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Journal Articles

Improved Anti-Tumor Response of Chimeric Antigen Receptor T Cell (CART) Therapy after GM-CSF Inhibition Is Mechanistically Supported By a Novel Direct Interaction of GM-CSF with Activated Carts

Michelle J. Cox, Charles J. Kuhlmann, Rosalie M. Sterner, Reona Sakemura, MD PhD, Sutapa Sinha, PhD, Raphael Mwangi, MS, Nancy Scott, MS, Mehrdad Hefazi, MD, Omar Ahmed, Dale Chappell, Cameron Durrant, Claudia Manriquez Roman, Kendall J. Schick, Erin E. Tapper, Paulina Horvei, MD, Michael W. Ruff, MD, Sameer A. Parikh, MD, Neil E. Kay, MD, Saad S. Kenderian, MD

Blood (2019) 134 (Supplement_1): 3868.

https://doi.org/10.1182/blood-2019-129349

Published: 2019

Journal Articles

Modelling the Progression of a Preleukemic Stage to Overt Leukemia in Children with Down Syndrome

Blood (2018) 132 (Supplement 1): 543.

https://doi.org/10.1182/blood-2018-99-116661

Published: 2018

Journal Articles

Paraneoplastic Leukemoid Reaction Associated with Increased Levels of and Tumor Overexpression of Receptors for G-CSF, GM-CSF, and IL-6: A Clinico-Pathological-Molecular Study

Alejandro Recio Boiles, MD, Eric M. Lander, MD, George S. Watts, PhD, Steffan T. Nawrocki, PhD, Andrew M. Yeager, MD

Blood (2018) 132 (Supplement 1): 4945.

https://doi.org/10.1182/blood-2018-99-115736

Published: 2018

Journal Articles

Innovative Hematopoietic Gene-Therapy Concepts for Hereditary Pulmonary Alveolar Proteinosis Utilizing Hematopoietic Stem Cell Derived Macrophages

Nico Lachmann, PhD, Christine Happle, MD, Takuji Suzuki, MD, Miriam Hetzel, Kevin A. Link, PhD, Adele Mucci, Paritha Arumugam, PhD, Jens Bankstahl, PhD, Dagmar Dilloo, MD, Punam Malik, MD, Carolyn Lutzko, PhD, Axel Schambach, MD PhD, Bruce Colston Trapnell, MD, Gesine Hansen, MD, Thomas Moritz, MD

Blood (2015) 126 (23): 4417.

https://doi.org/10.1182/blood.V126.23.4417.4417

Published: 2015

Journal Articles

Mutations in CD58 and Other Immune System Related Genes in Hodgkin Lymphoma

Fazlyn Reeny Abdul Razak, Arjan Diepstra, MD PhD, Lydia Visser, PhD, Anke Van den Berg, PhD

Blood (2015) 126 (23): 1439.

https://doi.org/10.1182/blood.V126.23.1439.1439

Published: 2015

Journal Articles

A Novel, Oncogenic CSF2RB Mutation Found in a Primary Leukemia Sample Results in Constitutive Signaling, Increased Receptor Stability, and Formation of Intermolecular Complexes

Kevin M Watanabe-Smith, BS, Cristina E. Tognon, PhD, Jeffrey W. Tyner, PhD, Brian J. Druker, MD, Anupriya Agarwal, PhD

Blood (2015) 126 (23): 3670.

https://doi.org/10.1182/blood.V126.23.3670.3670

Published: 2015

Journal Articles

The GM-CSF Receptor Alpha Chain (CSF2RA) Functions As a Novel Ligand-Independent Tumor Suppressor in t(8;21) AML

Stephanie Weng, BS, Dong-Er Zhang, PhD

Blood (2015) 126 (23): 3589.

https://doi.org/10.1182/blood.V126.23.3589.3589

Published: 2015

Journal Articles

Regulation of Hematopoiesis by Cholesterol

Alan R. Tall, MD

Blood (2014) 124 (21): SCI-53.

https://doi.org/10.1182/blood.V124.21.SCI-53.SCI-53

Published: 2014

Journal Articles

RUNX1-ETO Expressing Hematopoietic Stem/Progenitor Cells (HSPCs) Display a Hypersensitivity To GM-CSF That Reduces Leukemogenic Potential

Stephanie Weng, BS, Shinobu Matsuura, DVM, PhD, Miao-Chia Lo, PhD, Kentson Lam, BA, Dan Ran, MD PhD, Dong-Er Zhang, PhD

Blood (2013) 122 (21): 1258.

https://doi.org/10.1182/blood.V122.21.1258.1258

Published: 2013

Journal Articles

STAT3-Activated GM-CSFRα Shuttles To The Nucleus and Protects CLL Cells From Apoptosis

Ping Li, PhD, Uri Rozovski, MD, David Harris, Lui Zhiming, Alessandra Ferrajoli, MD, Carlos E. Bueso-Ramos, MD, PhD, Inbal Hazan-Halevy, Srdana Grugurevic, William G. Wierda, MD, PhD, Jan A. Burger, MD, PhD, Susan O'Brien, MD, Stefan H. Faderl, MD, Michael J. Keating, MD, Zeev Estrov, MD

Blood (2013) 122 (21): 4118.

https://doi.org/10.1182/blood.V122.21.4118.4118

Published: 2013

Journal Articles

CD26 Truncation of GM-CSF and IL-3 Alters Their Functional Interactions

Heather A. O'Leary, PhD, Charlie Mantel, Scott Cooper, BS, Christina J Walker, BS, Hal E. Broxmeyer, Ph.D.

Blood (2012) 120 (21): 1240.

https://doi.org/10.1182/blood.V120.21.1240.1240

Published: 2012

Journal Articles

Anti-Myeloma Effects of the Janus Kinase 2 (JAK2) Inhibitor SAR503 Alone and in Combination Treatment

Haiming Chen, MD., Ph.D, Mingjie Li, Jennifer Li, Kevin Delijani, Danielle Rauch, Kevin DeCorso, Andrew Prajogi, Cathy S Wang, Eric Sanchez, Benjamin Bonavida, Ph.D, James R. Berenson, MD

Blood (2012) 120 (21): 4986.

https://doi.org/10.1182/blood.V120.21.4986.4986

Published: 2012

Journal Articles

Batf3 -Dependent CD11b low/− Peripheral Dendritic Cells Are GM-CSF-Independent and Are Not Required for Th Cell Priming After Subcutaneous Immunization

Brian T. Edelson, MD, PhD, Kenneth M. Murphy, MD, PhD

Blood (2011) 118 (21): 1113.

https://doi.org/10.1182/blood.V118.21.1113.1113

Published: 2011

Journal Articles

Inhibition of STAT5 Phosphorylation by Anti-GM-CSF Monoclonal Antibodies: Validation of a New Whole Blood Assay

Karine Grivel, MSc, Laurent Magnenat, PhD, Maxime Moulard, PhD

Blood (2011) 118 (21): 4728.

https://doi.org/10.1182/blood.V118.21.4728.4728

Published: 2011

Journal Articles

Stress Response Gadd45a Gene Functions as Tumor Suppressor In MYC Expressing Myeloid Cells Modulating Apoptosis and Cytokine Receptor Expression.

Alisha A Mohamed-Hadley, B.S, Dan Liebermann

Blood (2010) 116 (21): 1556.

https://doi.org/10.1182/blood.V116.21.1556.1556

Published: 2010

Journal Articles

Endogenous Oncogenic Nras Mutation Leads to Aberrant GM-CSF Signaling In Granulocytic/Monocytic Precursors In a Murine Model of Chronic Myelomonocytic Leukemia

Jinyong Wang, PhD, Yangang Liu, PhD, Zeyang Li, PhD, Juan Du, PhD, Myung-Jeom Ryu, PhD, Philip Taylor, Mark D. Fleming, MD, DPhil, Ken H Young, PhD, Henry Pitot, PhD, Jing Zhang, PhD

Blood (2010) 116 (21): 4180.

https://doi.org/10.1182/blood.V116.21.4180.4180

Published: 2010

Journal Articles

Alternative modes of GM-CSF receptor activation revealed using activated mutants of the common β-subunit

Michelle Perugini, Anna L. Brown, Diana G. Salerno, Grant W. Booker, Cvetan Stojkoski, Timothy R. Hercus, Angel F. Lopez, Margaret L. Hibbs, Thomas J. Gonda, Richard J. D'Andrea

Blood (2010) 115 (16): 3346–3353.

https://doi.org/10.1182/blood-2009-08-235846

Published: 2010

Includes: Supplemental data

Journal Articles

PI3 Kinase, Phospholipase C (PLC)-γ, and RasGRPs Act Cooperatively to Activate the Ras-Extracellular-Related Kinase (ERK) Pathway in Response to Cytokines in Normal and Kras Mutant Myeloid Cells.

Ernesto Diaz-Flores, PhD, Hana Leah Goldschmidt, BA, Philippe Depeille, Ph.D, Victor Ng, BA, Jeroen Roose, Assistant, Professor, Kevan Shokat, Ph.D., Benjamin S. Braun, MD, PhD, Kevin Shannon, MD

Blood (2009) 114 (22): 2512.

https://doi.org/10.1182/blood.V114.22.2512.2512

Published: 2009

Journal Articles

Soluble GM-CSF Receptor α Is Cytotoxic to Myeloid Cells in a Manner That Is Independent of GM-CSF Binding Inhibition.

Jeffrey R Gardner, BS, MBA, Mark Lawrence Heaney, MD, PhD, Linghao Niu, PhD

Blood (2009) 114 (22): 3618.

https://doi.org/10.1182/blood.V114.22.3618.3618

Published: 2009

Journal Articles

CREB Deficiency: A Potential Critical Factor for Selective GM-CSF Hypersensitivity in Juvenile Myelomonocytic Leukemia.

Y. Lucy Liu, MD, PhD, Priyangi A Malaviarachchi, BS, Shelly Y. Lensing, MS, Robert P. Castleberry, MD, Peter Dean Emanuel, MD

Blood (2009) 114 (22): 2604.

https://doi.org/10.1182/blood.V114.22.2604.2604

Published: 2009

NARROW

Improved Anti-Tumor Response of Chimeric Antigen Receptor T Cell (CART) Therapy after GM-CSF Inhibition Is Mechanistically Supported By a Novel Direct Interaction of GM-CSF with Activated Carts

Modelling the Progression of a Preleukemic Stage to Overt Leukemia in Children with Down Syndrome

Paraneoplastic Leukemoid Reaction Associated with Increased Levels of and Tumor Overexpression of Receptors for G-CSF, GM-CSF, and IL-6: A Clinico-Pathological-Molecular Study

Innovative Hematopoietic Gene-Therapy Concepts for Hereditary Pulmonary Alveolar Proteinosis Utilizing Hematopoietic Stem Cell Derived Macrophages

Mutations in CD58 and Other Immune System Related Genes in Hodgkin Lymphoma

A Novel, Oncogenic CSF2RB Mutation Found in a Primary Leukemia Sample Results in Constitutive Signaling, Increased Receptor Stability, and Formation of Intermolecular Complexes

The GM-CSF Receptor Alpha Chain (CSF2RA) Functions As a Novel Ligand-Independent Tumor Suppressor in t(8;21) AML

Regulation of Hematopoiesis by Cholesterol

RUNX1-ETO Expressing Hematopoietic Stem/Progenitor Cells (HSPCs) Display a Hypersensitivity To GM-CSF That Reduces Leukemogenic Potential

STAT3-Activated GM-CSFRα Shuttles To The Nucleus and Protects CLL Cells From Apoptosis

CD26 Truncation of GM-CSF and IL-3 Alters Their Functional Interactions

Anti-Myeloma Effects of the Janus Kinase 2 (JAK2) Inhibitor SAR503 Alone and in Combination Treatment

Batf3 -Dependent CD11b low/− Peripheral Dendritic Cells Are GM-CSF-Independent and Are Not Required for Th Cell Priming After Subcutaneous Immunization

Inhibition of STAT5 Phosphorylation by Anti-GM-CSF Monoclonal Antibodies: Validation of a New Whole Blood Assay

Stress Response Gadd45a Gene Functions as Tumor Suppressor In MYC Expressing Myeloid Cells Modulating Apoptosis and Cytokine Receptor Expression.

Endogenous Oncogenic Nras Mutation Leads to Aberrant GM-CSF Signaling In Granulocytic/Monocytic Precursors In a Murine Model of Chronic Myelomonocytic Leukemia

Alternative modes of GM-CSF receptor activation revealed using activated mutants of the common β-subunit

PI3 Kinase, Phospholipase C (PLC)-γ, and RasGRPs Act Cooperatively to Activate the Ras-Extracellular-Related Kinase (ERK) Pathway in Response to Cytokines in Normal and Kras Mutant Myeloid Cells.

Soluble GM-CSF Receptor α Is Cytotoxic to Myeloid Cells in a Manner That Is Independent of GM-CSF Binding Inhibition.

CREB Deficiency: A Potential Critical Factor for Selective GM-CSF Hypersensitivity in Juvenile Myelomonocytic Leukemia.

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American Society of Hematology

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American Society of Hematology

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