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Journal Articles

Notch-Mediated Expansion of Human Hematopoietic Stem and Progenitor Cells By Culture Under Hypoxia

Daisuke Araki, MD, Stefan Cordes, MD PhD, Fayaz Seifuddin, PhD, Luigi J. Alvarado, PhD, Mehdi Pirooznia, MD PhD, Richard H. Smith, PhD, Andre Larochelle, MD PhD

Blood (2020) 136 (Supplement 1): 28–29.

https://doi.org/10.1182/blood-2020-141121

Published: 2020

Journal Articles

Long-Term Eltrombopag for Bone Marrow Failure Depletes Total Body Iron

David J Young, MDPhD, Xing Fan, MD, Emma Groarke, MD, Bhavisha A Patel, MD, Ronan Desmond, MD, Thomas Winkler, MD, Andre Larochelle, MD PhD, Katherine R. Calvo, MD PhD, Neal S. Young, MD, Cynthia E. Dunbar, MD

Blood (2020) 136 (Supplement 1): 39–40.

https://doi.org/10.1182/blood-2020-141375

Published: 2020

Journal Articles

Phase II Study of Eltrombopag in Subjects with Fanconi Anemia

Daisuke Araki, MD, Ma Evette Barranta, Fariba Chinian, MS, Julie Erb-Alvarez, MPH, Thomas Winkler, MD, Neelam Giri, MD, Andre Larochelle, MD PhD

Blood (2019) 134 (Supplement_1): 3753.

https://doi.org/10.1182/blood-2019-123151

Published: 2019

Journal Articles

A Novel Proteomic Profiling of the Bone Marrow Microenvironment Reveals Elevated Levels of the Chemokine CCL23 Isoforms in Acute Myeloid Leukemia

Blood (2019) 134 (Supplement_1): 2709.

https://doi.org/10.1182/blood-2019-122121

Published: 2019

Journal Articles

Eltrombopag Improves Erythroid Differentiation in a Human iPSC Model of Diamond Blackfan Anemia

Husam Qanash, MSc, Kaari Linask, Jeanette Beers, Keyvan Keyvanfar, Sara Young-Baird, Waleed Hakami, Richard H. Smith, Jizhong Zou, Andre Larochelle, MD PhD

Blood (2019) 134 (Supplement_1): 1214.

https://doi.org/10.1182/blood-2019-121822

Published: 2019

Journal Articles

Robust Cell Selections and Depletions across Various Hematopoietic Cell Fractions on the Clinimacs Plus Instrument

Thejaswi Bikkani, MBBS, Katherine Li, Anusha Rao, Angela Pickett, Xiaobai Li, PhD, Minoo Battiwalla, MD, Richard W. Childs, MD, John Barrett, MD, Andre Larochelle, MD PhD, Elizabeth Kang, MD, David F. Stroncek, Sandhya R. Panch, MD MPH

Blood (2018) 132 (Supplement 1): 3818.

https://doi.org/10.1182/blood-2018-99-118582

Published: 2018

Journal Articles

Generation of Fanconi Anemia iPSC Clones By Addition of a Small Molecule Inhibitor of p53 during Reprogramming

Husam Qanash, MSc, Kaari Linask, Jeannette Beers, Jizhong Zou, Andre Larochelle, MD PhD

Blood (2018) 132 (Supplement 1): 3857.

https://doi.org/10.1182/blood-2018-99-116896

Published: 2018

Journal Articles

Modulation of Mesodermal Patterning Combined with High VEGFA Concentrations Promote Robust Arterial Hemogenic Endothelium Differentiation from Human iPSCs

Juan Pablo Ruiz, BS, Andre Larochelle, MD PhD

Blood (2018) 132 (Supplement 1): 5093.

https://doi.org/10.1182/blood-2018-99-119332

Published: 2018

Journal Articles

Hypoxia and Notch Signaling Synergistically Expand Long-Term Repopulating Human Hematopoietic Stem/Progenitor Cells

Heather D. Huntsman, PhD, Daisuke Araki, MD, Richard H. Smith, PhD, Andre Larochelle, MD PhD

Blood (2018) 132 (Supplement 1): 2557.

https://doi.org/10.1182/blood-2018-99-119388

Published: 2018

Journal Articles

Heterodimerization of TPO and IFNγ Impairs Human Hematopoietic Stem/Progenitor Cell Signaling and Survival in Chronic Inflammation

Luigi J. Alvarado, PhD, Alessio Andreoni, PhD, Heather D. Huntsman, PhD, Hai Cheng, MD, Jay R. Knutson, PhD, Andre Larochelle, MD PhD

Blood (2017) 130 (Supplement 1): 4.

https://doi.org/10.1182/blood.V130.Suppl_1.4.4

Published: 2017

Journal Articles

Eltrombopag Promotes DNA Repair in Human Hematopoietic Stem and Progenitor Cells: Implications for the Treatment of Fanconi Anemia

Kacey Linnea Guenther, BS, Patali Shikhi Cheruku, BS, Richard H Smith, PhD, Andre Larochelle, MD PhD

Blood (2017) 130 (Supplement 1): 776.

https://doi.org/10.1182/blood.V130.Suppl_1.776.776

Published: 2017

Journal Articles

Concurrent Ex Vivo Differentiation of a Vascular Niche and Hematopoietic Stem/Progenitor Cells from Human iPSCs

Juan Pablo Ruiz, BS, Guibin Chen, MD, Michael Drakopoulos, BS, Luigi J. Alvarado, PhD, Manfred Boehm, MD, Andre Larochelle, MD PhD

Blood (2017) 130 (Supplement 1): 1162.

https://doi.org/10.1182/blood.V130.Suppl_1.1162.1162

Published: 2017

Journal Articles

Hypoxia Potentiates Notch-Induced Expansion of Human Hematopoietic Stem/Progenitor Cells

Jianfei Fu, MD, Heather D. Huntsman, PhD, Ayla Cash, B.Sc., Patali S. Cheruku, B.Sc., Richard H. Smith, PhD, Aibin Liang, MD PhD, Irwin D. Bernstein, MD, Andre Larochelle, MD PhD

Blood (2016) 128 (22): 2640.

https://doi.org/10.1182/blood.V128.22.2640.2640

Published: 2016

Journal Articles

Interferon-γ Perturbs Key Signaling Pathways Induced By Thrombopoietin, but Not Eltrombopag, in Human Hematopoietic Stem/Progenitor Cells

Hai Cheng, MD, Patali S. Cheruku, B.Sc., Luigi Alvarado, PhD, Ayla Cash, B.Sc., Cynthia E. Dunbar, MD, Neal S. Young, MD, Andre Larochelle, MD PhD

Blood (2016) 128 (22): 3870.

https://doi.org/10.1182/blood.V128.22.3870.3870

Published: 2016

Journal Articles

The Thrombopoietin Receptor Agonist Eltrombopag Has DNA Repair Activity in Human Hematopoietic Stem and Progenitor Cells

Patali S. Cheruku, B.Sc., Ayla Cash, B.Sc., Cynthia E. Dunbar, MD, Neal S. Young, MD, Andre Larochelle, MD, PhD

Blood (2015) 126 (23): 2407.

https://doi.org/10.1182/blood.V126.23.2407.2407

Published: 2015

Journal Articles

Eltrombopag Added to Standard Immunosuppression for Aplastic Anemia Accelerates Count Recovery and Increases Response Rates

Danielle M. Townsley, MD, Bogdan Dumitriu, MD, Phillip Scheinberg, MD, Ronan Desmond, MD, FRCPath, Xingmin Feng, PhD, Olga Rios, RN, Barbara Weinstein, RN, Janet Valdez, PA-C, Thomas Winkler, MD, Marie Desierto, BS, Harshraj Leuva, MBBS, Colin Wu, PhD, Katherine R. Calvo, MD, PhD, Andre Larochelle, MD, PhD, Cynthia E. Dunbar, MD, Neal S. Young, MD

Blood (2015) 126 (23): LBA-2.

https://doi.org/10.1182/blood.V126.23.LBA-2.LBA-2

Published: 2015

Journal Articles

Leukemic and Hematopoietic Stem Cells Compete for the Same Functional Marrow Niche in a MLL-AF9 Murine Leukemia Model

Ronan G. Desmond, MD, MRCP, FRCPath, Taha Bat, Olena Kamenyeva, Benjamin Mizukawa, MD, James C. Mulloy, PhD, Andre Larochelle, MD, PhD, Cynthia E. Dunbar, MD

Blood (2012) 120 (21): 4897.

https://doi.org/10.1182/blood.V120.21.4897.4897

Published: 2012

Journal Articles

Methylguanine Methyltransferase-Based In Vivo Selection Results in Only Transient Improvement in Long-Term Marking after Autologous Transplantation of Transduced Hematopoietic Stem Cells in Rhesus Macaques.

Andre Larochelle, MD, PhD, Uimook Choi, Ph.D., Nora Naumann, Ph.D, Josh R. Clevenger, Harry L. Malech, M.D., Cynthia E. Dunbar, M.D.

Blood (2006) 108 (11): 3272.

https://doi.org/10.1182/blood.V108.11.3272.3272

Published: 2006

Journal Articles

Mobilization as a Preparative Regimen for Hematopoietic Stem Cell (HSC) Transplantation in Rhesus Macaques.

Andre Larochelle, MD, PhD, Cynthia L. Perez, MSc, Allen Krouse, Mark Metzger, Simon Fricker, PhD, Gary Bridger, PhD, Donald Orlic, MD, Robert E. Donahue, DVM, Janis L. Abkowitz, MD, Cynthia E. Dunbar, MD

Blood (2005) 106 (11): 1709.

https://doi.org/10.1182/blood.V106.11.1709.1709

Published: 2005

Journal Articles

Estimating the Replication Rate of Hematopoietic Stem Cells in Non-Human Primates: A Test of Hayflick’s Hypothesis.

Bryan E. Shepherd, Hans-Peter Kiem, MD, Cynthia E. Dunbar, MD, Andre Larochelle, MD, PhD, Robert E. Donahue, DVM, Ruth Seggewiss, MD, Peter M. Lansdorp, MD, PhD, Peter Guttorp, PhD, Janis L. Abkowitz, MD

Blood (2005) 106 (11): 1710.

https://doi.org/10.1182/blood.V106.11.1710.1710

Published: 2005

NARROW

Notch-Mediated Expansion of Human Hematopoietic Stem and Progenitor Cells By Culture Under Hypoxia

Long-Term Eltrombopag for Bone Marrow Failure Depletes Total Body Iron

Phase II Study of Eltrombopag in Subjects with Fanconi Anemia

A Novel Proteomic Profiling of the Bone Marrow Microenvironment Reveals Elevated Levels of the Chemokine CCL23 Isoforms in Acute Myeloid Leukemia

Eltrombopag Improves Erythroid Differentiation in a Human iPSC Model of Diamond Blackfan Anemia

Robust Cell Selections and Depletions across Various Hematopoietic Cell Fractions on the Clinimacs Plus Instrument

Generation of Fanconi Anemia iPSC Clones By Addition of a Small Molecule Inhibitor of p53 during Reprogramming

Modulation of Mesodermal Patterning Combined with High VEGFA Concentrations Promote Robust Arterial Hemogenic Endothelium Differentiation from Human iPSCs

Hypoxia and Notch Signaling Synergistically Expand Long-Term Repopulating Human Hematopoietic Stem/Progenitor Cells

Heterodimerization of TPO and IFNγ Impairs Human Hematopoietic Stem/Progenitor Cell Signaling and Survival in Chronic Inflammation

Eltrombopag Promotes DNA Repair in Human Hematopoietic Stem and Progenitor Cells: Implications for the Treatment of Fanconi Anemia

Concurrent Ex Vivo Differentiation of a Vascular Niche and Hematopoietic Stem/Progenitor Cells from Human iPSCs

Hypoxia Potentiates Notch-Induced Expansion of Human Hematopoietic Stem/Progenitor Cells

Interferon-γ Perturbs Key Signaling Pathways Induced By Thrombopoietin, but Not Eltrombopag, in Human Hematopoietic Stem/Progenitor Cells

The Thrombopoietin Receptor Agonist Eltrombopag Has DNA Repair Activity in Human Hematopoietic Stem and Progenitor Cells

Eltrombopag Added to Standard Immunosuppression for Aplastic Anemia Accelerates Count Recovery and Increases Response Rates

Leukemic and Hematopoietic Stem Cells Compete for the Same Functional Marrow Niche in a MLL-AF9 Murine Leukemia Model

Methylguanine Methyltransferase-Based In Vivo Selection Results in Only Transient Improvement in Long-Term Marking after Autologous Transplantation of Transduced Hematopoietic Stem Cells in Rhesus Macaques.

Mobilization as a Preparative Regimen for Hematopoietic Stem Cell (HSC) Transplantation in Rhesus Macaques.

Estimating the Replication Rate of Hematopoietic Stem Cells in Non-Human Primates: A Test of Hayflick’s Hypothesis.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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