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David M Markusic
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Journal Articles

Combination Therapy to Enable AAV Re-Dosing and Mitigate Transgene Immunity in Liver-Targeted Gene Therapy

Jyoti Rana, Sandeep RP Kumar, Maite Munoz, Kentaro Yamada, Thais Bertollini, David M Markusic, Manuela Corti, Barry J Byrne, Roland W Herzog, Moanaro Biswas
Journal: Blood
Blood (2022) 140 (Supplement 1): 311–312.
https://doi.org/10.1182/blood-2022-169848
Published: 2022
Journal Articles

Update on clinical gene therapy for hemophilia

Clinical Trials & Observations
George Q. Perrin, Roland W. Herzog, David M. Markusic
Journal: Blood
Blood (2019) 133 (5): 407–414.
https://doi.org/10.1182/blood-2018-07-820720
Published: 2019
Journal Articles

Defining the Risk of Suboptimal AAV8-F9 Vector Delivery in Inhibitor Positive Hemophilia B Mice

David M Markusic, PhD, Brett Palaschak, BA
Journal: Blood
Blood (2016) 128 (22): 3508.
https://doi.org/10.1182/blood.V128.22.3508.3508
Published: 2016
Journal Articles

Clotting Factor VIII Overexpression Shows Signs of ER Stress but Does Not Cause Toxicity upon Gene Transfer

Irene Zolotukhin, MS, Brett Palaschak, BA, David M Markusic, PhD, Roland Herzog, PhD
Journal: Blood
Blood (2015) 126 (23): 3238.
https://doi.org/10.1182/blood.V126.23.3238.3238
Published: 2015
Journal Articles

Synergy between rapamycin and FLT3 ligand enhances plasmacytoid dendritic cell–dependent induction of CD4 + CD25 + FoxP3 + Treg

Moanaro Biswas, Debalina Sarkar, Sandeep R. P. Kumar, Sushrusha Nayak, Geoffrey L. Rogers, David M. Markusic, Gongxian Liao, Cox Terhorst, Roland W. Herzog
Journal: Blood
Blood (2015) 125 (19): 2937–2947.
https://doi.org/10.1182/blood-2014-09-599266
Published: 2015
Includes: Supplemental data
Journal Articles

Immune Response to FIX Is Dependent on Mouse Background Strain and Modulated By TLR4

David M Markusic, PhD
Journal: Blood
Blood (2014) 124 (21): 1479.
https://doi.org/10.1182/blood.V124.21.1479.1479
Published: 2014
Journal Articles

A David promoter with Goliath strength

David M. Markusic, Roland W. Herzog
Journal: Blood
Blood (2014) 123 (20): 3068–3069.
https://doi.org/10.1182/blood-2014-04-565507
Published: 2014
Journal Articles

Engineered AAV vector minimizes in vivo targeting of transduced hepatocytes by capsid-specific CD8 + T cells

Ashley T. Martino, Etiena Basner-Tschakarjan, David M. Markusic, Jonathan D. Finn, Christian Hinderer, Shangzhen Zhou, David A. Ostrov, Arun Srivastava, Hildegund C. J. Ertl, Cox Terhorst, Katherine A. High, Federico Mingozzi, Roland W. Herzog
Journal: Blood
Blood (2013) 121 (12): 2224–2233.
https://doi.org/10.1182/blood-2012-10-460733
Published: 2013
Includes: Supplemental data
Journal Articles

In Vivo Model to Evaluate Loss of Liver-Derived Factor IX Expression Caused by AAV Capsid-Specific CD8+ T Cells

David M Markusic, PhD, Ashley T Martino, Ph.D., Federico Mingozzi, PhD., Katherine A. High, MD, Roland W Herzog, PhD
Journal: Blood
Blood (2012) 120 (21): 2046.
https://doi.org/10.1182/blood.V120.21.2046.2046
Published: 2012
Journal Articles

Suppression of Inhibitor Formation in Protein and Gene Therapy for Hemophilia Using Ex Vivo Expanded Treg

Debalina Sarkar, PhD, David M Markusic, PhD, Cox Terhorst, PhD, Todd Brusko, PhD, Roland W Herzog, PhD
Journal: Blood
Blood (2012) 120 (21): 13.
https://doi.org/10.1182/blood.V120.21.13.13
Published: 2012
Journal Articles

The genome of self-complementary adeno-associated viral vectors increases Toll-like receptor 9–dependent innate immune responses in the liver

Ashley T. Martino, Masataka Suzuki, David M. Markusic, Irene Zolotukhin, Renee C. Ryals, Babak Moghimi, Hildegund C. J. Ertl, Daniel A. Muruve, Brendan Lee, Roland W. Herzog
Journal: Blood
Blood (2011) 117 (24): 6459–6468.
https://doi.org/10.1182/blood-2010-10-314518
Published: 2011
Includes: Supplemental data