Human BCL11A Erythroid Enhancer for Treatment of the Hemoglobinopathies

Fyodor D Urnov, PhD, Andreas Reik, PhD, Jeff Vierstra, PhD, Kai-Hsin Chang, PhD, Yuanyue Zhou, Andrea Mich, Jennifer Adrian, Lisa Fox, Nikoletta Psatha, PhD, Siyuan Tan, PhD, Evangelia Yannaki, MD, Stewart Craig, PhD, Edward J. Rebar, PhD, John Stamatoyannopoulos, MD, Thalia Papayannopoulou, MD, George Stamatoyannopoulos, MD DSci, Haiyan Jiang, PhD

Blood (2015) 126 (23): 204.

https://doi.org/10.1182/blood.V126.23.204.204

Published: 2015

Journal Articles

Plerixafor+G-CSF–mobilized CD34 + cells represent an optimal graft source for thalassemia gene therapy

Garyfalia Karponi, Nikoletta Psatha, Carsten Werner Lederer, Jennifer Eileen Adair, Fani Zervou, Nikolaos Zogas, Marina Kleanthous, Constantinos Tsatalas, Achilles Anagnostopoulos, Michel Sadelain, Isabelle Rivière, George Stamatoyannopoulos, Evangelia Yannaki

Blood (2015) 126 (5): 616–619.

https://doi.org/10.1182/blood-2015-03-629618

Published: 2015

Includes: Supplemental data

Journal Articles

PDCD2 Knockdown Promoted Induced Erythroid Differentiation in TF-1 Cells

Yanming Li, Shuge Liu, Hongzhu QU, Yadong Yang, Nan Ding, Xiuyan Ruan, George Stamatoyannopoulos, MD DSci, Xiangdong Fang

Blood (2014) 124 (21): 1331.

https://doi.org/10.1182/blood.V124.21.1331.1331

Published: 2014

Journal Articles

Plerixafor+G-CSF-Mobilized Blood From Thalassemic Mice Provides High Yields Of Long-Term Repopulating Cells With Enhanced Engrafting Capacity : Implications For Human Stem Cell Gene Therapy

Nikoleta Psatha, PhD student, Eleni Sgouramali, BSc, Athanasios Siametis, BSc, Elena Siapati, PhD, Panayotis Baliakas, MD, Varnavas Constantinou, MD, Achilles Anagnostopoulos, MD, Thalia Papayannopoulou, MD, George Stamatoyannopoulos, MD, Evangelia Yannaki, MD

Blood (2013) 122 (21): 4211.

https://doi.org/10.1182/blood.V122.21.4211.4211

Published: 2013

Journal Articles

Targeted Gene Modification In Hematopoietic Stem Cells: A Potential Treatment For Thalassemia and Sickle Cell Anemia

Blood (2013) 122 (21): 434.

https://doi.org/10.1182/blood.V122.21.434.434

Published: 2013

Journal Articles

Talen-Mediated Knock Outs Of Cis and Trans Elements Potentially Involved In Globin Gene Switching

Patrick A Navas, PHD, Yongqi Yan, PhD, Minerva E Sanchez, BS, Ericka M Johnson, BS, George Stamatoyannopoulos, MD, DSci

Blood (2013) 122 (21): 436.

https://doi.org/10.1182/blood.V122.21.436.436

Published: 2013

Journal Articles

Comprehensive Investigation of the Molecular Mechanism of Primitive Hematopoiesis Regulating by KLF3

Zhang Zhaojun, Xiong Qian, Wang Shaobin, Wang Hai, Zhang Qian, Qi Heyuan, Li Yanming, Sun Hongying, Chang Kai-Hsin, George Stamatoyannopoulos, John A. Stamatoyannopoulos, MD, Fang Xiangdong

Blood (2012) 120 (21): 4729.

https://doi.org/10.1182/blood.V120.21.4729.4729

Published: 2012

Journal Articles

Deciphering the Cis- and Trans- regulatory Roles of KLF6 in Primitive Hematopoiesis

Qian Xiong, Zhaojun Zhang, Hongzhu Qu, Xiuyan Ruan, Hai Wang, Qian Zhang, Heyuan Qi, Yanming Li, Hongying Sun, Kai-Hsin Chang, George Stamatoyannopoulos, John A. Stamatoyannopoulos, MD, Xiangdong Fang

Blood (2012) 120 (21): 4730.

https://doi.org/10.1182/blood.V120.21.4730.4730

Published: 2012

Journal Articles

Functional Analysis of FOXO3A Involved in Erythroid Differentiation

Hai Wang, Yadong Yang, Hongzhu QU, Xiuyan Ruan, Zhaojun Zhang, Qian Xiong, Heyuan Qi, George Stamatoyannopoulos, John A. Stamatoyannopoulos, MD, Xiangdong Fang

Blood (2012) 120 (21): 4731.

https://doi.org/10.1182/blood.V120.21.4731.4731

Published: 2012

Journal Articles

Hematopoietic Cell Mobilization for Gene Therapy of Adult Patients with Severe Beta-Thalassemia: The Challenge of Splenectomy and the Role of Plerixafor

Evangelia Yannaki, MD, Thalia Papayannopoulou, Erica Jonlin, PhD, Fani Zervou, Garyfalia Karponi, Angeliki Xagorari, PhD, Pamela S. Becker, MD, PhD, Nikoleta Psatha, Ioannis Batsis, MD, Panayotis Kaloyannidis, MD, Varvara Tahynopoulou, Varnavas Constantinou, Asimenia Bouinta, Konstantia Kotta, Aglaia Athanassiadou, PhD, Achilles Anagnostopoulos, Athanasios Fassas, MD, George Stamatoyannopoulos, MD, DSci

Blood (2011) 118 (21): 166.

https://doi.org/10.1182/blood.V118.21.166.166

Published: 2011

Journal Articles

Limitations of G-CSF Mobilization in Splenectomized Patients with Beta-Thalassemia Major: Implications for Thalassemia Gene Therapy.

Evangelia Yannaki, MD, Thalia Papayannopoulou, MD, Erica Jonlin, PhD, Ioannis Batsis, MD, Pamela S. Becker, MD, PhD, Fani Zervou, BS, Angeliki Xagorari, PhD, Garyfalia Karponi, BS, Varvara Tahynopoulou, BS, Panayotis Kaloyannidis, MD, Varnavas Constantinou, MD, Achilles Anagnostopoulos, MD, Athanasios Fassas, MD, George Stamatoyannopoulos, MD, DSci

Blood (2009) 114 (22): 2150.

https://doi.org/10.1182/blood.V114.22.2150.2150

Published: 2009

Journal Articles

Potent Induction of Human γ Globin Gene Expression by Largazole, a New Histone Deacetylase Inhibitor.

Hua Cao, MD, PhD, Rui Gao Fei, MD, Albert A. Bowers, Thomas J. Greshock, Tenaya Newkirt, Kenneth A. Miller, James E. Bradner, MD, Nathan West, Robert M. Williams, Thalia Papayannopoulou, MD, George Stamatoyannopoulos, MD, DSci

Blood (2009) 114 (22): 2022.

https://doi.org/10.1182/blood.V114.22.2022.2022

Published: 2009

Journal Articles

Chromatin Profiling of the Globin Loci of Human ES Cells and ES-Derived Erythroid Cells.

Xiangdong Fang, PhD, MD, Kai-Hsin Chang, Daniel Bates, Morgan Diegel, Richard Sandstrom, Molly Weaver, Michael O. Dorschner, Peter J. Sabo, Thalia Papayannopoulou, MD, George Stamatoyannopoulos, MD, DSci, John Stamatoyannopoulos

Blood (2009) 114 (22): 2535.

https://doi.org/10.1182/blood.V114.22.2535.2535

Published: 2009

Journal Articles

Histone acetylation at the human β-globin locus changes with developmental age

Wenxuan Yin, Gráinne Barkess, Xiangdong Fang, Ping Xiang, Hua Cao, George Stamatoyannopoulos, Qiliang Li

Blood (2007) 110 (12): 4101–4107.

https://doi.org/10.1182/blood-2007-05-091256

Published: 2007

Includes: Supplemental data

Journal Articles

Regulation of Globin Gene Expression and Erythroid Differentiation by Sp/KLF Factors.

Jie Hong, Hu, George Stamatoyannopoulos, Chao-Zhong Song

Blood (2005) 106 (11): 4241.

https://doi.org/10.1182/blood.V106.11.4241.4241

Published: 2005

Journal Articles

Differences of globin transgene expression in stably transfected cell lines and transgenic mice

Qiliang Li, David W. Emery, Hemei Han, Jin Sun, Man Yu, George Stamatoyannopoulos

Blood (2005) 105 (8): 3346–3352.

https://doi.org/10.1182/blood-2004-03-0987

Published: 2005

NARROW

Human GATA1 Driven By the Human Μicro LCR/β-Globin Promoter Rescues the Erythroid but Not the Megakaryocytic Phenotype Induced in Mice By the Gata1 low Mutation

Reactivation of γ-globin in adult β-YAC mice after ex vivo and in vivo hematopoietic stem cell genome editing

In Vivo HSC Transduction and Selection Results in Long-Term, High-Level Expression of Human Gamma Globin in Peripheral Blood Erythrocytes of Mice

Introduction of Two Simultaneous Mutations By Genome Editing Greatly Enhances the Accumulation of the Endogenous Fetal Hemoglobin in Human Normal Erythroid Cells

Clinical-Scale Genome Editing of the Human BCL11A Erythroid Enhancer for Treatment of the Hemoglobinopathies

Plerixafor+G-CSF–mobilized CD34 + cells represent an optimal graft source for thalassemia gene therapy

PDCD2 Knockdown Promoted Induced Erythroid Differentiation in TF-1 Cells

Plerixafor+G-CSF-Mobilized Blood From Thalassemic Mice Provides High Yields Of Long-Term Repopulating Cells With Enhanced Engrafting Capacity : Implications For Human Stem Cell Gene Therapy

Targeted Gene Modification In Hematopoietic Stem Cells: A Potential Treatment For Thalassemia and Sickle Cell Anemia

Talen-Mediated Knock Outs Of Cis and Trans Elements Potentially Involved In Globin Gene Switching

Comprehensive Investigation of the Molecular Mechanism of Primitive Hematopoiesis Regulating by KLF3

Deciphering the Cis- and Trans- regulatory Roles of KLF6 in Primitive Hematopoiesis

Functional Analysis of FOXO3A Involved in Erythroid Differentiation

Hematopoietic Cell Mobilization for Gene Therapy of Adult Patients with Severe Beta-Thalassemia: The Challenge of Splenectomy and the Role of Plerixafor

Limitations of G-CSF Mobilization in Splenectomized Patients with Beta-Thalassemia Major: Implications for Thalassemia Gene Therapy.

Potent Induction of Human γ Globin Gene Expression by Largazole, a New Histone Deacetylase Inhibitor.

Chromatin Profiling of the Globin Loci of Human ES Cells and ES-Derived Erythroid Cells.

Histone acetylation at the human β-globin locus changes with developmental age

Regulation of Globin Gene Expression and Erythroid Differentiation by Sp/KLF Factors.

Differences of globin transgene expression in stably transfected cell lines and transgenic mice

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American Society of Hematology

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American Society of Hematology

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