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Felipe Prosper, MD
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Journal Articles

Measurable Residual Disease (MRD) in Elderly Acute Myeloid Leukemia (AML): Results from the Pethema-Flugaza Phase III Clinical Trial

Catia Patricia Simoes, MD, Bruno Paiva, PhD, David Martínez-Cuadron, MD, Juan-Miguel Bergua, MD, Susana Vives, MD, Jesús Lorenzo Algarra, Mar Tormo, MD, Pilar Martinez, MD, Josefina Serrano, MD, Pilar Herrera, MD, Fernando Ramos, MDPhD, Olga Salamero, MD, Esperanza Lavilla, Cristina Gil, Jose Luiz Lopez Lorenzo, MD, Maria-Belen Vidriales, MD, Jorge Labrador, José F. Falantes, Maria Jose Sayas, Rosa Ayala, MD PhD, Joaquin Martinez-Lopez, MD, Sara Villar, María José Calasanz, PhD, Felipe Prosper, MD, Jesús F. San-Miguel, Miguel A. Sanz, Pau Montesinos, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 32.
https://doi.org/10.1182/blood-2020-134651
Published: 2020
Journal Articles

Discordances between Immunofixation (IFx) and Minimal Residual Disease (MRD) Assessment with Next-Generation Flow (NGF) and Sequencing (NGS) in Patients (Pts) with Multiple Myeloma (MM): Clinical and Pathogenic Significance

Sara Rodríguez, PhD, Ibai Goicoechea, PhD, Katerina Gemenetzi, Cirino Botta, MDPhD, Andreas Agathangelidis, PhD, Noemi Puig, MD PhD, María Teresa Cedena, MD, Alejandro Medina, MD, Rafael Valdés-Mas, Juan José Garcés, José J Pérez, Leire Burgos, María José Calasanz, PhD, Diego Alignani, PhD, Amaia Vilas-Zornoza, PhD, Sarvide Sarai, Felipe Prosper, MD, Jose Angel Martinez-Climent, MD PhD, Alberto Orfao, MD PhD, Ramón García-Sanz, MD PhD, Ana Jiménez Ubieto, MDPhD, Joaquin Martinez Lopez, Juan Jose Lahuerta, MD PhD, Laura Rosinol, MD PhD, Joan Bladé, MD PhD, María-Victoria Mateos, MD PhD, Anastasia Chatzidimitriou, Jesus F. San-Miguel, MD PhD, Bruno Paiva, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 5–6.
https://doi.org/10.1182/blood-2020-136258
Published: 2020
Journal Articles

Waldenström's Macroglobulinemia (WM) Is Preceded By Clonal Lymphopoiesis Including MYD88 L265P in Progenitor B Cells

Sara Rodríguez, PhD, Cirino Botta, MDPhD, Jon Celay, PhD, Ibai Goicoechea, PhD, Cristina Jiménez, PhD, Maria J Garcia-Barchino, PhD, Rafael Valdés-Mas, Yolanda Carrasco, Juan José Garcés, Marta Larrayoz, PhD, Susana Santos, Diego Alignani, PhD, Amaia Vilas-Zornoza, PhD, Cristina Pérez Ruiz, Sonia Garate, Sarvide Sarai, Aitziber Lopez Lopez, Christian Reinhardt, MD, Isidro Sanchez-Garcia, PhD, Maria Jose Larrayoz, BSc, María José Calasanz, PhD, Felipe Prosper, MD, Marina Motta, MD, Giuseppe Rossi, MD, Antonio Sacco, RN, Massimo Gentile, Sara Duarte, Helena Vitoria, Catarina Geraldes, MD PhD, Artur Paiva, Ramón Garcia-Sanz, MD PhD, Aldo M. Roccaro, MDPhD, Jesus F. San-Miguel, MD PhD, Jose Angel Martinez-Climent, MD PhD, Bruno Paiva, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 42–43.
https://doi.org/10.1182/blood-2020-136982
Published: 2020
Journal Articles

Computational Systems Biology Models for the Identification of Metabolic Vulnerabilities in Multiple Myeloma

Luis Vitores V. Valcárcel, MSc, Raquel Ordoñez, PhD, Iñigo Apaolaza, MSc, Ana Valcárcel, Leire Garate, Cem Meydan, PhD, Bruno Paiva, PhD, Ari M Melnick, MD, Jesús San-Miguel, Francisco J. Planes, Xabier Agirre, PhD, Felipe Prosper, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3084.
https://doi.org/10.1182/blood-2019-123970
Published: 2019
Journal Articles

Circulating Tumor Cells (CTCs) for Comprehensive and Multiregional Non-Invasive Genetic Characterization of Multiple Myeloma (MM)

Juan José Garcés, Gabriel Bretones, Leire Burgos, Rafael Valdes-Mas, Diego Alignani, PhD, Diana Álvarez Puente, Ibai Goicoechea, PhD, Miguel García Álvarez, Sonia Garate, Idoia Rodriguez, Maria Jose Calasanz, PhD BSc, Paula Rodriguez, MD, Rafael Rios, MD PhD, Joaquin Martinez-Lopez, MD PhD, Pamela Millacoy, Luis Palomera, MD PhD, Rafael Del Orbe, MD PhD, Albert Pérez, MD, Xabier Agirre, PhD, Juan Flores-Montero, Luzalba Sanoja-Flores, Alberto Orfao, MD PhD, Halima El Omri, Felipe Prosper, MD PhD, Carlos Lopez-Otin, Jesús San-Miguel, Bruno Paiva, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3064.
https://doi.org/10.1182/blood-2019-126527
Published: 2019
Journal Articles

Single-Cell Characterization of the Multiple Myeloma (MM) Immune Microenvironment Identifies CD27-Negative T Cells As Potential Source of Tumor-Reactive Lymphocytes

Cirino Botta, MD, Cristina Pérez Ruiz, Ibai Goicoechea, PhD, Noemi Puig, MD PhD, María Teresa Cedena, Lourdes Cordon, Aintzane Zabaleta, PhD, Leire Burgos, Catarina Maia, Sara Rodríguez, PhD, Idoia Rodriguez, Sarai Sarvide, Diego Alignani, PhD, Amaia Vilas-Zornoza, PhD, Erika Lorenzo-Vivas, PhD, Laura Rosinol Dachs, Albert Oriol, MD, María Jesús Blanchard, Rafael Rios, MD PhD, Anna Sureda, MD PhD, Rafael Martínez, Jesús Martín, Joan Bargay, MD PhD, Javier De La Rubia, Marco Rossi, MD, Pierosandro Tagliaferri, MD, Pierfrancesco Tassone, MD, Massimo Gentile, Juana Merino, Felipe Prosper, MD PhD, Alberto Orfao, MD PhD, Maria-Victoria Mateos, Juan-José Lahuerta, MD PhD, Joan Bladé, MD PhD, Jesús San-Miguel, Bruno Paiva, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 506.
https://doi.org/10.1182/blood-2019-123974
Published: 2019
Journal Articles

The Pathogenesis of Multiple Myeloma (MM) Is Preceded By Mutated Lymphopoiesis and B Cell Oligoclonality That Persist in Patients with Negative Minimal Residual Disease (MRD)

Sara Rodríguez, PhD, Noemi Puig, MD PhD, Katerina Gemenetzi, Ibai Goicoechea, PhD, Cirino Botta, MD, Andreas Agathangelidis, PhD, Rafael Valdés-Mas, Juan José Garcés, María Teresa Cedena, José J Pérez, Leire Burgos, Maria Jose Calasanz, PhD BSc, Diego Alignani, PhD, Amaia Vilas-Zornoza, PhD, Erika Lorenzo-Vivas, PhD, Irene Aires, Idoia Rodriguez, Sarvide Sarai, Felipe Prosper, MD PhD, Jose Angel Martinez-Climent, MD PhD, Alberto Orfao, MD PhD, Ramón García-Sanz, MD PhD, Joaquin Martinez-Lopez, MD PhD, Juan-José Lahuerta, MD PhD, Laura Rosinol Dachs, Joan Bladé, MD, Maria-Victoria Mateos, Anastasia Hadzidimitriou, PhD, Jesús San-Miguel, Bruno Paiva, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 509.
https://doi.org/10.1182/blood-2019-128049
Published: 2019
Journal Articles

Mutational Profiling Predicts Clinical Outcomes to Azacytidine and Low Dose Cytarabine Plus Fludarabine (FLUGA) in Elderly Acute Myeloid Leukemia Patients Enrolled in the Pethema Phase III Flugaza Trial

Rosa M. Ayala, MD PhD, Inmaculada Rapado, David Martínez-Cuadron, MD, Esther Onecha, PhD, Laura Rufian, Miss, Alexandra Juarez, Juan Bergua Burgues, Susana Vives, MD, Jesús Lorenzo Algarra, Mar Tormo, MD PhD, Pilar Martinez, MD, Josefina Serrano, Pilar Herrera, MD, Fernando Ramos, Olga Salamero, MD, Esperanza Lavilla, Cristina Gil, MD, Jose Luis Lopez Lorenzo, MD, Maria-Belen Vidriales, MD, Jorge Labrador, MD, José F. Falantes, Maria Jose Sayas, Bruno Paiva, PhD, Eva Barragán, Felipe Prosper, MD PhD, Miguel A. Sanz, Joaquin Martinez Lopez, MD PhD, Pau Montesinos Fernandez, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3891.
https://doi.org/10.1182/blood-2019-127187
Published: 2019
Journal Articles

Differentiation Therapy with Novel Epigenetic Inhibitors in Acute Myeloid Leukemia

Edurne San Jose, Naroa Gimenez-Camino, Obdulia Rabal, Estibaliz Miranda, Leire Garate, Fernando Garcia, Ana Alfonso Pierola, MD PhD, Sara Villar, Jose J. Rifon Roca, MD, Antonio Pineda-Lucena, Bruno Paiva, PhD, Javier Muñoz, Jesús San-Miguel, Julen Oyarzabal, PhD, Xabier Agirre, PhD, Felipe Prósper, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3762.
https://doi.org/10.1182/blood-2019-125578
Published: 2019
Journal Articles

Characterization of Complete Lncrnas Transcriptome Reveals Expression of Lncrnas As a Prognostic Factor and Linc-Smilo As a Potential Therapeutic Target in Multiple Myeloma

Arantxa Carrasco, Teresa Ezponda, Cem Meydan, PhD, Luis Vitores Valcárcel, MSc, Raquel Ordoñez, PhD, Marta Kulis, PhD, Leire Garate, Estíbaliz Miranda, Victor Segura, PhD, Elizabeth Guruceaga, Amaia Vilas-Zornoza, PhD, Diego Alignani, PhD, Laura Castro, Marien Pascual, PhD, Ane Amundarain, Halima El Omri, Ruba Yasin, MBBS, MRCP, Maria Jose Calasanz, PhD BSc, Francisco J Planes, Bruno Paiva, PhD, Christopher Mason, PhD, Jesús San-Miguel, Inaki Martin Subero, PhD, Ari M Melnick, MD, Felipe Prosper, MD PhD, Xabier Agirre, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4323.
https://doi.org/10.1182/blood-2019-123008
Published: 2019
Journal Articles

Lncrnas As New Partners of Novel Chimeric Transcripts in Multiple Myeloma

Ane Amundarain, Luis Vitores Valcárcel, MSc, Raquel Ordoñez, PhD, Leire Garate, Estíbaliz Miranda, Xabier Cendoya, Maria Jose Calasanz, PhD BSc, Bruno Paiva, PhD, Jesús San-Miguel, Francisco J Planes, Felipe Prósper, MD PhD, Xabier Agirre, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4356.
https://doi.org/10.1182/blood-2019-122568
Published: 2019
Journal Articles

Waldenström's Macroglobulinemia (WM) Is Preceded By Clonal Lymphopoiesis Including MYD88 L265P in Progenitor B Cells

Sara Rodríguez, PhD, Cirino Botta, MD, Jon Celay, PhD, Ibai Goicoechea, PhD, Maria J Garcia-Barchino, PhD, Rafael Valdés-Mas, Yolanda Carrasco, Daniel Alameda, PhD, Juan José Garcés, Marta Larrayoz, PhD, Susana Santos, Diego Alignani, PhD, Amaia Vilas-Zornoza, PhD, Erika Lorenzo-Vivas, PhD, Cristina Pérez Ruiz, Sonia Garate, Sarvide Sarai, Amaia Gascue, Christian Reinhardt, MD, Isidro Sanchez-Garcia, PhD, Maria Jose Larrayoz, PhD, Maria Jose Calasanz, PhD BSc, Felipe Prosper, MD PhD, Marina Motta, Antonella Anastasia, Antonio Sacco, RN, Massimo Gentile, Sara Duarte, Helena Vitoria, Catarina Geraldes, MD PhD, Artur Paiva, Aldo M. Roccaro, MD PhD, Jesús San-Miguel, Jose Angel Martinez-Climent, MD PhD, Bruno Paiva, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1527.
https://doi.org/10.1182/blood-2019-126889
Published: 2019
Journal Articles

A Computational Based Approach for Identification and Validation of Gene Mutations As Surrogate Markers of Gene Essentiality in Acute Myeloid Leukemia

Fernando Carazo, Edurne San Jose, Leire Garate, Estibaliz Miranda, Ana Alfonso Pierola, MD PhD, Sara Villar, Jose J. Rifon Roca, MD, Bruno Paiva, PhD, Jesús San-Miguel, Xabier Agirre, PhD, Felipe Prósper, MD PhD, Angel Rubio
Journal: Blood
Blood (2019) 134 (Supplement_1): 1414.
https://doi.org/10.1182/blood-2019-126506
Published: 2019
Journal Articles

Strategy for Identification of an Inherited Leukemia Predisposition in a 299 Patients Cohort with Tumor-Only Sequencing Data

Almudena Aguilera Díaz, MSc, BS, Sara Palomino-Echeverria, MSc, BSc, Iria Vazquez, PhD BSc, Beñat Ariceta, BSc, Maria Jose Larrayoz, BSc, Amagoia Mañu, BSc, Zuriñe Blasco-Iturri, MSc, BSc, Matxalen Olivares Salaverri, MD, Maria Teresa Olave Rubio, MD, Teresa Bernal Del Castillo, MD PhD, Jose J. Rifon Roca, MD, Ana Alfonso Pierola, MD PhD, Felipe Prosper, MD PhD, Marta Fernández-Mercado, PhD MSc, BSc, Maria Jose Calasanz, PhD BSc
Journal: Blood
Blood (2019) 134 (Supplement_1): 1415.
https://doi.org/10.1182/blood-2019-126634
Published: 2019
Journal Articles

Multidimensional Immunophenotyping Identifies Hallmarks of Systemic Light-Chain Amyloidosis (AL) and Maps the Disease in the Crossroad between MGUS and Multiple Myeloma (MM)

Noemi Puig, MD PhD, Bruno Paiva, MD PhD, Marta Lasa, Leire Burgos, José J Pérez, Juana Merino, Cristina Moreno, Maria-Belen Vidriales, MD, Dolores Gómez, María Teresa Cedena, Enrique M. Ocio, MD, Ramon Lecumberri, MD PhD, Alfonso García de Coca, MD PhD, Jorge Labrador, MD, Esther González Garcia, MD, Luis Palomera, MD PhD, Mercedes Gironella, MD, Valentin Cabañas, MD, Maria Casanova, MD, Albert Oriol, MD, Isabel Krsnik, MD PhD, Albert Pérez, MD, Javier De La Rubia, MD, José Enrique de la Puerta, Felipe De Arriba, PhD, Felipe Prosper, MD PhD, Joaquin Martinez Lopez, MD PhD, Quentin Lecrevisse, Javier Verde, Maria-Victoria Mateos, MD PhD, Juan Jose Lahuerta, MD PhD, Alberto Orfao, MD PhD, Jesús F San-Miguel, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3170.
https://doi.org/10.1182/blood-2018-99-119281
Published: 2018
Journal Articles

Transcriptomic Profiling of Circulating Tumor Cells (CTCs) in Multiple Myeloma (MM): A New Model to Understand Disease Dissemination

Juan José Garcés, Michal Šimíček, Marco Vicari, Lucie Brozova, MSc, Leire Burgos, Renata Bezděková, MSc., Diego Alignani, PhD, Maria Jose Calasanz, BSc, PhD, Katerina Growkova, Ludek Pour, MD, Rafael Rios, MD PhD, Joaquin Martinez-Lopez, MD PhD, Pamela Millacoy, Luis Palomera, MD PhD, Rafael Del Orbe, Sonia Garate, Laura Blanco, Patricia Maiso, PhD, Zuzana Chyra, Alexander Vdovin, Tomas Jelinek, Cirino Botta, MD, Halima El Omri, Xabier Agirre, PhD, Felipe Prosper, MD PhD, Roman Hajek, MD PhD, Jesus F San-Miguel, MD PhD, Bruno Paiva, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 245.
https://doi.org/10.1182/blood-2018-99-113331
Published: 2018
Journal Articles

Role of Measurable Residual Disease (MRD) in Redefining Complete Response (CR) in Elderly Patients with Acute Myeloid Leukemia (AML): Results from the Pethema-Flugaza Phase III Clinical Trial

Bruno Paiva, MD PhD, David Martínez-Cuadron, MD, Juan Miguel Miguel Bergua Burgues, Susana Vives, MD, Jesús Lorenzo Algarra, Mar Tormo, MD PhD, Pilar Martínez-Sánchez, MD, Josefina Serrano, MD, Pilar Herrera, MD, Fernando Ramos, Olga Salamero, MD, Esperanza Lavilla, Cristina Gil, MD, Jose Luiz Lopez Lorenzo, MD, Maria-Belen Vidriales, MD, Jorge Labrador, MD, José F. Falantes, MD, Maria Jose Sayas, Juana Merino, Ana Alfonso, MD, Felipe Prosper, MD PhD, Jesus F San-Miguel, MD PhD, Miguel A. Sanz, MD, Pau Montesinos, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 433.
https://doi.org/10.1182/blood-2018-99-113299
Published: 2018
Journal Articles

Genetic Profiling and Novel Recurrent Chromosomal Alterations in Patients with Light Chain Amyloidosis

Isabel Cuenca, MSc, Beatriz Sanchez-Vega, PhD, Bruno Paiva, MD PhD, David Gomez-Sanchez, Santiago Barrio, PhD, Diego Alignani, PhD, Marta Lasa, Ramon Lecumberri, MD PhD, Felipe Prosper, MD PhD, Enrique M. Ocio, MD, Maria Esther González, Alfonso García de Coca, MD PhD, Javier De La Rubia, MD, Mercedes Gironella, MD, Luis Palomera, MD PhD, Albert Oriol, MD, Maria Casanova, MD, Valentin Cabañas, MD, Francisco Taboada, PhD, Albert Pérez, MD, Felipe De Arriba, PhD, Noemi Puig, MD PhD, Juan Jose Lahuerta, MD PhD, Maria-Victoria Mateos, MD PhD, Jesus F San-Miguel, MD PhD, Joaquin Martinez Lopez, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4488.
https://doi.org/10.1182/blood-2018-99-114543
Published: 2018
Journal Articles

Understanding the Cellular Origin and Pathogenic Transcriptional Programs in Multiple Myeloma (MM) and Light-Chain Amyloidosis (AL) through the Dissection of the Normal Plasma Cell (PC) Development

Daniel Alameda, PhD, Marco Vicari, MD, David Lara-Astiaso, PhD, Marta Lasa, Noemi Puig, MD PhD, Maria Teresa Cedena Romero, MD PhD, Idoia Rodriguez, Diego Alignani, PhD, Amaia Vilas-Zornoza, PhD, Ibai Goicoechea, PhD, Sarai Sarvide, Enrique M. Ocio, MD, Ramon Lecumberri, MD PhD, Alfonso García de Coca, MD PhD, Jorge Labrador, MD, Esther González Garcia, MD, Luis Palomera, MD PhD, Mercedes Gironella, MD, Valentin Cabañas, MD, Maria Casanova, MD, Albert Oriol, MD, Isabel Krsnik, MD PhD, Albert Pérez, MD, Joaquin Martinez Lopez, MD PhD, Maria-Victoria Mateos, MD PhD, Juan-José Lahuerta, MD PhD, Felipe Prosper, MD PhD, Assaf Weiner, PhD, Ido Amit, PhD, Jesús F San-Miguel, MD, Bruno Paiva, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 188.
https://doi.org/10.1182/blood-2018-188
Published: 2018
Journal Articles

Long Non-Coding RNAs Annotation and Their Involvement in Multiple Myeloma

Arantxa Carrasco, Teresa Ezponda, Cem Meydan, PhD, Marta Kulis, Raquel Ordoñez, Leire Garate, Victor Segura, PhD, Diego Alignani, Bruno Paiva, PhD, Jesus San Miguel, MD PhD, José I. Martin Subero, PhD, Ari Melnick, MD, Felipe Prosper, MD, Xabier Agirre, PhD
Journal: Blood
Blood (2016) 128 (22): 4420.
https://doi.org/10.1182/blood.V128.22.4420.4420
Published: 2016