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Journal Articles

Preventing Primate GvHD Using a Novel Antagonistic Anti-CD28 Antibody Plus Rapamycin: Downregulation of CD8 Activation and Preservation of the Naïve Cell Phenotype Predicts GvHD-Free Survival

Benjamin Watkins, MD, Aneesah P. Garrett, Jingyang Chen, Scott N. Furlan, MD, Kelly Hamby, Bernard Vanhove, PhD, Leslie S. Kean, MD PhD

Blood (2014) 124 (21): 2425.

https://doi.org/10.1182/blood.V124.21.2425.2425

Published: 2014

Journal Articles

Synergistic Control of Acute GvHD: Effectively Down-Regulating T Cell Proliferation and Cytotoxicity with Combined mTOR Inhibition and CD28:CD80/86 Costimulation Blockade.

Natalia Kozyr, Ph.D., Swetha Ramakrishnan, Aneesah Polnett, Kelly Hamby, Divya Tiwari, MD, Taylor Deane, Linda Stempora, Joe Jenkins, Elizabeth Strobert, Anapatricia Garcia, DVM, PhD, Prachi Sharma, Cynthia Courtney, Angela Panoskaltsis-Mortari, Cynthia R. Giver, PhD, Edmund K. Waller, MD, PhD, Bruce R. Blazar, MD, Leslie S. Kean, MD, PhD

Blood (2012) 120 (21): 2998.

https://doi.org/10.1182/blood.V120.21.2998.2998

Published: 2012

Journal Articles

Defining the Primate GvHD Transcriptome: Network Analysis Identifies the Key Pathways Responsible for GvHD Pathogenesis and the Mechanisms of Partial GvHD Control with Sirolimus

Natalia Kozyr, Ph.D., Carly GK Ziegler, Swetha Ramakrishnan, Aneesah Polnett, Kelly Hamby, Taylor Deane, Linda Stempora, Bruce R. Blazar, MD, Leslie S. Kean, MD, PhD

Blood (2012) 120 (21): 1888.

https://doi.org/10.1182/blood.V120.21.1888.1888

Published: 2012

Journal Articles

GVHD after haploidentical transplantation: a novel, MHC-defined rhesus macaque model identifies CD28 − CD8 + T cells as a reservoir of breakthrough T-cell proliferation during costimulation blockade and sirolimus-based immunosuppression

Blood (2010) 116 (24): 5403–5418.

https://doi.org/10.1182/blood-2010-06-289272

Published: 2010

Includes: Supplemental data

Journal Articles

Sirolimus and GvHD Control: the Rhesus Macaque GvHD Model Reveals That Sirolimus Preferentially Inhibits T Cell Proliferation While Permitting Breakthrough T cell Activation After MHC-Mismatched Hematopoietic Stem Cell Transplantation

Karnail Singh, Swetha Srinivasan, Angela Panoskaltsis-Mortari, PhD, Sharon Sen, Kelly Hamby, Taylor Deane, Linda Stempora, Frank Leopardi, John Shires, Jonathan Beus, Benjamin Byrd, Bruce R. Blazar, MD, Leslie Kean, MD, PhD

Blood (2010) 116 (21): 2549.

https://doi.org/10.1182/blood.V116.21.2549.2549

Published: 2010

Journal Articles

GvHD After Haploidentical Transplant: A Novel, MHC-Defined Rhesus Macaque Model Identifies CD28-Negative CD8+ T Cells as a Reservoir of Breakthrough T Cell Proliferation During Costimulation Blockade and Sirolimus-Based Immunosuppression

Swetha Srinivasan, Weston P. Miller IV, MD, Angela Panoskalltsis-Mortari, Sharon Sen, Kelly Hamby, Taylor Deane, Linda Stempora, Karnail Singh, Jonathan Beus, Bruce R. Blazar, MD, Leslie Kean, MD, PhD

Blood (2010) 116 (21): 2550.

https://doi.org/10.1182/blood.V116.21.2550.2550

Published: 2010

Journal Articles

Identification of a Costimulation Blockade Resistant Mechanism of Bone Marrow Allograft Rejection Induced by Infection with a Murine EBV Homologue.

Jonathan Beus, Kelly Hamby, Allan D Kirk, MD, PhD, Christian P Larsen, MD, DPhil, Samuel H Speck, PhD, Leslie Kean, MD, PhD

Blood (2010) 116 (21): 1461.

https://doi.org/10.1182/blood.V116.21.1461.1461

Published: 2010

Journal Articles

Berkeley Sickle Cell Disease Mice Exhibit Multifaceted Immune Hyper-Activation, and Avidly Reject Allogeneic Bone Marrow Transplantation.

Leslie S. Kean, MD, PhD, Kelly Hamby, Jennifer Perry, David R. Archer, PhD

Blood (2007) 110 (11): 2251.

https://doi.org/10.1182/blood.V110.11.2251.2251

Published: 2007

Journal Articles

MHC-Matched Stem Cell Transplantation in Rhesus Macaques Using a Costimulation Blockade-Based Immunomodulation Platform.

Leslie S. Kean, MD, PhD, Kelly Hamby, Taylor Deane, Thomas C. Pearson, MD/PhD, Christian P. Larsen, MD/Phd

Blood (2007) 110 (11): 1189.

https://doi.org/10.1182/blood.V110.11.1189.1189

Published: 2007

Journal Articles

Berkeley Sickle Mice Demonstrate CD8- and NK1.1-Dependent Increased Rejection of Allogeneic Hematopoietic Stem Cell Transplants.

Leslie Kean, MD, PhD, Kelly Hamby, Jennifer Perry, Christian Larsen, MD/PhD, David Archerq, PhD

Blood (2005) 106 (11): 2332.

https://doi.org/10.1182/blood.V106.11.2332.2332

Published: 2005

Journal Articles

NK Cells Efficiently Prevent Engraftment of Donor Stem Cells after Tolerigenic Bone Marrow Transplantation.

Leslie Kean, MD, PhD, Kelly Hamby, Thomas Pearson, MD/PhD, Christian Larsen, MD/PhD

Blood (2005) 106 (11): 3025.

https://doi.org/10.1182/blood.V106.11.3025.3025

Published: 2005

NARROW

Preventing Primate GvHD Using a Novel Antagonistic Anti-CD28 Antibody Plus Rapamycin: Downregulation of CD8 Activation and Preservation of the Naïve Cell Phenotype Predicts GvHD-Free Survival

Synergistic Control of Acute GvHD: Effectively Down-Regulating T Cell Proliferation and Cytotoxicity with Combined mTOR Inhibition and CD28:CD80/86 Costimulation Blockade.

Defining the Primate GvHD Transcriptome: Network Analysis Identifies the Key Pathways Responsible for GvHD Pathogenesis and the Mechanisms of Partial GvHD Control with Sirolimus

GVHD after haploidentical transplantation: a novel, MHC-defined rhesus macaque model identifies CD28 − CD8 + T cells as a reservoir of breakthrough T-cell proliferation during costimulation blockade and sirolimus-based immunosuppression

Sirolimus and GvHD Control: the Rhesus Macaque GvHD Model Reveals That Sirolimus Preferentially Inhibits T Cell Proliferation While Permitting Breakthrough T cell Activation After MHC-Mismatched Hematopoietic Stem Cell Transplantation

GvHD After Haploidentical Transplant: A Novel, MHC-Defined Rhesus Macaque Model Identifies CD28-Negative CD8+ T Cells as a Reservoir of Breakthrough T Cell Proliferation During Costimulation Blockade and Sirolimus-Based Immunosuppression

Identification of a Costimulation Blockade Resistant Mechanism of Bone Marrow Allograft Rejection Induced by Infection with a Murine EBV Homologue.

Berkeley Sickle Cell Disease Mice Exhibit Multifaceted Immune Hyper-Activation, and Avidly Reject Allogeneic Bone Marrow Transplantation.

MHC-Matched Stem Cell Transplantation in Rhesus Macaques Using a Costimulation Blockade-Based Immunomodulation Platform.

Berkeley Sickle Mice Demonstrate CD8- and NK1.1-Dependent Increased Rejection of Allogeneic Hematopoietic Stem Cell Transplants.

NK Cells Efficiently Prevent Engraftment of Donor Stem Cells after Tolerigenic Bone Marrow Transplantation.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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