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Journal Articles

Genomic Architecture and Clonal Dynamics of Early Relapsed BCP-ALL

Zeljko Antic, MD, Jiangyan Yu, MSc, Simon V. van Reijmersdal, Renske Kuiper, Edwin Sonneveld, PhD, Frank N. van Leeuwen, PhD, Peter M. Hoogerbrugge, MD PhD, Esmé Waanders, PhD, Roland P. Kuiper, PhD

Blood (2016) 128 (22): 4072.

https://doi.org/10.1182/blood.V128.22.4072.4072

Published: 2016

Journal Articles

Targeted Locus Amplification & Next Generation Sequencing for the Detection of Recurrent and Novel Gene Fusions for Improved Treatment Decisions in Pediatric Acute Lymphoblastic Leukemia

Roland P. Kuiper, PhD, Simon V. van Reijmersdal, Marieke Simonis, PhD, Jiangyan Yu, MSc, Edwin Sonneveld, PhD, Blanca Scheijen, PhD, Judith M. Boer, PhD, Aurélie Boeree, BSc, Petra Klous, MSc, Peter M Hoogerbrugge, MD PhD, Mehmet Yilmaz, MSc, Frank N. van Leeuwen, PhD, Monique L. Den Boer, PhD, Erik Splinter, PhD

Blood (2015) 126 (23): 696.

https://doi.org/10.1182/blood.V126.23.696.696

Published: 2015

Journal Articles

Tumor Suppressors BTG1 and IKZF1 Cooperate during Mouse Leukemia Development and Impact Relapse Rate in Childhood Acute Lymphoblastic Leukemia

Blanca Scheijen, PhD, Esther Tijchon, Dorette van Ingen Schenau, Rene Marke, Liesbeth van Emst, Laurens T Van Der Meer, PhD, Roland P Kuiper, PhD, Judith M. Boer, PhD, Rob Pieters, MD PhD, Peter M Hoogerbrugge, MD PhD, Monique L. Den Boer, PhD, Frank N van Leeuwen, PhD

Blood (2015) 126 (23): 905.

https://doi.org/10.1182/blood.V126.23.905.905

Published: 2015

Journal Articles

Genetic Architecture of Relapsed Pediatric B Cell Precursor Acute Lymphoblastic Leukemia Are Related to the Intensity of Upfront Therapy

Jiangyan Yu, MSc, Esmé Waanders, PhD, Simon V. van Reijmersdal, Edwin Sonneveld, PhD, Frank N. van Leeuwen, PhD, Rob Pieters, MD PhD, Ad Geurts van Kessel, PhD, Peter M. Hoogerbrugge, MD PhD, Roland P. Kuiper, PhD

Blood (2015) 126 (23): 247.

https://doi.org/10.1182/blood.V126.23.247.247

Published: 2015

Journal Articles

Cathepsin B Mediated Lysosomal Degradation in Macrophages Controls the Pharmacokinetics of the Therapeutic Protein Asparaginase

Laurens T Van Der Meer, PhD, Samantha YA Terry, PhD, Dorette van Ingen Schenau, MSc, Kiki Andree, MSc, Gerben M Franssen, BSc, Debbie Roeleveld, MSc, Bart Metselaar, PhD, Thomas Reinheckel, PhD, Peter M Hoogerbrugge, MD PhD, Otto C Boerman, PhD, Frank N van Leeuwen, PhD

Blood (2015) 126 (23): 3768.

https://doi.org/10.1182/blood.V126.23.3768.3768

Published: 2015

Journal Articles

Crispr/Cas9 Based Kinome Screen Identifies Novel Targets That Determine Sensitivity for Asparaginase Therapy in Acute Lymphoblastic Leukemia

Laurens T Van Der Meer, PhD, Jiangyan Yu, MSc, Miriam Butler, MSc, Jolien M R van der Meer, MSc, Roland P Kuiper, PhD, Frank N van Leeuwen, PhD

Blood (2015) 126 (23): 2629.

https://doi.org/10.1182/blood.V126.23.2629.2629

Published: 2015

Journal Articles

Tumor Suppressors Btg1 and Btg2 Regulate B Lineage Commitment through Modulation of Ebf1 Activity

Esther Tijchon, MSc, Liesbeth van Emst, Bsc, Dorette van Ingen Schenau, MSc, Laurensia Yuniati, MSc, Jorn Havinga, MSc, Felice Tirone, PhD, Jean-Pierre Rouault, PhD, Peter M Hoogerbrugge, MD PhD, Frank N. van Leeuwen, PhD, Blanca Scheijen, PhD

Blood (2014) 124 (21): 4311.

https://doi.org/10.1182/blood.V124.21.4311.4311

Published: 2014

Journal Articles

The Leukemia-Associated Protein BTG1 Is Required for ATF4-Mediated Cellular Stress Responses

Laurensia Yuniati, MSc, Laurens T van der Meer, PhD, Geert JV Poelmans, MD PhD, Sander AL Palit, BSc, Caroline Rodenbach, Dorette S van IngenSchenau, MSc, Peter M Hoogerbrugge, MD PhD, Blanca Scheijen, PhD, Frank N van Leeuwen, PhD

Blood (2014) 124 (21): 3587.

https://doi.org/10.1182/blood.V124.21.3587.3587

Published: 2014

Journal Articles

The Therapeutic Protein Asparaginase Is Efficiently Cleared By Bone Barrow and Spleen Resident Macrophages

Laurens T van der Meer, PhD, Samantha YA Terry, PhD, Dorette S van IngenSchenau, MSc, Kiki C Andree, MSc, Peter M Hoogerbrugge, MD PhD, Otto C Boerman, PhD, Frank N van Leeuwen, PhD

Blood (2014) 124 (21): 3630.

https://doi.org/10.1182/blood.V124.21.3630.3630

Published: 2014

Journal Articles

The Majority of RAS Pathway Mutations Detected in Relapsed B-Cell Precursor Acute Lymphoblastic Leukemia Are Present in Major or Minor Subclones at Diagnosis

Jiangyan Yu, Esmé Waanders, PhD, Simon V. van Reijmersdal, Edwin Sonneveld, PhD, Peter M Hoogerbrugge, MD PhD, Frank N. van Leeuwen, PhD, Ad Geurts van Kessel, PhD, Roland P. Kuiper, PhD

Blood (2014) 124 (21): 2397.

https://doi.org/10.1182/blood.V124.21.2397.2397

Published: 2014

Journal Articles

Btg1-Deficiency Promotes ETV6-RUNX1-Mediated Leukemic Transformation By Upregulation of BCL6

Esther Tijchon, MSc, Liesbeth van Emst, Bsc, Dorette van Ingen Schenau, MSc, Laurens T van der Meer, PhD, Simone de Rijk, BSc, Owen Williams, PhD, Peter M Hoogerbrugge, MD PhD, Blanca Scheijen, PhD, Frank N. van Leeuwen, PhD

Blood (2014) 124 (21): 5193.

https://doi.org/10.1182/blood.V124.21.5193.5193

Published: 2014

Journal Articles

Effect of IKZF1 Deletions on Signal Transduction Pathways in Philadelphia Chromosome-Negative B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL)

Naomi E van der Sligte, Frank JG Scherpen, Arja ter Elst, PhD, Victor Guryev, PhD, Frank N van Leeuwen, PhD, Evelina SJM de Bont, MD PhD

Blood (2014) 124 (21): 3770.

https://doi.org/10.1182/blood.V124.21.3770.3770

Published: 2014

Journal Articles

Loss Of BTG1 Function Promotes ETV6-RUNX1 -Mediated Leukemic Transformation

Esther J.H. Tijchon, MSc, Liesbeth van Emst, BSc, Dorette van Ingen Schenau, Msc, Laurens T. van der Meer, PhD, Owen Williams, PhD, Peter M. Hoogerbrugge, Blanca Scheijen, PhD, Frank N. van Leeuwen, PhD

Blood (2013) 122 (21): 2545.

https://doi.org/10.1182/blood.V122.21.2545.2545

Published: 2013

Journal Articles

B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) Specific Copy Number Alterations Are Unique For Progressive Pediatric Chronic Myeloid Leukemia (CML): A Large Cohort Study

Naomi E van der Sligte, Manuela Krumbholz, PhD, Agata Pastorczak, MD, Blanca Scheijen, PhD, Josephine T. Tauer, Christina Nowasz, Edwin Sonneveld, PhD, Truuske H. de Bock, PhD, Tiny G. Meeuwsen - de Boer, BSc, Simon V. van Reijmersdal, BSc, Roland P. Kuiper, PhD, Jutta Bradtke, PhD, Markus Metzler, MD, Meinolf Suttorp, Evelina S. De Bont, Frank N. van Leeuwen, PhD

Blood (2013) 122 (21): 2715.

https://doi.org/10.1182/blood.V122.21.2715.2715

Published: 2013

Journal Articles

P190 BCR-ABL1 Signaling Modulates The Function Of Tumor Suppressor Protein IKZF1

Marc Demkes, BSc, Edwin Lasonder, PhD, Edo Luijten, BSc, Peter M. Hoogerbrugge, Frank N. van Leeuwen, PhD, Blanca Scheijen, PhD

Blood (2013) 122 (21): 3809.

https://doi.org/10.1182/blood.V122.21.3809.3809

Published: 2013

Journal Articles

Loss Of Tumor Suppressor BTG1 Enhances ATF4 Function and Promotes Cell Survival

Laurens T. van der Meer, PhD, Laurensia Yuniati, MSc, Esther J.H. Tijchon, MSc, Liesbeth van Emst, BSc, Manon Alkema, Caroline Rodenbach, Blanca Scheijen, PhD, Peter M. Hoogerbrugge, Frank N. van Leeuwen, PhD

Blood (2013) 122 (21): 3796.

https://doi.org/10.1182/blood.V122.21.3796.3796

Published: 2013

Journal Articles

Loss Of IKZF1 Function Mediates Resistance Towards Glucocorticoid-Induced Apoptosis

Jorn Havinga, MSc, Laurensia Yuniati, MSc, Marc Demkes, BSc, Dorette van Ingen Schenau, Msc, Roland P. Kuiper, PhD, Peter M. Hoogerbrugge, Frank N. van Leeuwen, PhD, Blanca Scheijen, PhD

Blood (2013) 122 (21): 3865.

https://doi.org/10.1182/blood.V122.21.3865.3865

Published: 2013

Journal Articles

Identification of distinct protein Signatures Associated with genetic Abnormalities In Acute Lymphoblastic Leukemia

Roland P. Kuiper, PhD, Blanca Scheijen, PhD, Agata Pastorczak, MD, Simon V. van Reijmersdal, BSc, Deborah A. Thomas, MD, Niangxiang Zhang, PhD, Kevin R. Coombes, PhD, Hagop M. Kantarjian, MD, Elias J. Jabbour, MD, Eveline S.J.M De Bont, MD, PhD, Frank N. van Leeuwen, PhD, Steven M. Kornblau, MD

Blood (2013) 122 (21): 1313.

https://doi.org/10.1182/blood.V122.21.1313.1313

Published: 2013

Journal Articles

Leukemia Cells with a BCR-ABL1-Like signature and/or IKZF1 deletions, but Not High CRLF2 Expression, Are Predictive of an Unfavorable Prognosis in Childhood B Cell Precursor Acute Lymphoblastic Leukemia

Arian Van Der Veer, Esmee Waanders, PhD, Rob Pieters, MD, PhD, Marieke E. Willemse, Simon Reijmersdaal, Lisa J Russell, PhD, Christine J Harrison, PhD, FRCPath, William E. Evans, PharmD, Vincent H.J. van der Velden, PhD, Peter M. Hoogerbrugge, Frank N. van Leeuwen, PhD, G. Escherich, Martin Horstman, Leila mohammadi Khankahdani, Dimitris Rizopoulos, Hester A. de Groot-Kruseman, PhD, Edwin Sonneveld, PhD, Roland P. Kuiper, PhD, Monique L. Den Boer, PhD

Blood (2012) 120 (21): 880.

https://doi.org/10.1182/blood.V120.21.880.880

Published: 2012

Journal Articles

Tumor Suppressors BTG1 and BTG2 Fulfill Both Unique and Overlapping Functions During Normal B Lymphocyte Development

Esther J.H. Tijchon, MSc, Liesbeth van Emst, BSc, Jørn Havinga, MSc, Jean-Pierre Rouault, PhD, Felice Tirone, PhD, Peter M. Hoogerbrugge, MD, PhD, Blanca Scheijen, PhD, Frank N. van Leeuwen, PhD

Blood (2012) 120 (21): 1303.

https://doi.org/10.1182/blood.V120.21.1303.1303

Published: 2012

NARROW

Genomic Architecture and Clonal Dynamics of Early Relapsed BCP-ALL

Targeted Locus Amplification & Next Generation Sequencing for the Detection of Recurrent and Novel Gene Fusions for Improved Treatment Decisions in Pediatric Acute Lymphoblastic Leukemia

Tumor Suppressors BTG1 and IKZF1 Cooperate during Mouse Leukemia Development and Impact Relapse Rate in Childhood Acute Lymphoblastic Leukemia

Genetic Architecture of Relapsed Pediatric B Cell Precursor Acute Lymphoblastic Leukemia Are Related to the Intensity of Upfront Therapy

Cathepsin B Mediated Lysosomal Degradation in Macrophages Controls the Pharmacokinetics of the Therapeutic Protein Asparaginase

Crispr/Cas9 Based Kinome Screen Identifies Novel Targets That Determine Sensitivity for Asparaginase Therapy in Acute Lymphoblastic Leukemia

Tumor Suppressors Btg1 and Btg2 Regulate B Lineage Commitment through Modulation of Ebf1 Activity

The Leukemia-Associated Protein BTG1 Is Required for ATF4-Mediated Cellular Stress Responses

The Therapeutic Protein Asparaginase Is Efficiently Cleared By Bone Barrow and Spleen Resident Macrophages

The Majority of RAS Pathway Mutations Detected in Relapsed B-Cell Precursor Acute Lymphoblastic Leukemia Are Present in Major or Minor Subclones at Diagnosis

Btg1-Deficiency Promotes ETV6-RUNX1-Mediated Leukemic Transformation By Upregulation of BCL6

Effect of IKZF1 Deletions on Signal Transduction Pathways in Philadelphia Chromosome-Negative B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL)

Loss Of BTG1 Function Promotes ETV6-RUNX1 -Mediated Leukemic Transformation

B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) Specific Copy Number Alterations Are Unique For Progressive Pediatric Chronic Myeloid Leukemia (CML): A Large Cohort Study

P190 BCR-ABL1 Signaling Modulates The Function Of Tumor Suppressor Protein IKZF1

Loss Of Tumor Suppressor BTG1 Enhances ATF4 Function and Promotes Cell Survival

Loss Of IKZF1 Function Mediates Resistance Towards Glucocorticoid-Induced Apoptosis

Identification of distinct protein Signatures Associated with genetic Abnormalities In Acute Lymphoblastic Leukemia

Leukemia Cells with a BCR-ABL1-Like signature and/or IKZF1 deletions, but Not High CRLF2 Expression, Are Predictive of an Unfavorable Prognosis in Childhood B Cell Precursor Acute Lymphoblastic Leukemia

Tumor Suppressors BTG1 and BTG2 Fulfill Both Unique and Overlapping Functions During Normal B Lymphocyte Development

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