Abstract
Molecular measurable residual disease can persist in core-binding factor acute myeloid leukemia in otherwise disease-free patients. Utilizing cell sorting followed by fluorescent in situ hybridization, we show that detection is due to mast cells.
Subjects:
Myeloid Neoplasia
References
1.
Faber
ZJ
, Chen
X
, Gedman
AL
, et al. The genomic landscape of core-binding factor acute myeloid leukemias
. Nat Genet
. 2016
;48
(12
):1551
-1556
.2.
Qin
W
, Chen
X
, Shen
HJ
, et al. Comprehensive mutation profile in acute myeloid leukemia patients with RUNX1-RUNX1T1 or CBFB-MYH11 fusions
. Turk J Haematol
. 2022
;39
(2
):84
-93
.3.
Liu
P
, Liu
JP
, Sun
SJ
, et al. CBFB-MYH11 fusion sequesters RUNX1 in cytoplasm to prevent DNMT3A recruitment to target genes in AML
. Front Cell Dev Biol
. 2021
;9
:675424
.4.
Beghini
A
. Core binding factor leukemia: chromatin remodeling moves towards oncogenic transcription
. Cancers (Basel)
. 2019
;11
(12
):1973
.5.
Downing
JR
. The AML1-ETO chimaeric transcription factor in acute myeloid leukaemia: biology and clinical significance
. Br J Haematol
. 1999
;106
(2
):296
-308
.6.
Dong
ZMD
, Ramakrishnan
A
, Chauncey
TR
, et al. No adverse effect of residual neoplastic mast cells in systemic mastocytosis associated with acute myeloid leukemia with T(8;21)(Q22;Q22); Runx1-Runx1t1 after bone marrow transplantation
. Ann Clin Pathol
. 2014
;2
(1
):1009
.7.
Hilmi
FAI
, Al-Sabbagh
A
, Soliman
DS
, et al. Acute myeloid leukemia with Inv(16)(p13q22) associated with hidden systemic mastocytosis: case report and review of literature
. Clin Med Insights Blood Disord
. 2017
;10
:1179545x17700858
.8.
Pullarkat
ST
, Pullarkat
V
, Lagoo
A
, et al. Characterization of bone marrow mast cells in acute myeloid leukemia with t(8;21) (q22;q22); RUNX1-RUNX1T1
. Leuk Res
. 2013
;37
(11
):1572
-1575
.9.
Pullarkat
V
, Bedell
V
, Kim
Y
, et al. Neoplastic mast cells in systemic mastocytosis associated with t(8;21) acute myeloid leukemia are derived from the leukemic clone
. Leuk Res
. 2007
;31
(2
):261
-265
.10.
Wang
YY
, Zhou
GB
, Yin
T
, et al. AML1-ETO and C-KIT mutation/overexpression in t(8;21) leukemia: implication in stepwise leukemogenesis and response to Gleevec
. Proc Natl Acad Sci U S A
. 2005
;102
(4
):1104
-1109
.11.
Xie
W
, Wang
SA
, Yin
CC
, et al. Acute myeloid leukemia with t(8;21)(q22;q22.1)/RUNX1-RUNX1T1 and KIT Exon 8 mutation is associated with characteristic mastocytosis and dismal outcomes
. Exp Mol Pathol
. 2019
;108
:131
-136
.12.
Heuser
M
, Freeman
SD
, Ossenkoppele
GJ
, et al. 2021 Update on MRD in acute myeloid leukemia: a consensus document from the European LeukemiaNet MRD Working Party
. Blood
. 2021
;138
(26
):2753
-2767
.13.
Escribano
L
, Orfao
A
, Díaz-Agustin
B
, et al. Indolent systemic mast cell disease in adults: immunophenotypic characterization of bone marrow mast cells and its diagnostic implications
. Blood
. 1998
;91
(8
):2731
-2736
.14.
Metcalfe
DD
. Mast cells and mastocytosis
. Blood
. 2008
;112
(4
):946
-956
.15.
Swerdlow
SH
, Campo
E
, Harris
NL
, et al. Myeloproliferative neoplasms. In: Swerdlow
SH
, Campo
E
, Harris
NL
, eds. WHO classification of tumours of haematopoietic and lymphoid tissue
. 4th ed.. Lyon; International Agency for Research on Cancer
; 2008
.16.
Carter
MC
, Metcalfe
DD
, Komarow
HD
. Mastocytosis
. Immunol Allergy Clin North Am
. 2014
;34
(1
):181
-196
.17.
Cherian
S
, McCullouch
V
, Miller
V
, Dougherty
K
, Fromm
JR
, Wood
BL
. Expression of CD2 and CD25 on mast cell populations can be seen outside the setting of systemic mastocytosis
. Cytometry B Clin Cytom
. 2016
;90
(4
):387
-392
.© 2024 American Society of Hematology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
2024
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