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Bin Zhang, PhD
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Journal Articles

Long-Term Safety and Efficacy of Orelabrutinib Monotherapy in Chinese Patients with Relapsed or Refractory Mantle Cell Lymphoma: A Multicenter, Open-Label, Phase II Study

Yuqin Song, MD PhD, Yongping Song, MD, Lihong Liu, MD, Mingzhi Zhang, MD, Zhiming Li, MD PhD, Chunyan Ji, MD, Wei Xu, MD PhD, Ting Liu, MD PhD, Bing Xu, MD PhD, Xin Wang, MDPhD, Sujun Gao, Huilai Zhang, MD PhD, Yu Hu, MD, Yan Li, Ying Cheng, Haiyan Yang, MD PhD, Junning Cao, Zunmin Zhu, MD, Jianda Hu, MDPhD, Wei Zhang, Hongmei Jing, MD PhD, Kaiyang Ding, Zhengguang Lu, Bin Zhang, PhD, Renbin Zhao, PhD, Zhixin Xu, MD PhD, Jun Zhu, BS
Journal: Blood
Blood (2020) 136 (Supplement 1): 1.
https://doi.org/10.1182/blood-2020-141781
Published: 2020
Journal Articles

Updated Results from the Phase II Study of Orelabrutinib Monotherapy in Chinese Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia/Small Cell Leukemia

Wei Xu, MD PhD, Yongping Song, MD, Tingyu Wang, Shenmiao Yang, Lihong Liu, MD, Yu Hu, MD, Wei Zhang, Jianfeng Zhou, MD PhD, Sujun Gao, Kaiyang Ding, Huilai Zhang, MD PhD, Zunmin Zhu, MD, Shun-Qing Wang, Bing Xu, MD PhD, Jianda Hu, Ting Liu, MD PhD, Chunyan Ji, MD, Zhongjun Xia, MDPhD, Yan Li, PhDMD, Xin Wang, MDPhD, Huaqiang Zhu, MD, Renbin Zhao, PhD, Bin Zhang, PhD, Zhixin Xu, MD PhD, Jianyong Li, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 26–27.
https://doi.org/10.1182/blood-2020-134531
Published: 2020
Journal Articles

Effective Novel Fto Inhibitors Show Potent Anti-Cancer Efficacy and Suppress Drug Resistance

Rui Su, PhD, Lei Dong, PhD, Yangchan Li, Li Han, Min Gao, Mark Wunderlich, MS, Xiaolan Deng, Hongzhi Li, PhD, Lei Gao, Chenying Li, MD, Sean Robison, Brandon Tan, Ying Qing, Xi Qin, Emily Prince, Jun Xie, Hanjun Qin, Yue Huang, Wei Li, Chao Shen, PhD, Jie Sun, PhD, Kulkarni Prakash, Hengyou Weng, PhD, Huilin Huang, PhD, Zhenhua Chen, PhD, Bin Zhang, PhD, Xiwei Wu, PhD, Mark J Olsen, Markus Müschen, MD PhD, Guido Marcucci, MD, Salgia Ravi, Ling Li, PhD, Caiguang Yang, Zejuan Li, MD, James C Mulloy, Minjie Wei, David A Horne, PhD, Jianjun Chen, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 233.
https://doi.org/10.1182/blood-2019-124535
Published: 2019
Journal Articles

Safety, Tolerability and Efficacy of Orelabrutinib, Once a Day, to Treat Chinese Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia/Small Cell Leukemia

Wei Xu, MD PhD, Yongping Song, Zengjun Li, Shenmiao Yang, Lihong Liu, Yu Hu, Wei Zhang, Jianfeng Zhou, Sujun Gao, PhD, Kaiyang Ding, Huilai Zhang, MD, Zunmin Zhu, MD, Shunqing Wang, Bing Xu, Jianda Hu, PhD, Ting Liu, MD, Chunyan Ji, Zhongjun Xia, MD, Yan Li, PhDMD, Xin Wang, MD PhD, Zhixin Xu, Renbin Zhao, Bin Zhang, PhD, Alan Zhu, Jianyong Li, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4319.
https://doi.org/10.1182/blood-2019-123331
Published: 2019
Journal Articles

Anti-MiR-126 Therapy for Inv(16) Acute Myeloid Leukemia

Lianjun Zhang, PhD, Le Xuan Truong Nguyen, PhD, Dijiong Wu, MD, Casey J Brewer, PhD, Xin He, PhD, Man Li, PhD, Dandan Zhao, MD, Guerry Jeanne Cook, PhD, Jing Qi, PhD, Herman Wu, BS, Bin Zhang, PhD, Ling Li, PhD, Marcin Kortylewski, PhD, Guido Marcucci, MD, Ya-Huei Kuo, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3914.
https://doi.org/10.1182/blood-2019-123468
Published: 2019
Journal Articles

Restore the Secretion and Activity of Factor VIII Mutants By Proteostasis Regulator

Wei Wei, MD PhD, Zhigang Liu, PhD, Bin Zhang, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1104.
https://doi.org/10.1182/blood-2019-129156
Published: 2019
Journal Articles

A 14q32.31 Genomic-Imprinted DLK1-DIO3 microrna promotes Leukemogenesis By Inducing Stem Cell Quiescence and Inhibiting NK Cell Anti-Cancer Immunity

Giovannino Silvestri, PhD, Rossana Trotta, PhD, Lorenzo Stramucci, PhD, Shuzhen Wang, PhD, Ann-Kathrin Eisfeld, MD, Bin Zhang, PhD, Klara Srutova, PhD, Gabriel Pineda, PhD, Catriona Jamieson, MD PhD, Fabio Stagno, MD, Paolo Vigneri, MD PhD, Georgios Nteliopoulos, PhD, Martin Guimond, PhD, Peter Hokland, MD DMSc, Michael W. Deininger, Francesco Dazzi, PhD, Dragana Milojkovic, MBBS, MD, Jane Apperley, MB, ChB, MD, Guido Marcucci, MD, Xiaoxuan Fan, PhD, Maria R. Baer, MD, Bruno Calabretta, MD PhD, Danilo Perrotti, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4141.
https://doi.org/10.1182/blood-2019-131113
Published: 2019
Journal Articles

Spred1 Insufficiency in the Hematopoietic and/or Vascular Compartments of the Bone Marrow (BM) Niche Promotes Aggressive Leukemogenesis in Chronic Myelogenous Leukemia (CML)

Junjing Qiao, MD PhD, Dandan Zhao, MD, Le Xuan Truong Nguyen, PhD, Herman Wu, BS, Gang Liu, PhD, Shanshan Suo, MD, Huafeng Wang, Yasmin Elhajmoussa, Chen Liang, MD, David Snyder, MD, Haris Ali, MD, Steven Rosen, MD, Nadia Carlesso, MD, Ling Li, PhD, Ya-Huei Kuo, PhD, Guido Marcucci, MD, Bin Zhang, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3791.
https://doi.org/10.1182/blood-2019-127616
Published: 2019
Journal Articles

FLT3-ITD Activates Cytoplasmic Drosha-Dependent Non-Canonical Mechanisms of Mir-155 Biogenesis in Acute Myeloid Leukemia

Le Xuan Truong Nguyen, PhD, Bin Zhang, PhD, Dinh Hoa Hoang, BS, Dandan Zhao, MD, Sergio Branciamore, Davide Maestrini, PhD, Yu-Lin SU, PhD, Sonia Rodriguez, PhD, Flavia Pichiorri, PhD, Steven Rosen, MD, Michael A. Caligiuri, MD, Stephen J. Forman, MD, Ling Li, PhD, Marcin Kortylewski, PhD, Russell Rockne, PhD, Ya-Huei Kuo, PhD, Nadia Carlesso, MD, Guido Marcucci, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2722.
https://doi.org/10.1182/blood-2019-131871
Published: 2019
Journal Articles

Targeting MiR-126 Blocks Progression of Myelodysplastic Syndrome and Transformation into Acute Myeloid Leukemia

Huafeng Wang, MD, Jie Sun, PhD, Dandan Zhao, MD, Hongyan Tong, Herman Wu, BS, Xia Li, PhD, Yingwan Luo, MD, Dan Dong, PhD, Tinisha McDonald, MS, Anthony Stein, MD, Monzr M. Al Malki, MD, Flavia Pichiorri, PhD, Nadia Carlesso, MD, Ya-Huei Kuo, PhD, Bin Zhang, PhD, Guido Marcucci, MD, Ling Li, PhD, Jie Jin, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1707.
https://doi.org/10.1182/blood-2019-130375
Published: 2019
Journal Articles

Safety and Efficacy of Orelabrutinib Monotherapy in Chinese Patients with Relapsed or Refractory Mantle Cell Lymphoma: A Multicenter, Open-Label, Phase II Study

Yuqin Song, MD PhD, Yongping Song, MD, Lihong Liu, Mingzhi Zhang, Zhiming Li, Chunyan Ji, Wei Xu, MD PhD, Ting Liu, MD, Bing Xu, Xin Wang, MD PhD, Sujun Gao, Huilai Zhang, MD, Yu Hu, Yan Li, Ying Cheng, Haiyan Yang, Junning Cao, MD, Zunmin Zhu, Jianda Hu, PhD, Wei Zhang, Hongmei Jing, Kaiyang Ding, Zhengguang Lu, Bin Zhang, PhD, Renbin Zhao, Zhixin Xu, Jun Zhu, BS
Journal: Blood
Blood (2019) 134 (Supplement_1): 755.
https://doi.org/10.1182/blood-2019-126305
Published: 2019
Journal Articles

Association of Gene Expression Patterns in Bone Marrow Cells with Likelihood of Treatment Free Remission after TKI Discontinuation

Jianbo He, MD, Sahee Park, Soo Young Choi, David Crossman, Bin Zhang, PhD, Puneet Agarwal, PhD, Andrew Zhang, Su Chu, MD, Dong-Wook Kim, MD PhD, Ravi Bhatia, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1721.
https://doi.org/10.1182/blood-2018-99-114137
Published: 2018
Journal Articles

Antileukemic Activity of 8-Chloro-Adenosine (8-Cl-Ado) Is Mediated By Mir-155 Degradation and ErbB3 Binding Protein (Ebp1)-Dependent p53 Activation: A Novel Therapeutic Approach for FLT3-ITD Acute Myeloid Leukemia (AML)

Ralf Buettner, PhD, Le Xuan Truong Nguyen, PhD, Bijender Kumar, PhD, Corey James Morales, BA, BS, Chao Liu, PhD, Lisa S Chen, PhD, Tea Pemovska, PhD, Ryan Thompson, BS, Ling Li, PhD, Dinh Hoa Hoang, BS, Bin Zhang, PhD, Lucy Ghoda, PhD, Claudia Kowolik, PhD, Mika Kontro, MD, Krister Wennerberg, PhD, Calum Leitch, PhD, Xiaochun Yu, MD PhD, Ching-Cheng Chen, PhD, David Horne, PhD, Varsha Gandhi, PhD, Vinod A. Pullarkat, MD, Guido Marcucci, Steven T Rosen
Journal: Blood
Blood (2018) 132 (Supplement 1): 3938.
https://doi.org/10.1182/blood-2018-99-119880
Published: 2018
Journal Articles

Inhibition of PRMT1 Mediated FLT3 Arginine Methylation As a Potent Therapeutic Strategy for MLL-r ALL

Yinghui Zhu, PhD, Xin He, PhD, Haojie Dong, PhD, Jie Sun, PhD, Hanying Wang, PhD, Lei Zhang, PhD, Yunan Miao, PhD, Jian Jin, PhD, Yudao Shen, PhD, Jianjun Chen, PhD, Markus Muschen, MD, Chun-Wei Chen, PhD, Marina Y. Konopleva, MD PhD, Weili Sun, MD PhD, Bin Zhang, PhD, Ya-Huei Kuo, PhD, Nadia Carlesso, MD PhD, Guido Marcucci, Ling Li, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 892.
https://doi.org/10.1182/blood-2018-99-115139
Published: 2018
Journal Articles

PRMT1 Mediated FLT3 Methylation As a Therapeutic Vulnerability in FLT3-ITD + AML

Xin He, PhD, Yinghui Zhu, PhD, Haojie Dong, PhD, Sierra Min Li, Zonghui Ding, PhD, Jie Sun, PhD, Juan Du, MDPhD, Hanying Wang, PhD, Lianjun Zhang, PhD, Yudao Shen, PhD, Hairui Su, BS, PhD, Samer K. Khaled, MD, Dandan Zhao, MD, Lei Zhang, PhD, Robert Hickey, Bin Zhang, PhD, Ya-Huei Kuo, PhD, Xinyang Zhao, PhD, Jian Jin, PhD, Nadia Carlesso, MD PhD, Jianjun Chen, PhD, Yang Xu, MD, Guido Marcucci, Ling Li, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 760.
https://doi.org/10.1182/blood-2018-99-112766
Published: 2018
Journal Articles

Targeted Delivery of CpG-Mir-146a Mimic Oligonucleotides As a Therapeutic Strategy to Reduce NF-Κb-Mediated Pathogenic Inflammation and Myeloid Leukemia Progression

Yu-Lin SU, PhD, Zhuoran Zhang, PhD, Mati Mann, PhD, Xiuli Wang, PhD, Le Xuan Truong Nguyen, PhD, Bin Zhang, PhD, Ling Li, PhD, Piotr Swiderski, PhD, Mark Boldin, MD PhD, Stephen J Forman, Guido Marcucci, Marcin Kortylewski, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3501.
https://doi.org/10.1182/blood-2018-99-115637
Published: 2018
Journal Articles

Adaptive NK Cells Are Expanded By NKG2C-Agonist Antibodies and Retain Their Cytotoxic and Secretory Properties

Aimee Merino, MD PhD, Phillip Dougherty, BS, Bin Zhang, PhD, J.P. Houchins, PhD, Jeffrey S. Miller, MD, Frank Cichocki, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3695.
https://doi.org/10.1182/blood-2018-99-113669
Published: 2018
Journal Articles

CAR22/19 Cocktail Therapy for Patients with Refractory/Relapsed B-Cell Malignancies

Liang Huang, MDPhD, Na Wang, MD PhD, Yang Cao, Chunrui Li, MDPhD, Yi Xiao, MD PhD, Min Xiao, MD PhD, Xiaoxi Zhou, MD, PhD, Gaoxiang Wang, MDPhD, Zhenya Hong, MD, PhD, Miao Zhen, MD, PhD, Weixu Meng, MD PhD, Bin Zhang, PhD, Yicheng Zhang, MDPhD, Guido Marcucci, Tongcun Zhang, PhD, Jianfeng Zhou, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1408.
https://doi.org/10.1182/blood-2018-99-113714
Published: 2018
Journal Articles

Downregulation of Mir-142 Promotes Leukemia Growth in Philadelphia Chromosome-Positive (Ph+) Acute Lymphoblastic Leukemia (ALL): A Possible Novel Therapeutic Target?

Huafeng Wang, Bin Zhang, PhD, Wei-Le Wang, BS, Dandan Zhao, MD, Ling Li, PhD, Herman Wu, BS, Le Xuan Truong Nguyen, PhD, Weixu Meng, MD PhD, Tinisha McDonald, MS, Flavia Pichiorri, PhD, Ya-Huei Kuo, PhD, Jianjun Chen, PhD, Nadia Carlesso, MD PhD, Ibrahim Aldoss, MD, Vinod A. Pullarkat, MD, Monzr Al Malki, MD, Anthony S. Stein, MD, Mark Boldin, MD PhD, Jie Jin, MD PhD, Guido Marcucci
Journal: Blood
Blood (2018) 132 (Supplement 1): 1338.
https://doi.org/10.1182/blood-2018-99-119599
Published: 2018
Journal Articles

Anti-IL1RAP/CD3 Bispecific Antibody (BsAb) Is a Promising Novel and Effective Therapy for Acute Myeloid Leukemia (AML)

Weixu Meng, MD PhD, Marissa Del Real, PhD, Guowei Wei, PhD, Rochelle Hernandez, Emanuela Marcucci, Allen Lin, Tinisha Mcdonald, Dandan Zhao, MD, Herman Wu, BS, Nadia Carlesso, MD PhD, Larry W Kwak, MDPhD, Ling Li, PhD, Ya-Huei Kuo, PhD, Anthony S. Stein, MD, Vinod Pullarkat, MD MRCP, Ryotaro Nakamura, MD, Steven T. Rosen, MD, Stephen J. Forman, MD FACP, Bin Zhang, PhD, Lihua Budde, MD PhD, Guido Marcucci, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1361.
https://doi.org/10.1182/blood.V130.Suppl_1.1361.1361
Published: 2017