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Elizabeth R Macari
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Journal Articles

Multiplex Prime Editing and PASSIGE TM for Non-Viral Generation of an Allogeneic CAR-T Cell Product

Emily J Pomeroy, Andrew V Anzalone, Christopher J Podracky, Noah B Bloch, Reyna Chang, Arika A Dwivedi, Kanut Laoharawee, Alan J Wilhelm, David P Waterman, Justin G Tedeschi, Upasana Sunil Arvindam, Elizabeth R Macari, Jennifer L Gori, Jeremy S Duffield
Journal: Blood
Blood (2023) 142 (Supplement 1): 4803.
https://doi.org/10.1182/blood-2023-181869
Published: 2023
Journal Articles

Lovo-cel (bb1111) Gene Therapy for Sickle Cell Disease: Updated Clinical Results and Investigations into Two Cases of Anemia from Group C of the Phase 1/2 HGB-206 Study

Mark C. Walters, Alexis A. Thompson, Janet L. Kwiatkowski, Suhag Parikh, Markus Y. Mapara, Stacey Rifkin-Zenenberg, Banu Aygun, Kimberly A. Kasow, Alex Miller, Lixin Zhang, Anjulika Chawla, Elizabeth R. Macari, Francis J. Pierciey, Jr., John F. Tisdale, Julie Kanter
Journal: Blood
Blood (2022) 140 (Supplement 1): 26–28.
https://doi.org/10.1182/blood-2022-162288
Published: 2022
Journal Articles

Calmodulin Inhibition Rescues DBA Models with Ribosomal Protein Deficiency through Reduction of RSK Signaling

Elizabeth R Macari, PhD, Alison M Taylor, PhD, David Raiser, PhD, Kavitha Siva, PhD, Katherine McGrath, Jessica M Humphries, Johan Flygare, MDPhD, Benjamin L. Ebert, MDPhD, Leonard I. Zon, MD
Journal: Blood
Blood (2016) 128 (22): 332.
https://doi.org/10.1182/blood.V128.22.332.332
Published: 2016
Journal Articles

Calmodulin Inhibition Rescues the Effects of Ribosomal Protein Deficiency in in Vitro and In Vivo Diamond Blackfan Anemia Models

Elizabeth R Macari, PhD, Alison Taylor, PhD, David Raiser, PhD, Kavitha Siva, PhD, Katherine McGrath, Jessica M Humphries, Johan Flygare, MD PhD, Benjamin L Ebert, MD PhD, Leonard I. Zon, MD
Journal: Blood
Blood (2015) 126 (23): 672.
https://doi.org/10.1182/blood.V126.23.672.672
Published: 2015
Journal Articles

Modeling Diamond Blackfan Anemia in Vivo Using Human Induced Pluripotent Stem Cells

Sergei Doulatov, PhD, Linda T Vo, Elizabeth R Macari, PhD, Stephanie S Chou, Manav Gupta, Michelle Godfrey, Katherine McGrath, Thorsten M Schlaeger, PhD, Leonard I. Zon, MD, George Q. Daley, MD PhD
Journal: Blood
Blood (2014) 124 (21): 359.
https://doi.org/10.1182/blood.V124.21.359.359
Published: 2014
Journal Articles

Whole-exome sequencing and functional studies identify RPS29 as a novel gene mutated in multicase Diamond-Blackfan anemia families

Lisa Mirabello, Elizabeth R. Macari, Lea Jessop, Steven R. Ellis, Timothy Myers, Neelam Giri, Alison M. Taylor, Katherine E. McGrath, Jessica M. Humphries, Bari J. Ballew, Meredith Yeager, Joseph F. Boland, Ji He, Belynda D. Hicks, Laurie Burdett, Blanche P. Alter, Leonard Zon, Sharon A. Savage
Journal: Blood
Blood (2014) 124 (1): 24–32.
https://doi.org/10.1182/blood-2013-11-540278
Published: 2014
Includes: Supplemental data
Journal Articles

Functional Consequences Of RPS29 Germline Mutations In Diamond-Blackfan Anemia

Lisa Mirabello, PhD, Elizabeth R Macari, PhD, Lea Jessop, PhD, Timothy Myers, PhD, Neelam Giri, MD, Alison M. Taylor, PhD, Katherine E. McGrath, Jessica M. Humphries, Bari J Ballew, PhD, Meredith Yeager, PhD, Joseph F Boland, Ji He, Belynda D Hicks, Laurie Burdett, PhD, Blanche P Alter, MD, MPH, Leonard I. Zon, MD, Sharon A Savage, MD
Journal: Blood
Blood (2013) 122 (21): 2465.
https://doi.org/10.1182/blood.V122.21.2465.2465
Published: 2013
Journal Articles

Simvastatin and t-butylhydroquinone suppress KLF1 and BCL11A gene expression and additively increase fetal hemoglobin in primary human erythroid cells

Elizabeth R. Macari, Emily K. Schaeffer, Rachel J. West, Christopher H. Lowrey
Journal: Blood
Blood (2013) 121 (5): 830–839.
https://doi.org/10.1182/blood-2012-07-443986
Published: 2013
Journal Articles

Simvastatin and tBHQ Act Synergistically to Increase γ-Globin Gene Expression Through the Transcription Factors KLF2 and NRF2

Elizabeth R Macari, BS, Christopher H. Lowrey, MD
Journal: Blood
Blood (2011) 118 (21): 2149.
https://doi.org/10.1182/blood.V118.21.2149.2149
Published: 2011
Journal Articles

Induction of human fetal hemoglobin via the NRF2 antioxidant response signaling pathway

Elizabeth R. Macari, Christopher H. Lowrey
Journal: Blood
Blood (2011) 117 (22): 5987–5997.
https://doi.org/10.1182/blood-2010-10-314096
Published: 2011
Journal Articles

Exploiting the NRF2/Antioxidant Response Element Signaling Pathway to Induce γ-Globin Gene Expression and HbF Production

Elizabeth R. Macari, BS, Rachel J. West, PhD, Christopher H. Lowrey, MD
Journal: Blood
Blood (2010) 116 (21): 2074.
https://doi.org/10.1182/blood.V116.21.2074.2074
Published: 2010
Journal Articles

Dual-Specificity Phosphatases (DUSPs) Are Potential Targets for Pharmacologic Induction of Fetal Hemoglobin

Cynthia K Hahn, BA, Rachel J West, PhD, Elizabeth R Macari, BS, Emily K Schaeffer, BSc, Christopher H. Lowrey, MD
Journal: Blood
Blood (2010) 116 (21): 2075.
https://doi.org/10.1182/blood.V116.21.2075.2075
Published: 2010