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Journal Articles

CRISPR-edited megakaryocytes for rapid screening of platelet gene functions

Emilie Montenont, Seema Bhatlekar, Shancy Jacob, Yasuhiro Kosaka, Bhanu K. Manne, Olivia Lee, Ivan Parra-Izquierdo, Emilia Tugolukova, Neal D. Tolley, Matthew T. Rondina, Paul F. Bray, Jesse W. Rowley
Journal: Blood Advances
Blood Adv (2021) 5 (9): 2362–2374.
https://doi.org/10.1182/bloodadvances.2020004112
Published: 2021
Includes: Supplemental data
Journal Articles

Activated IL-6 signaling contributes to the pathogenesis of, and is a novel therapeutic target for, CALR -mutated MPNs

Manjola Balliu, Laura Calabresi, Niccolò Bartalucci, Simone Romagnoli, Laura Maggi, Rossella Manfredini, Matteo Lulli, Paola Guglielmelli, Alessandro Maria Vannucchi
Journal: Blood Advances
Blood Adv (2021) 5 (8): 2184–2195.
https://doi.org/10.1182/bloodadvances.2020003291
Published: 2021
Includes: Supplemental data
Journal Articles

Deciphering the mechanisms of CC-122 resistance in DLBCL via a genome-wide CRISPR screen

Zhongying Mo, Scott Wood, Shawn Namiranian, Reina Mizukoshi, Stephanie Weng, In Sock Jang, Celia Fontanillo, Joshua M. Baughman, Arianna Silva-Torres, Michelle Slade, Marwa Khater, Kai Wang, Mark Rolfe, Gang Lu
Journal: Blood Advances
Blood Adv (2021) 5 (7): 2027–2039.
https://doi.org/10.1182/bloodadvances.2020003431
Published: 2021
Includes: Supplemental data
Journal Articles

A CRISPR RNA-binding protein screen reveals regulators of RUNX1 isoform generation

Amanda G. Davis, Jaclyn M. Einstein, Dinghai Zheng, Nathan D. Jayne, Xiang-Dong Fu, Bin Tian, Gene W. Yeo, Dong-Er Zhang
Journal: Blood Advances
Blood Adv (2021) 5 (5): 1310–1323.
https://doi.org/10.1182/bloodadvances.2020002090
Published: 2021
Includes: Supplemental data
Journal Articles

Correction of β-thalassemia by CRISPR/Cas9 editing of the α-globin locus in human hematopoietic stem cells

Giulia Pavani, Anna Fabiano, Marine Laurent, Fatima Amor, Erika Cantelli, Anne Chalumeau, Giulia Maule, Alexandra Tachtsidi, Jean-Paul Concordet, Anna Cereseto, Fulvio Mavilio, Giuliana Ferrari, Annarita Miccio, Mario Amendola
Journal: Blood Advances
Blood Adv (2021) 5 (5): 1137–1153.
https://doi.org/10.1182/bloodadvances.2020001996
Published: 2021
Includes: Supplemental data
Journal Articles

In vivo HSPC gene therapy with base editors allows for efficient reactivation of fetal γ-globin in β-YAC mice

Chang Li, Aphrodite Georgakopoulou, Arpit Mishra, Sucheol Gil, R. David Hawkins, Evangelia Yannaki, André Lieber
Journal: Blood Advances
Blood Adv (2021) 5 (4): 1122–1135.
https://doi.org/10.1182/bloodadvances.2020003702
Published: 2021
Includes: Supplemental data
Journal Articles

CRISPR-based screens uncover determinants of immunotherapy response in multiple myeloma

Poornima Ramkumar, Anthony B. Abarientos, Ruilin Tian, Meghan Seyler, Jaime T. Leong, Merissa Chen, Priya Choudhry, Torsten Hechler, Nina Shah, Sandy W. Wong, Thomas G. Martin, III, Jeffrey L. Wolf, Kole T. Roybal, Andreas Pahl, Jack Taunton, Arun P. Wiita, Martin Kampmann
Journal: Blood Advances
Blood Adv (2020) 4 (13): 2899–2911.
https://doi.org/10.1182/bloodadvances.2019001346
Published: 2020
Includes: Supplemental data
Journal Articles

BCL-W is dispensable for the sustained survival of select Burkitt lymphoma and diffuse large B-cell lymphoma cell lines

Sarah T. Diepstraten, Catherine Chang, Lin Tai, Jia-nan Gong, Ping Lan, Alexander C. Dowell, Graham S. Taylor, Andreas Strasser, Gemma L. Kelly
Journal: Blood Advances
Blood Adv (2020) 4 (2): 356–366.
https://doi.org/10.1182/bloodadvances.2019000541
Published: 2020
Includes: Supplemental data
Journal Articles

The stem cell–specific long noncoding RNA HOXA10-AS in the pathogenesis of KMT2A -rearranged leukemia

Sina Al-Kershi, Raj Bhayadia, Michelle Ng, Lonneke Verboon, Stephan Emmrich, Lucie Gack, Adrian Schwarzer, Till Strowig, Dirk Heckl, Jan-Henning Klusmann
Journal: Blood Advances
Blood Adv (2019) 3 (24): 4252–4263.
https://doi.org/10.1182/bloodadvances.2019032029
Published: 2019
Includes: Supplemental data
Journal Articles

High-efficiency CRISPR induction of t(9;11) chromosomal translocations and acute leukemias in human blood stem cells

Johan Jeong, Astraea Jager, Pablo Domizi, Mara Pavel-Dinu, Linda Gojenola, Masayuki Iwasaki, Michael C. Wei, Feng Pan, James L. Zehnder, Matthew H. Porteus, Kara L. Davis, Michael L. Cleary
Journal: Blood Advances
Blood Adv (2019) 3 (19): 2825–2835.
https://doi.org/10.1182/bloodadvances.2019000450
Published: 2019
Includes: Supplemental data
Journal Articles

Genome-wide CRISPR screens reveal genetic mediators of cereblon modulator toxicity in primary effusion lymphoma

Ajinkya Patil, Mark Manzano, Eva Gottwein
Journal: Blood Advances
Blood Adv (2019) 3 (14): 2105–2117.
https://doi.org/10.1182/bloodadvances.2019031732
Published: 2019
Includes: Supplemental data
Journal Articles

CRISPR genome editing of murine hematopoietic stem cells to create Npm1-Alk causes ALK + lymphoma after transplantation

Soumya Sundara Rajan, Lingxiao Li, Mercedes F. Kweh, Kranthi Kunkalla, Amit Dipak Amin, Nitin K. Agarwal, Francisco Vega, Jonathan H. Schatz
Journal: Blood Advances
Blood Adv (2019) 3 (12): 1788–1794.
https://doi.org/10.1182/bloodadvances.2018025247
Published: 2019
Includes: Supplemental data
Journal Articles

Critical role of Jumonji domain of JMJD1C in MLL-rearranged leukemia

Jesus Izaguirre-Carbonell, Luke Christiansen, Robert Burns, Jesse Schmitz, Chenxuan Li, Rebekah L. Mokry, Theresa Bluemn, Yongwei Zheng, Jian Shen, Karen-Sue Carlson, Sridhar Rao, Demin Wang, Nan Zhu
Journal: Blood Advances
Blood Adv (2019) 3 (9): 1499–1511.
https://doi.org/10.1182/bloodadvances.2018026054
Published: 2019
Includes: Supplemental data
Journal Articles

Fluorescent labeling of CRISPR/Cas9 RNP for gene knockout in HSPCs and iPSCs reveals an essential role for GADD45b in stress response

Masoud Nasri, Perihan Mir, Benjamin Dannenmann, Diana Amend, Tessa Skroblyn, Yun Xu, Klaus Schulze-Osthoff, Maksim Klimiankou, Karl Welte, Julia Skokowa
Journal: Blood Advances
Blood Adv (2019) 3 (1): 63–71.
https://doi.org/10.1182/bloodadvances.2017015511
Published: 2019
Includes: Supplemental data
Journal Articles

microRNA-22 promotes megakaryocyte differentiation through repression of its target, GFI1

Cary N. Weiss, Keisuke Ito
Journal: Blood Advances
Blood Adv (2019) 3 (1): 33–46.
https://doi.org/10.1182/bloodadvances.2018023804
Published: 2019
Includes: Supplemental data
Journal Articles

Erythrocyte β spectrin can be genetically targeted to protect mice from malaria

Patrick M. Lelliott, Hong Ming Huang, Matthew W. Dixon, Arman Namvar, Adam J. Blanch, Vijay Rajagopal, Leann Tilley, Cevayir Coban, Brendan J. McMorran, Simon J. Foote, Gaetan Burgio
Journal: Blood Advances
Blood Adv (2017) 1 (26): 2624–2636.
https://doi.org/10.1182/bloodadvances.2017009274
Published: 2017
Includes: Supplemental data