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Deep PIM kinase substrate profiling reveals new rational cotherapeutic strategies for acute myeloid leukemia

Tejashree Joglekar, Alexander Chin, Alin Voskanian-Kordi, Seungchul Baek, Azim Raja, Apurv Rege, Weiliang Huang, Maureen Kane, Marikki Laiho, Thomas R. Webb, Xiaoxuan Fan, Michael Rubenstein, Charles J. Bieberich, Xiang Li
Journal: Blood Advances
Blood Adv (2024) 8 (15): 3880–3892.
https://doi.org/10.1182/bloodadvances.2022008144
Published: 2024
Includes: Supplemental data
Journal Articles

The E592K variant of SF3B1 creates unique RNA missplicing and associates with high-risk MDS without ring sideroblasts

In Young Choi, Jonathan P. Ling, Jian Zhang, Eric Helmenstine, Wencke Walter, Panagiotis Tsakiroglou, Riley E. Bergman, Céline Philippe, James L. Manley, Kevin Rouault-Pierre, Bing Li, Daniel H. Wiseman, Kiran Batta, Madhu Ouseph, Elsa Bernard, Benjamin Dubner, Xiao Li, Torsten Haferlach, Anna Koget, Salman Fazal, Tania Jain, Christopher D. Gocke, Amy E. DeZern, William Brian Dalton
Journal: Blood Advances
Blood Adv (2024) 8 (15): 3961–3971.
https://doi.org/10.1182/bloodadvances.2023011260
Published: 2024
Includes: Supplemental data
Journal Articles

Targeting CD38 with isatuximab and a novel CD38/CD3×CD28 trispecific T-cell engager in older patients with acute myeloid leukemia

Esperanza Martín-Sánchez, Laura Blanco, Peter S. Kim, Kamlesh Bisht, Hongfang Wang, Helgi Van de Velde, Tomas Jelinek, Catia Simoes, Felipe Prosper, Jesus F. San Miguel, Ana Alfonso, Juan Bergua, Rebeca Rodríguez-Veiga, Susana Vives, David Martínez-Cuadrón, Pau Montesinos, Bruno Paiva, Aintzane Zabaleta
Journal: Blood Advances
Blood Adv (2024) 8 (15): 3875–3879.
https://doi.org/10.1182/bloodadvances.2024013212
Published: 2024
Includes: Supplemental data
Journal Articles

Molecular and Clinical Characterization of ETNK1-mutated Myeloid Neoplasms: The Mayo Clinic Experience

Steven Tessier, Rong He, Patricia T. Greipp, David S Viswanatha, Kurt R Bessonen, Terra L Lasho, James M Foran, Cecilia Arana-Yi, Naseema Gangat, Ayalew Tefferi, Mithun Vinod Shah, Hassan B Alkhateeb, Shujun Liu, Animesh D Pardanani, Mrinal M. Patnaik, Aref Al-Kali
Journal: Blood Advances
Blood Adv bloodadvances.2024013255.
https://doi.org/10.1182/bloodadvances.2024013255
Published: 2024
Includes: Supplemental data
Journal Articles

Diabetes mellitus, metformin, and the risk of MPN

Ivan Krecak, Sanja Klobucar, Josipa Budimir, Marko Skelin, Marko Lucijanic
Journal: Blood Advances
Blood Adv bloodadvances.2024013772.
https://doi.org/10.1182/bloodadvances.2024013772
Published: 2024
Journal Articles

Impact of patient demographics on treatment outcomes in AML: a population-based registry in England, 2013-2020

Hanhua Liu, Simon J Stanworth, Sean McPhail, Mark Bishton, Brian Rous Rous, Andrew Bacon, Tom Coats
Journal: Blood Advances
Blood Adv bloodadvances.2024013102.
https://doi.org/10.1182/bloodadvances.2024013102
Published: 2024
Includes: Supplemental data
Journal Articles

Differential inflammatory conditioning of the bone marrow by acute myeloid leukemia and its impact on progression

Valentina R Minciacchi, Christina Karantanou, Jimena Bravo, Raquel S. Pereira, Costanza Zanetti, Theresa Krack, Rahul Kumar, Katrin Bankov, Sylvia Hartmann, Brian JP Huntly, Eshwar Meduri, Wolfram Ruf, Daniela S. Krause
Journal: Blood Advances
Blood Adv bloodadvances.2024012867.
https://doi.org/10.1182/bloodadvances.2024012867
Published: 2024
Includes: Supplemental data
Journal Articles

Interleukin-1beta, JAK2V617F mutation and inflammation in MPNs

Sylvie Hermouet, Hans Carl Hasselbalch
Journal: Blood Advances
Blood Adv bloodadvances.2024013528.
https://doi.org/10.1182/bloodadvances.2024013528
Published: 2024
Journal Articles

Venetoclax: a new player in the treatment of children with high-risk myeloid malignancies?

Riccardo Masetti, Francesco Baccelli, Davide Leardini, Franco Locatelli
Journal: Blood Advances
Blood Adv (2024) 8 (13): 3583–3595.
https://doi.org/10.1182/bloodadvances.2023012041
Published: 2024
Journal Articles

Nilotinib vs. Dasatinib in Achieving MR4.5 for de novo Chronic Myeloid Leukemia: the Randomized JALSG CML212 Study

Itaru Matsumura, Shigeki Ohtake, Yoshiko Atsuta, Mio Kurata, Yosuke Minami, Naoto Takahashi, Chiaki Nakaseko, Noriyoshi Iriyama, Katsumichi Fujimaki, Kazuhiko Kakihana, Yoji Ogasawara, Takaaki Ono, Masaya Okada, Tetsuzo Tauchi, Toshihiro Miyamoto, Kazunori Ohnishi, Emiko Sakaida, Shin Fujisawa, Yukio Kobayashi, Norio Asou, Tomoki Naoe, Hitoshi Kiyoi, Yasushi Miyazaki
Journal: Blood Advances
Blood Adv bloodadvances.2024012655.
https://doi.org/10.1182/bloodadvances.2024012655
Published: 2024
Includes: Supplemental data
Journal Articles

Genetic deletion of JAM-C in pre-leukemic cells rewires leukemic stem cell gene expression program in AML

Julien M.P. Grenier, Céline Testut, Matthieu Bal, Florence Bardin, Maria De Grandis, Véronique Gelsi-Boyer, Julien Vernerny, Marjorie C Delahaye, Samuel Granjeaud, Christophe Zemmour, Jean-François Spinella, Triantafyllos Chavakis, Stephane JC Mancini, Jean-Marie Boher, Josée Hébert, Guy Sauvageau, Norbert Vey, Juerg Schwaller, Marie-Anne Hospital, Cyril Fauriat, Michel A Aurrand-Lions
Journal: Blood Advances
Blood Adv bloodadvances.2023011747.
https://doi.org/10.1182/bloodadvances.2023011747
Published: 2024
Includes: Supplemental data
Journal Articles

Intensive Induction Chemotherapy versus Hypomethylating Agents in Combination with Venetoclax in NPM1-mutant AML

Jan Philipp Bewersdorf, Shai Shimony, Rory M. Shallis, Yiwen Liu, Guillaume Berton, Eva Johanna Schaefer, Amer M. Zeidan, Aaron D Goldberg, Eytan M. Stein, Guido Marcucci, Rebecca Bystrom, R. Coleman Lindsley, Evan C. Chen, Jorge Miguel Ramos Perez, Anthony S. Stein, Vinod A Pullarkat, Ibrahim Aldoss, Daniel J DeAngelo, Donna S. Neuberg, Richard M. Stone, Sylvain Garciaz, Brian J. Ball, Maximilian Stahl
Journal: Blood Advances
Blood Adv bloodadvances.2024012858.
https://doi.org/10.1182/bloodadvances.2024012858
Published: 2024
Includes: Supplemental data
Journal Articles

Blockage of BCL-XL overcomes venetoclax resistance across BCL2 + lymphoid malignancies irrespective of BIM status

Alexandra Dolnikova, Dmitry Kazantsev, Magdalena Klanova, Eva Pokorna, Dana Sovilj, Cristina Daniela Kelemen, Liliana Tuskova, Eva Hoferkova, Marek Mraz, Karel Helman, Nikola Curik, Katerina Machova Polakova, Ladislav Andera, Marek Trneny, Pavel Klener
Journal: Blood Advances
Blood Adv (2024) 8 (13): 3532–3543.
https://doi.org/10.1182/bloodadvances.2024012906
Published: 2024
Includes: Supplemental data
Journal Articles

Treatment approach and outcomes of patients with accelerated/blast-phase myeloproliferative neoplasms in the current era

Anand A. Patel, James J. Yoon, Hannah Johnston, Marta B. Davidson, Rory M. Shallis, Evan C. Chen, Madelyn Burkart, Timothy S. Oh, Sunil G. Iyer, Ellen Madarang, Chandrasekar Muthiah, Iyana Gross, Raven Dean, Joshua Kassner, Auro Viswabandya, Rafael Madero-Marroquin, Raajit K. Rampal, Guru Subramanian Guru Murthy, Terrence Bradley, Yasmin Abaza, Jacqueline S. Garcia, Vikas Gupta, Kristen M. Pettit, John F. Cursio, Olatoyosi Odenike
Journal: Blood Advances
Blood Adv (2024) 8 (13): 3468–3477.
https://doi.org/10.1182/bloodadvances.2024012880
Published: 2024
Includes: Supplemental data
Journal Articles

Clonal hematopoiesis and inflammation in the vasculature: CHIVE, a prospective, longitudinal clonal hematopoiesis cohort and biorepository

Clinical Trials & Observations
Morgan L. Shannon, J. Brett Heimlich, Sydney Olson, Ariana Debevec, Zachary Copeland, Ashwin Kishtagari, Caitlyn Vlasschaert, Christina Snider, Alexander J. Silver, Donovan Brown, Travis Spaulding, Manasa Bhatta, Kelly Pugh, Shannon S. Stockton, Jessica Ulloa, Yaomin Xu, Muhamed Baljevic, Javid Moslehi, Eiman Jahangir, P. Brent Ferrell, David Slosky, Alexander G. Bick, Michael R. Savona
Journal: Blood Advances
Blood Adv (2024) 8 (13): 3453–3463.
https://doi.org/10.1182/bloodadvances.2023011510
Published: 2024
Includes: Supplemental data
Journal Articles

Lysosomal degradation targets mutant calreticulin and the thrombopoietin receptor in myeloproliferative neoplasms

Amanpreet Kaur, Arunkumar Venkatesan, Malathi Kandarpa, Moshe Talpaz, Malini Raghavan
Journal: Blood Advances
Blood Adv (2024) 8 (13): 3372–3387.
https://doi.org/10.1182/bloodadvances.2023011432
Published: 2024
Includes: Supplemental data
Journal Articles

Exacerbation of thromboinflammation by JAK2 V617F mutation worsens the prognosis of cerebral venous sinus thrombosis

Marie-Charlotte Bourrienne, Véronique Le Cam Duchez, Dorothée Faille, Carine Farkh, Mialitiana Solo Nomenjanahary, Juliette Gay, Stéphane Loyau, Clément Journé, Sébastien Dupont, Véronique Ollivier, Jean-Luc Villeval, Isabelle Plo, Valérie Edmond, Martine Jandrot-Perrus, Sylvie Labrouche-Colomer, Bruno Cassinat, Emmanuelle Verger, Jean-Philippe Desilles, Benoît Ho-Tin-Noé, Aude Triquenot Bagan, Mikaël Mazighi, Nadine Ajzenberg
Journal: Blood Advances
Blood Adv (2024) 8 (12): 3330–3343.
https://doi.org/10.1182/bloodadvances.2023011692
Published: 2024
Includes: Multimedia, Supplemental data
Journal Articles

Blood cell JAKtivation aggravates cerebral venous thrombosis

Brandi Reeves
Journal: Blood Advances
Blood Adv (2024) 8 (12): 3327–3329.
https://doi.org/10.1182/bloodadvances.2024012977
Published: 2024
Journal Articles

Optimized cytogenetic risk-group stratification of KMT2A -rearranged pediatric acute myeloid leukemia

Romy E. van Weelderen, Christine J. Harrison, Kim Klein, Yilin Jiang, Jonas Abrahamsson, Todd Alonzo, Richard Aplenc, Nira Arad-Cohen, Emmanuelle Bart-Delabesse, Barbara Buldini, Barbara De Moerloose, Michael N. Dworzak, Sarah Elitzur, José M. Fernández Navarro, Alan Gamis, Robert B. Gerbing, Bianca F. Goemans, Hester A. de Groot-Kruseman, Erin Guest, Shau-Yin Ha, Henrik Hasle, Charikleia Kelaidi, Hélène Lapillonne, Guy Leverger, Franco Locatelli, Takako Miyamura, Ulrika Norén-Nyström, Sophia Polychronopoulou, Mareike Rasche, Jeffrey E. Rubnitz, Jan Stary, Anne Tierens, Daisuke Tomizawa, C. Michel Zwaan, Gertjan J. L. Kaspers
Journal: Blood Advances
Blood Adv (2024) 8 (12): 3200–3213.
https://doi.org/10.1182/bloodadvances.2023011771
Published: 2024
Includes: Supplemental data
Journal Articles

Characterization of Cases with the Rare Cytogenetic Abnormality i(7)(p10) Reveals an Association with IDH2 Mutated AML

Anna Stengel, Katharina Hörst, Constanze Kühn, Manja Meggendorfer, Wolfgang Kern, Torsten Haferlach, Claudia Haferlach
Journal: Blood Advances
Blood Adv bloodadvances.2024013225.
https://doi.org/10.1182/bloodadvances.2024013225
Published: 2024
Includes: Supplemental data