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Journal Articles

Pharmacological Inhibition of the RNA m 6 a Writer METTL3 As a Novel Therapeutic Strategy for Acute Myeloid Leukemia

Konstantinos Tzelepis, Etienne De Braekeleer, PhD MSc, Eliza Yankova, PhD, Justyna Rak, PhD, Demetrios Aspris, MSc, Ana Filipa Domingues, PhD, Richard Fosbeary, Alan Hendrick, PhD, Dan Leggate, PhD, Yaara Ofir-Rosenfeld, PhD, Alexandra Sapetschnig, PhD, Cristina Pina, MDDPhil, Mark Albertella, PhD, Wesley Blackaby, PhD, Oliver Rausch, PhD, George S. Vassiliou, FRCPath, MRCP, PhD, Tony Kouzarides, PhD

Blood (2019) 134 (Supplement_1): 403.

https://doi.org/10.1182/blood-2019-127962

Published: 2019

Journal Articles

X-Ray Crystallographic and Single-Molecule Fluorescence Studies of Beta-2 Glycoprotein I Reveal an Alternative Mechanism of Autoantibody Recognition

William Planer, M.S., Zhiwei Chen, M.S., Mathivanan Chinnaraj, PhD, Xiaobing Zuo, PhD, Vittorio Pengo, MD, Paolo Macor, PhD, Francesco Tedesco, MD, Nicola Pozzi, PhD

Blood (2019) 134 (Supplement_1): 91.

https://doi.org/10.1182/blood-2019-122064

Published: 2019

Journal Articles

Binding of Factor VIII to D'D3 and A2 Domains of Von Willebrand Factor Facilitates Mechanical Unraveling of the A2 Domain

Wenjing Cao, MD,PhD, Wenpeng Cao, Wei Zhang, X. Long Zheng, MD, PhD, Xiaohui (Frank) Zhang, PhD

Blood (2019) 134 (Supplement_1): 95.

https://doi.org/10.1182/blood-2019-125115

Published: 2019

Journal Articles

A FULLY Human Bispecific Antibody Functionally Rescues Factor VIII Deficiency EX VIVO

Wei Wang, PhD, John Blackwood, PhD, Roberto Magliozzi, PhD, Leonardo Moraes, PhD, Jeffrey Hollins, PhD, Alessandro Sinopoli, PhD, Bertie Chi, PhD, Laura Mitchell, PhD, Chris Sellick, PhD, Claire Pearce, PhD, Igor Theurl, MD PhD, Volker Germaschewski, Jacob Galson, PhD, Luca Badiali, PhD, Karen Dickson, PhD, Allan Bradley, PhD, E-Chiang Lee, PhD

Blood (2019) 134 (Supplement_1): 2410.

https://doi.org/10.1182/blood-2019-123359

Published: 2019

Journal Articles

CCS1477: A Novel Small Molecule Inhibitor of p300/CBP Bromodomain for the Treatment of Acute Myeloid Leukaemia and Multiple Myeloma

Nigel Brooks, PhD, Meera Raja, PhD, Barbara W Young, PhD, Gary J Spencer, PhD, Tim CP Somervaille, MD PhD, Neil A Pegg, PhD

Blood (2019) 134 (Supplement_1): 2560.

https://doi.org/10.1182/blood-2019-124707

Published: 2019

Journal Articles

In Vitro and In Vivo Characterization of Marstacimab, an Anti-TFPI Antibody

Chuenlei Parng, PhD, Macy Jin, PhD, Matthew Holsti, PhD, Susan Benard, Swapnil Rakhe, MS, Sunita R. Patel-Hett, PhD, Alison Joyce, Rob Webster, Debra D Pittman, MS

Blood (2019) 134 (Supplement_1): 2391.

https://doi.org/10.1182/blood-2019-130327

Published: 2019

Journal Articles

Loxo-305, a Highly Selective and Non-Covalent Next Generation BTK Inhibitor, Inhibits Diverse BTK C481 Substitution Mutations

Eliana B. Gomez, PhD, Lippincott Isabel, PhD, Mary S. Rosendahal, PhD, Stephen M. Rothenberg, MD PhD, Steven W. Andrews, PhD, Barb J. Brandhuber, PhD

Blood (2019) 134 (Supplement_1): 4644.

https://doi.org/10.1182/blood-2019-126114

Published: 2019

Journal Articles

Modulation of TET2 Activity By Ascorbic Acid and Factors Affecting Lysine Acetylation

Blood (2018) 132 (Supplement 1): 4346.

https://doi.org/10.1182/blood-2018-99-119712

Published: 2018

Journal Articles

Targeting NAD + Modulating Enzymes to Improve HSC Function in Aging and Bone Marrow Failure

Phillip J Maciejewski, Yihong Guan, Metis Hasipek, PhD, Anand D. Tiwari, PhD, Dale Grabowski, BS, James G Phillips, PhD, Yogenthiran Saunthararajah, MD, Jaroslaw P. Maciejewski, Babal K. Jha

Blood (2018) 132 (Supplement 1): 3840.

https://doi.org/10.1182/blood-2018-99-119300

Published: 2018

Journal Articles

Small Molecular Modulators of Histone Demethylases Selectively Inhibits Growth of Hematopoietic Malignancies

Xin Xu, PhD, Wilhelm G Dirks, PhD, Hans G. Drexler, MD PhD, Zhenbo Hu, MD PhD

Blood (2018) 132 (Supplement 1): 3941.

https://doi.org/10.1182/blood-2018-99-112376

Published: 2018

Journal Articles

Transfusion of Soluble Target Antigens to Pre-Immunized Recipients: A Previously Overlooked Mechanism in Transfusion-Related Acute Lung Injury

Behnaz Bayat, PhD, Kaspar Nielsen, MD, Monika Burg-Roderfeld, PhD, Gregor Bein, MD PhD, Ulrich J Sachs, MD PhD

Blood (2018) 132 (Supplement 1): 524.

https://doi.org/10.1182/blood-2018-99-112505

Published: 2018

Journal Articles

HMGB1 Causes Anemia of Inflammation By Modulating Erythropoietin Signal Transduction

Brian M Dulmovits, MS, Julien Papoin, MS, Jian Hua Li, MS, Huan Yang, PhD, Ronak H Shah, MS, Ryo Kurita, PhD, Yukio Nakamura, MD PhD, Yousef Al-Abed, MD, Lily Huang, PhD, Betty Diamond, MD, Jeffrey M Lipton, MD PhD, Mohandas Narla, DSc, Ulf Andersson, MDPhD, Kevin Tracey, MD, Lionel Blanc, PhD

Blood (2018) 132 (Supplement 1): 628.

https://doi.org/10.1182/blood-2018-99-119553

Published: 2018

Journal Articles

Coagulation Factor XII Plays an Important Role in Procoagulant Activity of Apoptotic Cells

Aizhen Yang, Yi Wu, MD PhD

Blood (2018) 132 (Supplement 1): 2457.

https://doi.org/10.1182/blood-2018-99-118223

Published: 2018

Journal Articles

Assessment of Romiplostim Immunogenicity in Adult Patients in Clinical Trials and in a Global Registry

Troy E. Barger, BSc, Andy Boshier, MBChB, MSc, Vibha Jawa, PhD, June Kim, PhD, Daniel T. Mytych, PhD, Joseph Park, MD PhD, David J. Kuter, MD DPhil

Blood (2018) 132 (Supplement 1): 2427.

https://doi.org/10.1182/blood-2018-99-113484

Published: 2018

Journal Articles

Biochemical Characteristics of Emicizumab Activity with Factors IXa, X, and VIIa

Dougald Monroe, PhD, Maureane Hoffman, MD

Blood (2018) 132 (Supplement 1): 1167.

https://doi.org/10.1182/blood-2018-99-116888

Published: 2018

Journal Articles

Characterization of Interaction of Factor VIII with Engineered Variants of a Single-Chain Variable Antibody Fragment

Svetlana A Shestopal, PhD, Leonid A Parunov, PhD, Mikhail V Ovanesov, PhD, Timothy K Lee, PhD, Andrey G Sarafanov, PhD

Blood (2018) 132 (Supplement 1): 1170.

https://doi.org/10.1182/blood-2018-99-115455

Published: 2018

Journal Articles

Anti-Glycoprotein V Autoantibodies in Patients with Immune Thrombocytopenia: Regularly Detectable and Functionally Relevant

Richard Vollenberg, MD, Rabie Jouni, Peter A. A. Norris, BSc, Monika Burg-Roderfeld, PhD, Nina Cooper, MD, Mathias J Rummel, MD PhD, Gregor Bein, MD PhD, Irene Marini, Alan H Lazarus, PhD, Tamam Bakchoul, MD PhD, Ulrich J Sachs, MD PhD

Blood (2018) 132 (Supplement 1): 1141.

https://doi.org/10.1182/blood-2018-99-118090

Published: 2018

Journal Articles

Site-Directed Pegylation at Specific Sites Significantly Prolongs the Half-Life of A1A2A3-VWF By Markedly Attenuating LRP1-Mediated Clearance

Jamie M O'Sullivan, Judicael Fazavana, PhD, Alain Chan, PhD, Niamh Cooke, PhD, Virginie Terraube, Justin Cohen, PhD, Debra D Pittman, MS, Orla Cunningham, PhD, Matthew Lambert, James S O'Donnell, MD PhD

Blood (2018) 132 (Supplement 1): 1165.

https://doi.org/10.1182/blood-2018-99-114966

Published: 2018

Journal Articles

A Novel and Potent Inhibitor of E-Selectin, GMI-1687, Attenuates Thrombus Formation and Augments Chemotherapeutic Intervention of AML in Preclinical Models Following Subcutaneous Administration

John Peterson, PhD, Myung-Gi Baek, PhD, Silvia Locatelli-Hoops, PhD, Ji-Won Lee, PhD, Lingquan Deng, PhD, David A Stewart, Theodore AG Smith, PhD, Daniel Durant Myers, DVM, MPH, William E Fogler, PhD, John L Magnani, PhD

Blood (2018) 132 (Supplement 1): 4678.

https://doi.org/10.1182/blood-2018-99-116779

Published: 2018

Journal Articles

A Small Molecular Agonist of Histone Demethylase KDM3B Selectively Represses MLL -Rearranged Acute Leukemia

Xin Xu, PhD, Wilhelm G Dirks, PhD, Hans G. Drexler, MD PhD, Zhenbo Hu, MD PhD

Blood (2018) 132 (Supplement 1): 4682.

https://doi.org/10.1182/blood-2018-99-112018

Published: 2018

NARROW

Pharmacological Inhibition of the RNA m 6 a Writer METTL3 As a Novel Therapeutic Strategy for Acute Myeloid Leukemia

X-Ray Crystallographic and Single-Molecule Fluorescence Studies of Beta-2 Glycoprotein I Reveal an Alternative Mechanism of Autoantibody Recognition

Binding of Factor VIII to D'D3 and A2 Domains of Von Willebrand Factor Facilitates Mechanical Unraveling of the A2 Domain

A FULLY Human Bispecific Antibody Functionally Rescues Factor VIII Deficiency EX VIVO

CCS1477: A Novel Small Molecule Inhibitor of p300/CBP Bromodomain for the Treatment of Acute Myeloid Leukaemia and Multiple Myeloma

In Vitro and In Vivo Characterization of Marstacimab, an Anti-TFPI Antibody

Loxo-305, a Highly Selective and Non-Covalent Next Generation BTK Inhibitor, Inhibits Diverse BTK C481 Substitution Mutations

Modulation of TET2 Activity By Ascorbic Acid and Factors Affecting Lysine Acetylation

Targeting NAD + Modulating Enzymes to Improve HSC Function in Aging and Bone Marrow Failure

Small Molecular Modulators of Histone Demethylases Selectively Inhibits Growth of Hematopoietic Malignancies

Transfusion of Soluble Target Antigens to Pre-Immunized Recipients: A Previously Overlooked Mechanism in Transfusion-Related Acute Lung Injury

HMGB1 Causes Anemia of Inflammation By Modulating Erythropoietin Signal Transduction

Coagulation Factor XII Plays an Important Role in Procoagulant Activity of Apoptotic Cells

Assessment of Romiplostim Immunogenicity in Adult Patients in Clinical Trials and in a Global Registry

Biochemical Characteristics of Emicizumab Activity with Factors IXa, X, and VIIa

Characterization of Interaction of Factor VIII with Engineered Variants of a Single-Chain Variable Antibody Fragment

Anti-Glycoprotein V Autoantibodies in Patients with Immune Thrombocytopenia: Regularly Detectable and Functionally Relevant

Site-Directed Pegylation at Specific Sites Significantly Prolongs the Half-Life of A1A2A3-VWF By Markedly Attenuating LRP1-Mediated Clearance

A Novel and Potent Inhibitor of E-Selectin, GMI-1687, Attenuates Thrombus Formation and Augments Chemotherapeutic Intervention of AML in Preclinical Models Following Subcutaneous Administration

A Small Molecular Agonist of Histone Demethylase KDM3B Selectively Represses MLL -Rearranged Acute Leukemia

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American Society of Hematology

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ASH Publications

American Society of Hematology

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