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Journal Articles

Nicotinamide Phosphoribosyltransferase Inhibitors Induce Apoptosis of AML Stem Cells through Dysregulation of Lipid Metabolism

Amit Subedi, PhD, Qiang Liu, PhD BSc, David Sharon, PhD, Severine Cathelin, PhD, Gary D Bader, Changjiang Xu, Veronique Voisin, PhD, Angelo D'Alessandro, PhD, Eric R Lechman, PhD, John E. Dick, PhD FRS, Mark D. Minden, Jean C.Y. Wang, MD, Steven M Chan, MD PhD

Blood (2020) 136 (Supplement 1): 25–26.

https://doi.org/10.1182/blood-2020-142404

Published: 2020

Journal Articles

Mir-125b Regulates the Self-Renewal of Acute Myeloid Leukemia Stem Cells through PTPN18 and GSK3

Qiang Liu, PhD BSc, Olga I. Gan, PhD, Gabriela Krivdova, BSc, Aaron Trotman-Grant, Stephanie M. Dobson, PhD, Karin G. Hermans, Mark D. Minden, Shai Izraeli, MD, John E. Dick, PhD FRS, Jean C.Y. Wang, MD PhD, Eric R. Lechman,, PhD

Blood (2020) 136 (Supplement 1): 16–17.

https://doi.org/10.1182/blood-2020-141733

Published: 2020

Journal Articles

Functional Investigation of the Argonaute Proteins in Human Hematopoietic Stem and Progenitor Cells

Gordon G. L. Wong, BS, Gabriela Krivdova, BSc, Olga I. Gan, PhD, Jessica L. McLeod, John E. Dick, PhD FRS, Eric R. Lechman, PhD

Blood (2020) 136 (Supplement 1): 32.

https://doi.org/10.1182/blood-2020-142963

Published: 2020

Journal Articles

Erythropoiesis Failure in Diamond-Blackfan Anemia Starts at the Oligopotent Common Myeloid and Megakaryocyte-Erythroid Progenitor Stage

Richard N Armstrong, PhDBSc, Mariana Benicio, PhD, Houtan Moshiri, PhD, Hongbing Li, PhD, Bozana Zlateska, MD MSc, Olga I. Gan, PhD, Eric R Lechman, PhD, John E. Dick, PhD FRS, Yigal Dror, MD FRCPC

Blood (2020) 136 (Supplement 1): 37.

https://doi.org/10.1182/blood-2020-143103

Published: 2020

Journal Articles

A Human Model of Down Syndrome Associated Leukemia Reveals Different Cell of Origins for Initiation and Progression

Elvin Wagenblast, PhD, Joana Araújo, MD, Olga I. Gan, PhD, Sarah K Cutting, Alex Murison, Jessica L. McLeod, Gabriela Krivdova, BSc, Maria Azkanaz, Sabrina A Smith, Johann K Hitzler, MD, John E. Dick, PhD FRS, Eric R Lechman, PhD

Blood (2020) 136 (Supplement 1): 11–12.

https://doi.org/10.1182/blood-2020-135867

Published: 2020

Journal Articles

Elevated Expression of Mir-130a in t(8,21) AML Reinforces the Aberrant Molecular Program of AML1-ETO

Gabriela Krivdova, BSc, Veronique Voisin, PhD, Sajid Marhon, Schoof E Erwin, Martino Gabra, Jessica L. McLeod, Leonardo Salmena, Mark D. Minden, Eric R. Lechman,, PhD, John E. Dick, PhD FRS

Blood (2020) 136 (Supplement 1): 41–42.

https://doi.org/10.1182/blood-2020-142652

Published: 2020

Journal Articles

Understanding Pre-Leukemia in Trisomy 21 Human HSC and Modeling Progression Towards Down Syndrome Associated Leukemia Using CRISPR/Cas9 at Single Cell Resolution

Elvin Wagenblast, PhD, Olga I. Gan, PhD, Maria Azkanaz, Sabrina A. Smith, Joana Araújo, MD, Lorien Shakib, Jessica L. McLeod, Gabriela Krivdova, Johann K. Hitzler, MD, Eric R. Lechman, PhD, John E. Dick, PhD

Blood (2019) 134 (Supplement_1): 2531.

https://doi.org/10.1182/blood-2019-129259

Published: 2019

Journal Articles

Modeling the Initiation and Evolution of Down Syndrome Associated Leukemia Using CRISPR/Cas9

Elvin Wagenblast, PhD, Gabriela Krivdova, BSc, MSc, Lorien Shakib, Maria Azkanaz, Olga I. Gan, Eric R. Lechman,, PhD MSC, John E. Dick

Blood (2018) 132 (Supplement 1): 3891.

https://doi.org/10.1182/blood-2018-99-110363

Published: 2018

Journal Articles

Functional and Molecular Consequences of Trisomy 21 on Human Fetal Hematopoiesis

Elvin Wagenblast, PhD, Gabriela Krivdova, BSc, MSc, Olga I. Gan, PhD, Johann K. Hitzler, MD, John E. Dick, PhD, Eric R. Lechman, PhD

Blood (2018) 132 (Supplement 1): 1317.

https://doi.org/10.1182/blood-2018-99-119734

Published: 2018

Journal Articles

Targeting the Mitochondrial Metallochaperone Cox17 Reduces DNA Methylation and Promotes AML Differentiation through a Copper Dependent Mechanism

Blood (2018) 132 (Supplement 1): 1339.

https://doi.org/10.1182/blood-2018-99-111015

Published: 2018

Journal Articles

Microrna-130a Regulates Hematopoietic Stem Cell Self-Renewal By Repressing Chromatin Modifiers and Shaping the Accessible Chromatin Landscape

Gabriela Krivdova, BSc, MSc, Schoof E Erwin, Veronique Voisin, PhD, Alex Murison, Karin G. Hermans, Laura Garcia Prat, Olga I. Gan, Elvin Wagenblast, PhD, Aaron Trotman-Grant, Eric R. Lechman,, PhD MSC, Mark D. Minden, MD PhD, John E. Dick, PhD

Blood (2018) 132 (Supplement 1): 3824.

https://doi.org/10.1182/blood-2018-99-116866

Published: 2018

Journal Articles

Inhibiting the Mitochondrial Sulfhydryl Oxidase Alr Reduces Cox17 and Alters Mitochondrial Cristae Structure Leading to the Differentiation of AML and Stem Cells

Danny V. Jeyaraju, PhD, Veronique Voisin, Changjiang Xu, Samir H. Barghout, BSPharm, MSc, Dilshad H. Khan, Rose Hurren, BSc, Marcela Gronda, MSc, Xiaoming Wang, Yulia Jitkova, PhD, David Sharon, PhD, Sanduni U. Liyanage, Hon. B. Sc, PhD, Joelle Soriano, Eric R. Lechman, PhD, Neil MacLean, Mark D. Minden, MD PhD, Steven M. Chan, MDPhD, John E. Dick, PhD, Gary D Bader, Aaron D. Schimmer, MDPhD

Blood (2017) 130 (Supplement 1): 881.

https://doi.org/10.1182/blood.V130.Suppl_1.881.881

Published: 2017

Journal Articles

Mir-125a Confers Multi-Lineage Long-Term Repopulating Stem Cell Activity to Human Hematopoietic Committed Progenitors

Eric R. Lechman, PhD, Karin G. Hermans, PhD, Erwin M. Schoof, PhD, Aaron Trotman-Grant, BS, Stephanie M Dobson, MSc, Gabriela Krivdova, MS, Janneke J. Elzinga, James A. Kennedy, MDPhD, Olga I Gan, PhD, John E Dick, PhD

Blood (2015) 126 (23): 900.

https://doi.org/10.1182/blood.V126.23.900.900

Published: 2015

Journal Articles

Modeling the Multi-Step Pathogenesis of Acute Myeloid Leukemia of Down Syndrome

Eric R. Lechman, PhD, Karin G. Hermans, PhD, Stephanie M. Dobson, BSc, Olga I. Gan, PhD, James A. Kennedy, MDPhD, John Chen, PhD, Johann K. Hitzler, MD, John E. Dick, PhD

Blood (2014) 124 (21): 3579.

https://doi.org/10.1182/blood.V124.21.3579.3579

Published: 2014

Journal Articles

Mir-126 Governs Human Leukemia Stem Cell Quiescence and Chemotherapy Resistance

Eric R. Lechman, PhD, Bernhard Gentner, MD, Peter van Galen, Stanley Wai-Kwong Ng, Kolja Eppert, PhD, Rene Marke, Liran Slush, MD, James A. Kennedy, MD PhD, Amanda Mitchell, PhD, Weihsu Claire Chen, PhD, Veronique Voisin, PhD, Gary Bader, PhD, Mark D. Minden, MD, PhD, Jun Lu, PhD, Jean C.Y. Wang, MD PhD, Luigi Naldini, John E. Dick, PhD

Blood (2013) 122 (21): 1647.

https://doi.org/10.1182/blood.V122.21.1647.1647

Published: 2013

Journal Articles

Enforced Expression Of Mir-125b Promotes the in vivo expansion Of Human Lin neg cord Blood Multi-Lymphoid Progenitors and Leukemia Stem Cells

Karin G. Hermans, PhD, Eric R. Lechman, PhD, Stephanie M. Dobson, BSc, Mark D. Minden, MD PhD, John E. Dick, PhD

Blood (2013) 122 (21): 1648.

https://doi.org/10.1182/blood.V122.21.1648.1648

Published: 2013

Journal Articles

A Mechanistic Role For Mir-126, a Hematopoietic Stem Cell Microrna, In Acute Leukemias

Alice Giustacchini, PhD, Silvia Nucera, MD, Eric R. Lechman, PhD, Cristiana Fanciullo, Francesco E Boccalatte, Tiziana Plati, Anna Ranghetti, Luca Vago, MD, PhD, Massimo Bernardi, MD, Maurilio Ponzoni, MD, John E. Dick, PhD, Luigi Naldini, MD, PhD, Bernhard Gentner, MD

Blood (2013) 122 (21): 886.

https://doi.org/10.1182/blood.V122.21.886.886

Published: 2013

Journal Articles

MicroRNA Expression Profiling in Sorted AML Subpopulations: A Possible Role for miR-155/BIC in Stem Cell Maintenance and Leukemogenesis.

Eric R. Lechman, PhD, Kristin J. Hope, B.S., Fernando J. Suarez Saiz, MD, Katsuto Takenaka, MD, Carlo M. Croce, MD, Mark D. Minden, MD, PhD, John E. Dick, Ph.D

Blood (2005) 106 (11): 466.

https://doi.org/10.1182/blood.V106.11.466.466

Published: 2005

NARROW

Nicotinamide Phosphoribosyltransferase Inhibitors Induce Apoptosis of AML Stem Cells through Dysregulation of Lipid Metabolism

Mir-125b Regulates the Self-Renewal of Acute Myeloid Leukemia Stem Cells through PTPN18 and GSK3

Functional Investigation of the Argonaute Proteins in Human Hematopoietic Stem and Progenitor Cells

Erythropoiesis Failure in Diamond-Blackfan Anemia Starts at the Oligopotent Common Myeloid and Megakaryocyte-Erythroid Progenitor Stage

A Human Model of Down Syndrome Associated Leukemia Reveals Different Cell of Origins for Initiation and Progression

Elevated Expression of Mir-130a in t(8,21) AML Reinforces the Aberrant Molecular Program of AML1-ETO

Understanding Pre-Leukemia in Trisomy 21 Human HSC and Modeling Progression Towards Down Syndrome Associated Leukemia Using CRISPR/Cas9 at Single Cell Resolution

Modeling the Initiation and Evolution of Down Syndrome Associated Leukemia Using CRISPR/Cas9

Functional and Molecular Consequences of Trisomy 21 on Human Fetal Hematopoiesis

Targeting the Mitochondrial Metallochaperone Cox17 Reduces DNA Methylation and Promotes AML Differentiation through a Copper Dependent Mechanism

Microrna-130a Regulates Hematopoietic Stem Cell Self-Renewal By Repressing Chromatin Modifiers and Shaping the Accessible Chromatin Landscape

Inhibiting the Mitochondrial Sulfhydryl Oxidase Alr Reduces Cox17 and Alters Mitochondrial Cristae Structure Leading to the Differentiation of AML and Stem Cells

Mir-125a Confers Multi-Lineage Long-Term Repopulating Stem Cell Activity to Human Hematopoietic Committed Progenitors

Modeling the Multi-Step Pathogenesis of Acute Myeloid Leukemia of Down Syndrome

Mir-126 Governs Human Leukemia Stem Cell Quiescence and Chemotherapy Resistance

Enforced Expression Of Mir-125b Promotes the in vivo expansion Of Human Lin neg cord Blood Multi-Lymphoid Progenitors and Leukemia Stem Cells

A Mechanistic Role For Mir-126, a Hematopoietic Stem Cell Microrna, In Acute Leukemias

MicroRNA Expression Profiling in Sorted AML Subpopulations: A Possible Role for miR-155/BIC in Stem Cell Maintenance and Leukemogenesis.

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ASH Publications

American Society of Hematology

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ASH Publications

American Society of Hematology

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