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Journal Articles

Development of a Novel Lymph Node-Based 3D Culture System Promoting Chronic Lymphocytic Leukemia Proliferation and Survival

Marco Haselager, MSc, Eduard Perelaer, Arnon P. Kater, MDPhD, Eric Eldering, PhD

Blood (2020) 136 (Supplement 1): 47–48.

https://doi.org/10.1182/blood-2020-141962

Published: 2020

Journal Articles

Electron Transport Chain Inhibition Suppresses CD40 Expression and Sensitizes Chronic Lymphocytic Leukaemia Cells to Venetoclax

Zhenghao Chen, Gaspard Cretenet, Valeria Carnazzo, Gerritje J. W. van der Windt, Arnon P. Kater, MDPhD, Eric Eldering, PhD

Blood (2020) 136 (Supplement 1): 35.

https://doi.org/10.1182/blood-2020-142618

Published: 2020

Journal Articles

Effects of Ibrutinib on Metabolic Alterations and Micro-Environmental Signalling in Chronic Lymphocytic Leukaemia

Zhenghao Chen, Gaspard Cretenet, Beatriz Valle-Argos, Francesco Forconi, MD PhD FRCPath, Arnon P. Kater, MDPhD, Graham Packham, PhD, Eric Eldering, PhD

Blood (2020) 136 (Supplement 1): 36–37.

https://doi.org/10.1182/blood-2020-142839

Published: 2020

Journal Articles

First Evidence of Restoration of T and NK Cell Compartment after Venetoclax Treatment

Iris de Weerdt, MD, Tom Hofland, MSc, Johan Dobber, Julie Dubois, Eric Eldering, PhD, Mehrdad Mobasher, MD MPH, Fransien Croon-de Boer, Mels Hoogendoorn, MD PhD, Gerjo A. Velders, PhD MD, Marjolein van der Klift, Mark-David Levin, MD PhD, Sabina Kersting, MDPhD, Sanne Tonino, MD PhD, Arnon P. Kater, MD

Blood (2018) 132 (Supplement 1): 1860.

https://doi.org/10.1182/blood-2018-99-116283

Published: 2018

Journal Articles

First Evidence of Dysfunctional Antigen-Specific T Cell Responses in Experimental CLL As a Model for Studies of Autologous T Cell-Based Therapies

Anne W. J. Martens, MSc, Felix M Wensveen, PhD, Ramon Arens, PhD, Eric Eldering, PhD, Gerritje J. W. van der Windt, PhD, Arnon P. Kater, MD

Blood (2018) 132 (Supplement 1): 3694.

https://doi.org/10.1182/blood-2018-99-114679

Published: 2018

Journal Articles

Chronic Lymphocytic Leukemia Cells Impair Mitochondrial Fitness in CD8 + T Cells and Impede CAR T Cell Efficacy

Jaco A. C. Van Bruggen, MSc, Anne W. J. Martens, MSc, Joseph A Fraietta, PhD, Tom Hofland, MSc, Sanne Tonino, MD PhD, Eric Eldering, PhD, Mark-David Levin, MDPhD, Peter J. Siska, MD, Sanne Endstra, Jeffrey C Rathmell, PhD, Carl H June, MD, David L. Porter, MD, J. Joseph Melenhorst, PhD, Gerritje J. W. van der Windt, PhD, Arnon P. Kater, MD

Blood (2018) 132 (Supplement 1): 235.

https://doi.org/10.1182/blood-2018-99-115911

Published: 2018

Journal Articles

A New Therapeutic Hypothesis: Nonsense-Mediated Decay Is an Exploitable Target in Multiple Myeloma

Alexander Leeksma, MD, Ingrid A.M. Derks, Brett Garrick, Torsten Trowe, Aldo Jongejan, PhD, Perry Moerland, PhD, Arnon P. Kater, MD, Eric Eldering, PhD, Ellen Filvaroff, PhD

Blood (2018) 132 (Supplement 1): 1937.

https://doi.org/10.1182/blood-2018-99-114801

Published: 2018

Journal Articles

Bcl-2 Members As Drug Target and Biomarkers for Response to Ibrutinib and Venetoclax in CLL

Eric Eldering, PhD, Victor Peperzak, PhD, Hanneke ter Burg, Stacey M. Fernandes, MS, Jennifer R. Brown, MD PhD, Arnon P. Kater, MD PhD

Blood (2016) 128 (22): 2043.

https://doi.org/10.1182/blood.V128.22.2043.2043

Published: 2016

Journal Articles

Targeting BCR-Independent Proliferation of CLL Cells

Slinger Erik, PhD, Arnon P. Kater, MD PhD, Rachel Thijssen, MSc, Eric Eldering, PhD

Blood (2015) 126 (23): 2916.

https://doi.org/10.1182/blood.V126.23.2916.2916

Published: 2015

Journal Articles

Assessment of p53 and ATM Functionality in Chronic Lymphocytic Leukemia By Multiplex Ligation-Dependent Probe Amplification

Doreen te Raa, Perry Moerland, Alexander Leeksma, Ingrid Derks, Martin Loden, Veronika Navrkalova, Martin Trbusek, PhD, Dieuwertje Luijks, Thorsten Zenz, MD, Anna Skowronska, PhD, Tatjana Stankovic, Mels Hoogendoorn, MD PhD, Marinus H. J. van Oers, Eric Eldering, PhD, Arnon P. Kater, MD PhD

Blood (2015) 126 (23): 2918.

https://doi.org/10.1182/blood.V126.23.2918.2918

Published: 2015

Journal Articles

CLL Disease Severity Is Enhanced in Tcl1 Mice Deficient for Pro-Apoptotic Regulator Noxa

Erik Slinger, PhD, Felix Wensveen, PhD, Arnon P. Kater, MD PhD, Eric Eldering, PhD

Blood (2015) 126 (23): 4144.

https://doi.org/10.1182/blood.V126.23.4144.4144

Published: 2015

Journal Articles

Combined Inhibition of Phosphatidylinositol 3-Kinase (PI3K) Isoform α and δ By the Pan-Class I PI3K Inhibitor SAR245409 (XL765) in Primary Chronic Lymphocytic Leukemia Cells Blocks Survival, Adhesion and Proliferation

Rachel Thijssen, Gregor van Bochove, Martin FM de Rooij, Johanna ter Burg, Marcel Spaargaren, PhD, Coumaran Egile, PhD, Marie Jose Kersten, MD PhD, Eric Eldering, PhD, Arnon P. Kater, MD PhD

Blood (2014) 124 (21): 4691.

https://doi.org/10.1182/blood.V124.21.4691.4691

Published: 2014

Journal Articles

Combined Inhibition of mTOR and DNA-PK Blocks Survival, Adhesion, Proliferation and Chemoresistance in Primary Chronic Lymphocytic Leukemia (CLL) Cells

Rachel Thijssen, Gregor van Bochove, Ingrid AM Derks, Johanna ter Burg, Martin FM de Rooij, Marcel Spaargaren, PhD, Marie Jose Kersten, MD PhD, Eric Eldering, PhD, Arnon P. Kater, MD PhD

Blood (2014) 124 (21): 1981.

https://doi.org/10.1182/blood.V124.21.1981.1981

Published: 2014

Journal Articles

Possible Mechanisms Of Resistance To The Novel BH3-Mimetic ABT-199 In In Vitro Lymph Node Models Of CLL – The Role Of Abl and Btk

Rachel Thijssen, Christian R Geest, Martin FM de Rooij, Nora Liu, Bogdan I Florea, Katinka Weller, Hermen S Overkleeft, Marinus H.J. Van Oers, MD, PhD, Marcel Spaargaren, PhD, Arnon P. Kater, MD PhD, Eric Eldering, PhD

Blood (2013) 122 (21): 4188.

https://doi.org/10.1182/blood.V122.21.4188.4188

Published: 2013

Journal Articles

The Impact Of Subclonal Versus Clonal Novel Recurrent Mutations On Treatment Outcome In Previously Untreated High Risk CLL Patients: Results From The HOVON68 Trial

Doreen te Raa, MD, Arnon P. Kater, MD PhD, Wendim Ghidey Alemayehu, Alexander Jethwa, Jennifer Hullein, Eric Eldering, PhD, Tatjana Stankovic, MD, PhD, Thorsten Zenz, MD, Christian H Geisler, Marinus H.J. Van Oers, MD, PhD

Blood (2013) 122 (21): 2861.

https://doi.org/10.1182/blood.V122.21.2861.2861

Published: 2013

Journal Articles

CMV-Specific CD8 + T-CELL Function Is NOT Impaired In CLL

Doreen te Raa, MD, Fernanda Pascutti, PhD, Juan J Garcia-Vallejo, PhD, Emilie Reinen, Ester B.M. Remmerswaal, René A.W. Van Lier, PhD, Eric Eldering, PhD, Marinus H.J. Van Oers, MD, PhD, Sanne H. Tonino, MD PhD, Arnon P. Kater, MD PhD

Blood (2013) 122 (21): 2862.

https://doi.org/10.1182/blood.V122.21.2862.2862

Published: 2013

Journal Articles

The Broad Kinase Inhibitor Dasatinib in Combination with Fludarabine in Patients with Refractory Chronic Lymphocytic Leukemia: A Multicenter Phase 2 Study

Arnon P. Kater, MD PhD, Marjolijn Spiering, Rob D Liu, Marielle M Beckers, Sanne H. Tonino, Simon M. G. J. Daenen, Jeanette K Doorduijn, Nienke A Lankheet, Dieuwertje M Luijks, Doreen te Raa, MD, Eric Eldering, PhD, Marinus H.J. Van Oers, MD, PhD

Blood (2012) 120 (21): 1798.

https://doi.org/10.1182/blood.V120.21.1798.1798

Published: 2012

Journal Articles

Assessment of p53 Functionality in Chronic Lymphocytic Leukemia by Different Assays; An Eric-Wide Approach.

Doreen te Raa, MD, Jitka Malcikova, Dr, PhD, Marek Mraz, Sarka Pospisilova, PhD, Magali Le Garff-Tavernier, Helene Merle-Beral, MD, PhD, Tatjana Stankovic, MD., PhD, Marinus H. J. van Oers, MD PhD, Eric Eldering, PhD, Stephan Stilgenbauer, MD, Thorsten Zenz, MD, PhD, Arnon P. Kater, MD PhD

Blood (2012) 120 (21): 2872.

https://doi.org/10.1182/blood.V120.21.2872.2872

Published: 2012

Journal Articles

SF3B1 Mutations in CLL Are Equivalent to p53/ATM Dysfunction and Cause Defective Puma Upregulation in Response to Chemotherapy

Doreen te Raa, MD, Ingrid AM Derks, Dieuwertje M Luijks, Jacoline van Laar, Hanneke Monsuur, Ceri Oldreive, Alexander Jethwa, Jennifer Hüllein, Tatjana Stankovic, MD PhD, Thorsten Zenz, MD, Marinus H.J. Van Oers, MD, PhD, Arnon P. Kater, MD PhD, Eric Eldering, PhD

Blood (2012) 120 (21): 711.

https://doi.org/10.1182/blood.V120.21.711.711

Published: 2012

Journal Articles

Mapping the Targets of Dasatinib in Chronic Lymphocytic Leukemia Reveals Distinct Roles for Abl and Btk in Drug Resistance and Adhesion, and Explains Clinical Effects On Lymph Node Reduction

Eric Eldering, PhD, Christian R Geest, Martin FM de Rooij, Nora Liu, Bogdan I Florea, Marinus H.J. Van Oers, MD, PhD, Hermen S Overkleeft, Marcel Spaargaren, PhD, Arnon P. Kater, MD PhD

Blood (2012) 120 (21): 3900.

https://doi.org/10.1182/blood.V120.21.3900.3900

Published: 2012

NARROW

Development of a Novel Lymph Node-Based 3D Culture System Promoting Chronic Lymphocytic Leukemia Proliferation and Survival

Electron Transport Chain Inhibition Suppresses CD40 Expression and Sensitizes Chronic Lymphocytic Leukaemia Cells to Venetoclax

Effects of Ibrutinib on Metabolic Alterations and Micro-Environmental Signalling in Chronic Lymphocytic Leukaemia

First Evidence of Restoration of T and NK Cell Compartment after Venetoclax Treatment

First Evidence of Dysfunctional Antigen-Specific T Cell Responses in Experimental CLL As a Model for Studies of Autologous T Cell-Based Therapies

Chronic Lymphocytic Leukemia Cells Impair Mitochondrial Fitness in CD8 + T Cells and Impede CAR T Cell Efficacy

A New Therapeutic Hypothesis: Nonsense-Mediated Decay Is an Exploitable Target in Multiple Myeloma

Bcl-2 Members As Drug Target and Biomarkers for Response to Ibrutinib and Venetoclax in CLL

Targeting BCR-Independent Proliferation of CLL Cells

Assessment of p53 and ATM Functionality in Chronic Lymphocytic Leukemia By Multiplex Ligation-Dependent Probe Amplification

CLL Disease Severity Is Enhanced in Tcl1 Mice Deficient for Pro-Apoptotic Regulator Noxa

Combined Inhibition of Phosphatidylinositol 3-Kinase (PI3K) Isoform α and δ By the Pan-Class I PI3K Inhibitor SAR245409 (XL765) in Primary Chronic Lymphocytic Leukemia Cells Blocks Survival, Adhesion and Proliferation

Combined Inhibition of mTOR and DNA-PK Blocks Survival, Adhesion, Proliferation and Chemoresistance in Primary Chronic Lymphocytic Leukemia (CLL) Cells

Possible Mechanisms Of Resistance To The Novel BH3-Mimetic ABT-199 In In Vitro Lymph Node Models Of CLL – The Role Of Abl and Btk

The Impact Of Subclonal Versus Clonal Novel Recurrent Mutations On Treatment Outcome In Previously Untreated High Risk CLL Patients: Results From The HOVON68 Trial

CMV-Specific CD8 + T-CELL Function Is NOT Impaired In CLL

The Broad Kinase Inhibitor Dasatinib in Combination with Fludarabine in Patients with Refractory Chronic Lymphocytic Leukemia: A Multicenter Phase 2 Study

Assessment of p53 Functionality in Chronic Lymphocytic Leukemia by Different Assays; An Eric-Wide Approach.

SF3B1 Mutations in CLL Are Equivalent to p53/ATM Dysfunction and Cause Defective Puma Upregulation in Response to Chemotherapy

Mapping the Targets of Dasatinib in Chronic Lymphocytic Leukemia Reveals Distinct Roles for Abl and Btk in Drug Resistance and Adhesion, and Explains Clinical Effects On Lymph Node Reduction

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American Society of Hematology

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ASH Publications

American Society of Hematology

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