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Journal Articles

Development and characterization of prototypes for in vitro and in vivo mouse models of ibrutinib-resistant CLL

Burcu Aslan, Gorkem Kismali, Lisa S. Chen, LaKesla R. Iles, Mikhila Mahendra, Michael Peoples, Mihai Gagea, Natalie W. Fowlkes, Xiaofeng Zheng, Jing Wang, Christopher P. Vellano, Joseph R. Marszalek, Maria Teresa Sabrina Bertilaccio, Varsha Gandhi
Journal: Blood Advances
Blood Adv (2021) 5 (16): 3134–3146.
https://doi.org/10.1182/bloodadvances.2020003821
Published: 2021
Includes: Supplemental data
Journal Articles

Antileukemic efficacy of a potent artemisinin combined with sorafenib and venetoclax

Blake S. Moses, Samantha McCullough, Jennifer M. Fox, Bryan T. Mott, Søren M. Bentzen, MinJung Kim, Jeffrey W. Tyner, Rena G. Lapidus, Ashkan Emadi, Michelle A. Rudek, Tami J. Kingsbury, Curt I. Civin
Journal: Blood Advances
Blood Adv (2021) 5 (3): 711–724.
https://doi.org/10.1182/bloodadvances.2020003429
Published: 2021
Includes: Supplemental data
Journal Articles

Targeting phosphatidylinositol 3 kinase-β and -δ for Bruton tyrosine kinase resistance in diffuse large B-cell lymphoma

Neeraj Jain, Satishkumar Singh, Georgios Laliotis, Amber Hart, Elizabeth Muhowski, Kristyna Kupcova, Tereza Chrbolkova, Tamer Khashab, Sayan Mullick Chowdhury, Anuvrat Sircar, Fazal Shirazi, Ram Kumar Singh, Lapo Alinari, Jiangjiang Zhu, Ondrej Havranek, Philip Tsichlis, Jennifer Woyach, Robert Baiocchi, Felipe Samaniego, Lalit Sehgal
Journal: Blood Advances
Blood Adv (2020) 4 (18): 4382–4392.
https://doi.org/10.1182/bloodadvances.2020001685
Published: 2020
Includes: Supplemental data
Journal Articles

AKT signaling restrains tumor suppressive functions of FOXO transcription factors and GSK3 kinase in multiple myeloma

Timon A. Bloedjes, Guus de Wilde, Chiel Maas, Eric Eldering, Richard J. Bende, Carel J. M. van Noesel, Steven T. Pals, Marcel Spaargaren, Jeroen E. J. Guikema
Journal: Blood Advances
Blood Adv (2020) 4 (17): 4151–4164.
https://doi.org/10.1182/bloodadvances.2019001393
Published: 2020
Includes: Supplemental data
Journal Articles

A phase 1/2 study of the oral FLT3 inhibitor pexidartinib in relapsed/refractory FLT3-ITD–mutant acute myeloid leukemia

Clinical Trials & Observations
Catherine C. Smith, Mark J. Levis, Olga Frankfurt, John M. Pagel, Gail J. Roboz, Richard M. Stone, Eunice S. Wang, Paul L. Severson, Brian L. West, Mai H. Le, Sabine Kayser, Bao Lam, Henry H. Hsu, Chao Zhang, Gideon Bollag, Alexander E. Perl
Journal: Blood Advances
Blood Adv (2020) 4 (8): 1711–1721.
https://doi.org/10.1182/bloodadvances.2020001449
Published: 2020
Includes: Supplemental data
Journal Articles

Quizartinib-resistant FLT3 -ITD acute myeloid leukemia cells are sensitive to the FLT3-Aurora kinase inhibitor CCT241736

Andrew S. Moore, Amir Faisal, Grace W. Y. Mak, Farideh Miraki-Moud, Vassilios Bavetsias, Melanie Valenti, Gary Box, Albert Hallsworth, Alexis de Haven Brandon, Cristina P. R. Xavier, Randal Stronge, Andrew D. J. Pearson, Julian Blagg, Florence I. Raynaud, Rajesh Chopra, Suzanne A. Eccles, David C. Taussig, Spiros Linardopoulos
Journal: Blood Advances
Blood Adv (2020) 4 (7): 1478–1491.
https://doi.org/10.1182/bloodadvances.2019000986
Published: 2020
Includes: Supplemental data
Journal Articles

The EGFL7-ITGB3-KLF2 axis enhances survival of multiple myeloma in preclinical models

Yousef Salama, Andries Hendrik Heida, Kazuaki Yokoyama, Satoshi Takahashi, Koichi Hattori, Beate Heissig
Journal: Blood Advances
Blood Adv (2020) 4 (6): 1021–1037.
https://doi.org/10.1182/bloodadvances.2019001002
Published: 2020
Includes: Supplemental data
Journal Articles

Combination of dasatinib with chemotherapy in previously untreated core binding factor acute myeloid leukemia: CALGB 10801

Clinical Trials & Observations
Guido Marcucci, Susan Geyer, Kristina Laumann, Weiqiang Zhao, Donna Bucci, Geoffrey L. Uy, William Blum, Ann-Kathrin Eisfeld, Timothy S. Pardee, Eunice S. Wang, Wendy Stock, Jonathan E. Kolitz, Jessica Kohlschmidt, Krzysztof Mrózek, Clara D. Bloomfield, Richard M. Stone, Richard A. Larson
Journal: Blood Advances
Blood Adv (2020) 4 (4): 696–705.
https://doi.org/10.1182/bloodadvances.2019000492
Published: 2020
Journal Articles

IκB kinase 2 is not essential for platelet activation

Manuel Salzmann, Sonja Bleichert, Bernhard Moser, Marion Mussbacher, Mildred Haase, Bastian Hoesel, Waltraud C. Schrottmaier, Julia B. Kral-Pointner, Makoto Itakura, Katy Schmidt, Alice Assinger, Johannes A. Schmid
Journal: Blood Advances
Blood Adv (2020) 4 (4): 638–643.
https://doi.org/10.1182/bloodadvances.2019001044
Published: 2020
Includes: Supplemental data
Journal Articles

Gilteritinib is a clinically active FLT3 inhibitor with broad activity against FLT3 kinase domain mutations

Clinical Trials & Observations
Theodore C. Tarver, Jason E. Hill, Leena Rahmat, Alexander E. Perl, Erkut Bahceci, Kenichi Mori, Catherine C. Smith
Journal: Blood Advances
Blood Adv (2020) 4 (3): 514–524.
https://doi.org/10.1182/bloodadvances.2019000919
Published: 2020
Includes: Supplemental data
Journal Articles

Expression of the prosurvival kinase HCK requires PAX5 and mutated MYD88 signaling in MYD88-driven B-cell lymphomas

Xia Liu, Jiaji G. Chen, Manit Munshi, Zachary R. Hunter, Lian Xu, Amanda Kofides, Nickolas Tsakmaklis, Maria G. Demos, Maria Luisa Guerrera, Gloria G. Chan, Cristina Jimenez, Christopher J. Patterson, Kirsten Meid, Andrew Keezer, Jorge J. Castillo, Steven P. Treon, Guang Yang
Journal: Blood Advances
Blood Adv (2020) 4 (1): 141–153.
https://doi.org/10.1182/bloodadvances.2019000947
Published: 2020
Journal Articles

Clinical diagnostics and treatment strategies for Philadelphia chromosome–like acute lymphoblastic leukemia

Clinical Trials & Observations
Richard C. Harvey, Sarah K. Tasian
Journal: Blood Advances
Blood Adv (2020) 4 (1): 218–228.
https://doi.org/10.1182/bloodadvances.2019000163
Published: 2020
Journal Articles

Inhibition of the mutated c-KIT kinase in AML1-ETO–positive leukemia cells restores sensitivity to PARP inhibitor

Margaret Nieborowska-Skorska, Elisabeth M. Paietta, Ross L. Levine, Hugo F. Fernandez, Martin S. Tallman, Mark R. Litzow, Tomasz Skorski
Journal: Blood Advances
Blood Adv (2019) 3 (23): 4050–4054.
https://doi.org/10.1182/bloodadvances.2019000756
Published: 2019
Includes: Supplemental data
Journal Articles

Ether lipid metabolism by AADACL1 regulates platelet function and thrombosis

Stephen P. Holly, Nidhi Gera, Putianqi Wang, Alexander Wilson, Ziqiang Guan, Ling Lin, Brian Cooley, Hammodah R. Alfar, Ruchi G. Patil, Raymond Piatt, Tina M. Leisner, Wolfgang Bergmeier, Rinku Majumder, Leslie V. Parise
Journal: Blood Advances
Blood Adv (2019) 3 (22): 3818–3828.
https://doi.org/10.1182/bloodadvances.2018030767
Published: 2019
Includes: Supplemental data
Journal Articles

Integrated phosphoproteomics and transcriptional classifiers reveal hidden RAS signaling dynamics in multiple myeloma

Yu-Hsiu T. Lin, Gregory P. Way, Benjamin G. Barwick, Margarette C. Mariano, Makeba Marcoulis, Ian D. Ferguson, Christoph Driessen, Lawrence H. Boise, Casey S. Greene, Arun P. Wiita
Journal: Blood Advances
Blood Adv (2019) 3 (21): 3214–3227.
https://doi.org/10.1182/bloodadvances.2019000303
Published: 2019
Includes: Supplemental data
Journal Articles

Reticulocyte and red blood cell deformation triggers specific phosphorylation events

Pedro L. Moura, Maria A. Lizarralde Iragorri, Olivier Français, Bruno Le Pioufle, Johannes G. G. Dobbe, Geert J. Streekstra, Wassim El Nemer, Ashley M. Toye, Timothy J. Satchwell
Journal: Blood Advances
Blood Adv (2019) 3 (17): 2653–2663.
https://doi.org/10.1182/bloodadvances.2019000545
Published: 2019
Includes: Multimedia, Supplemental data
Journal Articles

The role of aurora A and polo-like kinases in high-risk lymphomas

Clinical Trials & Observations
Carlos Murga-Zamalloa, Kedar V. Inamdar, Ryan A. Wilcox
Journal: Blood Advances
Blood Adv (2019) 3 (11): 1778–1787.
https://doi.org/10.1182/bloodadvances.2019000232
Published: 2019
Journal Articles

Murine platelet production is suppressed by S1P release in the hematopoietic niche, not facilitated by blood S1P sensing

Hira Niazi, Nesrine Zoghdani, Ludovic Couty, Alexandre Leuci, Anja Nitzsche, Maria L. Allende, Boubacar Mariko, Rameez Ishaq, Yetki Aslan, Pierre Hadrien Becker, Salomé L. Gazit, Sonia Poirault-Chassac, Benoit Decouture, Veronique Baudrie, Erica De Candia, Mari Kono, Ammar Benarab, Pascale Gaussem, Pierre-Louis Tharaux, Jerold Chun, Sylvain Provot, Najet Debili, Patrice Therond, Richard L. Proia, Christilla Bachelot-Loza, Eric Camerer
Journal: Blood Advances
Blood Adv (2019) 3 (11): 1702–1713.
https://doi.org/10.1182/bloodadvances.2019031948
Published: 2019
Includes: Supplemental data
Journal Articles

Hematopoietic cytokines mediate resistance to targeted therapy in FLT3-ITD acute myeloid leukemia

Pamela J. Sung, Mayumi Sugita, Holly Koblish, Alexander E. Perl, Martin Carroll
Journal: Blood Advances
Blood Adv (2019) 3 (7): 1061–1072.
https://doi.org/10.1182/bloodadvances.2018029850
Published: 2019
Includes: Supplemental data
Journal Articles

Leflunomide regulates c-Myc expression in myeloma cells through PIM targeting

Ralf Buettner, Corey Morales, Enrico Caserta, Estelle Troadec, Emine G. Gunes, Domenico Viola, Jihane Khalife, Hongzhi Li, Jonathan J. Keats, Austin Christofferson, Xiwei Wu, Timothy W. Synold, Joycelynne Palmer, James F. Sanchez, Alexander Pozhitkov, Nagarajan Vaidehi, Guido Marcucci, Amrita Krishnan, Michael A. Rosenzweig, Flavia Pichiorri, Steven T. Rosen
Journal: Blood Advances
Blood Adv (2019) 3 (7): 1027–1032.
https://doi.org/10.1182/bloodadvances.2018027227
Published: 2019
Includes: Supplemental data