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Issue Archive

Volume 5, Issue 22
November 23 2021
Issue Cover

Table of Contents

EXCEPTIONAL CASE REPORT

VITT following Ad26.COV2.S vaccination presenting without radiographically demonstrable thrombosis
Clinical Trials & Observations
Vanessa E. Kennedy,Chelsea C. Wong,Jessica M. Hong,Theodore Peng,Sam Brondfield,Linda M. Reilly,Patricia Cornett,Andrew D. Leavitt
View Articletitled, VITT following Ad26.COV2.S vaccination presenting without radiographically demonstrable thrombosis

STIMULUS REPORT

Single-cell polyfunctional proteomics of CD4 cells from patients with AML predicts responses to anti–PD-1–based therapy
Hussein A. Abbas,Zoe Alaniz,Sean Mackay,Matthew Cyr,Jing Zhou,Ghayas C. Issa,Mansour Alfayez,Jairo Matthews,Steven M. Kornblau,Elias Jabbour,Guillermo Garcia-Manero,Marina Konopleva,Michael Andreeff,Naval Daver
View Articletitled, Single-cell polyfunctional proteomics of CD4 cells from patients with AML predicts responses to anti–PD-1–based therapy
Supplemental data
Molecular diagnosis of T-cell lymphoma: a correlative study of PCR-based T-cell clonality assessment and targeted NGS
Charlotte Syrykh,Pauline Gorez,Sarah Péricart,David Grand,Frédéric Escudié,Bastien Cabarrou,Lucie Obéric,Loïc Ysebaert,Laurence Lamant,Camille Laurent,Solène M. Evrard,Pierre Brousset
View Articletitled, Molecular diagnosis of T-cell lymphoma: a correlative study of PCR-based T-cell clonality assessment and targeted NGS
Supplemental data
Coevolving JAK2V617F+relapsed AML and donor T cells with PD-1 blockade after stem cell transplantation: an index case
Livius Penter,Satyen H. Gohil,Teddy Huang,Emily M. Thrash,Dominik Schmidt,Shuqiang Li,Mariano Severgnini,Donna Neuberg,F. Stephen Hodi,Kenneth J. Livak,Robert Zeiser,Pavan Bachireddy,Catherine J. Wu
View Articletitled, Coevolving JAK2<sup>V617F+</sup>relapsed AML and donor T cells with PD-1 blockade after stem cell transplantation: an index case
Supplemental data

REVIEW ARTICLE

Gut microbiome in pediatric acute leukemia: from predisposition to cure
Riccardo Masetti,Edoardo Muratore,Davide Leardini,Daniele Zama,Silvia Turroni,Patrizia Brigidi,Susanna Esposito,Andrea Pession
View Articletitled, Gut microbiome in pediatric acute leukemia: from predisposition to cure
Juvenile myelomonocytic leukemia in the molecular era: a clinician’s guide to diagnosis, risk stratification, and treatment
Astrid Wintering,Christopher C. Dvorak,Elliot Stieglitz,Mignon L. Loh
View Articletitled, Juvenile myelomonocytic leukemia in the molecular era: a clinician’s guide to diagnosis, risk stratification, and treatment
PARP1 as a therapeutic target in acute myeloid leukemia and myelodysplastic syndrome
Christina-Nefeli Kontandreopoulou,Panagiotis T. Diamantopoulos,Despina Tiblalexi,Nefeli Giannakopoulou,Nora-Athina Viniou
View Articletitled, PARP1 as a therapeutic target in acute myeloid leukemia and myelodysplastic syndrome

CLINICAL TRIALS AND OBSERVATIONS

CNS involvement in AML at diagnosis is rare and does not affect response or survival: data from 11 ECOG-ACRIN trials
Clinical Trials & Observations
Chezi Ganzel,Ju-Whei Lee,Hugo F. Fernandez,Elisabeth M. Paietta,Selina M. Luger,Hillard M. Lazarus,Larry D. Cripe,Dan Douer,Peter H. Wiernik,Jacob M. Rowe,Martin S. Tallman,Mark R. Litzow
View Articletitled, CNS involvement in AML at diagnosis is rare and does not affect response or survival: data from 11 ECOG-ACRIN trials
Suboptimal iron deficiency screening in pregnancy and the impact of socioeconomic status in a high-resource setting
Clinical Trials & Observations
Jennifer Teichman,Rosane Nisenbaum,Andrea Lausman,Michelle Sholzberg
View Articletitled, Suboptimal iron deficiency screening in pregnancy and the impact of socioeconomic status in a high-resource setting
Supplemental data
Dasatinib and dexamethasone followed by hematopoietic cell transplantation for adults with Ph-positive ALL
Clinical Trials & Observations
Matthew J. Wieduwilt,Jun Yin,Meir Wetzler,Geoffrey L. Uy,Bayard L. Powell,Jonathan E. Kolitz,Michaela Liedtke,Wendy Stock,Jan H. Beumer,Ryan J. Mattison,Elizabeth Storrick,Susan M. Christner,Lionel D. Lewis,Steven Devine,Richard M. Stone,Richard A. Larson
View Articletitled, Dasatinib and dexamethasone followed by hematopoietic cell transplantation for adults with Ph-positive ALL
Supplemental data
Decreased parasite burden and altered host response in children with sickle cell anemia and severe anemia with malaria
Clinical Trials & Observations
Ryan C. Henrici,Casey L. Sautter,Caitlin Bond,Robert O. Opoka,Ruth Namazzi,Dibyadyuti Datta,Russell E. Ware,Andrea L. Conroy,Chandy C. John
View Articletitled, Decreased parasite burden and altered host response in children with sickle cell anemia and severe anemia with malaria
Supplemental data
Phase 1b study of the BET protein inhibitor RO6870810 with venetoclax and rituximab in patients with diffuse large B-cell lymphoma
Clinical Trials & Observations
Michael Dickinson,Javier Briones,Alex F. Herrera,Eva González-Barca,Nilanjan Ghosh,Raul Cordoba,Sarah C. Rutherford,Eirini Bournazou,Emily Labriola-Tompkins,Izolda Franjkovic,Evelyne Chesne,Jurriaan Brouwer-Visser,Katharina Lechner,Barbara Brennan,Eveline Nüesch,Mark DeMario,Dominik Rüttinger,Martin Kornacker,Martin Hutchings
View Articletitled, Phase 1b study of the BET protein inhibitor RO6870810 with venetoclax and rituximab in patients with diffuse large B-cell lymphoma
Supplemental data

HEALTH SERVICES AND OUTCOMES

How to write a guideline: a proposal for a manuscript template that supports the creation of trustworthy guidelines
Robby Nieuwlaat,Wojtek Wiercioch,Jan L. Brozek,Nancy Santesso,Robert Kunkle,Pablo Alonso-Coello,David R. Anderson,Shannon M. Bates,Philipp Dahm,Alfonso Iorio,Wendy Lim,Gary H. Lyman,Saskia Middeldorp,Paul Monagle,Reem A. Mustafa,Ignacio Neumann,Thomas L. Ortel,Bram Rochwerg,Sara K. Vesely,Daniel M. Witt,Adam Cuker,Holger J. Schünemann
View Articletitled, How to write a guideline: a proposal for a manuscript template that supports the creation of trustworthy guidelines
Supplemental data

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Defining the AHR-regulated transcriptome in NK cells reveals gene expression programs relevant to development and function
Prashant Trikha,Jena E. Moseman,Aarohi Thakkar,Amanda R. Campbell,Ezgi Elmas,Jennifer A. Foltz,Nitin Chakravarti,James R. Fitch,Elaine R. Mardis,Dean A. Lee
View Articletitled, Defining the AHR-regulated transcriptome in NK cells reveals gene expression programs relevant to development and function
Supplemental data

LYMPHOID NEOPLASIA

Circulating tumor DNA for comprehensive noninvasive monitoring of lymphoma treated with ibrutinib plus nivolumab
Alessio Bruscaggin,Lodovico Terzi di Bergamo,Valeria Spina,Brendan Hodkinson,Gabriela Forestieri,Ferdinando Bonfiglio,Adalgisa Condoluci,Wei Wu,Maria C. Pirosa,Martin R. Faderl,Ricardo Koch,Michael Schaffer,John D. Alvarez,Nele Fourneau,Bernhard Gerber,Georg Stussi,Emanuele Zucca,Sriram Balasubramanian,Davide Rossi
View Articletitled, Circulating tumor DNA for comprehensive noninvasive monitoring of lymphoma treated with ibrutinib plus nivolumab
Supplemental data
A simplified frailty score predicts survival and can aid treatment-intensity decisions in older patients with DLBCL
Clinical Trials & Observations
Kathrine T. Isaksen,Maria Adele Mastroianni,Marit Rinde,Leiv Sindre Rusten,Dlawer Abdulla Barzenje,Lloyd Frode Ramslien,Marit Slaaen,Marianne Brenn Jerm,Erlend B. Smeland,Siri Rostoft,Knut Liestøl,Marianne Brodtkorb,Harald Holte
View Articletitled, A simplified frailty score predicts survival and can aid treatment-intensity decisions in older patients with DLBCL
Supplemental data

MYELOID NEOPLASIA

A CIBERSORTx-based immune cell scoring system could independently predict the prognosis of patients with myelodysplastic syndromes
Clinical Trials & Observations
Yu-Hung Wang,Hsin-An Hou,Chien-Chin Lin,Yuan-Yeh Kuo,Chi-Yuan Yao,Chia-Lang Hsu,Mei-Hsuan Tseng,Cheng-Hong Tsai,Yen-Ling Peng,Chein-Jun Kao,Wen-Chien Chou,Hwei-Fang Tien
View Articletitled, A CIBERSORTx-based immune cell scoring system could independently predict the prognosis of patients with myelodysplastic syndromes
Supplemental data
Transcription factor MEF2D is required for the maintenance of MLL-rearranged acute myeloid leukemia
Lianzhong Zhao,Pengcheng Zhang,Phillip M. Galbo, Jr,Xinyue Zhou,Sajesan Aryal,Shaowei Qiu,Hao Zhang,Yang Zhou,Chunliang Li,Deyou Zheng,Ravi Bhatia,Rui Lu
View Articletitled, Transcription factor MEF2D is required for the maintenance of MLL-rearranged acute myeloid leukemia
Supplemental data
A clinically applicable gene expression–based score predicts resistance to induction treatment in acute myeloid leukemia
Clinical Trials & Observations
Christian Moser,Vindi Jurinovic,Sabine Sagebiel-Kohler,Bianka Ksienzyk,Aarif M. N. Batcha,Annika Dufour,Stephanie Schneider,Maja Rothenberg-Thurley,Cristina M. Sauerland,Dennis Görlich,Wolfgang E. Berdel,Utz Krug,Ulrich Mansmann,Wolfgang Hiddemann,Jan Braess,Karsten Spiekermann,Philipp A. Greif,Sebastian Vosberg,Klaus H. Metzeler,Jörg Kumbrink,Tobias Herold
View Articletitled, A clinically applicable gene expression–based score predicts resistance to induction treatment in acute myeloid leukemia
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Vesicular formation regulated by ERK/MAPK pathway mediates human erythroblast enucleation
Chao An,Yumin Huang,Mengjia Li,Fumin Xue,Dingrui Nie,Huizhi Zhao,Lixiang Chen,Karina Yazdanbakhsh,Ling Sun,Zhongxing Jiang,Narla Mohandas,Xiuli An
View Articletitled, Vesicular formation regulated by ERK/MAPK pathway mediates human erythroblast enucleation
Supplemental data

THROMBOSIS AND HEMOSTASIS

Role of ribosomal RNA released from red cells in blood coagulation in zebrafish and humans
Abdulmajeed Alharbi,Neha Iyer,Ayah Al Qaryoute,Revathi Raman,David J. Burks,Rajeev K. Azad,Pudur Jagadeeswaran
View Articletitled, Role of ribosomal RNA released from red cells in blood coagulation in zebrafish and humans
Supplemental data
Polyphosphate expression by cancer cell extracellular vesicles mediates binding of factor XII and contact activation
Young Jun Shim,Victor Chatterjee,Shadi Swaidani,Ravi Kumar Alluri,Suman Kundu,Alona Merkulova,Dana Angelini,Dewen You,Samantha A. Whitney,Edward P. Feener,John Barnard,Alvin H. Schmaier,Alok A. Khorana,Keith R. McCrae
View Articletitled, Polyphosphate expression by cancer cell extracellular vesicles mediates binding of factor XII and contact activation
Supplemental data

TRANSPLANTATION

Initial therapy for chronic graft-versus-host disease: analysis of practice variation and failure-free survival
Joseph Pidala,Lynn Onstad,Paul J. Martin,Betty K. Hamilton,Corey Cutler,Carrie L. Kitko,Paul A. Carpenter,George L. Chen,Mukta Arora,Mary E. D. Flowers,Sally Arai,Amin Alousi,Jennifer White,David Jacobsohn,Iskra Pusic,Stephanie J. Lee
View Articletitled, Initial therapy for chronic graft-versus-host disease: analysis of practice variation and failure-free survival
Supplemental data
Third-party type 2 innate lymphoid cells prevent and treat GI tract GvHD
Danny W. Bruce,Oleg Kolupaev,Sonia J. Laurie,Hemamalini Bommiasamy,Heather Stefanski,Bruce R. Blazar,James M. Coghill,Jonathan S. Serody
View Articletitled, Third-party type 2 innate lymphoid cells prevent and treat GI tract GvHD
Supplemental data
Graft rejection markers in children undergoing hematopoietic cell transplant for bone marrow failure
Anthony Sabulski,Kasiani C. Myers,Jack J. Bleesing,Alexandra Duell,Adam Lane,Ashley Teusink-Cross,Stella M. Davies,Sonata Jodele
View Articletitled, Graft rejection markers in children undergoing hematopoietic cell transplant for bone marrow failure

RESEARCH LETTER

Doppler ultrasound screening in patients with newly diagnosed heparin-induced thrombocytopenia
Clinical Trials & Observations
Elyse I. Harris,Luke D. Zurbriggen,Matthew J. Brunner,Eliot C. Williams
View Articletitled, Doppler ultrasound screening in patients with newly diagnosed heparin-induced thrombocytopenia
Assessment and reporting of quality-of-life measures in pivotal clinical trials of hematological malignancies
Clinical Trials & Observations
Samer Al Hadidi,Rammurti T. Kamble,George Carrum,Helen E. Heslop,Carlos Almeida Ramos
View Articletitled, Assessment and reporting of quality-of-life measures in pivotal clinical trials of hematological malignancies
Cost-effectiveness analysis of oral azacitidine maintenance therapy in acute myeloid leukemia
Clinical Trials & Observations
Jan Philipp Bewersdorf,Kishan K. Patel,Scott F. Huntington,Amer M. Zeidan
View Articletitled, Cost-effectiveness analysis of oral azacitidine maintenance therapy in acute myeloid leukemia
Supplemental data
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