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Journal Articles

Lgr5 Functions As a Critical Negative Regulator of Wnt/β-Catenin Signaling and Is Essential for B-Lymphopoiesis and Malignant B-Cell Transformation

Kadriye Nehir Cosgun, PhD, Gauri Deb, MS, PhD, Xin Yang, MD, Gang Xiao, PhD, Teresa Sadras, PhD, Jaewoong Lee, PhD, Lai N Chan, PhD, Kohei Kume, PhD, Lu Yang, PhD, Huimin Geng, PhD, John Chan, MD, Joo Y. Song, MD, Hassan Jumaa, PhD, Andrew G. Polson, PhD, Hans Clevers, MD PhD, Markus Müschen, MD PhD

Blood (2019) 134 (Supplement_1): 748.

https://doi.org/10.1182/blood-2019-127263

Published: 2019

Journal Articles

Combined Single-Cell DNA Genotyping and Protein Quantification (DAb-seq) in Acute Myeloid Leukemias Reveals Distinct Immunophenotypic Subsets Among Pathogenic Clones

Benjamin Demaree, Cyrille Delley, PhD, Cheryl Peretz, MD, Harish Vasudevan, MD PhD, David Ruff, Aik Ooi, PhD, Catherine C. Smith, MD, Adam Abate, PhD

Blood (2019) 134 (Supplement_1): 2088.

https://doi.org/10.1182/blood-2019-127048

Published: 2019

Journal Articles

A New Mechanism for T-ALL Leukemogenesis: Early Expression of Alpha-Beta TCR Occurs in a Natural Subset of CD4-CD8- Double Negative (DN) Thymocytes Where MHC Engagement May Drive NOTCH Mutation and Tumor Initiation

Kimberly G Laffey, PhD, Robert J Stiles, BS, Melissa Ludescher, MS, Tessa Davis, MS, Shariq S Khwaja, MD, Richard J. Bram, MD, Peter J Wettstein, PhD, Venkataraman Ramachandran, MD, Cory E Johnson, BS, Richard Hammer, MD, Chi-Ren Shyu, PhD, Diana Gil, PhD, Adam G Schrum, PhD

Blood (2019) 134 (Supplement_1): 1463.

https://doi.org/10.1182/blood-2019-131897

Published: 2019

Journal Articles

DT2216, a Synthetic Proteolytic Selectively Targeting Bcl-X L for Ubiquitination and Degradation in Tumor Cells but Not in Platelets, Is a Safer and More Potent Antitumor Agent Than Navitoclax

Sajid Khan, PhD, Xuan Zhang, BMBS, Dongwen Lv, PhD, Yonghan He, MD, Peiyi Zhang, MS, Xingui Liu, PhD, Dinesh Thummuri, PhD, Qi Zhang, PhD, Marina Y. Konopleva, MD PhD, Robert A. Hromas, MD, Guangrong Zheng, Daohong Zhou, MD

Blood (2018) 132 (Supplement 1): 2698.

https://doi.org/10.1182/blood-2018-99-114762

Published: 2018

Journal Articles

Lgr5 Enables Positive B-Cell Selection and Tumor-Initiation in B-Cell Malignancies

Kadriye Nehir Cosgun, PhD, Gauri Deb, MS, PhD, Xin Yang, MD, Gang Xiao, PhD, Teresa Sadras, PhD, Franziska Auer, PhD, Jaewoong Lee, PhD, Anthony Abarientos, BSc, Maurizio Mangolini, PhD, Ali Aghajanirefah, PhD, Huimin Geng, PhD, Hassan Jumaa, PhD, Andrew G. Polson, PhD, Hans Clevers, MD PhD, Markus Muschen, MD

Blood (2018) 132 (Supplement 1): 547.

https://doi.org/10.1182/blood-2018-99-116956

Published: 2018

Journal Articles

Macrophage Factor Xa Signaling Promotes Cancer Immune Evasion

Claudine Graf, MD PhD, Petra Wilgenbus, Maki Kitano, Stephan Macher-Göppinger, Wolfram Ruf, MD

Blood (2018) 132 (Supplement 1): 135.

https://doi.org/10.1182/blood-2018-99-119167

Published: 2018

Journal Articles

High Molecular Weight Kininogen Alters the Tumor Microenvironment and Reduces Tumor Stem Cell Content

Meenal Shukla, James Hale, PhD, Justin Lathia, PhD, Keith McCrae, MD

Blood (2017) 130 (Supplement 1): 2340.

https://doi.org/10.1182/blood.V130.Suppl_1.2340.2340

Published: 2017

Journal Articles

AML-Associated Somatic Mutations Can be Detected in Stem and Progenitor Populations in Patients with Antecedent Multiple Myeloma Years before Onset of Therapy-Related Transformation

Ashwin Sridharan, Carolina D. Schinke, MD, George Georgiev, Mariana Da Silva Ferreira, Kith Pradhan, PhD, Yu Xia, PhD, Maya Panjikaran, MS, Gregory Sims, Chirag Bhagat, Armin Graber, Christoph Heuck, MD, Daisy Alapat, MD, Niels Weinhold, PhD, Sarah K Johnson, PhD, Bart Barlogie, MD PhD, Gareth J. Morgan, MD PhD, Ulrich G. Steidl, MDPhD, Britta Will, PhD, Amit Verma, MD

Blood (2017) 130 (Supplement 1): 2706.

https://doi.org/10.1182/blood.V130.Suppl_1.2706.2706

Published: 2017

Journal Articles

Therapeutic targeting of acute myeloid leukemia stem cells

Daniel A. Pollyea, Craig T. Jordan

Blood (2017) 129 (12): 1627–1635.

https://doi.org/10.1182/blood-2016-10-696039

Published: 2017

Journal Articles

CD25 Enables Oncogenic BCR Signaling and Represents a Therapeutic Target in Refractory B Cell Malignancies

Jae-Woong Lee, PhD, Huimin Geng, PhD, Zhengshan Chen, MD PhD, Lars Klemm, BSc, MSc, Kadriye Nehir Cosgun, PhD, Gang Xiao, PhD, Behzad Masouleh, Christian Hurtz, PhD, Samir Parekh, MD, Steven M. Kornblau, MD, Ari Melnick, MD, Abul Abbas, Elisabeth Paietta, Markus Müschen, MD PhD

Blood (2016) 128 (22): 4088.

https://doi.org/10.1182/blood.V128.22.4088.4088

Published: 2016

Journal Articles

Dynamical Modeling of Clonal Evolution in Paired Primary and Relapsed Follicular Lymphoma Predicts a Link Between Cell Migration and Evolutionary Heterogeneity

Matthias Horn, PhD, Markus Kreuz, PhD, Ralf Küppers, PhD, Markus Loeffler, MD PhD

Blood (2016) 128 (22): 2929.

https://doi.org/10.1182/blood.V128.22.2929.2929

Published: 2016

Journal Articles

Analysis of Mutational Signatures Suggest That Aid Has an Early and Driver Role in Multiple Myeloma

Blood (2016) 128 (22): 116.

https://doi.org/10.1182/blood.V128.22.116.116

Published: 2016

Journal Articles

Engineering of Trispecific Molecule That Induces Natural Killer Cell Expansion While Mediating CD133-Specific Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC)

Jörg Uwe Schmohl, MD, Martin Felices, PhD, Jeffrey S. Miller, MD, Dan Vallera, PhD

Blood (2016) 128 (22): 3518.

https://doi.org/10.1182/blood.V128.22.3518.3518

Published: 2016

Journal Articles

Loss of Function RUNX1 Mutations Restrict Protein Biosynthesis during Pre-Leukemia and MDS Transition but Not after Leukemic Transformation

Xiongwei Cai, PhD, Yoshihiro Hayashi, MD PhD, Mark Wunderlich, MS, Nancy A. Speck, PhD, James C. Mulloy, PhD, Gang Huang, PhD, Yi Zheng, PhD

Blood (2016) 128 (22): 3860.

https://doi.org/10.1182/blood.V128.22.3860.3860

Published: 2016

Journal Articles

Probing the AML Surfaceome for Chimeric Antigen Receptor (CAR) Targets

Fabiana Perna, MDPhD, Samuel Berman, Jorge Mansilla-Soto, PhD, Mohamad Hamieh, PhD, Rupa Juthani, MD, Rajesh Soni, PhD, Justin Eyquem, PhD, Ronald Hendrickson, PhD, Cameron Brennan, MD, Michel Sadelain, MD PhD

Blood (2016) 128 (22): 526.

https://doi.org/10.1182/blood.V128.22.526.526

Published: 2016

Journal Articles

Innate Immune Signaling in Regulation of Immunity

Giorgio Trinchieri, MD

Blood (2016) 128 (22): SCI-26.

https://doi.org/10.1182/blood.V128.22.SCI-26.SCI-26

Published: 2016

Journal Articles

Tris DBA Palladium Overcomes Hypoxia Mediated Drug Resistance in Multiple Myeloma

Pilar De La Puente, PhD, Barbara Muz, PhDMSc, Feda Azab, BPharm, Micah John Luderer, BS, MS, Jack L. Arbiser, MD, PhD, Abdel Kareem Azab, BPharm, PhD

Blood (2015) 126 (23): 2978.

https://doi.org/10.1182/blood.V126.23.2978.2978

Published: 2015

Journal Articles

Apurinic/Apyrimidinic Endonuclease 1 Induced Genomic Instability Causes T-Cell Acute Lymphoblastic Leukemia in Zebrafish

Jianhong Lin, MD M.Sc, Chun Yang, MD PhD, Ariel Kwart, B.S., Jianjun Zhao, MD PhD, Mehmet K Samur, PhD, Weihong Zhang, MD, Purushothama Nanjappa, M.S., Teresa Calimeri, MD PhD, Xiubao Ren, MD, Dongdong Ma, MD PhD, Xiaofeng Jiang, MD PhD, Yi Zhou, PhD, Masood Shammas, PhD, Kenneth C. Anderson, MD, Jon C. Aster, MD PhD, Leonard I. Zon, MD, Robert I. Handin, MD, Nikhil C. Munshi, MD

Blood (2015) 126 (23): 1431.

https://doi.org/10.1182/blood.V126.23.1431.1431

Published: 2015

Journal Articles

Tumor Microenvironment Regulates Survival of Mantle Cell Lymphoma Cells through Various Signaling Pathways

Lalit Sehgal, PhD, Khashab Tamer, MD, Xin Wang, MD, Rohit Mathur, PhD, Zuzana Berkova, PhD, Jorge E. Romaguera, MD, Alma Rodriguez, MD, Sattva S. Neelapu, MD, Felipe Samaniego, MD

Blood (2015) 126 (23): 4775.

https://doi.org/10.1182/blood.V126.23.4775.4775

Published: 2015

Journal Articles

Wild-Type Kras Inhibits Nras Q61R/+ -Induced Leukemias

Zhi Wen, PhD MD, Jing Zhang, PhD

Blood (2015) 126 (23): 1249.

https://doi.org/10.1182/blood.V126.23.1249.1249

Published: 2015

NARROW

Lgr5 Functions As a Critical Negative Regulator of Wnt/β-Catenin Signaling and Is Essential for B-Lymphopoiesis and Malignant B-Cell Transformation

Combined Single-Cell DNA Genotyping and Protein Quantification (DAb-seq) in Acute Myeloid Leukemias Reveals Distinct Immunophenotypic Subsets Among Pathogenic Clones

A New Mechanism for T-ALL Leukemogenesis: Early Expression of Alpha-Beta TCR Occurs in a Natural Subset of CD4-CD8- Double Negative (DN) Thymocytes Where MHC Engagement May Drive NOTCH Mutation and Tumor Initiation

DT2216, a Synthetic Proteolytic Selectively Targeting Bcl-X L for Ubiquitination and Degradation in Tumor Cells but Not in Platelets, Is a Safer and More Potent Antitumor Agent Than Navitoclax

Lgr5 Enables Positive B-Cell Selection and Tumor-Initiation in B-Cell Malignancies

Macrophage Factor Xa Signaling Promotes Cancer Immune Evasion

High Molecular Weight Kininogen Alters the Tumor Microenvironment and Reduces Tumor Stem Cell Content

AML-Associated Somatic Mutations Can be Detected in Stem and Progenitor Populations in Patients with Antecedent Multiple Myeloma Years before Onset of Therapy-Related Transformation

Therapeutic targeting of acute myeloid leukemia stem cells

CD25 Enables Oncogenic BCR Signaling and Represents a Therapeutic Target in Refractory B Cell Malignancies

Dynamical Modeling of Clonal Evolution in Paired Primary and Relapsed Follicular Lymphoma Predicts a Link Between Cell Migration and Evolutionary Heterogeneity

Analysis of Mutational Signatures Suggest That Aid Has an Early and Driver Role in Multiple Myeloma

Engineering of Trispecific Molecule That Induces Natural Killer Cell Expansion While Mediating CD133-Specific Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC)

Loss of Function RUNX1 Mutations Restrict Protein Biosynthesis during Pre-Leukemia and MDS Transition but Not after Leukemic Transformation

Probing the AML Surfaceome for Chimeric Antigen Receptor (CAR) Targets

Innate Immune Signaling in Regulation of Immunity

Tris DBA Palladium Overcomes Hypoxia Mediated Drug Resistance in Multiple Myeloma

Apurinic/Apyrimidinic Endonuclease 1 Induced Genomic Instability Causes T-Cell Acute Lymphoblastic Leukemia in Zebrafish

Tumor Microenvironment Regulates Survival of Mantle Cell Lymphoma Cells through Various Signaling Pathways

Wild-Type Kras Inhibits Nras Q61R/+ -Induced Leukemias

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American Society of Hematology

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ASH Publications

American Society of Hematology

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