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Journal Articles

AK002, a Novel Humanized Monoclonal Antibody to Siglec-8, Inhibits Mast Cell Activity and Depletes Eosinophils in Ex Vivo Bone Marrow Tissue from Patients with Systemic Mastocytosis

Bradford A Youngblood, PhD, Emily C Brock, John Leung, Alan T Chang, Christopher Bebbington, PhD, Nenad Tomasevic, PhD

Blood (2018) 132 (Supplement 1): 1104.

https://doi.org/10.1182/blood-2018-99-119232

Published: 2018

Journal Articles

A Recombinant Antibody to Siglec-8 Shows Selective ADCC Activity Against Mast Cells from Systemic Mastocytosis Patients

Rustom Falahati, PhD, Jessica Bright, Alejandro Dorenbaum, MD, Christopher Bebbington, PhD, Nenad Tomasevic, PhD, Diane Lidke, PhD, Tracy I. George, MD, Jason Gotlib, MD

Blood (2015) 126 (23): 4092.

https://doi.org/10.1182/blood.V126.23.4092.4092

Published: 2015

Journal Articles

GM-CSF–dependent pSTAT5 sensitivity is a feature with therapeutic potential in chronic myelomonocytic leukemia

Eric Padron, Jeffrey S. Painter, Sateesh Kunigal, Adam W. Mailloux, Kathy McGraw, Jessica M. McDaniel, Eunhee Kim, Christopher Bebbington, Mark Baer, Geoffrey Yarranton, Jeffrey Lancet, Rami S. Komrokji, Omar Abdel-Wahab, Alan F. List, Pearlie K. Epling-Burnette

Blood (2013) 121 (25): 5068–5077.

https://doi.org/10.1182/blood-2012-10-460170

Published: 2013

Includes: Supplemental data

Journal Articles

Preclinical Characterization of KB003, a Novel Humaneered™ Monoclonal Anti-GM-CSF Antibody, Demonstrates That the GM-CSF Signaling Axis Is a Therapeutic Target in Chronic Myelomonocytic Leukemia (CMML)

Eric Padron, MD, Jeffrey S Painter, BS, Adam W Mailloux, PhD, Kathy L. McGraw, Jessica M. McDaniel, BS, Christopher Bebbington, DPhil., Mark Baer, PhD, Geoffrey Yarranton, PhD, Jeffrey E Lancet, MD, Rami S. Komrokji, MD, Alan F. List, MD, P.K. Epling-Burnette, PharmD, PhD

Blood (2012) 120 (21): 3793.

https://doi.org/10.1182/blood.V120.21.3793.3793

Published: 2012

Journal Articles

A Recombinant Antibody to EphA3 for the Treatment of Hematologic Malignancies: Research Update and Interim Phase 1 Study Results

Anne Hagey, M.D., Jeffrey E. Lancet, MD, Varghese Palath, PhD, Andrew H Wei, MBBS, PhD, Martin Lackmann, PhD, Jorge E. Cortes, Andrew Boyd, MD, PhD, Dan Shochat, PhD, Geoffrey Yarranton, PhD, Christopher Bebbington, DPhil., Jonathan A. Leff, MD

Blood (2011) 118 (21): 4893.

https://doi.org/10.1182/blood.V118.21.4893.4893

Published: 2011

Journal Articles

GM-CSF Signaling Abnormalities in Chronic Myelomonocytic Leukemia

Eric Padron, MD, Jeffrey S. Painter, B.S., Adam W Mailloux, PhD, Jessica M. McDaniel, BS, Christopher Bebbington, DPhil., Mark Baer, PhD, Rami S. Komrokji, MD, Alan F. List, MD, Pearlie K Epling-Burnette, Pharm D, PhD

Blood (2011) 118 (21): 1713.

https://doi.org/10.1182/blood.V118.21.1713.1713

Published: 2011

Journal Articles

A Recombinant Antibody to EphA3 with Pro-Apoptotic and Enhanced ADCC Activity Against Various Hematologic Malignancies Shows Selective Inhibition of Colony Formation From Long-Term Culture-Initiating Cells (LTC-ICs) In Primary Leukemia Samples

Varghese Palath, PhD, Rohini Vekhande, Mark Baer, PhD, Wendy Ching, PhD, Nenad Tomasevic, PhD, David Martinez, Christina Yi, Swathi Bhaskar, Kenneth Luehrsen, Jason Williams, John Leung, Alan F. List, MD, Ling Zhang, MD, Martin Lackmann, PhD, Andrew Boyd, MD, PhD, Andrew Scott, PhD, Daniela Cilloni, MD, PhD, Geoffrey Yarranton, PhD, Christopher Bebbington, DPhil.

Blood (2010) 116 (21): 2897.

https://doi.org/10.1182/blood.V116.21.2897.2897

Published: 2010

Journal Articles

A Recombinant Human Antibody to EphA3 with Pro-Apoptotic and Enhanced ADCC Activity Shows Selective Cytotoxicity against Myeloid Leukemia Cells and CD123-Positive Leukemic Stem Cells.

Varghese Palath, PhD, Rohini Vekhande, Andreia Lee, Jason Williams, Ling Zhang, MD, Alan F List, MD, Andrew Boyd, MD, PhD, Martin Lackmann, PhD, Andrew M Scott, PhD, Daniela Cilloni, MD, PhD, Geoffrey T. Yarranton, PhD, Christopher Bebbington, DPhil

Blood (2009) 114 (22): 1728.

https://doi.org/10.1182/blood.V114.22.1728.1728

Published: 2009

NARROW

AK002, a Novel Humanized Monoclonal Antibody to Siglec-8, Inhibits Mast Cell Activity and Depletes Eosinophils in Ex Vivo Bone Marrow Tissue from Patients with Systemic Mastocytosis

A Recombinant Antibody to Siglec-8 Shows Selective ADCC Activity Against Mast Cells from Systemic Mastocytosis Patients

GM-CSF–dependent pSTAT5 sensitivity is a feature with therapeutic potential in chronic myelomonocytic leukemia

Preclinical Characterization of KB003, a Novel Humaneered™ Monoclonal Anti-GM-CSF Antibody, Demonstrates That the GM-CSF Signaling Axis Is a Therapeutic Target in Chronic Myelomonocytic Leukemia (CMML)

A Recombinant Antibody to EphA3 for the Treatment of Hematologic Malignancies: Research Update and Interim Phase 1 Study Results

GM-CSF Signaling Abnormalities in Chronic Myelomonocytic Leukemia

A Recombinant Antibody to EphA3 with Pro-Apoptotic and Enhanced ADCC Activity Against Various Hematologic Malignancies Shows Selective Inhibition of Colony Formation From Long-Term Culture-Initiating Cells (LTC-ICs) In Primary Leukemia Samples

A Recombinant Human Antibody to EphA3 with Pro-Apoptotic and Enhanced ADCC Activity Shows Selective Cytotoxicity against Myeloid Leukemia Cells and CD123-Positive Leukemic Stem Cells.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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