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Hermen S Overkleeft
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Journal Articles

Possible Mechanisms Of Resistance To The Novel BH3-Mimetic ABT-199 In In Vitro Lymph Node Models Of CLL – The Role Of Abl and Btk

Rachel Thijssen, Christian R Geest, Martin FM de Rooij, Nora Liu, Bogdan I Florea, Katinka Weller, Hermen S Overkleeft, Marinus H.J. Van Oers, MD, PhD, Marcel Spaargaren, PhD, Arnon P. Kater, MD PhD, Eric Eldering, PhD
Journal: Blood
Blood (2013) 122 (21): 4188.
https://doi.org/10.1182/blood.V122.21.4188.4188
Published: 2013
Journal Articles

SAKK 65/08: A Phase I Trial of the HIV Protease Inhibitor Nelfinavir in Combination with Bortezomib Identifies Nelfinavir As FDA Approved, Oral Drug that Inhibits the Proteasome and Induces Proteotoxic Stress in Vivo and has Potential Antimyeloma Activity.

Christoph Driessen, MD, Dagmar Hess, MD, Thomas Pabst, MD, Sarah R Haile, Markus Joerger, MD, Roger von Moos, MD, Catherine Berset, Susanne Crowe, Hilde Rosing, PhD, Hermen S Overkleeft, Christiana Sessa, Marianne Kraus
Journal: Blood
Blood (2012) 120 (21): 2956.
https://doi.org/10.1182/blood.V120.21.2956.2956
Published: 2012
Journal Articles

Mapping the Targets of Dasatinib in Chronic Lymphocytic Leukemia Reveals Distinct Roles for Abl and Btk in Drug Resistance and Adhesion, and Explains Clinical Effects On Lymph Node Reduction

Eric Eldering, PhD, Christian R Geest, Martin FM de Rooij, Nora Liu, Bogdan I Florea, Marinus H.J. Van Oers, MD, PhD, Hermen S Overkleeft, Marcel Spaargaren, PhD, Arnon P. Kater, MD PhD
Journal: Blood
Blood (2012) 120 (21): 3900.
https://doi.org/10.1182/blood.V120.21.3900.3900
Published: 2012
Journal Articles

Selective Inhibition of the proteasome's β2 Catalytic Subunit Alone Does Not Induce Cytotoxicity, but Resensitizes Bortezomib-Refractory Myeloma Cells for Bortezomib Treatment

Marianne Kraus, Bobby Florea, Jürgen Bader, Nan Li, Paul Geurink, Wouter van der Linden, Hermen S Overkleeft, Christoph Driessen, MD
Journal: Blood
Blood (2011) 118 (21): 2915.
https://doi.org/10.1182/blood.V118.21.2915.2915
Published: 2011