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Christian R Geest
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Journal Articles

Possible Mechanisms Of Resistance To The Novel BH3-Mimetic ABT-199 In In Vitro Lymph Node Models Of CLL – The Role Of Abl and Btk

Rachel Thijssen, Christian R Geest, Martin FM de Rooij, Nora Liu, Bogdan I Florea, Katinka Weller, Hermen S Overkleeft, Marinus H.J. Van Oers, MD, PhD, Marcel Spaargaren, PhD, Arnon P. Kater, MD PhD, Eric Eldering, PhD
Journal: Blood
Blood (2013) 122 (21): 4188.
https://doi.org/10.1182/blood.V122.21.4188.4188
Published: 2013
Journal Articles

Mapping the Targets of Dasatinib in Chronic Lymphocytic Leukemia Reveals Distinct Roles for Abl and Btk in Drug Resistance and Adhesion, and Explains Clinical Effects On Lymph Node Reduction

Eric Eldering, PhD, Christian R Geest, Martin FM de Rooij, Nora Liu, Bogdan I Florea, Marinus H.J. Van Oers, MD, PhD, Hermen S Overkleeft, Marcel Spaargaren, PhD, Arnon P. Kater, MD PhD
Journal: Blood
Blood (2012) 120 (21): 3900.
https://doi.org/10.1182/blood.V120.21.3900.3900
Published: 2012
Journal Articles

The clinically active BTK inhibitor PCI-32765 targets B-cell receptor– and chemokine-controlled adhesion and migration in chronic lymphocytic leukemia

Brief Report
Martin F. M. de Rooij, Annemieke Kuil, Christian R. Geest, Eric Eldering, Betty Y. Chang, Joseph J. Buggy, Steven T. Pals, Marcel Spaargaren
Journal: Blood
Blood (2012) 119 (11): 2590–2594.
https://doi.org/10.1182/blood-2011-11-390989
Published: 2012
Includes: Supplemental data
Journal Articles

Role for BH3-Only Protein NOXA In Growth-Factor Deprivation and Early Erythropoiesis

Christian R. Geest, PhD, Felix M. Wensveen, PhD, Sten F.W.M. Libregts, PhD, Alex M. de Bruin, PhD, Ingrid A.M. Derks, PhD, Paul G. Ekert, Verena Labi, PhD, Andreas Villunger, PhD, Martijn A. Nolte, PhD, Eric Eldering, PhD
Journal: Blood
Blood (2010) 116 (21): 4235.
https://doi.org/10.1182/blood.V116.21.4235.4235
Published: 2010
Journal Articles

Variations of Noxa Levels Caused by p38 MAPK Signaling Result In Heterogeneous Sensitivity to ABT-737 In CD40L-Stimulated CLL Cells

Jacqueline M Tromp, MD, Christian R Geest, PhD, Judith Elias, Jacoline van Laar, Marinus H.J. Van Oers, MD, PhD, Eric Eldering
Journal: Blood
Blood (2010) 116 (21): 1825.
https://doi.org/10.1182/blood.V116.21.1825.1825
Published: 2010
Journal Articles

Tight control of MEK-ERK activation is essential in regulating proliferation, survival, and cytokine production of CD34 + -derived neutrophil progenitors

Christian R. Geest, Miranda Buitenhuis, Marian J. A. Groot Koerkamp, Frank C. P. Holstege, Edo Vellenga, Paul J. Coffer
Journal: Blood
Blood (2009) 114 (16): 3402–3412.
https://doi.org/10.1182/blood-2008-08-175141
Published: 2009
Includes: Supplemental data
Journal Articles

p38MAPK Inhibits Neutrophil Development through Phosphorylation of C/EBPα on Serine 21

Miranda Buitenhuis, PhD, Christian R. Geest, MSc, Annemieke G. Laarhoven, BSc, Marrie C.A. Bruin, MD, PhD, Marc B. Bierings, MD, PhD, Edo Vellenga, MD, PhD, Paul J. Coffer, PhD
Journal: Blood
Blood (2008) 112 (11): 888.
https://doi.org/10.1182/blood.V112.11.888.888
Published: 2008