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Journal Articles

IMPACT-TB: A Phase II Trial Assessing the Capacity of Low Dose Imatinib to Induce Myelopoiesis and Enhance Host Anti-Microbial Immunity Against Tuberculosis. Imatinib Mesylate per Oral As a Clinical Therapeutic for TB

Cynthia R. Giver, PhD, Pamela A Shaw, PhD, Helen Fletcher, PhD, Deepak Kaushal, PhD, Garcia Pamela, Deborah Omoyege, Gregory Bisson, MD, Tawanda Gumbo, MD, Robert Wallis, MD, Edmund K. Waller, PhDMD, Daniel Kalman, PhD

Blood (2019) 134 (Supplement_1): 1050.

https://doi.org/10.1182/blood-2019-130275

Published: 2019

Journal Articles

Transplanted Vasoactive Intestinal Peptide-Secreting Donor Plasmacytoid Dendritic Cells Migrate to Lymphoid Organs and GvHD Target Organs

Jingru Zhu, Yitong Wang, MD, Jingxia Li, MD, Yiwen Li, Alina Ulezko Antonova, Cynthia R. Giver, PhD, Jianming Li, PhD, Shuhua Wang, MD, Edmund K. Waller, PhDMD

Blood (2019) 134 (Supplement_1): 1918.

https://doi.org/10.1182/blood-2019-129628

Published: 2019

Journal Articles

Day 100 Levels of Blood Immune Cells Are Prognostic Biomarkers for Allogeneic Hematopoietic Stem Cell Transplant Outcomes: Results from BMT CTN 0201

Shanelle M. Fernando, Brent R. Logan, PhD, Mingwei Fei, MS, Stephanie J. Lee, MD PhD, Dennis Confer, MD, Alan Howard, PhD, Shanmuganathan Chandrakasan, MD, Cynthia R. Giver, PhD, Claudio Anasetti, MD, Edmund K. Waller, MD

Blood (2017) 130 (Supplement 1): 516.

https://doi.org/10.1182/blood.V130.Suppl_1.516.516

Published: 2017

Journal Articles

Hierarchical Differences in Defensin Gene Expression in Plasmacytoid Dendritic Cells and Progenitor Cells from Five Different Hematopoietic Stem Cell Transplant Graft Types

Cynthia R. Giver, PhD, Ernestine Anna Mahar, B.S., Sakura Hosoba, MD, Jeanne Kowalski, PhD, Sandra Seby, MSc, Xinyan A. Zhang, PhD MPH, Steven M. Devine, MD, Edmund K. Waller, MD

Blood (2017) 130 (Supplement 1): 1924.

https://doi.org/10.1182/blood.V130.Suppl_1.1924.1924

Published: 2017

Journal Articles

Efficacy of Early Post-Transplant Vaccination Using a Prime and Boost Strategy Is Independent of a Prior History of GvHD: Results from BMT CTN 0201

Edmund K. Waller, MD, Brent R. Logan, PhD, Mingwei Fei, MS, Alan Howard, PhD, John R. Wingard, MD, Claudio Anasetti, MD, Cynthia R. Giver, PhD

Blood (2017) 130 (Supplement 1): 1972.

https://doi.org/10.1182/blood.V130.Suppl_1.1972.1972

Published: 2017

Journal Articles

T Cell Activation By Plasmacytoid Dendritic Cells Is Augmented By Inhibition of Vasoactive Intestinal Polypeptide Signaling: Implications for Cellular Immunotherapy

Jingxia Li, Reema Panjwani, Jian-Ming Li, PhD, Cynthia R. Giver, PhD, Maryellen Malone, Edmund K Waller, MD PhD

Blood (2015) 126 (23): 3438.

https://doi.org/10.1182/blood.V126.23.3438.3438

Published: 2015

Journal Articles

Lateral Gene Transfer Contributing to Leukemogenesis

Joo Hyun Lee, BS, Cynthia R. Giver, PhD, Sravanti Rangaraju, MD MBBS, Edmund K Waller, MD PhD

Blood (2015) 126 (23): 1235.

https://doi.org/10.1182/blood.V126.23.1235.1235

Published: 2015

Journal Articles

Blocking VIP Signaling during Allogeneic Bone Marrow Transplantation Separates the Graft Versus Leukemia from Graft Versus Host Disease Activity of Donor CD8 T-Cells

Jian-Ming Li, PhD, Christopher T Petersen, Graduate, Jingxia Li, Graduate, Cynthia R. Giver, PhD, Bruce R. Blazar, MD, Edmund K Waller, MD PhD

Blood (2015) 126 (23): 1877.

https://doi.org/10.1182/blood.V126.23.1877.1877

Published: 2015

Journal Articles

Dose and Time-Dependent Association of Red Blood Cell Transfusion with Increased Risk of GvHD and Worse Survival after Allogeneic HSCT

Sakura Hosoba, MD, Edmund K. Waller, MD PhD, Sheilagh Barclay, MT(ASCP), Kirk A Easley, MS, Neeta Shenvi, MS, John Roback, MD PhD, James C. Zimring, MD PhD, Cynthia R. Giver, PhD

Blood (2014) 124 (21): 1555.

https://doi.org/10.1182/blood.V124.21.1555.1555

Published: 2014

Journal Articles

Administration of a Tryptophan Metabolite, Indole-3-Carboxaldehyde, Reduces Graft Versus Host Disease Morbidity and Mortality and Enhances Gastrointestinal Barrier Function in a Murine Model of Allogeneic Bone Marrow Transplantation

Edmund K. Waller, MD PhD, Cynthia R. Giver, PhD, Sravanti Rangaraju, MBBS, Alyson Swimm, BS, Akshay Sharma, MD, Muna Qayed, MD, Zachariah Defilipp, MD, Daniel Kalman, PhD

Blood (2014) 124 (21): 2420.

https://doi.org/10.1182/blood.V124.21.2420.2420

Published: 2014

Journal Articles

Defining the Primate T Cell Transcriptome during Graft Versus Host Disease: New Data Implicating the Hedgehog and Aurora Kinase Pathways in Pathogenesis and Prevention

Scott N. Furlan, MD, Benjamin Watkins, MD, Ryan P Flynn, Swetha Ramakrishnan, Karnail Singh, PhD, Cynthia R. Giver, PhD, Kelly Hanby, Linda Stempora, Aneesah P. Garrett, Carly GK Ziegler, Gregory Tharp, Steven Bosinger, Bruce R. Blazar, MD, Edmund K. Waller, MD PhD, Leslie S. Kean, MD PhD

Blood (2014) 124 (21): 2432.

https://doi.org/10.1182/blood.V124.21.2432.2432

Published: 2014

Journal Articles

Pharmacological Inhibition Of Semi-Direct Alloantigen Presentation and The Generation Of Cross-Dressed Antigen Presenting Cells: A Novel approach To Limit Graft Versus Host Disease Following Allogeneic Hematopoetic Stem Cell Transplantation

Sravanti Rangaraju, MBBS, Junghwa Choi, Cynthia R. Giver, PhD, Edmund K. Waller, MD, PhD

Blood (2013) 122 (21): 294.

https://doi.org/10.1182/blood.V122.21.294.294

Published: 2013

Journal Articles

Blocking VIP Signaling Abrogates Upregulation Of PD1 and Increases Proliferation Of Allo-Reactive T-Cells In a Mixed Lymphocyte Reaction

Emily R Summerbell, Cynthia R. Giver, PhD, Sravanti Rangaraju, MBBS, Katarzyna Anna Darlak, Graduate, Edmund K. Waller, MD, PhD

Blood (2013) 122 (21): 1041.

https://doi.org/10.1182/blood.V122.21.1041.1041

Published: 2013

Journal Articles

Allogeneic HSCT Patients Receiving More RBC Transfusions Are At Increased Risk For Development Of Grade 2-4 Acute Graft-Versus-Host Disease

Cynthia R. Giver, PhD, Zahir Ali, Sheilagh Barclay, Sakura Hosaba, MD, Qunna Li, John Roback, MD, PhD, Edmund K. Waller, MD, PhD

Blood (2013) 122 (21): 3298.

https://doi.org/10.1182/blood.V122.21.3298.3298

Published: 2013

Journal Articles

Synergistic Control of Acute GvHD: Effectively Down-Regulating T Cell Proliferation and Cytotoxicity with Combined mTOR Inhibition and CD28:CD80/86 Costimulation Blockade.

Natalia Kozyr, Ph.D., Swetha Ramakrishnan, Aneesah Polnett, Kelly Hamby, Divya Tiwari, MD, Taylor Deane, Linda Stempora, Joe Jenkins, Elizabeth Strobert, Anapatricia Garcia, DVM, PhD, Prachi Sharma, Cynthia Courtney, Angela Panoskaltsis-Mortari, Cynthia R. Giver, PhD, Edmund K. Waller, MD, PhD, Bruce R. Blazar, MD, Leslie S. Kean, MD, PhD

Blood (2012) 120 (21): 2998.

https://doi.org/10.1182/blood.V120.21.2998.2998

Published: 2012

Journal Articles

Lack of Host Bone Marrow-Derived Interleukin-12 Increased the Incidence of Allograft Rejection in Allogeneic Bone Marrow Transplantation

Ying Wang, MD, Jian-Ming Li, PhD, Wayne A.C. Harris, Cynthia R. Giver, PhD, Edmund K Waller, MD PhD

Blood (2011) 118 (21): 2960.

https://doi.org/10.1182/blood.V118.21.2960.2960

Published: 2011

Journal Articles

Blocking Vasoactive Intestinal Peptide Signaling Enhances Anti-Viral Immunity without Increased Graft Versus Host Disease in Murine Allogeneic Bone Marrow Transplantation

Jian-Ming Li, Ph.D, Ying Wang, MD, Katarzyna Darlak, Graduate, Lauren T Southerland, MD, Mohammad S Hossain, Ph.D, Cynthia R. Giver, PhD, James A. Waschek, Edmund K Waller, MD PhD

Blood (2011) 118 (21): 1002.

https://doi.org/10.1182/blood.V118.21.1002.1002

Published: 2011

Journal Articles

Thrombocytopenia Induced by Combination Administration of Romidepsin and Bortezomib In Mice Is Rapidly Reversible After Drug Treatment

Cynthia R. Giver, PhD, Darrell Nix, PhD, David L Jaye, MD, Edmund K Waller, Sagar Lonial, MD

Blood (2010) 116 (21): 4909.

https://doi.org/10.1182/blood.V116.21.4909.4909

Published: 2010

Journal Articles

Higher Numbers of Circulating Dendritic Cells and T-Cells Predict Response to Extracorporeal Photopheresis in Patients with Chronic Graft-Versus-Host Disease

Cynthia R. Giver, PhD, Mojtaba Akhtari, MD, Amelia A. Langston, MD, H. Jean Khoury, MD, Christopher R. Flowers, MD, Jonathan L. Kaufman, MD, Sagar Lonial, MD, Mary J. Lechowicz, MD, Charise L. Gleason, NP, M. Louette Vaughn, RN, Edmund K. Waller, MD, PhD

Blood (2008) 112 (11): 1183.

https://doi.org/10.1182/blood.V112.11.1183.1183

Published: 2008

Journal Articles

Short-Term Ionomycin Exposure Activates Naive Murine T-Cells and Induces a Rapid Phenotypic Shift to Memory T-Cell Status: Potential for Use as a Method To Reduce GvHD Activity of Allogeneic T-Cells.

Mohammad Hossain, PhD, Cynthia R. Giver, PhD, Ned Waller, MD, PhD

Blood (2007) 110 (11): 2182.

https://doi.org/10.1182/blood.V110.11.2182.2182

Published: 2007

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IMPACT-TB: A Phase II Trial Assessing the Capacity of Low Dose Imatinib to Induce Myelopoiesis and Enhance Host Anti-Microbial Immunity Against Tuberculosis. Imatinib Mesylate per Oral As a Clinical Therapeutic for TB

Transplanted Vasoactive Intestinal Peptide-Secreting Donor Plasmacytoid Dendritic Cells Migrate to Lymphoid Organs and GvHD Target Organs

Day 100 Levels of Blood Immune Cells Are Prognostic Biomarkers for Allogeneic Hematopoietic Stem Cell Transplant Outcomes: Results from BMT CTN 0201

Hierarchical Differences in Defensin Gene Expression in Plasmacytoid Dendritic Cells and Progenitor Cells from Five Different Hematopoietic Stem Cell Transplant Graft Types

Efficacy of Early Post-Transplant Vaccination Using a Prime and Boost Strategy Is Independent of a Prior History of GvHD: Results from BMT CTN 0201

T Cell Activation By Plasmacytoid Dendritic Cells Is Augmented By Inhibition of Vasoactive Intestinal Polypeptide Signaling: Implications for Cellular Immunotherapy

Lateral Gene Transfer Contributing to Leukemogenesis

Blocking VIP Signaling during Allogeneic Bone Marrow Transplantation Separates the Graft Versus Leukemia from Graft Versus Host Disease Activity of Donor CD8 T-Cells

Dose and Time-Dependent Association of Red Blood Cell Transfusion with Increased Risk of GvHD and Worse Survival after Allogeneic HSCT

Administration of a Tryptophan Metabolite, Indole-3-Carboxaldehyde, Reduces Graft Versus Host Disease Morbidity and Mortality and Enhances Gastrointestinal Barrier Function in a Murine Model of Allogeneic Bone Marrow Transplantation

Defining the Primate T Cell Transcriptome during Graft Versus Host Disease: New Data Implicating the Hedgehog and Aurora Kinase Pathways in Pathogenesis and Prevention

Pharmacological Inhibition Of Semi-Direct Alloantigen Presentation and The Generation Of Cross-Dressed Antigen Presenting Cells: A Novel approach To Limit Graft Versus Host Disease Following Allogeneic Hematopoetic Stem Cell Transplantation

Blocking VIP Signaling Abrogates Upregulation Of PD1 and Increases Proliferation Of Allo-Reactive T-Cells In a Mixed Lymphocyte Reaction

Allogeneic HSCT Patients Receiving More RBC Transfusions Are At Increased Risk For Development Of Grade 2-4 Acute Graft-Versus-Host Disease

Synergistic Control of Acute GvHD: Effectively Down-Regulating T Cell Proliferation and Cytotoxicity with Combined mTOR Inhibition and CD28:CD80/86 Costimulation Blockade.

Lack of Host Bone Marrow-Derived Interleukin-12 Increased the Incidence of Allograft Rejection in Allogeneic Bone Marrow Transplantation

Blocking Vasoactive Intestinal Peptide Signaling Enhances Anti-Viral Immunity without Increased Graft Versus Host Disease in Murine Allogeneic Bone Marrow Transplantation

Thrombocytopenia Induced by Combination Administration of Romidepsin and Bortezomib In Mice Is Rapidly Reversible After Drug Treatment

Higher Numbers of Circulating Dendritic Cells and T-Cells Predict Response to Extracorporeal Photopheresis in Patients with Chronic Graft-Versus-Host Disease

Short-Term Ionomycin Exposure Activates Naive Murine T-Cells and Induces a Rapid Phenotypic Shift to Memory T-Cell Status: Potential for Use as a Method To Reduce GvHD Activity of Allogeneic T-Cells.

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