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Journal Articles

Mechanistic basis and efficacy of targeting the β-catenin–TCF7L2–JMJD6–c-Myc axis to overcome resistance to BET inhibitors

Dyana T. Saenz, Warren Fiskus, Christopher P. Mill, Dimuthu Perera, Taghi Manshouri, Bernardo H. Lara, Vrajesh Karkhanis, Sunil Sharma, Stephen K. Horrigan, Prithviraj Bose, Tapan M. Kadia, Lucia Masarova, Courtney D. DiNardo, Gautam Borthakur, Joseph D. Khoury, Koichi Takahashi, Srividya Bhaskara, Charles Y. Lin, Michael R. Green, Cristian Coarfa, Craig M. Crews, Srdan Verstovsek, Kapil N. Bhalla
Journal: Blood
Blood (2020) 135 (15): 1255–1269.
https://doi.org/10.1182/blood.2019002922
Published: 2020
Includes: Supplemental data
Journal Articles

The Embryonic Program Activated during Blast Crisis of Chronic Myelogenous Leukemia (CML) Implicates a TCF7L2 and MYC Cooperative Chromatin Binding and Represents a Druggable Target

Christophe Desterke, PhD, Sarah Pagliaro, Pharm D, Patricia Hugues, Annelise Bennaceur-Griscelli, MD PhD, Ali G Turhan, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1632.
https://doi.org/10.1182/blood-2019-124796
Published: 2019
Journal Articles

Mechanistic Basis and Efficacy of Targeting β-Catenin-TCF7L2-JMJD6-MYC Axis to Overcome Resistance to BET Inhibitors

Christopher Peter Mill, PhD BA, Warren Fiskus, BSc,PhD, Dyana T. Saenz, PhD, Bernardo H Lara, Vrajesh Karkhanis, PhD, Taghi Manshouri, PhD, Isean Bhalla, Nancy Shao, James V Maher, Srdan Verstovsek, MD PhD, Kapil N. Bhalla, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 538.
https://doi.org/10.1182/blood-2019-125142
Published: 2019
Journal Articles

Transcriptional Signaling Centers Govern Human Erythropoiesis and Harbor Genetic Variations of Red Blood Cell Traits

Avik Choudhuri, PhD, Eirini Trompouki, PhD, Brian J. Abraham, PhD, Leandro Colli, MD, William Mallard, Min-Lee Yang, PhD, Divya Vinjamur, PhD, Alireza Ghamari, PhD, Satish Nandakumar, PhD, Kanen Hoi, Barbara Hummel, Sonja Boatman, Victoria Chan, Teresa V. Bowman, PhD, Song Yang, Yi Zhou, Sinichiro Takahashi, MD PhD, Alan B. Cantor, MD PhD, Vijay G. Sankaran, MD PhD, Santhi Ganesh, MD, Daniel E. Bauer, MD PhD, John Rinn, PhD, Stephen J Chanock, MD, Richard A. Young, PhD, Leonard I. Zon, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1277.
https://doi.org/10.1182/blood-2018-99-118637
Published: 2018
Journal Articles

Distinct Signaling Centers Define Stages of Human Erythropoiesis and Harbor Common Variations of Red Blood Cell Traits

Avik Choudhuri, PhD, Eirini Trompouki, PhD, Brian J Abraham, PhD, William Mallard, Min-Lee Yang, PhD, Alireza Ghamari, PhD, Kanen Hoi, Barbara Hummel, Sonja Boatman, Victoria Chan, Teresa V. Bowman, PhD, Song Yang, Yi Zhou, Sinichiro Takahashi, MD PhD, Alan B. Cantor, MD, PhD, Santhi Ganesh, MD, John Rinn, PhD, Richard A. Young, PhD, Leonard I. Zon, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 773.
https://doi.org/10.1182/blood.V130.Suppl_1.773.773
Published: 2017
Journal Articles

RASSF2 Functions As a Tumor Suppressor in t(8;21) AML Via Promotion of Apoptosis

Samuel A Stoner, Russell Dekelver, Miao-Chia Lo, Dong-Er Zhang, PhD
Journal: Blood
Blood (2014) 124 (21): 3590.
https://doi.org/10.1182/blood.V124.21.3590.3590
Published: 2014
Journal Articles

Identification of the Wnt Signalling Protein, TCF7L2 As a Significantly Overexpressed Transcription Factor in AML

Siti Sarah Daud, MMedSc, Sara L Pumford, MPhil, Marie N Gilmour, PhD, Amanda F Gilkes, MSc, Alan K Burnett, MD, Robert Hills, MA, MSc, DPhil, Alex Tonks, PhD, Richard L Darley, PhD
Journal: Blood
Blood (2012) 120 (21): 1281.
https://doi.org/10.1182/blood.V120.21.1281.1281
Published: 2012
Journal Articles

Lineage Regulators Direct BMP and Wnt Pathways to Cell-Specific Programs During Differentiation and Regeneration,

Teresa V. Bowman, PhD, Eirini Trompouki, PhD, Lee N Lawton, PhD, Zi Peng Fan, Dai-chen Wu, Anthony DiBiase, Corey S Martin, Jennifer N Cech, Anna K Sessa, Jocelyn L LeBlanc, Pulin Li, Ellen Durand, Christian Mosimann, Garrett C Heffner, PhD, George Q. Daley, MD, PhD, Robert F. Paulson, PhD, BA, Richard Young, PhD, Leonard I. Zon, MD
Journal: Blood
Blood (2011) 118 (21): 3387.
https://doi.org/10.1182/blood.V118.21.3387.3387
Published: 2011
Journal Articles

Large-Scale Integration of Gene Profiling Identifies TCF7L2/TCF4 as the Most Frequently Dysregulated Wnt Signaling Component In AML

Siti Sarah Daud, Alan K Burnett, MD, Richard L Darley, PhD, Alex Tonks, PhD
Journal: Blood
Blood (2010) 116 (21): 2480.
https://doi.org/10.1182/blood.V116.21.2480.2480
Published: 2010
Journal Articles

BMP and WNT-Directed Transcription Factors TCF7L2/TCF4 and SMAD1 Bind to Distinct Hematopoietic-Specific Target Genes Depending on Cell Lineage

Eirini Trompouki, PhD, Teresa V. Bowman, PhD, Lee N Lawton, PhD, Zi Peng Fan, Anthony DiBiase, Jennifer Cech, Anna Sessa, Jocelyn LeBlanc, Pulin Li, Garrett Heffner, PhD, George Q. Daley, MD, PhD, Richard Young, PhD, Leonard I. Zon, MD
Journal: Blood
Blood (2010) 116 (21): 3870.
https://doi.org/10.1182/blood.V116.21.3870.3870
Published: 2010
Journal Articles

ABCG2 Is Expressed in a Small Population of Circulating CLL B-Cells Characterized by Expression of Self-Renewal and Early B-Cell Development Genes and Resistance to Therapy

Grzegorz S. Nowakowski, Xiaosheng Wu, Jennifer L. Abrahamzon, Renee Tschumper, Neil E. Kay, Diane F. Jelinek
Journal: Blood
Blood (2008) 112 (11): 3156.
https://doi.org/10.1182/blood.V112.11.3156.3156
Published: 2008