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Journal Articles

Hotspot U2AF1 Mutations Determine Missplicing Selectivity: Novel Mechanisms Altering Splicing Factors

Vera Adema, PhD, Courtney E Hershberger, BS, Wencke Walter, PhD, Cassandra M Kerr, MS, Stephan Hutter, PhD, Yasunobu Nagata, MD PhD, Hassan Awada, Sunisa Kongkiatkamon, Christina Snider, Milo Co, Manja Meggendorfer, PhD, Aziz Nazha, MD, Hetty E. Carraway, MD MBA, Mikkael A. Sekeres, MD MS, Francesc Sole, PhD, Richard A Padgett, PhD, Torsten Haferlach, MD, Jaroslaw P. Maciejewski, MD PhD, Valeria Visconte, PhD

Blood (2019) 134 (Supplement_1): 2985.

https://doi.org/10.1182/blood-2019-129367

Published: 2019

Journal Articles

Casein Kinase 1 Delta Is a Novel Regulator of mRNA Translation and Druggable Target in Aggressive Lymphomas

Ipsita Pal, PhD, Sohani Das Sharma, PhD, Andre M. Grilo, PhD, Prabhjot S. Mundi, MD, Luigi Scotto, PhD, Abdullah Mahmood Ali, PhD, Luke E Berchowitz, PhD, Siddhartha Mukherjee, MD PhD, Owen O'Connor, MD PhD, Marko Jovanovic, PhD, Changchun Deng, MD PhD

Blood (2019) 134 (Supplement_1): 2864.

https://doi.org/10.1182/blood-2019-129528

Published: 2019

Journal Articles

FLT3-ITD Activates Cytoplasmic Drosha-Dependent Non-Canonical Mechanisms of Mir-155 Biogenesis in Acute Myeloid Leukemia

Le Xuan Truong Nguyen, PhD, Bin Zhang, PhD, Dinh Hoa Hoang, BS, Dandan Zhao, MD, Sergio Branciamore, Davide Maestrini, PhD, Yu-Lin SU, PhD, Sonia Rodriguez, PhD, Flavia Pichiorri, PhD, Steven Rosen, MD, Michael A. Caligiuri, MD, Stephen J. Forman, MD, Ling Li, PhD, Marcin Kortylewski, PhD, Russell Rockne, PhD, Ya-Huei Kuo, PhD, Nadia Carlesso, MD, Guido Marcucci, MD

Blood (2019) 134 (Supplement_1): 2722.

https://doi.org/10.1182/blood-2019-131871

Published: 2019

Journal Articles

The Inherited MDS Gene DDX41 Is Required for Ribosome Biogenesis and Cell Viability

Timothy M Chlon, PhD, Emily Stepanchick, Kwangmin Choi, PhD, Yi Zheng, PhD, Kathleen Hueneman, Ashley Davis, Daniel T. Starczynowski, PhD

Blood (2019) 134 (Supplement_1): 773.

https://doi.org/10.1182/blood-2019-127471

Published: 2019

Journal Articles

Targeting eIF4A Using MZ-735 Potently Induces Cell Death in Lymphoma Cells and Rapidly Represses mRNA Translation at the Global Level and in C-MYC and Other Oncogenes

Ipsita Pal, PhD, Yu Ri Kim, MD, Sohani Das Sharma, PhD, Prabhjot S. Mundi, MD, Andre M. Grilo, PhD, Luke E Berchowitz, PhD, Mingzhao Zhu, PhD, Hull G. Kenneth, PhD, Daniel Romo, PhD, Owen O'Connor, MD PhD, Marko Jovanovic, PhD, Changchun Deng, MD PhD

Blood (2019) 134 (Supplement_1): 4067.

https://doi.org/10.1182/blood-2019-131816

Published: 2019

Journal Articles

The Marine Natural Compound Elatol Is a Novel Protein Translation Inhibitor with Potent Activity Against Aggressive Non-Hodgkin Lymphomas

Tara Peters, BA, Joseph Tillotson, PhD, Sarah C Wilmore, BSc, Alison Yeomans, PhD, Graham Packham, PhD, Eli Chapman, PhD, Jonathan H. Schatz, MD, Lingxiao Li, PhD

Blood (2017) 130 (Supplement 1): 4112.

https://doi.org/10.1182/blood.V130.Suppl_1.4112.4112

Published: 2017

Journal Articles

Preclinical Evaluation of eFT226, a Novel, Potent and Selective eIF4A Inhibitor with Anti-Tumor Activity in B-Cell Malignancies

Blood (2017) 130 (Supplement 1): 1530.

https://doi.org/10.1182/blood.V130.Suppl_1.1530.1530

Published: 2017

Journal Articles

Nucleolin Controls Ribosome Biogenesis through Its RNA-Binding Properties

Julia Fremerey, PhD, Pavel Morozov, PhD, Cindy Meyer, PhD, Aitor Garzia, PhD, Marianna Teplova, PhD, Thomas Tuschl, PhD, Arndt Borkhardt, MD

Blood (2016) 128 (22): 5056.

https://doi.org/10.1182/blood.V128.22.5056.5056

Published: 2016

Journal Articles

TK216, a Novel, Small Molecule Inhibitor of the ETS-Family of Transcription Factors, Displays Anti-Tumor Activity in AML and DLBCL

Katayoun Jessen, PhD, Eric Moseley, PhD, Elaine Yee Lin Chung, PhD, Lauren Otuski, BS, Chiara Tarantelli, PhD, Eugenio Gaudio, PhD, James Breitmeyer, MD PhD, James Freddo, MD, Jeffrey Toretsky, MD, Francesco Bertoni, MD, Brian J Lannutti, PhD

Blood (2016) 128 (22): 4035.

https://doi.org/10.1182/blood.V128.22.4035.4035

Published: 2016

Journal Articles

Mutational Landscape of Aggressive Natural Killer Cell Leukemia and Drug Sensitivity Profiling Reveal Therapeutic Options in Natural Killer Cell Malignancies

Blood (2016) 128 (22): 2921.

https://doi.org/10.1182/blood.V128.22.2921.2921

Published: 2016

Journal Articles

Exome Sequencing of Aggressive Natural Killer Cell Leukemia and Drug Profiling Highlight Candidate Driver Pathways in Malignant Natural Killer Cells

Blood (2015) 126 (23): 700.

https://doi.org/10.1182/blood.V126.23.700.700

Published: 2015

Journal Articles

Prognostic Impact of Molecular Mutations in Acute Myeloid Leukemia (AML) and Myelodysplastic Syndromes (MDS) on Allogeneic Hematopoietic Cell Transplant (HCT) Outcomes: Adverse Impact of TET2 Mutations

Betty K. Hamilton, MD, Navneet S. Majhail, MD MS, Cassandra M Hirsch, Bartlomiej Przychodzen, MSc, Lisa A. Rybicki, MS, Marcos De Lima, MD, Matt Kalaycio, MD, Brian J. Bolwell, MD, Aaron T. Gerds, MD MS, Ronald Sobecks, MD, Rabi Hanna, MD, Mikkael A. Sekeres, MD MS, Jaroslaw P. Maciejewski, MD PhD

Blood (2015) 126 (23): 740.

https://doi.org/10.1182/blood.V126.23.740.740

Published: 2015

Journal Articles

Comprehensive Quantitative Proteomic Profiling of the Pharmacodynamic Changes Induced By MLN4924 in Acute Myeloid Leukemia Cells Reveals Rational Targets for Combination Therapy

Valeria Visconte, PhD, Steffan T. Nawrocki, PhD, Kevin R. Kelly, MD PhD, Yingchun Han, MD, Anthony Possemato, Sean Beausoleil, Aziz Nazha, MD, Jaroslaw P. Maciejewski, MD PhD, Hetty E. Carraway, MD MBA, Anjali S. Advani, MD, Mikkael A. Sekeres, MD MS, Jennifer S. Carew, PhD

Blood (2015) 126 (23): 1271.

https://doi.org/10.1182/blood.V126.23.1271.1271

Published: 2015

Journal Articles

Prognostic Impact of Molecular Mutations in AML at First Relapse

Anjali S. Advani, MD, Paul Elson, PhD, Valeria Visconte, PhD, Jennifer S. Carew, PhD, Jaime Fensterl, Bartlomiej Przychodzen, MSc, Mikkael A. Sekeres, MD MS, Cassandra M Hirsch, Alek Nielsen, John Desamito, Hetty E. Carraway, MD MBA, Aaron T. Gerds, MD MS, Betty K. Hamilton, MD, Sudipto Mukherjee, MD PhD, Ronald M. Sobecks, MD, Matt Kalaycio, MD, Yogen Saunthararajah, MD, Jaroslaw P. Maciejewski, MD PhD

Blood (2015) 126 (23): 3825.

https://doi.org/10.1182/blood.V126.23.3825.3825

Published: 2015

Journal Articles

Inhibiting CARD11 translation during BCR activation by targeting the eIF4A RNA helicase

Blood (2014) 124 (25): 3758–3767.

https://doi.org/10.1182/blood-2014-07-589689

Published: 2014

Includes: Supplemental data

Journal Articles

Somatic Mutational Landscape of AML with Inv(16) and t(8;21) Identifies Two Distinct Patterns in Relapse Tumors

Raman B. Sood, PhD, Nancy F Hansen, Frank X Donovan, Blake Carrington, Baishali Maskeri, Alice Young, Donna Bucci, Settara Chandrasekharaappa, James C Mullikin, Clara D. Bloomfield, MD, Guido Marcucci, MD, Paul Liu

Blood (2014) 124 (21): 2362.

https://doi.org/10.1182/blood.V124.21.2362.2362

Published: 2014

Journal Articles

DDX41 Is a Tumor Suppressor Gene Associated with Inherited and Acquired Mutations

Blood (2014) 124 (21): 125.

https://doi.org/10.1182/blood.V124.21.125.125

Published: 2014

Journal Articles

Exome Sequencing Identifies Somatic Mutations of DDX3X in Natural Killer/T-Cell Lymphoma

Blood (2014) 124 (21): 1663.

https://doi.org/10.1182/blood.V124.21.1663.1663

Published: 2014

Journal Articles

Altered Cellular Responses As Biomarkers for Fluoranthene Exposure to the Bone Marrow-Mesenchymal Stem Cells: Implications for Stem Cell-Based in Vitro Models That Help Determine the Associated Hematotoxicity

Hwan-Young Kim, Ji-Eun Noh, Hee-Jo Baek, MD PhD, Jae-Dong Moon, MD PhD, Jong-Hee Shin, MD PhD, Soon-Pal Suh, MD PhD, Hoon Kook, MD PhD, Dong-Wook Ryang, MD PhD, Myung-Geun Shin, MD PhD

Blood (2014) 124 (21): 5976.

https://doi.org/10.1182/blood.V124.21.5976.5976

Published: 2014

Journal Articles

PRPF8 Defects Cause Missplicing In Myeloid Malignancies

Amina Kurtovic Kozaric, PhD, Hideki Makishima, MD, PhD, Bartlomiej P Przychodzen, PhD, Jarnail Singh, PhD, Magda Maria Konarska, PhD, Zaher K. Otrock, MD, Megan Nakashima, PhD, Eric D. Hsi, MD, Kenichi Yoshida, MD, Seishi Ogawa, MD, PhD, Jaroslaw P. Maciejewski, MD, PhD

Blood (2013) 122 (21): 2838.

https://doi.org/10.1182/blood.V122.21.2838.2838

Published: 2013

NARROW

Hotspot U2AF1 Mutations Determine Missplicing Selectivity: Novel Mechanisms Altering Splicing Factors

Casein Kinase 1 Delta Is a Novel Regulator of mRNA Translation and Druggable Target in Aggressive Lymphomas

FLT3-ITD Activates Cytoplasmic Drosha-Dependent Non-Canonical Mechanisms of Mir-155 Biogenesis in Acute Myeloid Leukemia

The Inherited MDS Gene DDX41 Is Required for Ribosome Biogenesis and Cell Viability

Targeting eIF4A Using MZ-735 Potently Induces Cell Death in Lymphoma Cells and Rapidly Represses mRNA Translation at the Global Level and in C-MYC and Other Oncogenes

The Marine Natural Compound Elatol Is a Novel Protein Translation Inhibitor with Potent Activity Against Aggressive Non-Hodgkin Lymphomas

Preclinical Evaluation of eFT226, a Novel, Potent and Selective eIF4A Inhibitor with Anti-Tumor Activity in B-Cell Malignancies

Nucleolin Controls Ribosome Biogenesis through Its RNA-Binding Properties

TK216, a Novel, Small Molecule Inhibitor of the ETS-Family of Transcription Factors, Displays Anti-Tumor Activity in AML and DLBCL

Mutational Landscape of Aggressive Natural Killer Cell Leukemia and Drug Sensitivity Profiling Reveal Therapeutic Options in Natural Killer Cell Malignancies

Exome Sequencing of Aggressive Natural Killer Cell Leukemia and Drug Profiling Highlight Candidate Driver Pathways in Malignant Natural Killer Cells

Prognostic Impact of Molecular Mutations in Acute Myeloid Leukemia (AML) and Myelodysplastic Syndromes (MDS) on Allogeneic Hematopoietic Cell Transplant (HCT) Outcomes: Adverse Impact of TET2 Mutations

Comprehensive Quantitative Proteomic Profiling of the Pharmacodynamic Changes Induced By MLN4924 in Acute Myeloid Leukemia Cells Reveals Rational Targets for Combination Therapy

Prognostic Impact of Molecular Mutations in AML at First Relapse

Inhibiting CARD11 translation during BCR activation by targeting the eIF4A RNA helicase

Somatic Mutational Landscape of AML with Inv(16) and t(8;21) Identifies Two Distinct Patterns in Relapse Tumors

DDX41 Is a Tumor Suppressor Gene Associated with Inherited and Acquired Mutations

Exome Sequencing Identifies Somatic Mutations of DDX3X in Natural Killer/T-Cell Lymphoma

Altered Cellular Responses As Biomarkers for Fluoranthene Exposure to the Bone Marrow-Mesenchymal Stem Cells: Implications for Stem Cell-Based in Vitro Models That Help Determine the Associated Hematotoxicity

PRPF8 Defects Cause Missplicing In Myeloid Malignancies

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American Society of Hematology

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ASH Publications

American Society of Hematology

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