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COVER FIGURE
Homology models of the proton-coupled folate transporter in the inward-open (blue) and outward-open (green) conformations. The 11th transmembrane domain and the Asn411 residue are highlighted. This residue is located within the external gate of the protein protruding into the aqueous channel and shifts further into the channel when the protein is in the inward-open conformation and the gate is closed. Mutation of Asn411 to Lys411 markedly impaired transport function, resulting in the autosomal recessive disorder hereditary folate malabsorption. See the article by Aluri et al.