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Journal Articles

Phase II Trial of a Peptide Vaccine, Ocv-501 in Elderly Patients with Acute Myeloid Leukemia

Masaki Yamaguchi, MD PhD, Naoki Takezako, MD PhD, Toru Kiguchi, MD PhD, Shuichi Miyawaki, MD PhD, Yuji Heike, MD PhD, Kaori Mitsuki, Takahiro Yoshida, PhD, Ei Leen Liew, PhD MS, Tomoki Naoe, MD PhD

Blood (2018) 132 (Supplement 1): 29.

https://doi.org/10.1182/blood-2018-99-110013

Published: 2018

Journal Articles

Expression of the Tumor Suppressor WT1 Is Induced By PML-Rara in Acute Promyelocytic Leukemia.Â Â

Matt Christopher, MD PhD, Andrew Menssen, Margery Gang, Anand Upadhyaya, Lukas D Wartman, MD, Timothy James J Ley, MD

Blood (2017) 130 (Supplement 1): 2508.

https://doi.org/10.1182/blood.V130.Suppl_1.2508.2508

Published: 2017

Journal Articles

Regeneration of Tumor Antigen Specific CTLs Utilizing iPSC Technology for Off-the-Shelf Immunotherapy

Takuya Maeda, MD, Seiji Nagano, MD, Kyoko Masuda, PhD, Toshio Kitawaki, MD PhD, Keisuke Kataoka, MD PhD, Seishi Ogawa, MD PhD, Norimitsu Kadowaki, MD PhD, Akifumi Kondo Takaori, MD PhD, Hiroshi Kawamoto, MD PhD

Blood (2016) 128 (22): 4554.

https://doi.org/10.1182/blood.V128.22.4554.4554

Published: 2016

Journal Articles

A New Peptide Vaccine Ocv-501, Phase 1 Study in Patients with Acute Myeloid Leukemia and In Vitro Pharmacology

Tohru Sakura, MD, Yukio Kobayashi, MD PhD, Shuichi Miyawaki, MD PhD, Kazuyuki Toga, MS, Shinji Sogo, PhD, Yuji Heike, MD PhD

Blood (2016) 128 (22): 1643.

https://doi.org/10.1182/blood.V128.22.1643.1643

Published: 2016

Journal Articles

Immunotherapy with Chimeric Antigen Receptor Targeting Intracellular WT1 Gene Product Complexed with HLA-a*24:02 Molecule

Hiroaki Ikeda, MD PhD, Yasushi Akahori, PhD, Motohiro Yoneyama, Yuki Orito, Yoshihiro Miyahara, Yasunori Amaishi, Sachiko Okamoto, Junichi Mineno, PhD, Kazutoh Takesako, PhD, Hiroshi Fujiwara, MD PhD, Masaki Yasukawa, MD PhD, Hiroshi Shiku, MD PhD

Blood (2015) 126 (23): 4292.

https://doi.org/10.1182/blood.V126.23.4292.4292

Published: 2015

Journal Articles

A Phase 1/2 Study of WT1 Peptide Cancer Vaccine WT4869 in Patients with Myelodysplastic Syndromes (MDS)

Takahiro Suzuki, MD PhD, Yasunori Ueda, MD PhD, Michinori Ogura, MD PhD, Toshiki Uchida, MD PhD, Keiya Ozawa, MD PhD, Shigesaburo Miyakoshi, MDPhD, Tomoki Naoe, MD PhD, Makoto Murata, MD PhD, Masahiro Kizaki, MD PhD, Naokuni Uike, MD, Yasunobu Abe, MD PhD, Michihiro Hidaka, MD PhD, Shuzo Tagashira, Satoru Tsuchiya, Kazuma Ohyashiki, MD PhD, Yasushi Miyazaki, MD PhD

Blood (2015) 126 (23): 2868.

https://doi.org/10.1182/blood.V126.23.2868.2868

Published: 2015

Journal Articles

WT1 Protects Leukemic Cells from Cytotoxic Replicative Stress

Oliver H. Krämer, Prof. Dr., PhD

Blood (2014) 124 (21): 880.

https://doi.org/10.1182/blood.V124.21.880.880

Published: 2014

Journal Articles

Clinical Phase II Study of WT1 Peptide Vaccination in Pediatric Leukemia Patients after Stem Cell Transplantation and Analysis of Immunological Monitoring

Yoshiko Hashii, MD, PhD, Yoshihiro Oka, MD, PhD, Takako Miyamura, MD, PhD, Yusuke Oji, MD, PhD, Naoki Hosen, MD, PhD, Akihiro Tsuboi, MD, PhD, Haruo Sugiyama, MD, PhD, Keiichi Ozono, MD, PhD

Blood (2014) 124 (21): 672.

https://doi.org/10.1182/blood.V124.21.672.672

Published: 2014

Journal Articles

Mutation in Wilms' Tumor 1 Induces DNA Hypermethylation of PRC2 Targets, Blocks Myelomonocytic Differentiation, and Defines a Novel Subtype of AML Responsive to EZH2 Inhibition

Daniel Thomas, MD PhD, Subarna Sinha, PhD, Linda Yu, Namyoung Jung, BS, Bo Dai, PhD, Andrew J Gentles, PhD, Andrew P. Feinberg, MD, David Dill, PhD, Ravindra Majeti, MD PhD

Blood (2014) 124 (21): 780.

https://doi.org/10.1182/blood.V124.21.780.780

Published: 2014

Journal Articles

Engineered T Cell Receptor-Mimic Antibody, (TCRm) Chimeric Antigen Receptor (CAR) T Cells Against the Intracellular Protein Wilms Tumor-1 (WT1) for Treatment of Hematologic and Solid Cancers

Sarwish Rafiq, PhD, Tao Dao, MDPhD, Cheng Liu, PhD, David A. Scheinberg, MD PhD, Renier J Brentjens, MD PhD

Blood (2014) 124 (21): 2155.

https://doi.org/10.1182/blood.V124.21.2155.2155

Published: 2014

Journal Articles

WT1-Specific T Cells Exhibiting a Non-Exhausted, Functional Phenotype Can Be Generated From The Natural Repertoire Of Healthy Donors For Clinical Use

Sabine Schmied, MSc, Anne Richter, PhD, Mario Assenmacher, PhD, Juergen Schmitz, PhD

Blood (2013) 122 (21): 4504.

https://doi.org/10.1182/blood.V122.21.4504.4504

Published: 2013

Journal Articles

WT1 Protein Expression in Myeloid Malignancies: An Immunohistochemical Study

Anna Mozos, MD, Elena Bussaglia, PhD, Maite Carricondo, Camino Estivill, Pablo Fuentes, PhD, Tatjana Dedjulia, Matilde Parreno, PhD, Anna Aventin, MD, Jorge Sierra, MD, Jaime Prat, MD, PhD, FRCPath, Josep Nomdedeu, MD

Blood (2011) 118 (21): 4886.

https://doi.org/10.1182/blood.V118.21.4886.4886

Published: 2011

Journal Articles

Expression Pattern of WT1 Isoforms in Patients with Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome (MDS) and Severe Aplastic Anemia (SAA)

Karolina Kramarzova, Andre Willasch, Bernd Gruhn, Jiri Schwarz, MD, PhD, Jana Markova, Jan Stary, M.D., Jan Trka, MD, PhD, Ludmila Boublikova

Blood (2011) 118 (21): 2502.

https://doi.org/10.1182/blood.V118.21.2502.2502

Published: 2011

Journal Articles

T-cell immune responses to Wilms tumor 1 protein in myelodysplasia responsive to immunosuppressive therapy

Elaine M. Sloand, J. Joseph Melenhorst, Zachary C. G. Tucker, Loretta Pfannes, Jason M. Brenchley, Agnes Yong, Valeria Visconte, Colin Wu, Emma Gostick, Phillip Scheinberg, Matthew J. Olnes, Daniel C. Douek, David A. Price, A. John Barrett, Neal S. Young

Blood (2011) 117 (9): 2691–2699.

https://doi.org/10.1182/blood-2010-04-277921

Published: 2011

Includes: Supplemental data

Journal Articles

Efficient Selection of WT1-Specific Donor Lymphocytes by Streptamer Technology.

Xinchao Wang, Anita Schmitt, Xun Xu, Bao-An Chen, Mathias Freund, MD, Michael Schmitt

Blood (2009) 114 (22): 3311.

https://doi.org/10.1182/blood.V114.22.3311.3311

Published: 2009

Journal Articles

Wilms Tumor 1 Gene Mutations in Adult Acute T-Lymphoblastic Leukemia

Sandra Heesch, MS, Nicola Goekbuget, MD, Jutta Ortiz Tanchez, Cornelia Schlee, MS, Stefan Schwartz, Thomas Burmeister, MD, Dieter Hoelzer, MD, PhD, Eckhard Thiel, MD, PhD, Wolf K Hofmann, MD, Claudia D Baldus, MD

Blood (2008) 112 (11): 2516.

https://doi.org/10.1182/blood.V112.11.2516.2516

Published: 2008

Journal Articles

Human Langerhans-Type Dendritic Cells Break Tolerance against the Tumor Antigen, WT1, by a Largely IL-15-Dependent Mechanism.

Emanuela Romano, MD, Rosa Barreira da Silva, BS, Sharanya Chandrasekar, MS, Christian Münz, PhD, Glenn Heller, PhD, James W. Young, MD

Blood (2008) 112 (11): 1554.

https://doi.org/10.1182/blood.V112.11.1554.1554

Published: 2008

Journal Articles

Wilms’ Tumor 1 Gene Mutations in Childhood Acute Myeloid Leukemia: A New Prognostic factor with Implications for MRD Detection

Iris H.I.M. Hollink, MD, Marry M. van den Heuvel-Eibrink, MD, PhD, Martin Zimmermann, PhD, Brian V. Balgobind, MD, Susan T.C.J.M. Arentsen-Peters, Mariel Alders, PhD, Andre Willasch, MD, PhD, Gertjan J.L. Kaspers, MD, PhD, Jan Trka, MD, PhD, Andre Baruchel, MD, PhD, Siebold S.N. de Graaf, MD, PhD, Ursula Creutzig, Rob Pieters, MD, PhD, Dirk Reinhardt, MD, PhD, C. Michel Zwaan, MD, PhD

Blood (2008) 112 (11): 144.

https://doi.org/10.1182/blood.V112.11.144.144

Published: 2008

Journal Articles

Mutant Wilms’ Tumor 1 ( WT1 ) mRNA with Premature Termination Codons Is Sensitive to Nonsense-Mediated RNA Decay in Acute Myeloid Leukemia (AML)

Saman Abbas, Claudia Erpelinck, Chantal Goudswaard, B. Lowenberg, MD, Peter Valk, PhD

Blood (2008) 112 (11): 2538.

https://doi.org/10.1182/blood.V112.11.2538.2538

Published: 2008

Journal Articles

Two Novel WT-1 Derived Peptides Induce CD4+ peptide–specific T Cell Proliferation in Patients with Myelodysplastic Syndrome (MDS)

Monica Bocchia, Micaela Ippoliti, Marzia Defina, Rosaria Crupi, Maristella Tassi, Michela Rondoni, Alessandro Gozzetti, Francesco Lauria

Blood (2008) 112 (11): 5432.

https://doi.org/10.1182/blood.V112.11.5432.5432

Published: 2008

NARROW

Phase II Trial of a Peptide Vaccine, Ocv-501 in Elderly Patients with Acute Myeloid Leukemia

Expression of the Tumor Suppressor WT1 Is Induced By PML-Rara in Acute Promyelocytic Leukemia.Â Â

Regeneration of Tumor Antigen Specific CTLs Utilizing iPSC Technology for Off-the-Shelf Immunotherapy

A New Peptide Vaccine Ocv-501, Phase 1 Study in Patients with Acute Myeloid Leukemia and In Vitro Pharmacology

Immunotherapy with Chimeric Antigen Receptor Targeting Intracellular WT1 Gene Product Complexed with HLA-a*24:02 Molecule

A Phase 1/2 Study of WT1 Peptide Cancer Vaccine WT4869 in Patients with Myelodysplastic Syndromes (MDS)

WT1 Protects Leukemic Cells from Cytotoxic Replicative Stress

Clinical Phase II Study of WT1 Peptide Vaccination in Pediatric Leukemia Patients after Stem Cell Transplantation and Analysis of Immunological Monitoring

Mutation in Wilms' Tumor 1 Induces DNA Hypermethylation of PRC2 Targets, Blocks Myelomonocytic Differentiation, and Defines a Novel Subtype of AML Responsive to EZH2 Inhibition

Engineered T Cell Receptor-Mimic Antibody, (TCRm) Chimeric Antigen Receptor (CAR) T Cells Against the Intracellular Protein Wilms Tumor-1 (WT1) for Treatment of Hematologic and Solid Cancers

WT1-Specific T Cells Exhibiting a Non-Exhausted, Functional Phenotype Can Be Generated From The Natural Repertoire Of Healthy Donors For Clinical Use

WT1 Protein Expression in Myeloid Malignancies: An Immunohistochemical Study

Expression Pattern of WT1 Isoforms in Patients with Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome (MDS) and Severe Aplastic Anemia (SAA)

T-cell immune responses to Wilms tumor 1 protein in myelodysplasia responsive to immunosuppressive therapy

Efficient Selection of WT1-Specific Donor Lymphocytes by Streptamer Technology.

Wilms Tumor 1 Gene Mutations in Adult Acute T-Lymphoblastic Leukemia

Human Langerhans-Type Dendritic Cells Break Tolerance against the Tumor Antigen, WT1, by a Largely IL-15-Dependent Mechanism.

Wilms’ Tumor 1 Gene Mutations in Childhood Acute Myeloid Leukemia: A New Prognostic factor with Implications for MRD Detection

Mutant Wilms’ Tumor 1 ( WT1 ) mRNA with Premature Termination Codons Is Sensitive to Nonsense-Mediated RNA Decay in Acute Myeloid Leukemia (AML)

Two Novel WT-1 Derived Peptides Induce CD4+ peptide–specific T Cell Proliferation in Patients with Myelodysplastic Syndrome (MDS)

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American Society of Hematology

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American Society of Hematology

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