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Journal Articles

HMGA2 mRNA Expression in Patients with Myelodysplastic/Myeloproliferative Neoplasms (MDS/MPN)

Keiji Minakawa, Koki Ueda, MD PhD, Akiko Shichishima, MD PhD, Hiroshi Ohkawara, MD PhD, Kazuei Ogawa, MD PhD, Takayuki Ikezoe, MD PhD, Yayoi Shikama, MD PhD, Kenneth E Nollet, MD PhD, Kazuhiko Ikeda, MD PhD

Blood (2018) 132 (Supplement 1): 4384.

https://doi.org/10.1182/blood-2018-99-114399

Published: 2018

Journal Articles

Insufficiency of Non-Canonical PRC1 Complex Cooperates with an Activating JAK2 Mutation in the Pathogenesis of Myelofibrosis

Daisuke Shinoda, MD, Yaeko Nakajima-Takagi, PhD, Motohiko Oshima, PhD, Atsunori Saraya, Hironori Harada, MD PhD, Haruhiko Koseki, PhD, Kazuya Shimoda, MD PhD, Goro Sashida, MD PhD, Atsushi Iwama, MD PhD

Blood (2018) 132 (Supplement 1): 100.

https://doi.org/10.1182/blood-2018-99-117741

Published: 2018

Journal Articles

Presence of TP53 Mutation and Monosomal Karyotype Predict the Outcome of Patients with Acute Myeloid Leukemia in Non-Remission at Allogeneic Stem Cell Transplantation

Yuho Najima, MD, Daichi Sadato, MS, Yuka Harada, MD PhD, Chizuko Hirama, BS, Keisuke Oboki, MD PhD, Takashi Toya, MD PhD, Noriko Doki, MD PhD, Kyoko Haraguchi, MD PhD, Kota Yoshifuji, MD, Megumi Akiyama, MD, Kyoko Inamoto, MD, Aiko Igarashi, MD, Takeshi Kobayashi, MD, Kazuhiko Kakihana, MD PhD, Yoshiki Okuyama, MD PhD, Hisashi Sakamaki, MD PhD, Hironori Harada, MD PhD, Kazuteru Ohashi, MD PhD

Blood (2018) 132 (Supplement 1): 2168.

https://doi.org/10.1182/blood-2018-99-116469

Published: 2018

Journal Articles

XPO1 Inhibition Targets Transcriptional Vulnerability of FLT3-ITD+D835 Double Mutant AML through p53 Accumulation and Inhibition of Oncogenic Transcription Factors: Lesson Learned from Cage Sequencing of Primary AML Cells

Kotoko Yamatani, MD PhD, Yoko Tabe, MD PhD, Kazumasa Sekihara, PhD, Haeun Yang, Kaori Saito, Weiguo Zhang, MD PhD, Kazuho Ikeo, PhD, Sonoko Kinjo, Kaoru Mogushi, PhD, Masaki Hosoya, Yoshihide Hayashizaki, MD PhD, Yasunari Yamanaka, MD PhD, Hironori Harada, Takashi Miida, MD PhD, Marina Konopleva, MD PhD, Michael Andreeff, MD PhD

Blood (2017) 130 (Supplement 1): 1244.

https://doi.org/10.1182/blood.V130.Suppl_1.1244.1244

Published: 2017

Journal Articles

Human Germline HLTF E259K Mutation Identified in Familial MDS Patients Accumulates DNA Damage through Impaired PCNA Polyubiquitination

Kensuke Takaoka, Masahito Kawazu, Junji Koya, Akihide Yoshimi, Yosuke Masamoto, MD PhD, Hiroaki Maki, Takashi Toya, Takashi Kobayashi, Yasuhito Nannya, MD PhD, Shunya Arai, MD PhD, Hironori Ueno, Kenshi Suzuki, Hironori Harada, Atsushi Manabe, Yasuhide Hayashi, Hiroyuki Mano, MDPhD, Mineo Kurokawa, MD PhD

Blood (2017) 130 (Supplement 1): 4238.

https://doi.org/10.1182/blood.V130.Suppl_1.4238.4238

Published: 2017

Journal Articles

RUNX3 Promotes the Development of MDS/MPN Overlap Syndrome Via Enhancing Expression of Myc in the Absence of Tet2

Takako Yokomizo, PhD, Daiki Tanaka, Sho Kubota, PhD, Motohiko Oshima, PhD, Yuka Harada, MD PhD, Akinori Kanai, PhD, Atsushi Iwama, MD PhD, Hironori Harada, Motomi Osato, MD PhD, Goro Sashida, MD PhD

Blood (2017) 130 (Supplement 1): 2494.

https://doi.org/10.1182/blood.V130.Suppl_1.2494.2494

Published: 2017

Journal Articles

HMGA2 Orchestrates the Tumorgenesis of Myeloproliferative Neoplasms (MPN) in Corporation with JAK2 V617F

Koki Ueda, MD PhD, Kazuhiko Ikeda, MD PhD, Takayuki Ikezoe, MD PhD, Kazuei Ogawa, MD PhD, Yuko Hashimoto, MD PhD, Kayo Harada-Shirado, Hiroshi Ohkawara, MD PhD, Norio Komatsu, MD PhD, Kotaro Shide, MD PhD, Kazuya Shimoda, MD, PhD, Shuhei Koide, PhD, Motohiko Oshima, PhD, Atsushi Iwama, MD PhD, Yasuchika Takeishi, MD PhD

Blood (2016) 128 (22): 796.

https://doi.org/10.1182/blood.V128.22.796.796

Published: 2016

Journal Articles

Idarucizumab, a Specific Reversal Agent for Dabigatran: Immediate, Complete and Sustained Reversal of Dabigatran-Induced Anticoagulation in Japanese Healthy Male Volunteers

Joanne van Ryn, PhD, Masahiro Yasaka, MD PhD, Ippei Ikushima, MD PhD, Akiko Harada, PhD, Atsushi Taniguchi, MSc, Susumu Imazu, PhD, Stephen Norris, PhD, Dietmar Gansser, PhD, Joachim Stangier, PhD

Blood (2016) 128 (22): 2627.

https://doi.org/10.1182/blood.V128.22.2627.2627

Published: 2016

Journal Articles

Expression of HMGA2 Collaborates with JAK2V617F to Progress Myeloproliferative Neoplasms

Koki Ueda, MD PhD, Kazuhiko Ikeda, MD PhD, Kazuei Ogawa, MD PhD, Akiko Shichishima-Nakamura, MD PhD, Kotaro Shide, MD PhD, Kazuya Shimoda, MD PhD, Yuko Hashimoto, MD PhD, Philip J Mason, PhD, Monica Bessler, MD PhD, Yasuchika Takeishi, MD PhD

Blood (2015) 126 (23): 482.

https://doi.org/10.1182/blood.V126.23.482.482

Published: 2015

Journal Articles

A Randomized Study to Determine the Optimal Dose of Darbepoetin Alfa in Patients with Low- or Intermediate-1 Risk Myelodysplastic Syndromes

Hironori Harada, MD PhD, Hirohiko Shibayama, Jun Ho Jang, MD PhD, Ryutaro Shimazaki, Kinuko Mitani, MD, PhD, Kenichi Sawada, MD PhD, Hyeoung-Joon Kim, MD PhD

Blood (2014) 124 (21): 4642.

https://doi.org/10.1182/blood.V124.21.4642.4642

Published: 2014

Journal Articles

Dysregulation of the Let-7/HMGA2 Axis with Methylation of p16 Promoter As a Possible Target of Histone Deacetylase Inhibitor in Myeloproliferative Neoplasms

Kayo Shirado Harada, MD, Kazuhiko Ikeda, MD PhD, Kazuei Ogawa, MD PhD, Hiroshi Ohkawara, MD PhD, Yasuchika Takeishi, MD PhD

Blood (2014) 124 (21): 3213.

https://doi.org/10.1182/blood.V124.21.3213.3213

Published: 2014

Journal Articles

Novel Myelodysplastic Syndromes-like Mouse Models By Cooperating Genetic/Epigenetic Mutations Reveal the Critical Role of HIF-1α for Disease Development

Yoshihiro Hayashi, MD PhD, Yue Zhang, MD, Xiaomei Yan, MD PhD, Goro Sashida, MD PhD, Zefeng Xu, MD, Yunzhu Dong, Hironori Harada, MD PhD, Zhijian Xiao, MD, Gang Huang, PhD

Blood (2014) 124 (21): 362.

https://doi.org/10.1182/blood.V124.21.362.362

Published: 2014

Journal Articles

SETBP1 Mutations Drive Leukemic Transformation in ASXL1 -Mutated MDS

Daichi Inoue, MD PhD, Hirotaka Matsui, MD PhD, Hsin-An Hou, MD PhD, Wen-Chien Chou, MD PhD, Akiko Nagamachi, PhD, Jiro Kitaura, MD PhD, Kimihito Cojin Kawabata, MD PhD, Katsuhiro Togami, MD PhD, Reina Nagase, Sayuri Horikawa, Makoto Saika, MD, Jean-Baptiste Micol, MD, Yasutaka Hayashi, MD, Yuka Harada, MD PhD, Hironori Harada, MD PhD, Hwei-Fang Tien, MD PhD, Omar Abdel-Wahab, MD, Toshio Kitamura, MD PhD

Blood (2014) 124 (21): 525.

https://doi.org/10.1182/blood.V124.21.525.525

Published: 2014

Journal Articles

Mizutani A, Okajima K, Uchiba M, Noguchi T. Activated protein C reduces ischemia/reperfusion-induced renal injury in rats by inhibiting leukocyte activation. Blood . 2000;95(12): 3781-3787 . Mizutani A, Okajima K, Uchiba M, Isobe H, Harada N, Mizutani S, Noguchi T. Antithrombin reduces ischemia/reperfusion-induced renal injury in rats by inhibiting leukocyte activation through promotion of prostacyclin production. Blood . 2003;101(8): 3029-3036 .

Blood (2013) 122 (2): 302.

https://doi.org/10.1182/blood-2013-03-493585

Published: 2013

Journal Articles

Generation of a Novel Bispecific Antibody (ACE910) Against Activated Factor IX and Factor X Mimicking the Function of Factor VIII Cofactor Activity

Tomoyuki Igawa, PhD, Zenjiro Sampei, Tetsuhiro Soeda, PhD, Yukiko Okuyama-Nishida, PhD, Chifumi Moriyama, Tetsuya Wakabayashi, Eriko Tanaka, Atsushi Muto, Tetsuo Kojima, PhD, Takehisa Kitazawa, DVM, Kazutaka Yoshihashi, DVM, PhD, Aya Harada, Miho Funaki, Kenta Haraya, Tachibana Tatsuhiko, PhD, Sachiyo Suzuki, Keiko Esaki, Yoshiaki Nabuchi, PhD, Kunihiro Hattori, PhD

Blood (2012) 120 (21): 1126.

https://doi.org/10.1182/blood.V120.21.1126.1126

Published: 2012

Journal Articles

C-Jun Regulates Glucocorticoid-Mediated BIM Induction and Apoptosis in Leukemia Cells: An Alternative Target to Overcome Glucocorticoid-Resistance,

Nastaran Heidari, PhD, Christine B Marking, Mark A Hicks, Hisashi Harada, PhD

Blood (2011) 118 (21): 3486.

https://doi.org/10.1182/blood.V118.21.3486.3486

Published: 2011

Journal Articles

A Novel Direct STAT3 Inhibitor OPB-31121 Induces Tumor-Specific Growth Inhibition In a Wide Range of Hematopoietic Malignancies and Effectively Suppresses the Chemotherapy Resistant Quiescent Cells In Vivo

Fumihiko Hayakawa, MD, PhD, Keiki Sugimoto, Shingo Kurahashi, MD, Hironori Matsuyama, Yasuo Harada, Norikazu Hashimoto, Naoto Ohi, Takeshi Kodama, Takumi Sumida, Tomohiro Kinoshita, MD, PhD, Tomoki Naoe, MD, PhD

Blood (2010) 116 (21): 3277.

https://doi.org/10.1182/blood.V116.21.3277.3277

Published: 2010

Journal Articles

Mobilization of Hematopoietic Progenitors Following Myocardial Ischemic Injury Underpins the Physiological and Therapeutic Benefits of G-CSF on Myocardial Repair

Davi D J. Curtis, MD, PhD, Peter Kanellakis, Alex Bobik, PhD

Blood (2008) 112 (11): 474.

https://doi.org/10.1182/blood.V112.11.474.474

Published: 2008

Journal Articles

Treatment of Idiopathic Myelofibrosis Employing siRNA for Heat Shock Protein 47 (siRNA/HSP47) Encapsulated in Liposomes.

Junichi Watanabe, MD, Takuya Matsunaga, MD, PhD, Kazuyuki Murase, MD, PhD, Yasushi Sato, MD, PhD, Taiko Nagaya, Hirotoshi Ishiwatari, MD, Sho Takahashi, MD, PhD, Koichi Takada, MD, PhD, Masayoshi Kobune, MD, PhD, Kazuya Shimoda, MD, PhD, Mine Harada, MD, PhD, Yoshiro Niitsu, MD, PhD

Blood (2007) 110 (11): 4646.

https://doi.org/10.1182/blood.V110.11.4646.4646

Published: 2007

Journal Articles

Cardiac Myofibroblasts of Hematopoietic Origin Are Mobilized by G-CSF and Contribute to Cardiac Repair after Myocardial Infarction.

Hiroshi Kawada, MD, Jun Fujita, MD, Mitsuyo Tsuma, Yumi Matsuzaki, MD, Hideyuki Okano, MD, Keiichi Fukuda, MD, Tomomitsu Hotta, MD, Kiyoshi Ando, MD

Blood (2005) 106 (11): 1699.

https://doi.org/10.1182/blood.V106.11.1699.1699

Published: 2005

NARROW

HMGA2 mRNA Expression in Patients with Myelodysplastic/Myeloproliferative Neoplasms (MDS/MPN)

Insufficiency of Non-Canonical PRC1 Complex Cooperates with an Activating JAK2 Mutation in the Pathogenesis of Myelofibrosis

Presence of TP53 Mutation and Monosomal Karyotype Predict the Outcome of Patients with Acute Myeloid Leukemia in Non-Remission at Allogeneic Stem Cell Transplantation

XPO1 Inhibition Targets Transcriptional Vulnerability of FLT3-ITD+D835 Double Mutant AML through p53 Accumulation and Inhibition of Oncogenic Transcription Factors: Lesson Learned from Cage Sequencing of Primary AML Cells

Human Germline HLTF E259K Mutation Identified in Familial MDS Patients Accumulates DNA Damage through Impaired PCNA Polyubiquitination

RUNX3 Promotes the Development of MDS/MPN Overlap Syndrome Via Enhancing Expression of Myc in the Absence of Tet2

HMGA2 Orchestrates the Tumorgenesis of Myeloproliferative Neoplasms (MPN) in Corporation with JAK2 V617F

Idarucizumab, a Specific Reversal Agent for Dabigatran: Immediate, Complete and Sustained Reversal of Dabigatran-Induced Anticoagulation in Japanese Healthy Male Volunteers

Expression of HMGA2 Collaborates with JAK2V617F to Progress Myeloproliferative Neoplasms

A Randomized Study to Determine the Optimal Dose of Darbepoetin Alfa in Patients with Low- or Intermediate-1 Risk Myelodysplastic Syndromes

Dysregulation of the Let-7/HMGA2 Axis with Methylation of p16 Promoter As a Possible Target of Histone Deacetylase Inhibitor in Myeloproliferative Neoplasms

Novel Myelodysplastic Syndromes-like Mouse Models By Cooperating Genetic/Epigenetic Mutations Reveal the Critical Role of HIF-1α for Disease Development

SETBP1 Mutations Drive Leukemic Transformation in ASXL1 -Mutated MDS

Generation of a Novel Bispecific Antibody (ACE910) Against Activated Factor IX and Factor X Mimicking the Function of Factor VIII Cofactor Activity

C-Jun Regulates Glucocorticoid-Mediated BIM Induction and Apoptosis in Leukemia Cells: An Alternative Target to Overcome Glucocorticoid-Resistance,

A Novel Direct STAT3 Inhibitor OPB-31121 Induces Tumor-Specific Growth Inhibition In a Wide Range of Hematopoietic Malignancies and Effectively Suppresses the Chemotherapy Resistant Quiescent Cells In Vivo

Mobilization of Hematopoietic Progenitors Following Myocardial Ischemic Injury Underpins the Physiological and Therapeutic Benefits of G-CSF on Myocardial Repair

Treatment of Idiopathic Myelofibrosis Employing siRNA for Heat Shock Protein 47 (siRNA/HSP47) Encapsulated in Liposomes.

Cardiac Myofibroblasts of Hematopoietic Origin Are Mobilized by G-CSF and Contribute to Cardiac Repair after Myocardial Infarction.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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