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Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated CLL cells by selectively activating AKT

Roberto Negro, Stefania Gobessi, Pablo G. Longo, Yantao He, Zhong-Yin Zhang, Luca Laurenti, Dimitar G. Efremov
Journal: Blood
Blood (2012) 119 (26): 6278–6287.
https://doi.org/10.1182/blood-2012-01-403162
Published: 2012
Includes: Supplemental data
Journal Articles

Development of a Transgenic Mouse Model to Study the Role of ZAP-70 in the Development and Progression of Chronic Lymphocytic Leukemia

Stefania Gobessi, PhD, Sara Bennardo, BS, Pablo G Longo, MD, Brendan Doe, BS, Dimitar G Efremov, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 2830.
https://doi.org/10.1182/blood.V118.21.2830.2830
Published: 2011
Journal Articles

Overexpression of the Autoimmunity-Associated Tyrosine Phosphatase PTPN22 in CLL Cells Enhances Antiapoptotic B-Cell Receptor Signals Through Selective Activation of the AKT Pathway

Roberto Negro, PhD, Stefania Gobessi, PhD, Pablo G Longo, MD, Luca Laurenti, Dimitar G Efremov, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 619.
https://doi.org/10.1182/blood.V118.21.619.619
Published: 2011
Journal Articles

The Syk inhibitor fostamatinib disodium (R788) inhibits tumor growth in the Eμ- TCL1 transgenic mouse model of CLL by blocking antigen-dependent B-cell receptor signaling

Mirza Suljagic, Pablo G. Longo, Sara Bennardo, Emerald Perlas, Giuseppe Leone, Luca Laurenti, Dimitar G. Efremov
Journal: Blood
Blood (2010) 116 (23): 4894–4905.
https://doi.org/10.1182/blood-2010-03-275180
Published: 2010
Includes: Supplemental data
Journal Articles

Overexpression of the Protein Tyrosine Phosphatase Lyp Reduces the Responsiveness of Chronic Lymphocytic Leukemia B-Cells to B-Cell Receptor Ligation.

Roberto Negro, PhD, Pablo G Longo, MD, Michela Tarnani, MD, Stefania Gobessi, PhD, Luca Laurenti, MD, Dimitar G Efremov, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 800.
https://doi.org/10.1182/blood.V114.22.800.800
Published: 2009
Journal Articles

The Syk Inhibitor R788 (FosD) Inhibits Tumor Growth in the TCL1 Transgenic Mouse Model of CLL by Blocking Antigen-Dependent BCR Signaling.

Mirza Suljagic, DVM, PhD, Pablo G Longo, MD, Luca Laurenti, MD, Dimitar G Efremov, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 887.
https://doi.org/10.1182/blood.V114.22.887.887
Published: 2009
Journal Articles

Chronic Lymphocytic Leukemia B-Cells Lack or Express Markedly Reduced Levels of the Phosphatase PHLPP, Which Regulates B-Cell Receptor Induced AKT Activation.

Mirza Suljagic, DVM, PhD, Luca Laurenti, MD, Muhammad Alam, MD, Pablo G Longo, MD, Sami N Malek, MD, Dimitar G Efremov, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 2080.
https://doi.org/10.1182/blood.V112.11.2080.2080
Published: 2008
Journal Articles

Molecular Requirements for Syk-Mediated Intracellular Signaling and B-Cell Transformation

Laura Carsetti, BS, Luca Laurenti, MD, Stefania Gobessi, PhD, Pablo G Longo, MD, Giuseppe Leone, MD, Dimitar G Efremov, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 2837.
https://doi.org/10.1182/blood.V112.11.2837.2837
Published: 2008
Journal Articles

The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells

Pablo G. Longo, Luca Laurenti, Stefania Gobessi, Simona Sica, Giuseppe Leone, Dimitar G. Efremov
Journal: Blood
Blood (2008) 111 (2): 846–855.
https://doi.org/10.1182/blood-2007-05-089037
Published: 2008
Includes: Supplemental data
Journal Articles

The Akt/Mcl-1 Pathway Plays a Prominent Role in Mediating Pro-Survival Signals Derived from the B-Cell Receptor in Chronic Lymphocytic Leukemia B-Cells.

Pablo G. Longo, MD, Luca Laurenti, MD, Stefania Gobessi, PhD, Simona Sica, MD, Giuseppe Leone, MD, Dimitar G. Efremov, MD, PhD
Journal: Blood
Blood (2007) 110 (11): 341.
https://doi.org/10.1182/blood.V110.11.341.341
Published: 2007
Journal Articles

The Proliferative Response to CpG ODN Stimulation Predicts Disease Progression in B-Cell Chronic Lymphocytic Leukemia.

Luca Laurenti, MD, Pablo G. Longo, MD, Michela Tarnani, MD, Stefania Gobessi, PhD, Simona Sica, MD, Giuseppe Leone, MD, Dimitar G. Efremov, MD, PhD
Journal: Blood
Blood (2007) 110 (11): 3098.
https://doi.org/10.1182/blood.V110.11.3098.3098
Published: 2007
Journal Articles

ZAP-70 enhances B-cell–receptor signaling despite absent or inefficient tyrosine kinase activation in chronic lymphocytic leukemia and lymphoma B cells

Stefania Gobessi, Luca Laurenti, Pablo G. Longo, Simona Sica, Giuseppe Leone, Dimitar G. Efremov
Journal: Blood
Blood (2006) 109 (5): 2032–2039.
https://doi.org/10.1182/blood-2006-03-011759
Published: 2006
Includes: Supplemental data
Journal Articles

Monoclonal gammopathies and hepatitis C virus infection [letter] [see comments]

C Mussini, M Ghini, MT Mascia, P Giovanardi, G Zanni, I Lattuada, S Moreali, G Longo, MG Ferrari, G Torelli
Journal: Blood
Blood (1995) 85 (4): 1144–1145.
https://doi.org/10.1182/blood.V85.4.1144.bloodjournal8541144
Published: 1995