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Journal Articles

A CRISPR/Cas9-Generated Murine Model Reveals Cooperation between BCR Signaling and CDKN2A/2B and TP53 Disruption in Richter Syndrome

Supriya Chakraborty, PhD, Ilaria Fortunati, BS, Claudio Martines, MS, Brijesh Yadav, PhD, Marija Dimishkovska, PhD, Idanna Innocenti, MD PhD, Rosa Fazio, BS, Giovanni D'Arena, MD, Aleksandar Dimovski, MD PhD, Luca Laurenti, MD, Dimitar G Efremov, MD PhD

Blood (2019) 134 (Supplement_1): 4278.

https://doi.org/10.1182/blood-2019-128425

Published: 2019

Journal Articles

Serum IgM/Fcmr Interactions Inhibit BCR Signaling and Influence the Cinical Course of CLL

Stefania Gobessi, PhD, Luca Laurenti, MD, Fabiola Porro, MS, Claudio Martines, MS, Rosa Fazio, BS, Elena Xerxa, PhD, Idanna Innocenti, MD PhD, Antonella Zucchetto, Shih-Shih Chen, PhD, Xiao-Jie Yan, MD PhD, Nicholas Chiorazzi, MD, Valter Gattei, MD, Dimitar G Efremov, MD PhD

Blood (2018) 132 (Supplement 1): 4409.

https://doi.org/10.1182/blood-2018-99-118562

Published: 2018

Journal Articles

SHP1 Deficiency Is Responsible for the Constitutive Activation of the BCR Pathway in GCB DLBCL

Binu K Sasi, PhD, Sven Turkalj, BS, Hilal Kalkan, BS, Fabiola Porro, MS, Engin Bojnik, PhD, Beata Pyrzynska, PhD, Abdessamad Zerrouqi, PhD, Malgorzata Bobrowicz, PhD, Magdalena Winiarska, PhD, Valdemar Priebe, MS, Francesco Bertoni, MD, Larry Mansouri, PhD, Richard Rosenquist, MD PhD, Dimitar G Efremov, MD PhD

Blood (2018) 132 (Supplement 1): 2860.

https://doi.org/10.1182/blood-2018-99-118120

Published: 2018

Journal Articles

Hyper-Activation of the Adenosinergic Axis in the Eμ-TCL1 Chronic Lymphocytic Leukemia Mouse Model Offers Therapeutic Opportunities

Tiziana Vaisitti, PhD, Sara Serra, PhD, Cinzia Bologna, PhD, Nicoletta Vitale, PhD, Stefania Gobessi, PhD BS, Dimitar G Efremov, MD PhD, Silvia Deaglio, MD

Blood (2017) 130 (Supplement 1): 1721.

https://doi.org/10.1182/blood.V130.Suppl_1.1721.1721

Published: 2017

Journal Articles

Chlorambucil PLUS Rituximab As FRONT-LINE Therapy for Elderly and/or Unfit CLL Patients. LONG-TERM Follow-up and Correlation with Biologic-Based Risk Stratification

Blood (2016) 128 (22): 3240.

https://doi.org/10.1182/blood.V128.22.3240.3240

Published: 2016

Journal Articles

The Bcl-2 BH4 Antagonist Bda-366 Induces Apoptosis in CLL and DLBCL Cells through a Bcl-2 Independent Mechanism

Binu K Sasi, PhD, Tamara Vervloessem, PhD, Stefania Gobessi, PhD, Idanna Innocenti, MD, Luca Laurenti, Geert Bultynck, PhD, Dimitar G Efremov, MD PhD

Blood (2016) 128 (22): 2014.

https://doi.org/10.1182/blood.V128.22.2014.2014

Published: 2016

Journal Articles

FcμR Triggering Activates BCR Signaling Pathways and Increases Survival of CLL Cells

Stefania Gobessi, PhD, Binu K Sasi, PhD, Gabriele Pozzato, MD, Idanna Innocenti, MD, Luca Laurenti, Dimitar G Efremov, MD PhD

Blood (2016) 128 (22): 2015.

https://doi.org/10.1182/blood.V128.22.2015.2015

Published: 2016

Journal Articles

Serum IgM Activates BCR Signaling Pathways and Increases Survival of Chronic Lymphocytic Leukemia B Cells

Stefania Gobessi, PhD, Binu K Sasi, PhD, Luca Laurenti, MD, Dimitar G Efremov, MD PhD

Blood (2015) 126 (23): 4131.

https://doi.org/10.1182/blood.V126.23.4131.4131

Published: 2015

Journal Articles

Inhibition of SYK More Effectively Overcomes MCL-1 Mediated ABT-199 Resistance of BCR-Stimulated CLL Cells Than Inhibition of BTK or PI3Kdelta

Kamil Bojarczuk, PhD, Binu K Sasi, PhD, Stefania Gobessi, PhD, Idanna Innocenti, MD, Luca Laurenti, MD, Dimitar G Efremov, MD PhD

Blood (2015) 126 (23): 489.

https://doi.org/10.1182/blood.V126.23.489.489

Published: 2015

Journal Articles

Inhibitors Of B-Cell Receptor Molecules Affect Surface CD20 and Impair Antitumor Activity Of Anti-CD20 Monoclonal Antibodies

Kamil Bojarczuk, MSc, Magdalena Winiarska, PhD, Malgorzata Bobrowicz, MSc, Michal Dwojak, Nina Miazek, Piotr Zapala, Dimitar G Efremov, MD, PhD, Jakub Golab, M.D., Ph.D.

Blood (2013) 122 (21): 4217.

https://doi.org/10.1182/blood.V122.21.4217.4217

Published: 2013

Journal Articles

Chlorambucil PLUS Rituximab As FRONT-LINE THERAPY in Elderly or Unfit Patients Affected by B-CELL Chronic Lymphocytic Leukemia: Results of A Single-Centre Retrospective Analysis

Luca Laurenti, MD, Barbara Vannata, Idanna Innocenti, Francesco Autore, MD, Francesco Santini, Federica Sorà, Tommaso Za, Sara Marietti, Silvia Bellesi, Simona Sica, MD, Dimitar G Efremov, MD, PhD, Giuseppe Leone

Blood (2012) 120 (21): 4604.

https://doi.org/10.1182/blood.V120.21.4604.4604

Published: 2012

Journal Articles

The Nature of the Antigen Determines Leukemia Development and Behavior in the Eμ-TCL1 Transgenic Mouse Model of CLL

Sara Bennardo, BS, Stefano Iacovelli, BS, Stefania Gobessi, PhD, Mirza Suljagic, DVM, PhD, Daniel Bilbao, PhD, Julia Eckl-Dorna, MD, PhD, Hongsheng Wang, MD, PhD, Richard J. Cornall, MD, PhD, Stephen H Clarke, PhD, Carlo M. Croce, MD, Dimitar G Efremov, MD, PhD

Blood (2012) 120 (21): 181.

https://doi.org/10.1182/blood.V120.21.181.181

Published: 2012

Journal Articles

Expression of ZAP-70 Does Not Accelerate Leukemia Development and Progression in the Eμ-TCL1 Transgenic Mouse Model of Chronic Lymphocytic Leukemia

Stefania Gobessi, PhD, Francesca Belfiore, PhD, Sara Bennardo, BS, Brendan Doe, BS, Luca Laurenti, MD, Dimitar G Efremov, MD, PhD

Blood (2012) 120 (21): 925.

https://doi.org/10.1182/blood.V120.21.925.925

Published: 2012

Journal Articles

Development of a Transgenic Mouse Model to Study the Role of ZAP-70 in the Development and Progression of Chronic Lymphocytic Leukemia

Stefania Gobessi, PhD, Sara Bennardo, BS, Pablo G Longo, MD, Brendan Doe, BS, Dimitar G Efremov, MD, PhD

Blood (2011) 118 (21): 2830.

https://doi.org/10.1182/blood.V118.21.2830.2830

Published: 2011

Journal Articles

Overexpression of the Autoimmunity-Associated Tyrosine Phosphatase PTPN22 in CLL Cells Enhances Antiapoptotic B-Cell Receptor Signals Through Selective Activation of the AKT Pathway

Roberto Negro, PhD, Stefania Gobessi, PhD, Pablo G Longo, MD, Luca Laurenti, Dimitar G Efremov, MD, PhD

Blood (2011) 118 (21): 619.

https://doi.org/10.1182/blood.V118.21.619.619

Published: 2011

Journal Articles

Overexpression of the Protein Tyrosine Phosphatase Lyp Reduces the Responsiveness of Chronic Lymphocytic Leukemia B-Cells to B-Cell Receptor Ligation.

Roberto Negro, PhD, Pablo G Longo, MD, Michela Tarnani, MD, Stefania Gobessi, PhD, Luca Laurenti, MD, Dimitar G Efremov, MD, PhD

Blood (2009) 114 (22): 800.

https://doi.org/10.1182/blood.V114.22.800.800

Published: 2009

Journal Articles

Chronic Lymphocytic Leukemia Subset Expressing Mutated IGHV3-23 Has Peculiar Clinical and Biological Features.

Blood (2009) 114 (22): 1256.

https://doi.org/10.1182/blood.V114.22.1256.1256

Published: 2009

Journal Articles

The Syk Inhibitor R788 (FosD) Inhibits Tumor Growth in the TCL1 Transgenic Mouse Model of CLL by Blocking Antigen-Dependent BCR Signaling.

Mirza Suljagic, DVM, PhD, Pablo G Longo, MD, Luca Laurenti, MD, Dimitar G Efremov, MD, PhD

Blood (2009) 114 (22): 887.

https://doi.org/10.1182/blood.V114.22.887.887

Published: 2009

Journal Articles

Chronic Lymphocytic Leukemia B-Cells Lack or Express Markedly Reduced Levels of the Phosphatase PHLPP, Which Regulates B-Cell Receptor Induced AKT Activation.

Mirza Suljagic, DVM, PhD, Luca Laurenti, MD, Muhammad Alam, MD, Pablo G Longo, MD, Sami N Malek, MD, Dimitar G Efremov, MD, PhD

Blood (2008) 112 (11): 2080.

https://doi.org/10.1182/blood.V112.11.2080.2080

Published: 2008

Journal Articles

Molecular Requirements for Syk-Mediated Intracellular Signaling and B-Cell Transformation

Laura Carsetti, BS, Luca Laurenti, MD, Stefania Gobessi, PhD, Pablo G Longo, MD, Giuseppe Leone, MD, Dimitar G Efremov, MD, PhD

Blood (2008) 112 (11): 2837.

https://doi.org/10.1182/blood.V112.11.2837.2837

Published: 2008

NARROW

A CRISPR/Cas9-Generated Murine Model Reveals Cooperation between BCR Signaling and CDKN2A/2B and TP53 Disruption in Richter Syndrome

Serum IgM/Fcmr Interactions Inhibit BCR Signaling and Influence the Cinical Course of CLL

SHP1 Deficiency Is Responsible for the Constitutive Activation of the BCR Pathway in GCB DLBCL

Hyper-Activation of the Adenosinergic Axis in the Eμ-TCL1 Chronic Lymphocytic Leukemia Mouse Model Offers Therapeutic Opportunities

Chlorambucil PLUS Rituximab As FRONT-LINE Therapy for Elderly and/or Unfit CLL Patients. LONG-TERM Follow-up and Correlation with Biologic-Based Risk Stratification

The Bcl-2 BH4 Antagonist Bda-366 Induces Apoptosis in CLL and DLBCL Cells through a Bcl-2 Independent Mechanism

FcμR Triggering Activates BCR Signaling Pathways and Increases Survival of CLL Cells

Serum IgM Activates BCR Signaling Pathways and Increases Survival of Chronic Lymphocytic Leukemia B Cells

Inhibition of SYK More Effectively Overcomes MCL-1 Mediated ABT-199 Resistance of BCR-Stimulated CLL Cells Than Inhibition of BTK or PI3Kdelta

Inhibitors Of B-Cell Receptor Molecules Affect Surface CD20 and Impair Antitumor Activity Of Anti-CD20 Monoclonal Antibodies

Chlorambucil PLUS Rituximab As FRONT-LINE THERAPY in Elderly or Unfit Patients Affected by B-CELL Chronic Lymphocytic Leukemia: Results of A Single-Centre Retrospective Analysis

The Nature of the Antigen Determines Leukemia Development and Behavior in the Eμ-TCL1 Transgenic Mouse Model of CLL

Expression of ZAP-70 Does Not Accelerate Leukemia Development and Progression in the Eμ-TCL1 Transgenic Mouse Model of Chronic Lymphocytic Leukemia

Development of a Transgenic Mouse Model to Study the Role of ZAP-70 in the Development and Progression of Chronic Lymphocytic Leukemia

Overexpression of the Autoimmunity-Associated Tyrosine Phosphatase PTPN22 in CLL Cells Enhances Antiapoptotic B-Cell Receptor Signals Through Selective Activation of the AKT Pathway

Overexpression of the Protein Tyrosine Phosphatase Lyp Reduces the Responsiveness of Chronic Lymphocytic Leukemia B-Cells to B-Cell Receptor Ligation.

Chronic Lymphocytic Leukemia Subset Expressing Mutated IGHV3-23 Has Peculiar Clinical and Biological Features.

The Syk Inhibitor R788 (FosD) Inhibits Tumor Growth in the TCL1 Transgenic Mouse Model of CLL by Blocking Antigen-Dependent BCR Signaling.

Chronic Lymphocytic Leukemia B-Cells Lack or Express Markedly Reduced Levels of the Phosphatase PHLPP, Which Regulates B-Cell Receptor Induced AKT Activation.

Molecular Requirements for Syk-Mediated Intracellular Signaling and B-Cell Transformation

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American Society of Hematology

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American Society of Hematology

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