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Journal Articles

Staurosporine Induces Caspase-Dependent Proteolysis of MEF2D-Fusion Protein and Cell Death Selective to MEF2D-Fusion-Positive ALL Cells

Naoyuki Tange, MD, Fumihiko Hayakawa, MD, PhD, Takahiko Yasuda, MD, PhD, Hideyuki Yamamoto, MD, Daiki Hirano, MD, PhD, Shinobu Tsuzuki, MD,PhD, Hitoshi Kiyoi, MD PhD

Blood (2019) 134 (Supplement_1): 1349.

https://doi.org/10.1182/blood-2019-123602

Published: 2019

Journal Articles

The Optimal Treatment Strategy for Adult Patients with Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia in First Complete Remission in the Era of High-Intensity Chemotherapy

Blood (2019) 134 (Supplement_1): 4589.

https://doi.org/10.1182/blood-2019-126012

Published: 2019

Journal Articles

Dasatinib-Based Two-Step Induction Prior to Allogeneic Hematopoietic Cell Transplantation for Newly Diagnosed Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: Results of the JALSG Ph+ALL213 Study

Blood (2019) 134 (Supplement_1): 743.

https://doi.org/10.1182/blood-2019-123382

Published: 2019

Journal Articles

A Novel PAX5-KIDINS220 Fusion Protein Activates Multiple Signals Associated with Therapeutic Resistance

Takuyo Kanayama, MD, Toshihiko Imamura, MD PhD, Kenichi Sakamoto, MD PhD, Fumihiko Hayakawa, MD, PhD, Akihiko Tanizawa, MD PhD, Nobutaka Kiyokawa, MD PhD, Hajime Hosoi, MD PhD

Blood (2018) 132 (Supplement 1): 3928.

https://doi.org/10.1182/blood-2018-99-116022

Published: 2018

Journal Articles

Exosomes Derived from Cancer Associated Fibroblasts Elicit Survival and Drug Resistance of Primary Lymphoma Cells

Shunsuke Kunou, Kazuyuki Shimada, MD PhD, Tomoya Hikita, PhD, Tomohiro Aoki, MD PhD, Akihiko Sakamoto, PhD, Fumihiko Hayakawa, MD, PhD, Chitose Oneyama, PhD, Hitoshi Kiyoi, MD PhD

Blood (2018) 132 (Supplement 1): 4128.

https://doi.org/10.1182/blood-2018-99-111863

Published: 2018

Journal Articles

ZNF384-Fusion Proteins Have High Affinity to EP300, Which Increases Their Transcriptional Activities

Hideyuki Yamamoto, MD, Fumihiko Hayakawa, MD, PhD, Takahiko Yasuda, MD, PhD, Yuka Minamikawa, Naoyuki Tange, MD, Daiki Hirano, MD, Yuki Kojima, MD, PhD, Takanobu Morishita, MD, PhD, Shinobu Tsuzuki, MD, PhD, Hiroyuki Mano, MD,PhD, Tomoki Naoe, MD PhD, Hitoshi Kiyoi, MD PhD

Blood (2018) 132 (Supplement 1): 1554.

https://doi.org/10.1182/blood-2018-99-114414

Published: 2018

Journal Articles

Genomic and Clinical Characterization of Adult Ph-Negative B-Cell Acute Lymphoblastic Leukemia

Takahiko Yasuda, MD, PhD, Dai Nishijima, PhD, Shinya Kojima, PhD, Masahito Kawazu, MD, PhD, Toshihide Ueno, PhD, Shinobu Tsuzuki, MD PhD, Hitoshi Kiyoi, MD PhD, Itaru Matsumura, MD, Yasushi Miyazaki, MD PhD, Keizo Horibe, MD PhD, Hiroyuki Mano, MD, PhD, Tomoki Naoe, MD PhD, Masashi Sanada, MD PhD, Fumihiko Hayakawa, MD, PhD

Blood (2018) 132 (Supplement 1): 2821.

https://doi.org/10.1182/blood-2018-99-115716

Published: 2018

Journal Articles

High Expression of MEF2D-Fusion Protein Is Caused By Escaping from the Suppression By miRNA and Leads to Suppress Transcriptional Activity of PAX5

Hirano Daiki, MD, Fumihiko Hayakawa, MD PhD, Takahiko Yasuda, MDPhD, Naoyuki Tange, MD, Hideyuki Yamamoto, MD, Yuki Kojima, MD PhD, Takanobu Morishita, MD PhD, Naoto Imoto, MD PhD, Shinobu Tsuzuki, MDPhD, Hiroyuki Mano, MDPhD, Tomoki Naoe, MD PhD, Hitoshi Kiyoi, MD PhD

Blood (2017) 130 (Supplement 1): 3977.

https://doi.org/10.1182/blood.V130.Suppl_1.3977.3977

Published: 2017

Journal Articles

YM155 Induces Apoptosis through Proteasome-Dependent Degradation of MCL-1 in Primary Effusion Lymphoma

Yuki Kojima, MD, Fumihiko Hayakawa, MD PhD, Takanobu Morishita, MD, Keiki Sugimoto, PhD, Mizuho Iwase, Hideyuki Yamamoto, MD, Daiki Hirano, MD, Naoto Imoto, MD, Seiji Okada, MD, PhD, Hitoshi Kiyoi, MD PhD

Blood (2016) 128 (22): 3013.

https://doi.org/10.1182/blood.V128.22.3013.3013

Published: 2016

Journal Articles

Emetine Elicits Apoptosis of Intractable B-Cell Lymphoma Cells with MYC Rearrangement through Inhibition of Glycolytic Metabolism

Tomohiro Aoki, MD, Kazuyuki Shimada, MD PhD, Akihiko Sakamoto, PhD, Keiki Sugimoto, PhD, Takanobu Morishita, MD, Yuki Kojima, MD, Satoko Shimada, MD PhD, Seiichi Kato, MD PhD, Chisako Iriyama, MD PhD, Shunsuke Kuno, MD, Yasuhiko Harada, MD, Shigeo Nakamura, MD PhD, Akihiro Tomita, MD PhD, Fumihiko Hayakawa, MD PhD, Hitoshi Kiyoi, MD PhD

Blood (2016) 128 (22): 3019.

https://doi.org/10.1182/blood.V128.22.3019.3019

Published: 2016

Journal Articles

Effectiveness of High-Dose MTX Therapy for Adult Ph-Negative ALL By Randomized Trial: JALSG ALL202-O

Toru Sakura, Fumihiko Hayakawa, MD PhD, Isamu Sugiura, MD PhD, Kiyotoshi Imai, MD PhD, Noriko Usui, MD, Shin Fujisawa, MD, Tohru Murayama, Toshiaki Yujiri, MD PhD, Hitoshi Kiyoi, MD PhD, Kazunori Ohnishi, MD PhD, Yasushi Miyazaki, MD, Shigeki Ohtake, MD PhD, Yukio Kobayashi, MD PhD, Keitaro Matsuo, MDPhD, Tomoki Naoe, MD PhD

Blood (2015) 126 (23): 79.

https://doi.org/10.1182/blood.V126.23.79.79

Published: 2015

Journal Articles

A Photosensitizer Verteporfin Has Light-Independent Anti-Leukemic Activity for Ph-Positive Acute Lymphoblastic Leukemia and Synergistically Works with Dasatinib in Vivo

Takanobu Morishita, MD, Fumihiko Hayakawa, MD PhD, Keiki Sugimoto, PhD, Daiki Hirano, MD, Yuki Kojima, MD, Naoto Imoto, MD, Yuichiro Inagaki, MD, Tomoki Naoe, MDPhD, Hitoshi Kiyoi, MD PhD

Blood (2015) 126 (23): 1331.

https://doi.org/10.1182/blood.V126.23.1331.1331

Published: 2015

Journal Articles

Development of FF-10101, a Novel Irreversible FLT3 Inhibitor, Which Overcomes Drug Resistance Mutations

Toshiyuki Nakatani, PhD, Ken Uda, Takeshi Yamaura, Masaru Takasaki, Akimi Akashi, Fangli Chen, MD, Yuichi Ishikawa, MDPhD, Fumihiko Hayakawa, MD PhD, Shinji Hagiwara, PhD, Hitoshi Kiyoi, MD PhD, Tomoki Naoe, MD PhD

Blood (2015) 126 (23): 1353.

https://doi.org/10.1182/blood.V126.23.1353.1353

Published: 2015

Journal Articles

PAX5 Tyrosine Phosphorylation By Syk Co-Operatively Works with Its Serine Phosphorylation By ERK1/2 and Cancels PAX5-Dependent Repression of BLIMP1: A Mechanism of Antigen-Triggering Plasma Cell Differentiation through B Cell Receptor Signal

Yuichiro Inagaki, MD, Fumihiko Hayakawa, MD PhD, Yuki Kojima, MD, Takanobu Morishita, MD, Naoto Imoto, MD, Tomoki Naoe, MDPhD, Hitoshi Kiyoi, MD PhD

Blood (2014) 124 (21): 4349.

https://doi.org/10.1182/blood.V124.21.4349.4349

Published: 2014

Journal Articles

Development and Analysis of Novel Intravascular Large B-Cell Lymphoma NOD/Shi- Scid IL2Rγ null Mouse Xenograft Model

Kazuyuki Shimada, MD PhD, Satoko Shimada, MD PhD, Keiki Sugimoto, Fumihiko Hayakawa, MD PhD, Miyuki Katayama, MD PhD, Akihiro Hirakawa, PhD, Yusuke Takagi, MD, Shigeo Nakamura, MD PhD, Masao Seto, MD PhD, Tomoki Naoe, MDPhD, Akihiro Tomita, MD PhD, Hitoshi Kiyoi, MD PhD

Blood (2014) 124 (21): 497.

https://doi.org/10.1182/blood.V124.21.497.497

Published: 2014

Journal Articles

PAX5-PML Induces Pro B Acute Lymphoblastic Leukemia in Mice

Naoto Imoto, MD, Shingo Kurahashi, MD PhD, Fumihiko Hayakawa, MD PhD, Takahiko Yasuda, MD PhD, Keiki Sugimoto, Yuki Kojima, MD, Takanobu Morishita, MD, Yuichiro Inagaki, MD, Shinobu Tsuzuki, MD PhD, Tomoki Naoe, MDPhD, Hitoshi Kiyoi, MD PhD

Blood (2014) 124 (21): 887.

https://doi.org/10.1182/blood.V124.21.887.887

Published: 2014

Journal Articles

Treatment With Hedgehog Inhibitor, PF-04449913, Attenuates Leukemia-Initiation Potential In Acute Myeloid Leukemia Cells

Nobuaki Fukushima, MD, Yosuke Minami, MD, PhD, Fumihiko Hayakawa, MD, PhD, Hitoshi Kiyoi, MD, PhD, Anil Sadarangani, PhD, Catriona HM Jamieson, MD, PhD, Tomoki Naoe, MD, PhD

Blood (2013) 122 (21): 1649.

https://doi.org/10.1182/blood.V122.21.1649.1649

Published: 2013

Journal Articles

Outcome of Pediatric-Type Therapy for Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia (ALL) in Adolescents and Young Adults (AYA): A Study by the Japan Adult Leukemia Study Group (JALSG ALL202-U study)

Toru Sakura, MD, PhD, Fumihiko Hayakawa, MD, PhD, Toshiaki Yujiri, MD, Yasutaka Aoyama, MD, Eisei Kondo, MD, Katsumichi Fujimaki, MD, Yasunori Ueda, MD, PhD, Shigeki Ohtake, MD, PhD, Yasushi Miyazaki, MD, PhD, Shuichi Miyawaki, MD, PhD, Kazunori Ohnishi, MD, PhD, Tomoki Naoe, MD, PhD

Blood (2012) 120 (21): 1464.

https://doi.org/10.1182/blood.V120.21.1464.1464

Published: 2012

Journal Articles

Drug Development Targeting Microenvironment for Malignant Lymphoma

Keiki Sugimoto, Fumihiko Hayakawa, MD, PhD, Takahiko Yasuda, MD, Ph.D., Tomoki Naoe, MD, PhD

Blood (2012) 120 (21): 1661.

https://doi.org/10.1182/blood.V120.21.1661.1661

Published: 2012

Journal Articles

Wnt Signaling Is Associated with Anti-Apoptosis in the Interaction Between Acute Myeloid Leukemia Cells and Stromal Cells

Yosuke Minami, MD, PhD, Yosuke Niwa, Akihiro Abe, MD, PhD, Fumihiko Hayakawa, MD, PhD, Tomoki Naoe, MD, PhD

Blood (2012) 120 (21): 1366.

https://doi.org/10.1182/blood.V120.21.1366.1366

Published: 2012

NARROW

Staurosporine Induces Caspase-Dependent Proteolysis of MEF2D-Fusion Protein and Cell Death Selective to MEF2D-Fusion-Positive ALL Cells

The Optimal Treatment Strategy for Adult Patients with Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia in First Complete Remission in the Era of High-Intensity Chemotherapy

Dasatinib-Based Two-Step Induction Prior to Allogeneic Hematopoietic Cell Transplantation for Newly Diagnosed Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: Results of the JALSG Ph+ALL213 Study

A Novel PAX5-KIDINS220 Fusion Protein Activates Multiple Signals Associated with Therapeutic Resistance

Exosomes Derived from Cancer Associated Fibroblasts Elicit Survival and Drug Resistance of Primary Lymphoma Cells

ZNF384-Fusion Proteins Have High Affinity to EP300, Which Increases Their Transcriptional Activities

Genomic and Clinical Characterization of Adult Ph-Negative B-Cell Acute Lymphoblastic Leukemia

High Expression of MEF2D-Fusion Protein Is Caused By Escaping from the Suppression By miRNA and Leads to Suppress Transcriptional Activity of PAX5

YM155 Induces Apoptosis through Proteasome-Dependent Degradation of MCL-1 in Primary Effusion Lymphoma

Emetine Elicits Apoptosis of Intractable B-Cell Lymphoma Cells with MYC Rearrangement through Inhibition of Glycolytic Metabolism

Effectiveness of High-Dose MTX Therapy for Adult Ph-Negative ALL By Randomized Trial: JALSG ALL202-O

A Photosensitizer Verteporfin Has Light-Independent Anti-Leukemic Activity for Ph-Positive Acute Lymphoblastic Leukemia and Synergistically Works with Dasatinib in Vivo

Development of FF-10101, a Novel Irreversible FLT3 Inhibitor, Which Overcomes Drug Resistance Mutations

PAX5 Tyrosine Phosphorylation By Syk Co-Operatively Works with Its Serine Phosphorylation By ERK1/2 and Cancels PAX5-Dependent Repression of BLIMP1: A Mechanism of Antigen-Triggering Plasma Cell Differentiation through B Cell Receptor Signal

Development and Analysis of Novel Intravascular Large B-Cell Lymphoma NOD/Shi- Scid IL2Rγ null Mouse Xenograft Model

PAX5-PML Induces Pro B Acute Lymphoblastic Leukemia in Mice

Treatment With Hedgehog Inhibitor, PF-04449913, Attenuates Leukemia-Initiation Potential In Acute Myeloid Leukemia Cells

Outcome of Pediatric-Type Therapy for Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia (ALL) in Adolescents and Young Adults (AYA): A Study by the Japan Adult Leukemia Study Group (JALSG ALL202-U study)

Drug Development Targeting Microenvironment for Malignant Lymphoma

Wnt Signaling Is Associated with Anti-Apoptosis in the Interaction Between Acute Myeloid Leukemia Cells and Stromal Cells

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American Society of Hematology

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